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DOE OSTI2025

scRNA seq of an F1 cross of Marek’s disease resistant and susceptible chickens identifies allele specific expression signatures enriched in transcription modulators

Abstract Marek’s disease (MD), a T cell lymphoma disease in chickens, is caused by the Marek’s disease virus (MDV) found ubiquitously in the poultry industry. Genetically resistant Line 6 3 (L6) and susceptible Line 7 2 (L7) chickens have been instrumental to research on avian immune system response to MDV infection. In this study we characterized molecular signatures unique to splenic immune cell types across different genetic backgrounds 6 days after infection. Using three populations, L6, L7, and an F1 cross between L6xL7, we evaluated the immune cell transcriptome of responding cell types using single cell RNA sequencing. Several MDV genes were found expressed mainly in cytotoxic T cells while ICP4 and MEQ MDV genes were expressed across infected cell types. Using the F1 we quantified allele specific expression (ASE) of biallelic SNPs and found biased expression of parental alleles specific to immune cell subtypes. We identified 22 SNPs with ASE in response to MDV infection mapped to gene rich regions surrounding 59 genes of critical importance for chromatin remodeling and transcriptional regulation. Histone deacetylase genes (HDAC1 and HDAC8) had increased expression of L6 alleles, while small nuclear RNA genes (SNORA68 and SNORA72) expressed higher levels of L7 alleles with infection in T cell subsets. SNPs with ASE also mapped genes important for an adequate immune response including GNLY (cytotoxic activity) and PDIA3 (component of MHC class I peptide loading complex), and genes known to promote viral replication (MCM5 and EIF3M). These results show that functional variants associated with susceptibility to MD may have a bigger impact in subsets of immune cell types, and by characterizing the transcriptomes of these subtypes we can unravel molecular signatures specific to MD genomic resistance.

Science & Technology - Other Topics↗

DOE OSTI2025

Determining the complex second-order optical susceptibility in macroscale van der Waals heterobilayers

In this work, we report on the experimental characterization of the second-order susceptibility in MoSe 2 /WS 2 heterobilayers, including their hidden complex phases. To this end, we developed a heterodyne-detection scheme for second-harmonic generation and applied it to macroscale heterobilayer samples prepared using the gold-tape exfoliation method. The heterodyne scheme enabled us to distinguish the relative orientation of the crystal domains, and furthermore, it allowed us to characterize the complex phases of the susceptibility relative to a reference quartz sample. By comparing the results from the monolayer regions and the heterobilayer region over several hundred microns of the sample area, we determined that the contribution of interlayer effects to second-harmonic generation is within the experimental uncertainty arising from the sample inhomogeneity. The results here provide fundamental quantitative information necessary for the precise design of nanophotonic systems based on stacking engineering.

2D materials↗

DOE OSTI2026

Perturbative second-order optical susceptibility of bulk materials: a symmetry-enforced return to non-orthogonal localized basis sets

The second-order optical susceptibility of semiconductors $\chi^{(2)}_{ijk}(-2\omega;\omega,\omega)$ finds application in metrology, spectroscopy, telecommunications, material characterization, and quantum information. Pioneering calculations of $\chi^{(2)}_{ijk}(-2\omega;\omega,\omega)$ utilized non-orthogonal Gaussian orbitals centered at atoms. That formulation transitioned into plane-wave-based algorithms as time went by. As of late, nevertheless, multiple tools for calculating optical susceptibilities have recast the problem using Wannier (i.e. localized) orbitals, making a comeback onto frameworks based on localized basis sets. Here, in this work, we present an approach for calculating $\chi^{(2)}_{ijk}(-2\omega;\omega,\omega)$ reliant on numerical pseudo-atomic orbitals (PAOs) within perturbation theory in the velocity gauge. Its salient feature is a calculation of ‘Slater–Koster-like’ two-center integrals of the momentum operator in between PAOs identified by symmetry. The approach was successfully tested on paradigmatic cubic silicon carbide (3C-SiC) and gallium arsenide, for which linear responses are contributed as well.

