The Lack of a QBO‐MJO Connection in Climate Models With a Nudged Stratosphere
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Zane K. Martin↗
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Lack of effects of astemizole on vestibular ocular reflex, motion sickness, and cognitive performance in man
Astemizole was orally administered to 20 subjects in a randomized, double-blind design to assess the efficacy of this peripherally active antihistamine as an antimotion sickness drug possessing no central side-effects. Measures of vestibular ocular reflex (VOR) were made to evaluate the agent as a selective vestibular depressant. Following one week of orally administered astemizole (30 mg daily), a Staircase Profile Test, a VOR test, and a variety of tests of cognitive performance were administered. These tests revealed no statistically significant effects of astemizole. This leads to the conclusion that, although the drug probably reaches the peripheral vestibular apparatus in man by crossing the blood-vestibular barrier, a selective peripheral antihistamine (H1) action is inadequate to control motion sickness induced through cross-coupled accelerative semicircular canal stimulation in a rotating chair.
Kohl, Randall L.↗
Lack of effect of vasopressin replacement on renin hypersecretion in Brattleboro rats
The congenital vasopressin deficiency in homozygous Brattleboro rats with diabetes insipidus is associated with elevated plasma renin activity at rest and supernormal responses to stimuli that increase renin secretion. The mechanism underlying this phenomenon was investigated by infusing homozygous and heterozygous Brattleboro rats with a dose of arginine vasopressin that restored plasma vasopressin to normal in the homozygous animals. The resulting data indicate that increased renin secretion in homozygous rats results from increased sympathetic activity. Because circulating vasopressin does not cross the blood-brain barrier, it seems likely that the increased sympathetic activity is central in origin.
Golin, Raffaello M. A.↗
On the lack of a magnetic signature of Triton's magnetospheric interaction on the Voyager 2 flyby trajectory
There is strong, albeit indirect, evidence for a sub-Alfvenic and transonic interaction between Triton and the Neptunian magnetosphere. A new inspection of magnetic field data around Triton encounter shows no evidence for the interaction. It is shown that this is due to the geometry of Triton's Alfvenic wings, which were probably too far from the spacecraft during the encounter. The situation is complicated by finite ion gyroradius effects, which tend to smear out the simple Alfven wings such as encountered at Io.
Neubauer, F. M.↗
Lack of Evidence for Prenucleation Aggregate Formation in Lysozyme Crystal Growth Solutions
There have been numerous claims of large concentrations of prenucleation aggregates in supersaturated as well as undersaturated lysozyme solutions at high salt concentrations. The presence of these aggregates was derived from measurements of the light or neutron scattering intensity, ultracentrifugation and dialysis behavior, as well as over-simplified crystal growth kinetics considerations. In all these interpretations it has been assumed that lysozyme solutions are either ideal or that protein interactions are independent of salt concentration. Contrary to these presumptions, our static and dynamic light scattering experiments provide evidence that lysozyme forms highly non-ideal, strongly interacting solutions. At low salt concentrations, the scattering intensities fall well below the values expected for an ideal, monomeric solution at the same protein concentration, while diffusivities increase with increasing protein concentration. Upon increase in salt concentration, these trends are eventually reversed. This enhancement in scattering intensity and decrease in diffusivity was widely interpreted as sign of aggregate formation. Yet, a quantitative interpretation of the scattering behavior over the whole salt concentration range can only be given in terms of a transition from net repulsion to net attraction between lysozyme monomers. Increased salt screening of the electrostatic repulsion among the protein macro-ions, together with attractive protein interactions, such as van der Waals, hydrophobic and hydration forces, provide an unambiguous mechanism for the observed transition and a more physical interpretation of the various observations.
Muschol, Martin↗
Mars' "White Rock" Feature Lacks Evidence of an Aqueous Origin
The Thermal Emission Spectrometer on board the Mars Global Surveyor has observed "White Rock" and the data do not indicate the presence of evaporite minerals. We suggest it is a deposit of compacted or weakly cemented aeolian sediment.
Ruff, S. W.↗
The Mystery of the Mars North Polar Gravity-Topography Correlation(Or Lack Thereof)
Maps of moderately high resolution gravity data obtained from the Mars Global Surveyor (MGS) gravity calibration orbit campaign and high precision topography obtained from the Mars Orbiter Laser Altimeter (MOLA) experiment reveal relationships between gravity and topography in high northern latitudes of Mars. Figure 1 shows the results of a JPL spherical harmonic gravity model bandpass filtered between degrees 6 and 50 contoured over a MOLA topographic image. A positive gravity anomaly exists over the main North Polar cap, but there are at least six additional positive gravity anomalies, as well as a number of smaller negative anomalies, with no obvious correlation to topography. Additional information is contained in the original extended abstract.
