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At least 91 records · Page 5

Computational Modeling to Advance Novel Medical Isotopes for Radiotheranostics: A DOE-NIH Joint Workshop Executive Summary

The DOE-NIH Joint Workshop on Computational Modeling to Advance Novel Medical Isotopes for Radiotheranostics, held on September 27, 2024, brought together experts from government, academia, and industry to address critical challenges in radionuclide production and clinical translation. Here, the workshop emphasized interdisciplinary collaboration, particularly between the Department of Energy (DOE) and the National Institutes of Health (NIH), to strengthen the domestic isotope supply, streamline regulatory pathways, and further integrate computational tools into radiopharmaceutical therapy (RPT). Key discussions explored the role of AI-driven modeling, machine learning, and digital twin technologies in optimizing dosimetry, dynamically personalizing treatments, and reducing time to clinical adoption. Advances in predictive computational modeling were highlighted as essential for improving radionuclide yield, purity, and synthesis efficiency. Regulatory considerations and equitable access were central themes, with participants advocating for harmonized global standards, adaptive trial designs, and expanded infrastructure for clinical implementation. DOE computational and production infrastructure was emphasized. Future priorities identified include increased investment in radionuclide production infrastructure, expanded workforce development in radiopharmaceutical sciences and computational modeling, and the creation of robust public-private partnerships. The workshop concluded that continued strategic collaboration and sustained resources will be vital for advancing next-generation radiotheranostics, ensuring safe and effective therapies accessible to all patients.

digital twins↗

Human Subjects in Energy Technology and Policy Research (Symposium Report)

The U.S. Department of Energy (DOE) has a unique and wide-ranging research portfolio. One focus of the department’s research mission is to develop and promote the adoption of technologies that reduce greenhouse gas emissions and result in renewable and clean energy for the country. This research encompasses a surprisingly diverse array of studies, many of which involve the inclusion of human participants that go beyond traditional biomedical investigations. For example, individuals play an important role in DOE research on clean energy sources, development and testing of new energy-efficient technologies, and partnerships with local communities for equitable climate solutions.

29 ENERGY PLANNING, POLICY, AND ECONOMY↗

Solar Prize Round 5 Software Track: Abbreviated Final Technical Report

Solar Prize Round 5 launched two simultaneous tracks, the Hardware Track and the Software Track, to introduce software innovations into the Solar Prize for the first time. The primary goal of the prize is to accelerate the development, validation, and commercialization of innovative solar software solutions that will increase the competitiveness of the U.S. solar industry. This is accomplished with three escalating challenges, called the Ready!, Set!, and Go! Contests, where teams work to develop their concept from idea to potentially marketable product in less than one year. Competitors also have the option to compete in a Justice, Equity, Diversity, and Inclusion (JEDI) Contest, which recognizes solutions that enable underserved communities in the United States to overcome systemic solar barriers and share equitably in the societal benefits of solar deployment. The Prize concluded by awarding 2 final winners the Go! Contest prize and a 3rd winner to the JEDI Contest prize in the Software Track, after competing in the prize for a year and demonstrating their success through each phase.

14 SOLAR ENERGY↗

Machine-Learning-Based Mapping and Modeling of Solar Energy with Ultra-High Spatiotemporal Granularity