Huamán, Angiolo [Univ. of Arkansas, Fayetteville, ↗

DOE OSTI2024

Controlling 4 f antiferromagnetic dynamics via itinerant electronic susceptibility

Optical manipulation of magnetism holds promise for future ultrafast spintronics, especially with lanthanides and their huge, localized 4 f magnetic moments. These moments interact indirectly by spin polarizing the conduction electrons (the Ruderman-Kittel-Kasuya-Yosida exchange interaction), influenced by interatomic orbital overlap, and the conduction electron's susceptibility around the Fermi level. Here, we study this influence in a series of 4 f antiferromagnets, Gd T 2 Si 2 ( T = Co, Rh, Ir), using ultrafast resonant x-ray diffraction. We observe a twofold increase in the ultrafast intersublattice angular momentum transfer rate between the materials, originating from modifications in the conduction electron susceptibility, as confirmed by first-principles calculations. Published by the American Physical Society 2024

36 MATERIALS SCIENCE↗

DOE OSTI2025

Generalized susceptibilities and the properties of charm degrees of freedom across the QCD crossover temperature

We study the generalized charm susceptibilities in 2+1 flavor QCD on the lattice at several lattice spacings. We show that, below the chiral crossover, these susceptibilities are well described by the hadron resonance gas (HRG) model if charmed hadrons not listed in tables of the Particle Data Group are included. However, the HRG description abruptly breaks down just above the chiral crossover. To understand this, we use a model for the charm pressure in which it is expressed as the sum of partial pressures from charmed baryons, charmed mesons, and charm quarks. We present continuum estimates of these partial pressures and find that, while the partial pressures of charmed mesons and baryons drop below their respective HRG predictions, the charm quark pressure becomes nonzero above the chiral crossover.

73 NUCLEAR PHYSICS AND RADIATION PHYSICS↗

DOE OSTI2025

The diurnal susceptibility of subtropical clouds to aerosols

The diurnal susceptibility of clouds and their radiative properties to aerosols is examined during their Lagrangian transition from subtropical stratocumulus to shallow cumulus regimes. Using large-eddy simulations, we analyze the six-day evolution of an air mass along a 3800 km observed trajectory from the coast of Peru toward the equator. Pristine and polluted scenarios are simulated with forcing imposed from weather reanalysis. The polluted scenario exhibits stronger diurnal variations in cloud water, cloud fraction, and albedo, with enhanced nighttime entrainment and suppressed precipitation. The overall response of cloud properties and outgoing shortwave radiation to droplet number concentration follows a distinct diurnal pattern: strong positive cloud adjustments dominate at night and in the morning, while weak negative adjustments prevail in the afternoon. This cycle is driven by the competition between precipitation suppression, which enhances cloud water and coverage, and entrainment drying, which depletes them. In polluted conditions, enhanced entrainment leads to a deeper and more decoupled boundary layer that cannot be sustained by surface fluxes in the afternoon, resulting in negative cloud adjustments. The enhanced entrainment rate under polluted conditions is caused by the reduced sedimentation of cloud and precipitation water from the entrainment zone. While the Twomey effect dominates the diurnal average albedo response, the diurnal variation in the competing cloud adjustments lead to a near-neutral net susceptibility in the afternoon, highlighting the critical role of diurnally varying processes in aerosol-cloud interactions.

Geosciences↗

NASA NTRS1972

Effect of sleep-wake reversal and sleep deprivation on the circadian rhythm of oxygen toxicity seizure susceptibility.

Albino Sprague-Dawley rats were exposed in a previously O2 flushed, CO2 free chamber. The exposure began with attainment of 60 psi (gauge) and the end point was the first generalized oxygen toxicity seizure. Animals were exposed to reversal diurnal conditions since weanlings until their sleep-wake cycles had completely reversed, and then divided into four groups of 20 based on the time of day exposed. The time of exposure to oxygen at high pressure prior to seizure was now significantly longer in the group exposed from 1900 to 2000 hr and a reversal of the circadian rhythm of oxygen toxicity seizure susceptibility was noted. Animals maintained on normal diurnal conditions were deprived of sleep on the day of exposure for the 12 hours prior to exposure at 1900 hr, while controls were allowed to sleep. There was no significant differences in the time prior to seizure between the deprived animals and the controls with an n = 40. Thus the inherent threshold in susceptibility to high-pressure oxygen seizures seems not to be a function of sleep itself, but of some biochemical/physiologic event which manifests a circadian rhythm.

