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Search indexed NASA NTRS and DOE OSTI research on propulsion, heat transfer, battery materials and energy systems. Follow report and document links to the original sources.

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At least 91 records · Page 5
All sourcesNASA NTRSDOE OSTI
DOE OSTI2022

Regulation of Cell Wall Assembly: Myosin and Exocyst Involvement in Cellulose Synthase Delivery to the Plasma Membrane

Cellulose is the most abundant biopolymer on the planet and is produced in the primary and secondary cell wall of terrestrial plants by a plasma membrane (PM)-localized, multimeric protein complex. The catalytic enzyme, or cellulose synthase, belongs to a multigene family known as CESA. It is generally accepted that the behavior and trajectories of cellulose synthase complexes are oriented by the position of cortical microtubules, but how exactly these complexes are delivered and recycled from the PM remains poorly understood. Limited evidence suggests that microtubules determine the site for delivery of new complexes; however, abolishing microtubules with the inhibitor oryzalin has absolutely no effect on rates of delivery. Thus, there is a pressing need to explore the contribution of another component of the cortical cytoskeleton, actin filaments and the associated motor protein myosin, to the delivery and dynamics of CESA at the PM.

59 BASIC BIOLOGICAL SCIENCES↗
DOE OSTI2021

Nanoparticle Mediated Delivery of Therapeutic mRNA for Protection Against Lung Damage

Medical countermeasures (MCMs) based on messenger ribonucleic acid (mRNA) are promising due to their programmability, targeting precision and specificity, predictable physicochemical properties, and amenability to scalable manufacture. However, safe and effective delivery vehicles are needed, especially for targeting the lung. We developed a generalized approach to nanoparticle-mediated mRNA delivery to lung, and used it to evaluate candidate therapies. In initial studies, reporter mRNA was delivered using lipid-coated mesoporous silica nanoparticles (LC-MSNs) and lipid nanoparticles (LNPs), the latter with greater consistency. Then, mRNA encoding known protein therapies were delivered using LNPs. These formulations showed some toxicity in mice with lung damage, but those with IL-1RA, sACE2-Ig, and ANGPT1 mRNA were modestly therapeutic on balance. Our work advances the state of the art for mRNA delivery to lung, and provides a foundation for evaluating and characterizing mRNA-based lung therapies, including three that appear to be exceptionally promising.

59 BASIC BIOLOGICAL SCIENCES↗
DOE OSTI2023

Drones, Delivery Robots, Driverless Cars, and Intelligent Curbs for Increasing Energy Productivity of First/Last Mile Goods Movement

The objective of the project is to use empirical testing, life cycle assessment, and systems analysis to research and demonstrate energy improvement when using goods delivery drones, eVTOL, ground delivery robots and automated vehicles compared to a baseline network. The research will also develop proof-of-concept testing, a model, and simulation for a smart curb space as an intelligently-managed urban delivery zone demonstrating additional improvement in energy productivity.

Scherer, Sebastian↗
DOE OSTI2021

Efficient Hydrogen Delivery for Microbial Electrosynthesis via 3D-Printed Cathodes

The efficient delivery of electrochemically in situ produced H 2 can be a key advantage of microbial electrosynthesis over traditional gas fermentation. However, the technical details of how to supply large amounts of electric current per volume in a biocompatible manner remain unresolved. Here, we explored for the first time the flexibility of complex 3D-printed custom electrodes to fine tune H 2 delivery during microbial electrosynthesis. Using a model system for H 2 -mediated electromethanogenesis comprised of 3D fabricated carbon aerogel cathodes plated with nickel-molybdenum and Methanococcus maripaludis, we showed that novel 3D-printed cathodes facilitated sustained and efficient electromethanogenesis from electricity and CO 2 at an unprecedented volumetric production rate of 2.2 L CH4 /L catholyte /day and at a coulombic efficiency of 99%. Importantly, our experiments revealed that the efficiency of this process strongly depends on the current density. At identical total current supplied, larger surface area cathodes enabled higher methane production and minimized escape of H 2 . Specifically, low current density (<1 mA/cm 2 ) enabled by high surface area cathodes was found to be critical for fast start-up times of the microbial culture, stable steady state performance, and high coulombic efficiencies. Our data demonstrate that 3D-printing of electrodes presents a promising design tool to mitigate effects of bubble formation and local pH gradients within the boundary layer and, thus, resolve key critical limitations for in situ electron delivery in microbial electrosynthesis.