Despite the rapid growth of solar energy, we still lack a dynamic, high-fidelity database that tracks the spatiotemporal variations of solar PVs and their associated infrastructures across different places at a spatially resolved scale. The absence of such data presents a barrier to various applications such as solar PV growth projection, solar energy integration, solar incentive design, and climate risk assessment. In this project, we aim to bridge this gap by developing AI-based algorithms to extract granular information about solar PV installations and their associated infrastructures (i.e., distribution grids) from widely available unstructured data like remote sensing images and street views. As a result, we have built the Solar Energy Atlas, a fine-grained, large-scale geospatial overlay of distributed solar PVs and distribution grids. On top of it, we have advanced the understanding of solar adoption and distribution grid vulnerability to climate-induced extremes. Our major contributions can be summarized as follow: (1) By developing new AI algorithms, we have built the most comprehensive solar PV spatiotemporal database covering the entire US. This is the first time we obtained the exact GPS locations, size, subtype, and installation year information for rooftop solar PVs across the US. This database can be used for solar PV growth projection, solar energy integration, solar energy policy analysis and design, and spatially-resolved climate risk assessment. (2) Leveraging this database, we have uncovered the socioeconomic driving factors that are correlated with earlier onset of solar adoption and higher saturated adoption levels. We have identified the heterogeneity in the effects of different types of financial incentives on solar adoption and provided implications for tailoring incentive design based on local income levels to promote equitable solar adoption. (3) We have developed a distribution grid GIS mapping algorithm which can obtain granular geospatial and topology information about distribution grids using multi-modal open data, reducing the dependency on hard-to-obtain smart meter data of conventional approaches. It shows effectiveness in both the U.S. and Sub-Saharan Africa. Using this algorithm, we have uncovered the non-uniform vulnerability of distribution grids to wildfires in California in the aspects of undergrounding protection and Distributed Energy Resources (DER) preparedness. This has provided important implications for improving the affordability and equity of grid adaptation approaches. (3) We have made our produced database publicly available and provided user-friendly interface to enable various stakeholders and the general public to interact with the data. We have also integrated the produced data into the Data Commons platform to enable the public to access the data and correlate it with other location-specific characteristics simply using natural language as queries. The impact of our project is three-fold: (1) New algorithms for mapping solar PVs and distribution grids across space and time, which are open source to facilitate researchers and industry; (2) New databases of solar PVs and distribution grids that have been made publicly available for engineering, social, and policy applications; (3) New understandings and actionable insights on the potential approaches to promoting solar adoption and reducing energy infrastructure vulnerabilities. In this report, we start by discussing the project background and motivation (section 5), followed by the overview of project objectives (section 6). Results and discussion for each task are presented in section 7. Significant accomplishments are summarized in section 8. This report will be concluded by discussing the paths forwards (section 9), products (section 10), and team roles (section 11).

14 SOLAR ENERGY↗

Cyber Resilience and Social Equity: Twin Pillars of a Sustainable Energy Future

This paper examines the intersection of security and accessibility within energy systems amidst the rise of grid modernization and digitization, especially considering the regulatory changes and the imperatives of inclusive energy strategies. It addresses the dual need for secure, resilient infrastructure and a commitment to mitigate energy poverty while maintaining equitable access to energy. Amid escalating cybersecurity and physical threats, the paper advocates for sustainable energy delivery systems that ensure robust defenses without compromising the goals of reducing energy poverty and ensuring energy security. This paper identifies the pressing need for Cyber-Informed Engineering (CIE) and Secure-by-Design (SbD) principles, highlighting how these strategies can protect critical infrastructure and democratize access to secure energy, particularly for disadvantaged communities. The analysis underscores the challenges presented by the expansion of attack surfaces, interoperability requirements, and grid-edge analytics, offering innovative solutions that leverage advanced technologies and data-driven insights. Furthermore, this paper addresses the workforce development gap, emphasizing the necessity for public-private partnerships and vendor engagement in creating a skilled cybersecurity workforce. This paper has a dual focus on both the technological aspect of cybersecurity and the social dimension of equity within the context of sustainable energy development. It suggests a comprehensive examination of how these two critical elements interact and support the overarching goal of a sustainable energy future.

29 ENERGY PLANNING, POLICY, AND ECONOMY↗

Advancing community-engaged research for offshore wind on the West Coast

The Biden Administration has called for 30 GW of offshore wind (OSW) to be implemented by 2030 and 15 GW of floating OSW by 2035. Because floating OSW is a novel technology for the West Coast, the United States, and the world, there is limited information about the implications of floating OSW for coastal communities. Floating OSW faces a complex regulatory landscape and a wide set of interested parties that stand to gain or lose based on the development process and outcomes. Key agencies are often siloed in their mission space, with little attention or resources for innovation in planning. Furthermore, many communities along the West Coast of the U.S. have experienced the boom-and-bust cycles of large, extractive industries that use coastal resources to benefit consumers in other locations, while leaving behind few long-lasting benefits at the local level. These siloes in government and civic society, and the lack of trust born out of past failures, make it difficult for communities, government agencies, scientists, and industry to plan for OSW based on community values and concerns. There is a need to develop projects that more equitably distribute benefits while safeguarding the ocean ecosystems upon which coastal populations depend.