Dexter, J. D.↗

NASA NTRS1975

A rapid method for the determination of microbial susceptibility using the firefly luciferase assay for adenosine triphosphate (ATP)

Luciferase assay for adenosine triphosphate (ATP) was optimized for pure bacteria in broth in order to evaluate if changes in bacterial ATP content could be used as a rapid measure of antibiotic effect on microorganisms. Broth cultures of log phase bacteria were incubated at 310 K (37 C) for 2.5 hours at antimicrobial concentrations which resulted in the best discrimination between sensitive and resistant strains. Eighty-seven strains of 11 bacterial species were studied for their susceptibility to 12 commonly used antimicrobial agents: ampicillin, Penicillin G, nafcillin, carbenicillin, cephalothin, tetracycline, erythromycin, clindamycin, gentamicin, nitrofurantoin, colistin, and chloramplenicol. The major advantage of the ATP system over existing methods of rapid microbial susceptibility testing is that the assay can be made specific for bacterial ATP.

Vellend, H.↗

NASA NTRS1976

The frequency dependence of the viscous component of the magnetic susceptibility of lunar rock and soil samples

The susceptibility of two lunar samples (a soil and a low metamorphic grade breccia) has been measured in a weak field - 0.001 Oe - and as a function of frequency from 0.032 to 1.0 Hz. The measurements were made using a superconducting magnetometer. The results show that the susceptibility decreases linearly with the log of frequency. This observation is in agreement with a theoretical model for viscous decay based on the Neel theory of single-domain and superparamagnetic grains. The relation derived agrees with a model in which there is a uniform distribution of relaxation times.

Hanneken, J. W.↗

NASA NTRS1977

Susceptibility to hot corrosion of four nickel-base superalloys, NASA-TRW VIA, B-1900, 713C and IN-738

The susceptibility to hot corrosion of four nickel-base, cast superalloys has been studied at 900 and 1000 C. The test consisted of coating alloy samples with known amounts of Na2SO4 and oxidizing the coated samples isothermally in 1 atmosphere of slowly flowing oxygen, the weight-gain being monitored on a sensitive recording microbalance. Susceptibility to hot corrosion decreased in the order of decreasing molybdenum content of the alloys. Preoxidation of samples before hot-corrosion testing markedly increased the induction period observed prior to the inception of hot corrosion for all alloys tested. X-ray diffraction analyses of the oxide scales were made. All samples that underwent hot corrosion showed the presence of a (Ni,Co)MoO4 layer near the alloy-oxide interface. Several specimens displayed resistance to hot corrosion and these showed NaTaO3 as a prominent feature in their oxide scale. Our results may be interpreted as indicating that molybdenum in an alloy is detrimental, with respect to hot corrosion, while tantalum is beneficial.

Stearns, C. A.↗

NASA NTRS1979

Determination of antimicrobial susceptibilities on infected urines without isolation

A method is described for the quick determination of the susceptibilities of various unidentified bacteria contained in an aqueous physiological fluid sample, particularly urine, to one or more antibiotics. A bacterial adenosine triphosphate (ATP) assay is carried out after the elimination of non-bacterial ATP to determine whether an infection exists. If an infection does exist, a portion of the sample is further processed, including subjecting parts of the portion to one or more antibiotics. Growth of the bacteria in the parts are determined, again by an ATP assay, to determine whether the unidentified bacteria in the sample are susceptible to the antibiotic or antibiotics under test.

Picciolo, G. L.↗

NASA NTRS1979

Rotation at 30 RPM about the Z axis after 6 hours in the 10-deg head-down position - Effect on susceptibility to motion sickness

Intraindividual differences in susceptibility to motion sickness were measured in 14 subjects for two conditions of rotation at 30 rpm in the 10-deg head-down position. In one condition, subjects were in the 10-deg head-down position for 6 h prior to the onset of rotation; in the other condition, the delay was only 15 min. In both conditions, there were changes in vital capacity, indicating a redistribution of movable body fluids. Subjects tended to be less susceptible to motion sickness when they were recumbent for 6 h prior to rotation. These results are counterevidence for the hypothesis that shifts of body fluid are responsible in large part for the motion sickness elicited in orbital space flight.

Graybiel, A.↗

NASA NTRS1979

Some influences of vision on susceptibility to motion sickness

Two experiments were performed to evaluate the influence of vision on susceptibility to motion sickness during exposure to constant patterns of vestibular stimulation. The motion profile involved accelerating subjects at 20 deg/sec per sec to 300 deg/sec, maintaining them at that constant velocity for 30 sec, and decelerating them to a rapid stop in about 1.5 sec. The number of stops tolerated by a subject before reaching the motion sickness endpoint served as his score. In Experiment 1, subjects were tested twice with their eyes open and twice with their eyes blindfolded. They tolerated fewer sudden stops when permitted sight of the experimental chamber. In Experiment 2, the effect of having the eyes open or closed at different stages of the motion profile was evaluated. Having the eyes open during any stage of the test was more stressful than having the eyes closed, but this was especially true during the sudden stops. The findings are discussed in terms of their general implications for understanding (1) situations in which vision alone elicits symptoms of motion sickness, and (2) situations involving vestibular stimulation where vision heightens susceptibility.