03 NATURAL GAS↗
NASA NTRS1972

Mariner Venus-Mercury 1973 midcourse velocity requirements and delivery accuracy

The primary mission is described, which consists of encounters with Venus and Mercury; (a second encounter with Mercury is also possible). The exptected navigation sequences were simulated with a Monte Carlo computer program for the purpose of determining midcourse correction velocity requirements and delivery accuracies. These simulations provide sensitivity in velocity requirements and delivery accuracies to error sources affecting the navigation process. The orbit determination capability at the final pre-Venus maneuver is shown to be the dominant contributor to the velocity requirements for the primary mission. Similarly, the orbit determination capability at the final pre-Mercury maneuver is shown to be the dominant contributor to the delivery accuracy at Mercury.

Mckinley, E. L.↗
NASA NTRS1977

Space age health care delivery

Space age health care delivery is being delivered to both NASA astronauts and employees with primary emphasis on preventive medicine. The program relies heavily on comprehensive health physical exams, health education, screening programs and physical fitness programs. Medical data from the program is stored in a computer bank so epidemiological significance can be established and better procedures can be obtained. Besides health care delivery to the NASA population, NASA is working with HEW on a telemedicine project STARPAHC, applying space technology to provide health care delivery to remotely located populations.

Jones, W. L.↗
NASA NTRS1983

Silicon-Delivery Tube

Delivery tube transfers molten silicon between high-temperature vessel. Transport tube is sealed to delivery vessel and receiving vessel and slanted so gravity moves molten silicon. Contamination is prevented since molten silicon only contacts quartz delivery tube.

Bates, H. E.↗
NASA NTRS1992

A summary of porous tube plant nutrient delivery system investigations from 1985 to 1991

The Controlled Ecological Life Support System (CELSS) Program is a research effort to evaluate biological processes at a one person scale to provide air, water, and food for humans in closed environments for space habitation. This program focuses currently on the use of conventional crop plants and the use of hydroponic systems to grow them. Because conventional hydroponic systems are dependent on gravity to conduct solution flow, they cannot be used in the microgravity of space. Thus, there is a need for a system that will deliver water and nutrients to plant roots under microgravity conditions. The Plant Space Biology Program is interested in investigating the effect that the space environment has on the growth and development of plants. Thus, there is also a need to have a standard nutrient delivery method for growing plants in space for research into plant responses to microgravity. The Porous Tube Plant Nutrient Delivery System (PTPNDS) utilizes a hydrophilic, microporous material to control water and nutrient delivery to plant roots. It has been designed and analyzed to support plant growth independent of gravity and plans are progressing to test it in microgravity. It has been used successfully to grow food crops to maturity in an earth-bound laboratory. This document includes a bibliography and summary reports from the growth trials performed utilizing the PTPNDS.

Dreschel, T. W.↗
NASA NTRS1992

Delivery of cardiopulmonary resuscitation in the microgravity environment

The microgravity environment presents several challenges for delivering effective cardiopulmonary resuscitation (CPR). Chest compressions must be driven by muscular force rather than by the weight of the rescuer's upper torso. Airway stabilization is influenced by the neutral body posture. Rescuers will consist of crew members of varying sizes and degrees of physical deconditioning from space flight. Several methods of CPR designed to accommodate these factors were tested in the one G environment, in parabolic flight, and on a recent shuttle flight. Methods: Utilizing study participants of varying sizes, different techniques of CPR delivery were evaluated using a recording CPR manikin to assess adequacy of compressive force and frequency. Under conditions of parabolic flight, methods tested included conventional positioning of rescuer and victim, free floating 'Heimlich type' compressions, straddling the patient with active and passive restraints, and utilizing a mechanical cardiac compression assist device (CCAD). Multiple restrain systems and ventilation methods were also assessed. Results: Delivery of effective CPR was possible in all configurations tested. Reliance on muscular force alone was quickly fatiguing to the rescuer. Effectiveness of CPR was dependent on technique, adequate restraint of the rescuer and patient, and rescuer size and preference. Free floating CPR was adequate but rapidly fatiguing. The CCAD was able to provide adequate compressive force but positioning was problematic. Conclusions: Delivery of effective CPR in microgravity will be dependent on adequate resuer and patient restraint, technique, and rescuer size and preference. Free floating CPR may be employed as a stop gap method until patient restraint is available. Development of an adequate CCAD would be desirable to compensate for the effects of deconditioning.

Barratt, M. R.↗
NASA NTRS1996

Design Factors for Applying Cryogen Storage and Delivery Technology to Solar Thermal Propulsion

Thermodynamic Vent System (TVS) and Multilayer Insulation (MLI) technology, originally developed for long term storage of cryogen propellants in microgravity, is ideally suited for propellant storage and delivery systems for solar thermal propulsion. With this technology the heat-induced pressure rise in the tank provides the propellant delivery pressure without the need for an auxiliary pressurant system, and propellant delivery is used to remove the excess heat to control tank pressure. The factors to consider in designing such a balanced system, are presented. An example of a minimum system design is presented along with examples of laboratory-tested hardware.