Phillips, R. J.↗
Astronomers Ponder Lack of Planets in Globular Cluster
This videotape has seven segments, discussing and showing the evidence for the proposition that the galactic clusters do not have many planets. Specifically the segments show: (1) Dr. Ron Gilliland discussing the process of looking for "Hot Jupiters" (i.e., planets about the size of Jupiter, which are hotter than Jupiter) in the globular clusters, (2) a zoom into 47 Tucanae globular cluster, (3) an animation of a planet passing between the host star and the earth with a brightness graph, (4) the same animation as before without the graph, (5) Ron Gilliland of the Space Telescope Science Institute (STScI) discussing possible interpretations of his findings in the 47 Tucanae globular cluster, (6) Ron Gilliland examining the images of 47 Tucanae, and (7) images of 47 Tucanae watching for variations in brightness.
Source record↗
The Colocation, or Lack Thereof, of Deep Convection and Cold Tropopause Temperatures in the Tropical Winter Western Pacific
Recent work has suggested that dehydration near the tropical tropopause during the northern hemisphere winter is separate in place and time from the actual transfer of mass from the troposphere to the stratosphere. In fact, some work suggests that dehydration takes place in an environment where the motion is downward, with such downward motion induced either by radiative cooling over cold cloud tops or turbulent heat flux divergence due to convection. Radiative heating and cooling rates at the tropical tropopause are quite small and very sensitive to the temperature profile and underlying cloudiness. Given this, the idea of downward motion in the region of coldest temperatures and dehydration implies that coldest temperatures and underlying cloudiness are colocated. This may not necessarily be the case. This paper attempts to explore, on a preliminary basis: (1) The sensitivity of radiative heating rates at the tropical tropopause to details of the temperature profile and underlying cloudiness and (2) the relative positions of high cold clouds and cold tropopause temperatures.
Pfister, Leonhard↗
Why the Lack of Academic Literature on Export Controls?
Export controls is currently a relevant and dynamic topic. Given the growth of global operations and the high-tech nature of many products, an increase in awareness and understanding of the impacts of export controls are necessary. A structured approach to export controls has been in existence since 1949. Despite over 50 years of history, surprisingly little academic research and literature exists on the topic. This paper explores the current export control environment and explores possible reasons for the limited academic interest. Five possible reasons are discussed: (1) dynamic nature of the topic; (2) difficulty in ensuring accurate data; (3) Complexity of the problem; (4) relatively small economic impact; and (5) sensitive information. A research approach is recommended that considers these potential obstacles.
Kremic, Tibor↗
The diageotropica mutant of tomato lacks high specific activity auxin binding sites
Tomato plants homozygous for the diageotropica (dgt) mutation exhibit morphological and physiological abnormalities which suggest that they are unable to respond to the plant growth hormone auxin (indole-3-acetic acid). The photoaffinity auxin analog [3H]5N3-IAA specifically labels a polypeptide doublet of 40 and 42 kilodaltons in membrane preparations from stems of the parental variety, VFN8, but not from stems of plants containing the dgt mutation. In roots of the mutant plants, however, labeling is indistinguishable from that in VFN8. These data suggest that the two polypeptides are part of a physiologically important auxin receptor system, which is altered in a tissue-specific manner in the mutant.
NASA Discipline Number 29-20↗
Comparison of the lipid composition of oat root and coleoptile plasma membranes: lack of short-term change in response to auxin
The total lipid composition of plasma membranes (PM), isolated by the phase partitioning method from two different oat (Avena sativa L.) tissues, the root and coleoptile, was compared. In general, the PM lipid composition was not conserved between these two organs of the oat seedling. Oat roots contained 50 mole percent phospholipid, 25 mole percent glycolipid, and 25 mole percent free sterol, whereas comparable amounts in the coleoptile were 42, 39, and 19 mole percent, respectively. Individual lipid components within each lipid class also showed large variations between the two tissues. Maximum specific ATPase activity in the root PM was more than double the activity in the coleoptile. Treatment of coleoptile with auxin for 1 hour resulted in no detectable changes in PM lipids or extractable ATPase activity. Differences in the PM lipid composition between the two tissues that may define the limits of ATPase activity are discussed.
NASA Discipline Plant Biology↗
Lack of dependence on p53 for DNA double strand break repair of episomal vectors in human lymphoblasts
The p53 tumor suppressor gene has been shown to be involved in a variety of repair processes, and recent findings have suggested that p53 may be involved in DNA double strand break repair in irradiated cells. The role of p53 in DNA double strand break repair, however, has not been fully investigated. In this study, we have constructed a novel Epstein-Barr virus (EBV)-based shuttle vector, designated as pZEBNA, to explore the influence of p53 on DNA strand break repair in human lymphoblasts, since EBV-based vectors do not inactivate the p53 pathway. We have compared plasmid survival of irradiated, restriction enzyme linearized, and calf intestinal alkaline phosphatase (CIP)-treated pZEBNA with a Simian virus 40 (SV40)-based shuttle vector, pZ189, in TK6 (wild-type p53) and WTK1 (mutant p53) lymphoblasts and determined that p53 does not modulate DNA double strand break repair in these cell lines. Copyright 1999 Academic Press.
