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Search indexed NASA NTRS and DOE OSTI research on propulsion, heat transfer, battery materials and energy systems. Follow report and document links to the original sources.

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At least 91 records · Page 5
All sourcesNASA NTRSDOE OSTI
NASA NTRS2003

Cell separation using electric fields

The present invention involves methods and devices which enable discrete objects having a conducting inner core, surrounded by a dielectric membrane to be selectively inactivated by electric fields via irreversible breakdown of their dielectric membrane. One important application of the invention is in the selection, purification, and/or purging of desired or undesired biological cells from cell suspensions. According to the invention, electric fields can be utilized to selectively inactivate and render non-viable particular subpopulations of cells in a suspension, while not adversely affecting other desired subpopulations. According to the inventive methods, the cells can be selected on the basis of intrinsic or induced differences in a characteristic electroporation threshold, which can depend, for example, on a difference in cell size and/or critical dielectric membrane breakdown voltage. The invention enables effective cell separation without the need to employ undesirable exogenous agents, such as toxins or antibodies. The inventive method also enables relatively rapid cell separation involving a relatively low degree of trauma or modification to the selected, desired cells. The inventive method has a variety of potential applications in clinical medicine, research, etc., with two of the more important foreseeable applications being stem cell enrichment/isolation, and cancer cell purging.

Mangano, Joseph A.↗
NASA NTRS2009

Cell separation using electric fields

The present invention involves methods and devices which enable discrete objects having a conducting inner core, surrounded by a dielectric membrane to be selectively inactivated by electric fields via irreversible breakdown of their dielectric membrane. One important application of the invention is in the selection, purification, and/or purging of desired or undesired biological cells from cell suspensions. According to the invention, electric fields can be utilized to selectively inactivate and render non-viable particular subpopulations of cells in a suspension, while not adversely affecting other desired subpopulations. According to the inventive methods, the cells can be selected on the basis of intrinsic or induced differences in a characteristic electroporation threshold, which can depend, for example, on a difference in cell size and/or critical dielectric membrane breakdown voltage. The invention enables effective cell separation without the need to employ undesirable exogenous agents, such as toxins or antibodies. The inventive method also enables relatively rapid cell separation involving a relatively low degree of trauma or modification to the selected, desired cells. The inventive method has a variety of potential applications in clinical medicine, research, etc., with two of the more important foreseeable applications being stem cell enrichment/isolation, and cancer cell purging.

Mangano, Joseph↗
NASA NTRS1978

A method for localizing wing flow separation at stall to alleviate spin entry tendencies

A wing leading-edge modification has been developed, applicable at present to single-engine light aircraft, which produces stabilizing vortices at stall and beyond. These vortices have the effect of fixing the stall pattern of the wing such that the various portions of the wing upper surface stall nearly symmetrically. The lift coefficient produced is essentially constant to very high angles of attack above the stall angle of the unmodified wing. It is hypothesized that these characteristics will help prevent inadvertent spin entry after a stall. Results are presented from recent large-scale wind-tunnel tests of a complete light aircraft, both with and without the modification.

Feistel, T. W.↗
NASA NTRSDate not supplied

Aeroacoustic Study of a Subscale Large Civil Transport (STAR) Model – Part 1: Simulations

Results from a computational aeroacoustic study of the Subsonic Transport Aeroacoustic Research (STAR) model are presented. The model, a 26%-scale semispan Boeing 777-200 aircraft, was an inceptive configuration in a comprehensive simulation campaign to accurately predict the airframe noise of a full-scale, large civil transport during landing. The lengthy process of obtaining a high-fidelity, CFD-ready, vetted, digital representation of the model is described in detail. The simulations were performed with the STAR model installed in the NASA Ames 40- by 80-foot full-scale wind tunnel to enable direct comparisons with aerodynamic and acoustic measurements of the model, presented separately in Part 2 of the study. Two versions of the wind tunnel test section were considered. The entire test section was used to simulate the aerodynamic behavior of the model; an open-wall representation of the section was adopted during the acoustic simulations to eliminate wall reflections. To preserve the aerodynamic equivalency of the model for the two simulated tunnel configurations, the open-wall computations were executed at an angle-of-attack one degree higher than that of the corresponding closed-wall tunnel. The effect on aerodynamic behavior of several minor geometry alterations necessary to con-form the simulated to the tested model was assessed – the modifications considerably altered the strength and extent of a flow separation zone on the inboard segment of the flap. Also evaluated was the impact of spatial resolution on aerodynamic and acoustic characteristics of the model – in general, medium resolution was sufficient to establish convergence trends for averaged surface pressure behavior and proper localization of noise sources. After the aeroacoustic characteristics of the baseline configuration were predicted, a toboggan-shaped fairing designed to reduce main landing gear noise was evaluated computationally. Far-field noise spectra for the baseline and toboggan-equipped STAR model were calculated via a Ffowcs-Williams and Hawkings integral approach, with flow quantities on a permeable data surface enclosing the source regions used as input. Results from the simulations indicated that, while the fairing reduced gear noise in the near-field, it had a negligible effect on the far-field noise signature of the model. This trend agreed with previously published experimental results obtained during sub-scale, isolated gear tests and full-scale flight tests

