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At least 91 records · Page 5

Analytical method for predicting the pressure distribution about a nacelle at transonic speeds

The formulation and development of a computer analysis for the calculation of streamlines and pressure distributions around two-dimensional (planar and axisymmetric) isolated nacelles at transonic speeds are described. The computerized flow field analysis is designed to predict the transonic flow around long and short high-bypass-ratio fan duct nacelles with inlet flows and with exhaust flows having appropriate aerothermodynamic properties. The flow field boundaries are located as far upstream and downstream as necessary to obtain minimum disturbances at the boundary. The far-field lateral flow field boundary is analytically defined to exactly represent free-flight conditions or solid wind tunnel wall effects. The inviscid solution technique is based on a Streamtube Curvature Analysis. The computer program utilizes an automatic grid refinement procedure and solves the flow field equations with a matrix relaxation technique. The boundary layer displacement effects and the onset of turbulent separation are included, based on the compressible turbulent boundary layer solution method of Stratford and Beavers and on the turbulent separation prediction method of Stratford.

Keith, J. S.↗

The properties of and analytical methods for detection of LiOH and Li2CO3

Lithium hydroxide (LiOH) is used as a CO2 absorbent in the Shuttle Extravehicular Mobility Unit (EMU) Portable Life Support System (PLSS). The first objective was to survey parameters that may be used to indicate conversion of LiOH to Li2CO3, and compile a list of all possible properties, including physical, chemical, structural, and electrical, that may serve to indicate the occurrence of reaction. These properties were compiled for the reactant (LiOH), the intermediate monohydrate compound (LiOH.H2O), and the final product (Li2CO3). The second objective was to survey measurement and analytical techniques which may be used in conjunction with each of the properties identified above, to determine the extent of conversion of LiOH to Li2CO3. Both real-time and post-run techniques were of interest. The techniques were also evaluated in terms of complexity, technology readiness, materials/equipment availability, and cost, where possible.

Selvaduray, Guna↗

The Viking X ray fluorescence experiment - Analytical methods and early results

Ten samples of the Martian regolith have been analyzed by the Viking lander X ray fluorescence spectrometers. Because of high-stability electronics, inclusion of calibration targets, and special data encoding within the instruments the quality of the analyses performed on Mars is closely equivalent to that attainable with the same instruments operated in the laboratory. Determination of absolute elemental concentrations requires gain drift adjustments, subtraction of background components, and use of a mathematical response model with adjustable parameters set by prelaunch measurements on selected rock standards. Bulk fines at both Viking landing sites are quite similar in composition, implying that a chemically and mineralogically homogeneous regolith covers much of the surface of the planet. Important differences between samples include a higher sulfur content in what appear to be duricrust fragments than in fines and a lower iron content in fines taken from beneath large rocks than those taken from unprotected surface material. Further extensive reduction of these data will allow more precise and more accurate analytical numbers to be determined and thus a more comprehensive understanding of elemental trends between samples.

Clark, B. C., III↗

Analytical methods for superresolution dislocation identification in dark-field X-ray microscopy

In this work, we develop several inference methods to estimate the position of dislocations from images generated using dark-field X-ray microscopy (DFXM)—achieving superresolution accuracy and principled uncertainty quantification. Using the framework of Bayesian inference, we incorporate models of the DFXM contrast mechanism and detector measurement noise, along with initial position estimates, into a statistical model coupling DFXM images with the dislocation position of interest. We motivate several position estimation and uncertainty quantification algorithms based on this model. We then demonstrate the accuracy of our primary estimation algorithm on synthetic realistic DFXM images of edge dislocations in single-crystal aluminum. We conclude with a discussion of our methods’ impact on future dislocation studies and possible future research avenues.

36 MATERIALS SCIENCE↗

Morphologically-Directed Raman Spectroscopy as an Analytical Method for Subvisible Particle Characterization in Therapeutic Protein Product Quality

Abstract Subvisible particles (SVPs) are a critical quality attribute of injectable therapeutic proteins (TPs) that needs to be controlled due to potential risks associated with drug product quality. The current compendial methods routinely used to analyze SVPs for lot release provide information on particle size and count. However, chemical identification of individual particles is also important to address root-cause analysis. Herein, we introduce Morphologically-Directed Raman Spectroscopy (MDRS) for SVP characterization of TPs. The following particles were used for method development: (1) polystyrene microspheres, a traditional standard used in industry; (2) photolithographic (SU-8); and (3) ethylene tetrafluoroethylene (ETFE) particles, candidate reference materials developed by NIST. In our study, MDRS rendered high-resolution images for the ETFE particles (> 90%) ranging from 19 to 100 μm in size, covering most of SVP range, and generated comparable morphology data to flow imaging microscopy. Our method was applied to characterize particles formed in stressed TPs and was able to chemically identify individual particles using Raman spectroscopy. MDRS was able to compare morphology and transparency properties of proteinaceous particles with reference materials. The data suggests MDRS may complement the current TPs SVP analysis system and product quality characterization workflow throughout development and commercial lifecycle.

Science & Technology - Other Topics↗

Analytical methods for online data quality assessment

This chapter provides a comprehensive overview of the main steps for algorithmic sensor signal quality assessment, which can enhance the decision-making process for water resource recovery facility (WRRF) operation and optimization. It introduces the concept of redundancy as the basis for data quality assessment. It also explains the typical data processing pipeline, which consists of preliminary analysis, data pre-processing, and specific algorithmic approaches. Each of these processes is presented and discussed in three separate sections. Importantly, this chapter introduces the main approaches for data quality assessment, provides guidelines for selecting the most suitable one and the key performance indicators to evaluate them and explains how to collect metadata through such an algorithmic approach.

Aguado, Daniel↗

NCSP Analytical Methods Subtask 3, AMPX Development and Maintenance, and NCSP Nuclear Data Subtask 6, SAMMY Modernization

The modernization of SAMMY continued with the removal of all container array access for the main program. The container array was used due to the computer limitations at the time of the initial writing of SAMMY, but it prevented the use of some modern code testing options. Additionally, the authors continued to make the code more modular by shifting the storage of the energy grid and the covariance information to C++ storage, thus allowing for better unit testing and the elimination of scratch files. For AMPX, the authors continued to implement the new Evaluated Nuclear Data File format to allow AMPX to read new evaluations as they become available.

73 NUCLEAR PHYSICS AND RADIATION PHYSICS↗

Analytic Method to Determine Angle Suitability

A method is presented for determining if the connector adaptor assembly (CAA) for a particular unit, as determined by Coordinate Measurement Machine (CMM), is suitable for use in an Alternate Configuration (AC).

42 ENGINEERING↗