17 WIND ENERGY↗

From Silos to Synergy: Identifying a Roadmap for Cross-Sector Research to Accelerate the Clean Energy Transition

The U.S. Department of Energy's blueprints for the transportation, buildings, and electricity sectors call for substantial reductions in greenhouse gas (GHG) emissions by 2050. These plans focus on zero-emission vehicles, investments in transit, energy-efficient buildings, and the widespread adoption and deployment of renewable energy technologies like solar photovoltaics (PV), energy storage and energy-efficient appliances. However, these sectors are often studied and modeled in isolation, overlooking how household decisions to adopt clean technologies in one sector influence others. This study, led by an interdisciplinary team at the National Renewable Energy Laboratory (NREL), explores opportunities for cross-sector collaboration to drive more effective and equitable decarbonization. Through discussions with 22 NREL researchers across transportation, building, solar, and grid sectors, the study highlights the need for integrated tools and models that capture interactions between these sectors. Key insights include the need for data standardization and interoperability to enable cross-sector analysis and decision-making. Strengthening utility partnerships is also critical to align energy policies with decarbonization goals and manage the increased demand for renewable energy. The study also emphasizes the importance of equity in the clean energy transition, calling for targeted incentives and support to ensure that low-income and underserved communities benefit from clean technologies like electric vehicles and energy-efficient appliances. To support these efforts, innovative funding mechanisms must be expanded to facilitate interdisciplinary research, such as city-specific decarbonization plans and federal projects like DOE"s Standard Scenarios. By encouraging collaboration and integrating cross-sector insights, this study aims to provide a roadmap to accelerate the clean energy transition and ensure it is both sustainable and inclusive.

14 SOLAR ENERGY↗

PCAST: Report to the President on a Vision for Advancing Nutrition Science in the United States

The President’s Council of Advisors on Science and Technology (PCAST) is the sole body of advisors from outside the federal government charged with making science, technology, and innovation policy recommendations to the President and the White House. Established by Executive Order, it is an independent Federal Advisory Committee comprised of distinguished individuals from industry, academia, and non-profit organizations with a range of perspectives and expertise. On September 20, 2024, PCAST sent a report to the President with recommendations to advance nutrition science and to enable equitable access to the benefits of nutrition research.

59 BASIC BIOLOGICAL SCIENCES↗

Unraveling the Threads of Environmental Justice in Critical Mineral Extraction: A Framework for Regionalized Life Cycle Data

As we transition to a more sustainable energy system, the extraction and processing of critical minerals becomes increasingly important. However, these industries often raise concerns about environmental and social impacts, particularly in disadvantaged communities. To address these concerns, our research focuses on regionalizing environmental life cycle data to connect it with communities affected by mineral extraction. A framework was developed for collecting life cycle background data that supports the Justice40 Toolset, a market-based approach to evaluating net benefits and costs of critical mineral material recovery pathways. A goal was to alleviate public skepticism around mineral extraction processes, including secondary and unconventional feedstocks, by highlighting both environmental and social impacts. To achieve this, computational analysis and geospatial data science techniques were employed, such as within-scale and across-scale methods and proxy dataset usage. By doing so, we were able to develop a framework for identifying and disaggregating data down to regions small enough to support Justice40 goals. Our approach not only provides valuable tools fo insight into the environmental implications of mineral extraction but also helps policymakers evaluate the social impacts on local communities. This research contributes to a more just and equitable transition to a sustainable energy system, ensuring that marginalized voices are heard in decision-making process.