airframe noise↗
NASA NTRS1999

Enhanced protein electrophoresis technique for separating human skeletal muscle myosin heavy chain isoforms

Talmadge and Roy (J. Appl. Physiol. 1993, 75, 2337-2340) previously established a sodium dodecyl sulfate - polyacrylamide gel electrophoresis (SDS-PAGE) protocol for separating all four rat skeletal muscle myosin heavy chain (MHC) isoforms (MHC I, IIa, IIx, IIb); however, when applied to human muscle, the type II MHC isoforms (Ila, IIx) are not clearly distinguished. In this brief paper we describe a modification of the SDS-PAGE protocol which yields distinct and consistent separation of all three adult human MHC isoforms (MHC I, IIa, IIx) in a minigel system. MHC specificity of each band was confirmed by Western blot using three monoclonal IgG antibodies (mAbs) immunoreactive against MHCI (mAb MHCs, Novacastra Laboratories), MHCI+IIa (mAb BF-35), and MHCIIa+IIx (mAb SC-71). Results provide a valuable SDS-PAGE minigel technique for separating MHC isoforms in human muscle without the difficult task of casting gradient gels.

NASA Center JSC↗
NASA NTRS1976

Absorption cell - A modified multiple-traversal device

A modified White-type multiple-transversal absorption cell used with a 5-m Littrow spectrometer is described. It can be introduced at a focus of the radiation beam without altering the beam configuration. The conventional White cell consists of three mirrors of equal focal length, with a distance of two focal lengths separating one of the mirrors from a mirror pair. The modification in the design consists of the addition of two mirrors at a slant placed behind the solitary mirror of the conventional configuration. The mirror arrangement reproduces the configuration of the exit beam for any number of transversals of the cell.

Jennings, D. E.↗
NASA NTRS1977

Improvements and validation of the erythropoiesis control model for bed rest simulation

The most significant improvement in the model is the explicit formulation of separate elements representing erythropoietin production and red cell production. Other modifications include bone marrow time-delays, capability to shift oxyhemoglobin affinity and an algorithm for entering experimental data as time-varying driving functions. An area of model development is suggested by applying the model to simulating onset, diagnosis and treatment of a hematologic disorder. Recommendations for further improvements in the model and suggestions for experimental application are also discussed. A detailed analysis of the hematologic response to bed rest including simulation of the recent Baylor Medical College bed rest studies is also presented.

Leonard, J. I.↗
NASA NTRS1990

Experimental determination of convective heat transfer coefficients in the separated flow region of the Space Shuttle Solid Rocket Motor

A series of cold flow heat transfer tests was conducted with a 7.5-percent scale model of the Space Shuttle Rocket Motor (SRM) to measure the heat transfer coefficients in the separated flow region around the nose of the submerged nozzle. Modifications were made to an existing 7.5 percent scale model of the internal geometry of the aft end of the SRM, including the gimballed nozzle in order to accomplish the measurements. The model nozzle nose was fitted with a stainless steel shell with numerous thermocouples welded to the backside of the thin wall. A transient 'thin skin' experimental technique was used to measure the local heat transfer coefficients. The effects of Reynolds number, nozzle gimbal angle, and model location were correlated with a Stanton number versus Reynolds number correlation which may be used to determine the convective heating rates for the full scale Space Shuttle Solid Rocket Motor nozzle.

