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At least 91 records · Page 5

Pan-cancer evaluation of clinical value of mitotic network activity index (MNAI) and its predictive value for immunotherapy

Increased mitotic activity is associated with the genesis and aggressiveness of many cancers. To assess the clinical value of mitotic activity as prognostic biomarker, we performed a pan-cancer study on the mitotic network activity index (MNAI) constructed based on 54-gene mitotic apparatus network. Our pan-cancer assessment on TCGA (33 tumor types, 10,061 patients) and validation on other publicly available cohorts (23 tumor types, 9,209 patients) confirmed the significant association of MNAI with overall survival, progression-free survival, and other prognostic endpoints in multiple cancer types, including lower-grade gliomas (LGG), breast invasive carcinoma (BRCA), as well as many others. We also showed significant association between MNAI and genetic instability, which provides a biological explanation of its prognostic impact at pan-cancer landscape. Our association analysis revealed that patients with high MNAI benefitted more from anti-PD-1 and Anti-CTLA-4 treatment. In addition, we demonstrated that multimodal integration of MNAI and the AI-empowered Cellular Morphometric Subtypes (CMS) significantly improved the predictive power of prognosis compared to using MNAI and CMS alone. Our results suggest that MNAI can be used as a potential prognostic biomarker for different tumor types toward different clinical endpoints, and multimodal integration of MNAI and CMS exceeds individual biomarker for precision prognosis.

60 APPLIED LIFE SCIENCES↗

Synthesis of ARM User Facility Surface Rainfall Datasets to Construct a Best Estimate Value Added Product (PrecipBE)

Surface precipitation measurements are essential for Earth system model (ESM) evaluation and understanding cloud processes. An ever-growing need for robust, temporally evolving, and easy-to-use statistical datasets provides motivation for a baseline ground-based precipitation properties data product. The U.S. Department of Energy Atmospheric Radiation Measurement (ARM) user facility operates an extensive suite of precipitation instruments with various sensitivities and operating mechanisms, which render the decision of which instrument to use based on one or more fixed thresholds challenging and prone to errors and bias. Using a long-term instrument inter-comparison from a unique per-precipitation event perspective, rather than instantaneous sample comparison, we demonstrate that ARM rainfall-measuring instruments are generally consistent with each other at the statistical level. Inter-instrument deviations at the single event level can be large, especially for specific rainfall event properties such as maximum precipitation rates. A machine-learning (ML) analysis using a random forest regressor indicates that in some cases, depending on instrument, local site climatology, and/or specific deployment configuration, certain atmospheric state variables influence the measured quantities in an unpredictable manner. Thus, a-priori weighting of different instruments does not necessarily lead to more accurate and less biased synthesis of instrument data. These results motivate the design of the ARM precipitation best-estimate (PrecipBE) value-added product, which incorporates all valid precipitation data while considering data quality and other instrument limitations. PrecipBE consists of time series and tabular statistics datasets in an easy-to-use and insightful per-precipitation event format. It provides a large set of precipitation event properties supplemented with ancillary data from ARM datasets that correspond to the detected precipitation events. We describe the PrecipBE algorithm and demonstrate its use via the examination of a single-day output as well as a long-term trend analysis of precipitation events at the ARM Southern Great Plains (SGP) site, covering more than 30 years of data. The trend analysis tentatively suggests a long-term temporal tendency for mainly shorter and less intense precipitation events at the SGP site, but a long-term increase in annual rainfall by more than 36 mm (5 %) per decade. This rainfall trend is catalyzed primarily by more extreme event properties of relatively rare, intense precipitation events, with event total and 1 min maximum precipitation rate at a 1 year timeframe increasing up to 5 mm and 9 mm h −1 (several percent) per decade, respectively. While the currently available PrecipBE datasets (at https://adc.arm.gov/discovery/, last access: 8 December 2025) cover rainfall from multiple ARM deployments up to March 2025, PrecipBE is planned to be expanded to include solid-phase precipitation and will soon become an operational product with a several-day lag from real-time. We invite the ARM user community to leverage this new product and welcome user feedback to further enhance the dataset.

Silber, Israel [Pacific Northwest National Laborat↗

The economic value of remote sensing by satellite: An ERTS overview and the value of continuity of service. Volume 2: Source document

The economic value of an ERS system with a technical capability similar to ERTS, allowing for increased coverage obtained through the use of multiple active satellites in orbit is presented. A detailed breakdown of the benefits achievable from an ERS system is given and a methodology for their estimation is established. The ECON case studies in agriculture, water use, and land cover are described along with the current ERTS system. The cost for a projected ERS system is given.

Andrews, J.↗

The economic value of remote sensing of earth resources from space: An ERTS overview and the value of continuity of service. Volume 3: Intensive use of living resources, agriculture. Part 3: The integrated impact of improved (ERS) information on US agricultural commodities

The economic value of information produced by an assumed operational version of an earth resources survey satellite of the ERTS class is assessed. The theoretical capability of an ERTS system to provide improved agricultural forecasts is analyzed and this analysis is used as a reasonable input to the econometric methods derived by ECON. An econometric investigation into the markets for agricultural commodities is summarized. An overview of the effort including the objectives, scopes, and architecture of the analysis, and the estimation strategy employed is presented. The results and conclusions focus on the economic importance of improved crop forecasts, U.S. exports, and government policy operations. Several promising avenues of further investigation are suggested.