Davis, Tyler [NETL Site Support Contractor, Nation↗

EV Charging Infrastructure Energization An Overview of Approaches for Simplifying and Accelerating Timelines to Processing EV Charging Load Service Requests

The United States has seen significant growth in electric vehicle (EV) adoption, leading to increased demand for EV charging infrastructure. Over the past decade, EV charging infrastructure site developers, site hosts, and electric distribution utilities have navigated the process to integrate chargers onto the electric grid. Site developers and site hosts have raised the alarm that the integration process for high-powered EV charging projects does not meet the needs of the EV market for timeliness or cost. High-powered charging stations typically require a load service request or an agreement with the local utility to connect to the grid. The process of energizing a new high-powered charging site can be complex and time-consuming, often taking up to 2 years. This timeline is the result of current utility energization processes having been designed for construction projects that take longer to build (i.e., buildings). The specific challenges stem from various factors, including compartmentalization in application processes, the integration of EV charging process approvals with other distributed energy resources (DERs), and the need to ensure grid reliability. The energization process needs to evolve to meet the growing demand for high-powered EV charging. This white paper compiles information gathered through various conversations with key stakeholders, including utilities, utility regulators, EV charging operators, site developers, and authorities having jurisdiction (AHJ) as well as through an extensive literature review. This document identifies the challenges and provides potential solutions to streamline the process of connecting EV charging infrastructure to the power grid in the United States, serving as a starting point for future conversations around these solutions. The solutions noted in this white paper require collaborative efforts among utilities, regulators, and EV charging infrastructure developers to streamline the grid connection process for EV charging infrastructure. They are broadly organized into four areas: 1. Increase data access and transparency: Develop automated load service request tools, integrate hosting capacity and load service request analyses, incorporate EV adoption forecasts, and provide transparency on the processing queue. 2. Improve energization processes and timing: Create fast-track options based on prescreening criteria, provide flexibility or phased approvals in the load service request/interconnection process, build internal knowledge within utilities about EV charging technologies, and provide standardized workforce training. 3. Promote economic efficiency: Right size distribution components to accurately reflect the load requirements of EV charging infrastructure, make proactive investments in grid infrastructure based on EV adoption forecasts and growth projections, and consider energy equity and environmental justice factors such as equitable access to EV charging when planning infrastructure. 4. Improve grid reliability and resilience: Use load management/power control systems (PCS) at EV charging stations, adopt and implement harmonized standards for communication protocols and information models between the EV charging and grid control infrastructure, and address cybersecurity considerations by implementing robust security measures and standards for EV charging infrastructure—with particular emphasis on clarifying the security requirements for the interface to the grid. The objective of the solutions proposed in this white paper is to accelerate the timeline and decrease costs associated with connecting EV charging infrastructure to the grid. Electric utilities, utility regulators, EV charging infrastructure developers, and site hosts will first need to understand which solutions are available in their service territory, and if warranted, which combination of solutions would support their specific needs. Through the successful implementations of solutions at scale detailed here, industry will demonstrate a new and innovative ecosystem where timely deployment and energization of EV charging infrastructure with greater grid resiliency and reliability is a reality.

24 POWER TRANSMISSION AND DISTRIBUTION↗

Integrated Hydro-terrestrial Modeling 2.0: Progress and Path Forward on Building a National Capability

It is the role of the U.S. federal government and its supporting agencies, including academia and future scientists, to ensure that its people have sustained and equitable freshwater services, as well as the critical knowledge necessary to make decisions about the future as it relates to freshwater services. Clear and consistent information and guidance from federal agencies is critical. Integrated Hydro-Terrestrial Modeling (IHTM), as a United States (U.S.) national capability, focuses on understanding, quantifying, and managing the replenishment of water supply through hydrologic cycle processes and their governing forces. To provide that information, we need enhanced IHTM capabilities that capitalize on the strengths of each U.S. governmental agency and its core mission. The first IHTM workshop was held in 2019, and its subsequent report was published in 2020. The U.S. Global Change Research Program (USGCRP) and member agencies held a second IHTM workshop (IHTM 2.0) from October 31 to November 2, 2023 in Reston, Virginia. The IHTM 2.0 workshop focused on the need to support a multiscale framework to accelerate research insights, better integrate operational and planning perspectives, and bridge national-to-regional capabilities to address major interdependent societal water challenges. The workshop was organized according to a “WHAT” and “HOW” framework, with the common underlying “WHY” being the integrated water resource challenges and the “WHO” defined through interagency and cooperating academic partners. The report provides a summary of plenary presentations and breakout discussions, and a road map that focuses on near-term activities.