Whitesides, R. Harold↗
NASA NTRS1991

Global Expression for Representing Diatomic Potential-Energy Curves

A three-parameter expression that gives an accurate fit to diatomic potential curves over the entire range of separation for charge transfers between 0 and 1. It is based on a generalization of the universal binding-energy relation of Smith et al. (1989) with a modification that describes the crossover from a partially ionic state to the neutral state at large separations. The expression is tested by comparison with first-principles calculations of the potential curves ranging from covalently bonded to ionically bonded. The expression is also used to calculate spectroscopic constants form a curve fit to the first-principles curves. A comparison is made with experimental values of the spectroscopic constants.

Ferrante, John↗
NASA NTRS1992

A fast, uncoupled, compressible, two-dimensional, unsteady boundary layer algorithm with separation for engine inlets

A finite difference boundary layer algorithm was developed to model viscous effects when an inviscid core flow solution is given. This algorithm solved each boundary layer equation separately, then iterated to find a solution. Solving the boundary layer equations sequentially was 2.4 to 4.0 times faster than solving the boundary layer equations simultaneously. This algorithm used a modified Baldwin-Lomax turbulence model, a weighted average of forward and backward differencing of the pressure gradient, and a backward sweep of the pressure. With these modifications, the boundary layer algorithm was able to model flows with and without separation. The number of grid points used in the boundary layer algorithm affected the stability of the algorithm as well as the accuracy of the predictions of friction coefficients and momentum thicknesses. Results of this boundary layer algorithm compared well with experimental observations of friction coefficients and momentum thicknesses. In addition, when used interactively with an inviscid flow algorithm, this boundary layer algorithm corrected for viscous effects to give a good match with experimental observations for pressures in a supersonic inlet.

Roach, Robert L.↗
NASA NTRS1992

A fast, uncoupled, compressible, two-dimensional, unsteady boundary layer algorithm with separation for engine inlets

A finite difference boundary layer algorithm was developed to model viscous effects when an inviscid core flow solution is given. This algorithm solved each boundary layer equation separately, then iterated to find a solution. Solving the boundary layer equations sequentially was 2.4 to 4.0 times faster than solving the boundary layer equations simultaneously. This algorithm used a modified Baldwin-Lomax turbulence model, a weighted average of forward and backward differencing of the pressure gradient, and a backward sweep of the pressure. With these modifications, the boundary layer algorithm was able to model flows with and without separation. The number of grid points used in the boundary layer algorithm affected the stability of the algorithm affected the stability of the algorithm as well as the accuracy of the predictions of friction coefficients and momentum thicknesses. Results of this boundary layer algorithm compared well with experimental observations of friction coefficients and momentum thicknesses. In addition, when used interactively with an inviscid flow algorithm, this boundary layer algorithm corrected for viscous effects to give a good match with experimental observations for pressures in a supersonic inlet.

Roach, Robert L.↗
DOE OSTI2025

Engineering surface charges of nanofiltration membranes to maximize Li + /Mg 2+ separation properties

Polyamide-based nanofiltration (NF) membranes are attractive for Li + /Mg 2+ separation for lithium recovery from salt brine (containing mainly Mg 2+ ). However, Li + and Mg 2+ have similar hydration radii, resulting in a low separation factor (SF Li/Mg ). Herein, we demonstrate that SF Li/Mg can be significantly enhanced by optimizing the membrane surface positive charges. This results in an unexpected maximum SF Li/Mg at a solution pH slightly below its isoelectric point (IEP). Specifically, NF270 membrane was surface-grafted with 2-(methacryloyloxy)ethyltrimethylammonium chloride (META) or polyethylenimine (PEI) using bio-adhesive dopamine, forming a thin, stable, charged layer (20–40 nm) on the surface. The effects of solution pH and surface modification on the surface zeta potential (ZP) and single- and mixed-salt Li + /Mg 2+ separation properties are thoroughly investigated. For example, the META grafting increases the ZP from 9.2 to 16 mV and SF Li/Mg by 130 % from 35 to 80 at pH 4, superior to the state-of-the-art commercial NF membranes. Furthermore, this surface modification occurs at ≈22 °C in aqueous solutions and can be utilized to enhance commercial modules for practical applications.