Millis, Marc G.↗
NASA NTRS2007

Systems Analysis and Structural Design of an Unpressurized Cargo Delivery Vehicle

The International Space Station will require a continuous supply of replacement parts for ongoing maintenance and repair after the planned retirement of the Space Shuttle in 2010. These parts are existing line-replaceable items collectively called Orbital Replacement Units, and include heavy and oversized items such as Control Moment Gyroscopes and stowed radiator arrays originally intended for delivery aboard the Space Shuttle. Current resupply spacecraft have limited to no capability to deliver these external logistics. In support of NASA's Exploration Systems Architecture Study, a team at Langley Research Center designed an Unpressurized Cargo Delivery Vehicle to deliver bulk cargo to the Space Station. The Unpressurized Cargo Delivery Vehicle was required to deliver at least 13,200 lbs of cargo mounted on at least 18 Flight Releasable Attachment Mechanisms. The Crew Launch Vehicle design recommended in the Exploration Systems Architecture Study would be used to launch one annual resupply flight to the International Space Station. The baseline vehicle design developed here has a cargo capacity of 16,000 lbs mounted on up to 20 Flight Releasable Attachment Mechanisms. Major vehicle components are a 5.5m-diameter cargo module containing two detachable cargo pallets with the payload, a Service Module to provide propulsion and power, and an aerodynamic nose cone. To reduce cost and risk, the Service Module is identical to the one used for the Crew Exploration Vehicle design.

Wu, K. Chauncey↗
NASA NTRS2013

Advanced Space Transportation Concepts and Propulsion Technologies for a New Delivery Paradigm

This paper describes Advanced Space Transportation Concepts and Propulsion Technologies for a New Delivery Paradigm. It builds on the work of the previous paper "Approach to an Affordable and Productive Space Transportation System". The scope includes both flight and ground system elements, and focuses on their compatibility and capability to achieve a technical solution that is operationally productive and also affordable. A clear and revolutionary approach, including advanced propulsion systems (advanced LOX rich booster engine concept having independent LOX and fuel cooling systems, thrust augmentation with LOX rich boost and fuel rich operation at altitude), improved vehicle concepts (autogeneous pressurization, turbo alternator for electric power during ascent, hot gases to purge system and keep moisture out), and ground delivery systems, was examined. Previous papers by the authors and other members of the Space Propulsion Synergy Team (SPST) focused on space flight system engineering methods, along with operationally efficient propulsion system concepts and technologies. This paper continues the previous work by exploring the propulsion technology aspects in more depth and how they may enable the vehicle designs from the previous paper. Subsequent papers will explore the vehicle design, the ground support system, and the operations aspects of the new delivery paradigm in greater detail.

Robinson, John W.↗
NASA NTRS2014

Development of a Nutritional Delivery System to Feed Crew in a Pressurized Suit

The contingency scenario for an emergency cabin depressurization event may require crewmembers to subsist in a pressurized suit for up to 144 hours. This scenario requires the capability for safe nutrition delivery through a helmet feed port against a 4 psi pressure differential to enable crewmembers to maintain strength and cognition to perform critical tasks. Two nutritional delivery prototypes were developed and analyzed for compatibility with the helmet feed port interface and for operational effectiveness against the pressure differential. The bag-in-bag (BiB) prototype, designed to equalize the suit pressure with the beverage pouch and enable a crewmember to drink normally, delivered water successfully to three different subjects in suits pressurized to 4 psi. The Boa restrainer pouch, designed to provide mechanical leverage to overcome the pressure differential, did not operate sufficiently. Guidelines were developed and compiled for contingency beverages that provide macro-nutritional requirements, a minimum one-year shelf life, and compatibility with the delivery hardware. Evaluation results and food product parameters have the potential to be used to improve future prototype designs and develop complete nutritional beverages for contingency events. These feeding capabilities would have additional use on extended surface mission EVAs, where the current in-suit drinking device may be insufficient.