99 GENERAL AND MISCELLANEOUS↗

Distributed Energy Resource (DER) Integration Framework: Regulatory Innovation for DER Compensation and Cost Allocation

Existing regulatory approaches to DER lack the precision and granularity necessary to ensure that DER can continue to scale in a cost-effective manner that is aligned with the public interest. To address this need, with the support of the U.S. Department of Energy’s Office of Electricity, Berkeley Lab and Current Energy Group developed an illustrative regulatory framework. By adopting a technology-neutral and modular approach, the framework enables flexibility and scalability for DER providers, utilities, and regulators. Clear price signals and incentives encourage the provision of valuable grid services, while equitable cost allocation promotes efficient use of distribution capacity and interconnection resources. This approach mirrors traditional ratemaking principles for importing customers and positions DERs as integral components of a dynamic and cost-effective energy future.

24 POWER TRANSMISSION AND DISTRIBUTION↗

Effective Knowledge Dissemination for LMI Solar: The Roles of Community Organizations and State Governments

This report provides a detailed summary of a three-year effort by the Clean Energy States Alliance (CESA) on “Effective Knowledge Dissemination for LMI Solar: The Roles of Community Organizations and State Governments.” The core approach of this project was to work with state energy agencies (SEAs) and community-based organizations (CBOs) to improve their ability to share the knowledge and information that is needed for solar to be developed efficiently, equitably, and cost-effectively in low- and moderate-income (LMI) communities.

14 SOLAR ENERGY↗

Final Technical Report for Solar Prize Round 6

Solar Prize Round 6 had the primary goal to accelerate the development, validation, and commercialization of innovative solar software solutions that will increase the competitiveness of the U.S. solar industry. This is accomplished with three escalating challenges, called the Ready!, Set!, and Go! Contests, where teams work to develop their concept from idea to potentially marketable product in less than one year. Competitors also have the option to compete in a Justice, Equity, Diversity, and Inclusion (JEDI) Contest, which recognizes solutions that enable underserved communities in the United States to overcome systemic solar barriers and share equitably in the societal benefits of solar deployment. The Prize concluded by awarding 2 final winners the Go! Contest prize and 1 of those same winners the Go! Contest JEDI prize after competing in the prize for a year and demonstrating their success through each phase.

14 SOLAR ENERGY↗

ResStock Technical Reference Documentation (V.3.3.0)

ResStock™ is the best-in-class building stock energy model for simulating and publishing energy use, utility bills, and greenhouse gas emissions from the residential sector of the U.S. ResStock answers two primary questions: (1) How is energy used in the U.S. residential building stock? and (2) What is the timeseries aggregate impact of energy technologies? Specifically, ResStock quantifies energy use across geographical locations, demographic groups, building types, fuels, end uses, and time of day. Additionally, it details the impact of efficiency or electrification measures: total changes in the amount of energy used by measure; where or in what use cases efficiency or electrification upgrade measures save energy; when or at what times of day savings occur; and which building stock or demographic segments have the biggest savings potential. This model, and the datasets it produces, are foundational to identifying pathways to affordable and equitable decarbonization of the U.S. residential buildings sector.