Seidel, A. D.↗

The economic value of remote sensing of earth resources from space: An ERTS overview and the value of continuity of service. Volume 5: Inland water resources

The economic value of an ERTS system in the area of inland water resources management is investigated. Benefits are attributed to new capabilities for managing inland water resources in the field of power generation, agriculture, and urban water supply. These benefits are obtained in the area of equal capability (cost savings) and increased capability (equal budget), and are estimated by applying conservative assumptions to Federal budgeting information, Congressional appropriation hearings, and ERTS technical capabilities.

Wetzler, E.↗

The economic value of remote sensing of earth resources from space: An ERTS overview and the value of continuity of service. Volume 8: Atmosphere

The economic value of an ERS system in the resource area of atmosphere is determined. Benefits which arise from air pollution and cloud observations correlated to ground stations are discussed along with cost savings associated with air pollution monitoring by satellite. Social benefits due to more precise knowledge of the effects of pollution are presented.

Miles, R.↗

Model performance in spatiotemporal patterns of precipitation: New methods for identifying value added by a regional climate model: Value added by a regional climate model

Regional climate models (RCMs) are a standard tool for downscaling climate forecasts to finer spatial scales. The evaluation of RCMs against observational data is an important step in building confidence in the use of RCMs for future prediction. In addition to model performance in climatological means and marginal distributions, a model’s ability to capture spatio-temporal relationships is important. This study develops two approaches: (1) spatial correlation/variogram for a range of spatial lags, with total monthly precipitation and non-seasonal precipitation components used to assess the spatial variations of precipitation; and (2) spatio-temporal correlation for a wide range of distances, directions, and time lags, with daily precipitation occurrence used to detect the dynamic features of precipitation. These measures of spatial and spatio-temporal dependence are applied to a high-resolution RCM run and to the National Center for Environmental Prediction (NCEP)-U.S. Department of Energy (DOE) AMIP II reanalysis data (NCEP-R2), which provides initial and lateral boundary conditions for the RCM. The RCM performs better than NCEP-R2 in capturing both the spatial variations of total and non-seasonal precipitation components and the spatio-temporal correlations of daily precipitation occurrences, which are related to dynamic behaviors of precipitating systems. The improvements are apparent not just at resolutions finer than that of NCEP-R2, but also when the RCM and observational data are aggregated to the resolution of NCEP-R2.

54 ENVIRONMENTAL SCIENCES↗

Enhancing metaproteomics-The value of models and defined environmental microbial systems

Metaproteomics - the large-scale characterization of the entire protein complement of environmental microbiota at a given point in time - added unique features and possibilities to study environmental microbial communities and to unravel these “black boxes”. New technical challenges arose which were not an issue for classical proteome analytics before and choosing the appropriate model system applicable to the research question can be difficult. Here, we reviewed different model systems for metaproteome analysis. Following a short introduction to microbial communities and systems, we discussed the most used systems ranging from technical systems over rhizospheric models to systems for the medical field. This includes acid mine drainage, anaerobic digesters, activated sludge, planted fixed bed reactors, gastrointestinal simulators and in vivo models. Model systems are useful to evaluate the challenges encountered within (but not limited to) metaproteomics, including species complexity and coverage, biomass availability or reliable protein extraction. The implementation of model systems can be considered as a step forward to better understand microbial responses and ecological distribution of member organisms. In the future, novel improvements are necessary to fully engage complex environmental systems.

54 ENVIRONMENTAL SCIENCES↗

Modularized Production of Fuels and other Value-Added Products from Distributed, Wasted, or Stranded Feedstocks

Distributed, wasted, or stranded feedstocks, when converted and upgraded into fuels, could replace about 6% of the US demand for liquid fuels, which is about 25% of the net import of petroleum by the US. We review the current state of modular approaches for conversion of these feedstocks, including the technology and economics associated with processing carbon-containing waste and stranded, carbon-containing gas. The wide geographic distribution of the feedstocks will require technology that can be scaled down effectively and that can be manufactured, installed, operated and monitored in ways that gain economies of mass production rather than economies of throughput scaling.

Weber, Robert S.↗

Cost-effective valorization of 2,3-butanediol to high-value chemicals and jet fuel

Here, this work outlines an optimized process for converting 2,3-butanediol (BDO) into sustainable aviation fuel (SAF) and C4 chemicals. BDO is reactively separated from fermentation broth by forming dioxolanes, which are converted to isobutyraldehyde, methyl ethyl ketone (MEK), and 1,3-butadiene. These intermediates are reduced and dehydrated over Cu/ZSM-5 to form alkenes, which can be oligomerized and hydrotreated to jet-range alkanes. Previous BDO-dioxolane-alkene processes are limited by the requirement for a continuous aldehyde source for dioxolane formation. Brønsted acidic zeolites catalyze dioxolane deacetalization to form isobutyraldehyde and MEK in a >2:1 molar ratio, providing an internal, recyclable aldehyde source. Dioxolane formation optimization was performed to achieve >95% dioxolane yields over Amberlyst-15 and minimize isobutyraldehyde recycle. The overall BDO-dioxolane-fuel process yields an alkane mixture that enables at least a 50% v/v blend with Jet-A. Techno-economic analyses and life cycle assessments for this BDO-dioxolane-fuel process yield scenarios with <$2.50 per gallon gas equivalent and >58% reduction in CO2 emissions.

2,3-butanediol↗