Non-NASA Center↗
Evolution of EF-hand calcium-modulated proteins. III. Exon sequences confirm most dendrograms based on protein sequences: calmodulin dendrograms show significant lack of parallelism
In the first report in this series we presented dendrograms based on 152 individual proteins of the EF-hand family. In the second we used sequences from 228 proteins, containing 835 domains, and showed that eight of the 29 subfamilies are congruent and that the EF-hand domains of the remaining 21 subfamilies have diverse evolutionary histories. In this study we have computed dendrograms within and among the EF-hand subfamilies using the encoding DNA sequences. In most instances the dendrograms based on protein and on DNA sequences are very similar. Significant differences between protein and DNA trees for calmodulin remain unexplained. In our fourth report we evaluate the sequences and the distribution of introns within the EF-hand family and conclude that exon shuffling did not play a significant role in its evolution.
Non-NASA Center↗
Lack of deleterious effect of slow-release sodium fluoride treatment on cortical bone histology and quality in osteoporotic patients
We evaluated the effects of intermittent slow-release sodium fluoride (SRNaF) and continuous calcium citrate therapy on cortical bone histology, reflection ultrasound velocity (material strength) and back-scattered electron image analysis (BEI) in 26 osteoporotic patients before and following therapy. All measurements were made on transiliac crest bone biopsies obtained before and following 2 years of therapy in each patient. For all 26 patients there were no significant changes in cortical bone histomorphometric parameters. In 15 patients in whom bone material quality was assessed by reflection ultrasound, there was no change in velocity (4000 +/- 227 SD to 4013 +/- 240 m/s). BEI disclosed no mineralization defects or the presence of woven bone. Mean atomic number (density) of bone increased slightly, but significantly (9.261 +/- 0.311 to 9.457 +/- 0.223, P = 0.031). While these changes are less marked than those observed for cancellous bone, they indicate that this form of therapy does not adversely affect cortical bone remodelling.
NASA Discipline Regulatory Physiology↗
Magnetic cloud induced magnetic storms: a lack of classical substorm expansion phases
The purpose of this paper will be to examine a specific but important subset of magnetic storms, those that are caused by large southward, smoothly rotating magnetic fields: interplanetary magnetic clouds.
magnetic storms substorm expansion phases↗
The Lack of Halo Ultraluminous X-Ray Sources
The premise that Ultraluminous X-ray sources (ULXs) exist beyond the optical extent of nearby galaxies is investigated. A published catalog containing 41 ULX candidates located between 1 and approx. 3 times the standard D-{25} isophotal radius of their putative host galaxies is examined. Twenty-one of these sources have spectroscopically-confirmed distances. All 21 are background objects giving a 95\% probability that at least 37 of the 41 candidates are background sources. Thirty-nine of the 41 sources have X-ray-to-optical flux ratios, -1.6 1.6.) The uniform spatial distribution of the sample is also consistent with a background population. This evidence suggests that ULXs rarely, if at all, exist beyond the distribution of luminous matter in nearby galaxies and, as a consequence, there is no correlation between the population of ULXs and halo objects such as old globular clusters or Population III remnants.
Swartz, Douglas A.↗
Emergency Preparedness for Catastrophic Events at Small and Medium Sized Airports: Lacking or Not?
The implementation of security methods and processes in general has had a decisive impact on the aviation industry. However, efforts to effectively coordinate varied aspects of security protocols between agencies and general aviation components have not been adequately addressed. Whether or not overall security issues, especially with regard to planning for catastrophic terrorist events, have been neglected at the nation's smaller airports is the main topic of this paper. For perspective, the term general aviation is generally accepted to include all flying except for military and scheduled airline operations. Genera aviation makes up more than 1 percent of the U.S. Gross Domestic Product and supports almost 1.3 mission high-skilled jobs in professional services and manufacturing and hence is an important component of the aviation industry (AOPA, n.d.). In both conceptual and practical terms, this paper argues for the proactive management of security planning and repeated security awareness training from both an individual and an organizational perspective within the general aviation venue. The results of a research project incorporating survey data from general aviation and small commercial airport managers as well as Transportation Security Administration (TSA) employees are reported. Survey findings suggest that miscommunication does take place on different organizational levels and that between TSA employees and airport management interaction can be contentious and cooperation diminished. The importance of organizational training for decreasing conflict and increasing security and preparedness is discussed as a primary implication.
Sweet, Kathleen M.↗