Li+/Mg2+ separation↗
DOE OSTI2024

Titanium-Cerium Electrode-Decoupled Redox Flow Batteries Integrated With Fossil Fuel Assets For Load-Following, Long-Duration Energy Storage

Operation of fossil plants at partial capacity with frequent cycling results in decreased efficiency, increased emissions and increased wear and maintenance. The objective of this project is to advance the integration of a titanium-cerium electrode-decoupled redox flow battery (RFB) system with conventional fossil-fueled power plants through technical and economic system-level studies and component scale-up and R&D. The Ti-Ce chemistry has a pathway to meet the DOE cost targets of $\$$100/kWh and $\$$0.05/kWh-cycle owing to the use of low-cost, earth abundant elemental actives and incorporation of inexpensive carbon felt electrodes and non-fluorinated anion exchange membrane (AEM) separators. The initial unit cell design was scaled up, with some modifications made to improve ease of manufacturing, from 25 cm 2 cell area to 400 cm 2 . Electrochemical tests demonstrated operation at a current density up to 50 mA/cm 2 , which is on par with other commercial RFB offerings. Furthermore, the Ti-Ce technology developed by WashU was evaluated and tested by industrial team partner, Giner, Inc., in their modular 3-cell stack. Several cell design modifications and alternate component material selections were successfully implemented to accommodate this chemistry while reducing polarization and leakage. Results from stack testing show high columbic efficiency and indicate that further optimization of cell compression and components will lead to successful operation of the Ti-Ce ED-RFB over longer duration at the multi-cell stack level. Engineering and cost analysis showed that an RFB system with power output on the order of 100 MW and with a charge/discharge duration of approx. 12 hours is the most cost effective for integration with fossil plants. At this scale, projected cycling of fossil fuel power plants can be significantly reduced. The use of a storage system is shown to reduce the fossil plant standalone cost of electricity by $\$$7/MWh, through increased capacity factor and improved average efficiency, in the scenario of high penetration of renewable power.

20 FOSSIL-FUELED POWER PLANTS↗
DOE OSTI2026

Solvari SR, Simplifying Residential Solar to 1 SKU, with Extended Testing

Accelerated weathering and material compatibility testing for polymeric and asphaltic materials. NLR will be testing the durability of the polymeric materials proposed for use in the supporting structures designed by TESCI solar. This will include the bare materials and coupons attached to asphalt shingles. The exposure will be in damp heat and separately heat, humidity and UV light, all followed by mechanical evaluation. Modification 1 is an extension of the first round of testing with both a continuation of some of the same testing and addition of new testing methods and materials. The testing of materials in the condition of A3 looking at mechanical durability will be continued looking at the materials used in the mounting brackets. We will be adding in testing of the silicone adhesive to the module and of the module itself. For the mounting brackets, testing will also be conducted at multiple temperatures and humidity levels to allow for extrapolation to the field.

14 SOLAR ENERGY↗
NASA NTRS1972

Theoretical prediction of interference loading on aircraft stores. Part 3: Programmer's manual

A FORTRAN program is described for predicting interference loading on aircraft stores. An analysis of the program is presented from a programmer's point of view, including program organization, subroutine explanations, and FORTRAN variable definitions. This information is intended for use in any program modification, extension, or troubleshooting efforts. This manual is supplementary to the separately documented program theory and user information.

Danfernandes, F.↗
NASA NTRS1981

Limiting current in electron-beam welders

Damage to workpiece by excessive current in electron-beam welder is prevented by mechanism that accurately adjusts anode-to-cathode spacing. Mechanism is installed on standard Sciaky (or equivalent) electron-beam gun with only minimal modification. By turning knurled knob and observing digital readout of anode/cathode separation, machine operator adjusts welder for safe maximum current before welding begins.

Spiegel, K. W.↗
NASA NTRS1991

An algebraic RNG-based turbulence model for three-dimensional turbomachinery flows

An algebraic eddy viscosity turbulence model based on Renormalization Group (RNG) theory for complex three-dimensional turbomachinery flows is presented. Modifications are made to the baseline RNG model for wakes and separated flows. The model has several advantages over popular algebraic models most notably its lack of empirically determined coefficients. The model is used to compute the mean flow in a low speed axial compressor rotor. The agreement with blade boundary layer and radial flow experimental data is very good and shows improvement over the Baldwin-Lomax model. The development of the tip leakage vortex is also well predicted. The computed wake decay also compares favorably with recent experimental data.

Kirtley, K. R.↗