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Airborne bacterial communities and antibiotic resistance gene dynamics in PM2.5 during rainfall
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Pyroligneous acid mitigated dissemination of antibiotic resistance genes in soil
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The World-wide Randomized Antibiotic Envelope Infection Prevention (WRAP-IT) trial: Long-term follow-up
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Plasmid-encoded gene expression of pathogenic bacteria by antibiotic induction as detected by MALDI-TOF-TOF mass spectrometry and top-down proteomic analysis
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Cross-omics analysis revealed gut microbiome-related metabolic pathways underlying atherosclerosis development after antibiotics treatment
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Evaluating for-profit public benefit corporations as an additional structure for antibiotic development and commercialization
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Narrow-Spectrum Antibiotic Targeting of the Radical SAM Enzyme MqnE in Menaquinone Biosynthesis
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Cobalt-Doped Tungsten Oxide Nanoparticles for Electrochemical Sensing and Detection of a Penicillin Antibiotic: Amoxicillin
A sensitive electrochemical sensor for the determination of antibacterial amoxicillin (AMXL) in pharmaceutical dosage and environmental samples was developed, since its residues were found in water, food, and biological samples to pose adverse health risks such as immune–allergic reactions and antimicrobial resistance. WO 3 -based sensors are reported to provide higher sensitivity, selectivity, and stability during the electrochemical reaction. Considering this, Co-doped WO 3 nanostructures were synthesized by the hydrothermal method yielding a mixture of nanoparticle and nanorod structures and applied to the assay of AMXL. Extensive characterizations were carried out by SEM, XRD, TEM, and XPS analysis that confirm the monoclinic crystal structure with a uniform Co distribution in the WO 3 lattice. The optimum doping amount of Co in the lattice is found to be 1.80 at %. The electrochemical performance of the Co-WO 3 /carbon paste electrode (CPE) was evaluated for the determination of AMXL under optimum conditions using cyclic voltammetry, electrochemical impedance spectroscopy, and square wave voltammetry. The Co-WO 3 /CPE showed two linear detection ranges at 0.01–0.1 μM with the linear regression I pa = 3.73 [AMXL] + 0.77 with R 2 = 0.96 and at 0.1 to 30.0 μM with the linear regression I pa = 3.76 [AMXL] + 0.69 with R 2 = 0.95. The limit of detection was 9.1 nM (SNR = 3), and the limit of quantification was 30.6 nM (SNR = 10). The sensitivities for lower and higher concentration ranges were 63.22 and 63.73 μA μM –1 cm –2 , respectively. Furthermore, Co-WO 3 /CPE showed high selectivity and anti-interference capabilities. In conclusion, the sensing and disposable Co-WO 3 /CPE sensor showed a great potential for AMXL analysis in spiked soil, water, and Amoxil tablet samples with desirable percentage recovery.
Development of Antibiotics That Dysregulate the Neisserial ClpP Protease
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