32 ENERGY CONSERVATION, CONSUMPTION, AND UTILIZATI↗

Energy Efficient Mobility Systems (2023 Annual Progress Report)

This document summarizes the progress of VTO Energy Efficient Mobility Systems projects supported during the fiscal year 2023. DOE conducts research to understand how the changing mobility landscape will affect transportation energy consumption and identifies opportunities to create more efficient, affordable, reliable, accessible, equitable, and secure transportation options that enhance mobility for individuals and businesses. Within EERE, the EEMS Program is responsible for this research portfolio. This APR describes work that the EEMS Program conducted during FY 2023 in support of the EEMS Program goals.

32 ENERGY CONSERVATION, CONSUMPTION, AND UTILIZATI↗

Enhancing Biopreparedness through a Model System to Understand the Molecular Mechanisms that Lead to Pathogenesis and Disease Transmission: NW-BRaVE

The science of biopreparedness to counter biological threats hinges on understanding the fundamental principles and molecular mechanisms that lead to pathogenesis and disease transmission. Our vision to address this challenge is to create a powerful and user-friendly platform to elucidate the fundamental principles of how molecular interactions drive pathogen-host relationships and host shifts. We will enable groundbreaking discoveries by integrating a wide range of structural, genomics, proteomics, and other advanced omics measurements, along with evolutionary and artificial intelligence predictions. To make sure the system is applicable to real-world problems, we will develop it in the context of a tractable model system, the small, abundant, and accessible photosynthetic cyanobacteria and their constantly co-adapting viral pathogens, cyanophages. This model will maintain the system’s applicability to real-world problems and techniques, but the overall focus will be on elucidating general principles of detecting, assessing, and surveilling molecular interaction, adaptation, and coevolution that are system agnostic and therefore extensible to other viral-host interactions. Our overall objectives are to (1) identify the molecular complexes that comprise the cyanobacteria redox macromolecular subsystem and how they dynamically change with bacteriophage infection in situ, using cryo-electron tomography; (2) profile regulatory changes during infection using proteomics, multiomics, and experimental validation, and integrate the data with in situ structures; (3) use genomics and metagenomics to determine environmental and population factors across time scales that impact the interactions between marine cyanobacteria and their cyanophage parasites, predicting the evolutionary origins of in situ structural and functional interactions, convergence and coevolution; and (4) develop a data integration and transformation platform that facilitates the integration of in situ, proteomic, and evolutionary measurements of molecular interactions to surveil diverse hosts and parasites in various environmental contexts. These objectives address Focus Area 2 Reveal Molecular Interactions Across Biological Scales for Design of Targeted Interventions. Our powerful and user-friendly platform will enhance connections between the often-siloed fields of structure, molecular phenotype, and evolutionary genomics that are key to biopreparedness, but in need of integration (Figure 1). We will build an integrated navigation tool to facilitate the effective use of globally distributed experimental data for integrated analysis and predictive modeling. The project will develop, implement, and test a platform to assess host-pathogen molecular interactions, adaptation to hosts and host shifts, and coevolution between hosts and pathogens, successfully impacting the research community by revolutionizing abilities to study any host-pathogen interaction, encourage diverse community contributions, and gain fundamental insights into how proteins adapt to new contexts. This ability will be critical for designing early interventions to address future threats. We will build surveillance training capability, aiming for a fair and equitable response to future pandemics and biothreats.

59 BASIC BIOLOGICAL SCIENCES↗

Community-Engaged Energy Transition Planning in Holyoke

The overarching motivation of this project is to provide stakeholder-engaged research and education to enable a clean, equitable, and resilient energy transition. Presently, low-income communities and people of color are disproportionately burdened by environmental harm, while also being routinely left out of planning processes and benefits from infrastructure improvements. The Energy Transition Institute (ETI) addresses these issues in three ways: community engagement, educating diverse future leaders, and cutting-edge research. As municipalities across the Commonwealth plan their transition to a climate-friendly energy system, research from ETI will advance technical and social understanding of heating electrification, energy storage, demand flexibility, reliability and resiliency of power distribution infrastructure, with attention to equity. This will benefit surrounding communities, cities and towns across Massachusetts, and the global research community

14 SOLAR ENERGY↗