Lackner, J. R.↗

NASA NTRS1979

Motion sickness susceptibility during rotation at 30 rpm in free-fall parabolic flight

To make comparisons with experimental motion sickness susceptibility in Skylab missions, subjects were tested during free fall in parabolic flight and in ground-based simulation tests. They were rotated at 30 rpm in a rotating litter chair (RLC) with head fixed, head swiveling left-to-right, or with 90 degree forward and return head and body movements. Stressful accelerations similar to those in the Skylab RLC were generated only in the tests aloft, where subjects who made 'forward and return' movements (generating cross-coupled angular accelerations) were substantially more prone to motion sickness than those with either head fixed or head swiveling left-to-right. However, with head swiveling, susceptibility was slightly higher in the laboratory than aloft.

Graybiel, A.↗

NASA NTRS1981

Toward the assessment of the susceptibility of a digital system to lightning upset

Accomplishments and directions for further research aimed at developing methods for assessing a candidate design of an avionic computer with respect to susceptability to lightning upset are reported. Emphasis is on fault tolerant computers. Both lightning stress and shielding are covered in a review of the electromagnetic environment. Stress characterization, system characterization, upset detection, and positive and negative design features are considered. A first cut theory of comparing candidate designs is presented including tests of comparative susceptability as well as its analysis and simulation. An approach to lightning induced transient fault effects is included.

Tront, J. G.↗

NASA NTRS1982

The relative stress-corrosion-cracking susceptibility of candidate aluminum-lithium alloys for aerospace applications

Stress corrosion tests of Al-Li-Cu powder metallurgy alloys are described. Alloys investigated were Al-2.6% Li-1.4% and Al-2.6% Li-1.4% Cu-1.6% Mg. The base properties of the alloys were characterized. Process, heat treatment, and size/orientational effects on the tensile and fracture behavior were investigated. Metallurgical and electrochemical conditions are identified which provide reproducible and controlled parameters for stress corrosion evaluation. Preliminary stress corrosion test results are reported. Both Al-Li-Cu alloys appear more susceptible to stress corrosion crack initiation than 7075-T6 aluminum, with the magnesium bearing alloy being the most susceptible. Tests to determine the threshold stress intensity for the base and magnesium bearing alloys are underway. Twelve each, bolt loaded DCB type specimens are under test (120 days) and limited crack growth in these precracked specimens has been observed. General corrosion in the aqueous sodium chloride environment is thought to be obscuring results through crack tip blunting.

Pizzo, P. P.↗

NASA NTRS1982

Susceptibility of symmetric structures to nonlinear torsional coupling

The susceptibility to induced torsional response of symmetric building structures with nonliner resisting elements was investigated. Stability curves show the effect of the arrangement of the load resisting elements on induced torsional coupling in these nonliner but other wise symmetric structures. Universal upper and lower bound instability curves are also derived; these identify the susceptibility to torsional coupling of symmetric structures with different stiffness arrangements but which have equal mass and total lateral stiffness, and which are intended to model alternative structural strategies for lateral load resistance.

Pekau, O. A.↗

NASA NTRS1984

Upset susceptibility study employing circuit analysis and digital simulation

This paper describes an approach to predicting the susceptibility of digital systems to signal disturbances. Electrical disturbances on a digital system's input and output lines can be induced by activities and conditions including static electricity, lightning discharge, Electromagnetic Interference (EMI) and Electromagnetic Pulsation (EMP). The electrical signal disturbances employed for the susceptibility study were limited to nondestructive levels, i.e., the system does not sustain partial or total physical damage and reset and/or reload will bring the system to an operational status. The front-end transition from the electrical disturbances to the equivalent digital signals was accomplished by computer-aided circuit analysis. The Super-Sceptre (system for circuit evaluation of transient radiation effects) Program was used. Gate models were developed according to manufacturers' performance specifications and parameters resulting from construction processes characteristic of the technology. Digital simulation at the gate and functional level was employed to determine the impact of the abnormal signals on system performance and to study the propagation characteristics of these signals through the system architecture. Example results are included for an Intel 8080 processor configuration.

Carreno, V. A.↗