Glass, J. W.↗
NASA NTRS2008

Delivery of Colloid Micro-Newton Thrusters for the Space Technology 7 Mission

Two flight-qualified clusters of four Colloid Micro-Newton Thruster (CMNT) systems have been delivered to the Jet Propulsion Laboratory (JPL). The clusters will provide precise spacecraft control for the drag-free technology demonstration mission, Space Technology 7 (ST7). The ST7 mission is sponsored by the NASA New Millennium Program and will demonstrate precision formation flying technologies for future missions such as the Laser Interferometer Space Antenna (LISA) mission. The ST7 disturbance reduction system (DRS) will be on the ESA LISA Pathfinder spacecraft using the European gravitational reference sensor (GRS) as part of the ESA LISA Technology Package (LTP). Developed by Busek Co. Inc., with support from JPL in design and testing, the CMNT has been developed over the last six years into a flight-ready and flight-qualified microthruster system, the first of its kind. Recent flight-unit qualification tests have included vibration and thermal vacuum environmental testing, as well as performance verification and acceptance tests. All tests have been completed successfully prior to delivery to JPL. Delivery of the first flight unit occurred in February of 2008 with the second unit following in May of 2008. Since arrival at JPL, the units have successfully passed through mass distribution, magnetic, and EMI/EMC measurements and tests as part of the integration and test (I&T) activities including the integrated avionics unit (IAU). Flight software sequences have been tested and validated with the full flight DRS instrument successfully to the extent possible in ground testing, including full functional and 72 hour autonomous operations tests. Delivery of the cluster assemblies along with the IAU to ESA for integration into the LISA Pathfinder spacecraft is planned for the summer of 2008 with a planned launch and flight demonstration in late 2010.

Precision Formation Flying↗
NASA NTRS2018

Additive Construction with Mobile Emplacement (ACME) / Automated Construction of Expeditionary Structures (ACES) Materials Delivery System (MDS)

The purpose of the Automated Construction of Expeditionary Structures, Phase 3 (ACES 3) project is to incorporate the Liquid Goods Delivery System (LGDS) into the Dry Goods Delivery System (DGDS) structure to create an integrated and automated Materials Delivery System (MDS) for 3D printing structures with ordinary Portland cement (OPC) concrete. ACES 3 is a prototype for 3-D printing barracks for soldiers in forward bases, here on Earth. The LGDS supports ACES 3 by storing liquid materials, mixing recipe batches of liquid materials, and working with the Dry Goods Feed System (DGFS) previously developed for ACES 2, combining the materials that are eventually extruded out of the print nozzle. Automated Construction of Expeditionary Structures, Phase 3 (ACES 3) is a project led by the US Army Corps of Engineers (USACE) and supported by NASA. The equivalent 3D printing system for construction in space is designated Additive Construction with Mobile Emplacement (ACME) by NASA.

Mueller, R. P.↗
NASA NTRS2023

NASA X-HAB Water Delivery System

As part of the eXploration Systems and Habitation (X-HAB) Academic Innovation Challenge program of National Aeronautics and Space Administration (NASA), The Ohio State University was selected to improve the performance of NASA’s existing Vegetable Production System (VEGGIE), which is a deployable plant growth unit for International Space Station (ISS). During the academic year 2015-2016, The Ohio State University student team developed a passive water delivery system using capillary water transport principle (Jenson et al. 2016). The major design improvement made was directly connecting the water reservoir to the plant-rooting pillows using a single-interface capillary cord design. Harvestable plants were successfully grown from seeds using the single interface system. In addition, Nomex®, a fabric material composed of short nylon based fibers, was identified as the material for wicks. Finally, the water reservoir was modeled as a propellant management device (PMD) to ensure consistent and long term watering of the VEGGIE system. The PMDs are made of materials that utilize surface tension and adhesive forces to improve stability and fluid delivery. The team recommended using a sponge PMD in order to mitigate bubble obstruction, decrease system weight, and ensure reliable water delivery to the capillary interface.

Peter Ling↗
DOE OSTI2021

Microporous membrane for stereolithography resin delivery

A system for building a structure. The system includes a reservoir; an immiscible fluid in the reservoir; a membrane operatively connected to the reservoir; channels and delivery ports in the membrane; a microliter amount of curable resin; a delivery system for delivering the microliter amount of curable resin to channels and delivery ports in the membrane and to the reservoir in contact with the immiscible fluid in the reservoir; and an energy source adapted to deliver energy to the reservoir onto the microliter amount of curable resin for building the structure.

Deotte, Joshua R.↗
DOE OSTI2021

Gene editing through microfluidic delivery

Gene editing can be performed by introducing gene-editing components into a cell by mechanical cell disruption. Related apparatus, systems, techniques, and articles are also described. The methods and systems of the invention solve the problem of intracellular delivery of gene editing components and gene editing complexes to target cells. The results described herein indicate that delivery of gene editing components, e.g., protein, ribonucleic acid (RNA), and deoxyribonucleic acid (DNA), by mechanical disruption of cell membranes leads to successful gene editing. Because intracellular delivery of gene editing materials is a current challenge, the methods provide a robust mechanism to engineer target cells without the use of potentially harmful viral vectors or electric fields.

Sharei, Armon R.↗