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Results for “setting”
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Search for B s 0 → μ + μ − and B 0 → μ + μ − decays with the full CDF Run II data set
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Top-quark mass measurement in events with jets and missing transverse energy using the full CDF data set
Abstract Not Provided
Novel all-orders single-scale approach to QCD renormalization scale-setting
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Analysis of multicrystal pump-probe data sets. II. Scaling of ratio data sets
Abstract not provided
Polarimetric Synthetic-Aperture-Radar Change-Type Classification with a Hyperparameter-Free Open-Set Classifier.
Abstract not provided.
Parallel, Portable Algorithms for Distance-2 Maximal Independent Set and Graph Coarsening.
Abstract not provided.
Level-set multilayer growth model for predicting printability of buried native extreme ultraviolet mask defects
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Hierarchical material property representation in finite element analysis: Convergence behavior and the response of vertical fracture sets.
Abstract not provided.
Fuzzy sets, rough sets, and modeling evidence: Theory and Application. A Dempster-Shafer based approach to compromise decision making with multiattributes applied to product selection
The Dempster-Shafer theory of evidence is applied to a multiattribute decision making problem whereby the decision maker (DM) must compromise with available alternatives, none of which exactly satisfies his ideal. The decision mechanism is constrained by the uncertainty inherent in the determination of the relative importance of each attribute element and the classification of existing alternatives. The classification of alternatives is addressed through expert evaluation of the degree to which each element is contained in each available alternative. The relative importance of each attribute element is determined through pairwise comparisons of the elements by the decision maker and implementation of a ratio scale quantification method. Then the 'belief' and 'plausibility' that an alternative will satisfy the decision maker's ideal are calculated and combined to rank order the available alternatives. Application to the problem of selecting computer software is given.
A Globally Averaged Thermospheric Density Data Set Derived From Two‐Line Orbital Element Sets and Special Perturbations State Vectors
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A Method to Expand Sparse Set Acceleration Data to Full Set Strain Data.
Abstract not provided.
Strength and Cost Analysis of New Steel Sets as Roadway Support Project in Coal Mines
Roadway support in swelling soft rocks in coal mines has become a critical challenge in recent years. For deformation control in swelling soft rocks, high strength sets are preferred in sites. But high strength always means high costs. Therefore, higher strength sets with not too much cost will be more welcomed in situ. Based on this, three new sets, including a floor beam set, a roof + floor beams set, and a roof + floor beams + braces set, have been developed in the present research. Strength comparisons and costs comparisons have been conducted in this research. Results illustrate that compared with the original set, in the floor beam set, the relative strength of bottom corners reaches 2.964, while the relative cost reaches 1.294; compared with the original set, in the roof + floor beams set, the relative strength of the top arch reaches 2.345, while the relative strength of bottom corners reaches 2.964, and the relative cost reaches 1.568; and compared with the original set, in the roof + floor beams + braces set, the relative strength of the top arch reaches 2.635, and the relative strength of bottom corners reaches 5.905, but the relative cost reaches 1.930. Floor beam set and roof + floor beams set illustrate higher strength and not too higher costs than the original set. Although the roof + floor beams + braces set exhibit much higher strength, they also demonstrate much higher costs than the original set. These new sets can be chosen according to different geological conditions in situ.
Accumulated SET protein up-regulates and interacts with hnRNPK, increasing its binding to nucleic acids, the Bcl-xS repression, and cellular proliferation
Highlights: • hnRNPK is a new target of SET. • SET regulates hnRNPK. • SET and hnRNPK accumulation promotes tumorigenesis. • SET accumulation is a potential model to study genes regulated by SET-hnRNPK. - Abstract: SET and hnRNPK are proteins involved in gene expression and regulation of cellular signaling. We previously demonstrated that SET accumulates in head and neck squamous cell carcinoma (HNSCC); hnRNPK is a prognostic marker in cancer. Here, we postulate that SET and hnRNPK proteins interact to promote tumorigenesis. We performed studies in HEK293 and HNSCC (HN6, HN12, and HN13) cell lines with SET/hnRNPK overexpression and knockdown, respectively. We found that SET and/or hnRNPK protein accumulation increased cellular proliferation. SET accumulation up-regulated hnRNPK mRNA and total/phosphorylated protein, promoted hnRNPK nuclear location, and reduced Bcl-x mRNA levels. SET protein directly interacted with hnRNPK, increasing both its binding to nucleic acids and Bcl-xS repression. We propose that hnRNPK should be a new target of SET and that SET–hnRNPK interaction, in turn, has potential implications in cell survival and malignant transformation.
Stable SET knockdown in breast cell carcinoma inhibits cell migration and invasion
Highlights: • We employed RNA interference to knockdown SET expression in breast cancer cells. • Knockdown of SET expression inhibits cell proliferation, migration and invasion. • Knockdown of SET expression increases the activity and expression of PP2A. • Knockdown of SET expression decreases the expression of MMP-9. - Abstract: Breast cancer is the most malignant tumor for women, however, the mechanisms underlying this devastating disease remain unclear. SET is an endogenous inhibitor of protein phosphatase 2A (PP2A) and involved in many physiological and pathological processes. SET could promote the occurrence of tumor through inhibiting PP2A. In this study, we explore the role of SET in the migration and invasion of breast cancer cells MDA-MB-231 and ZR-75-30. The stable suppression of SET expression through lentivirus-mediated RNA interference (RNAi) was shown to inhibit the growth, migration and invasion of breast cancer cells. Knockdown of SET increases the activity and expression of PP2Ac and decrease the expression of matrix metalloproteinase 9 (MMP-9). These data demonstrate that SET may be involved in the pathogenic processes of breast cancer, indicating that SET can serve as a potential therapeutic target for the treatment of breast cancer.