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ISS Crew Transportation and Services Requirements Document

Under the guidance of processes provided by Crew Transportation Plan (CCT-PLN-1100), this document with its sister documents, Crew Transportation Technical Management Processes (CCT-PLN-1120), Crew Transportation Technical Standards and Design Evaluation Criteria (CCT-STD-1140), and Crew Transportation Operations Standards (CCT-STD-1150), and International Space Station (ISS) to Commercial Orbital Transportation Services Interface Requirements Document (SSP 50808), provides the basis for a National Aeronautics and Space Administration (NASA) certification for services to the ISS for the Commercial Provider. When NASA Crew Transportation System (CTS) certification is achieved for ISS transportation, the Commercial Provider will be eligible to provide services to and from the ISS during the services phase of the NASA Commercial Crew Program (CCP).

Commercial Crew Program↗

Crew Transportation Technical Management Processes

Under the guidance of processes provided by Crew Transportation Plan (CCT-PLN-1100), this document, with its sister documents, International Space Station (ISS) Crew Transportation and Services Requirements Document (CCT-REQ-1130), Crew Transportation Technical Standards and Design Evaluation Criteria (CCT-STD-1140), Crew Transportation Operations Standards (CCT STD-1150), and ISS to Commercial Orbital Transportation Services Interface Requirements Document (SSP 50808), provides the basis for a National Aeronautics and Space Administration (NASA) certification for services to the ISS for the Commercial Provider. When NASA Crew Transportation System (CTS) certification is achieved for ISS transportation, the Commercial Provider will be eligible to provide services to and from the ISS during the services phase.

Summary of the technical management process↗

Meteor Shower Forecast Improvements from a Survey of All-Sky Network Observations

Meteoroid impacts are capable of damaging spacecraft and potentially ending missions. In order to help spacecraft programs mitigate these risks, NASA's Meteoroid Environment Office (MEO) monitors and predicts meteoroid activity. Temporal variations in near-Earth space are described by the MEO's annual meteor shower forecast, which is based on both past shower activity and model predictions. The MEO and the University of Western Ontario operate sister networks of all-sky meteor cameras. These networks have been in operation for more than 7 years and have computed more than 20,000 meteor orbits. Using these data, we conduct a survey of meteor shower activity in the "fireball" size regime using DBSCAN. For each shower detected in our survey, we compute the date of peak activity and characterize the growth and decay of the shower's activity before and after the peak. These parameters are then incorporated into the annual forecast for an improved treatment of annual activity.

Moorhead, Althea V.↗

Soil Crystallinity As a Climate Indicator: Field Experiments on Earth and Mars

Soil crystallinity is largely determined by leaching rates, as high leaching rates favor the rapid precipitation of short order or poorly-crystalline phases like the aluminosilicate allophane. High leaching rates can occur due to high precipitation rates, seasonal monsoons, or weathering of glass, but are also caused by the rapid onset of seasonal melting of snow and ice in cold environments. Thus, cold climate soils are commonly dominated by poorly crystalline phases, which mature into kaolin minerals over time. Thus, we hypothesize that, in some contexts, soils with high abundances of poorly crystalline phases could indicate formation under cold climatic conditions. This model could be helpful in interpreting the poorly-constrained paleoclimate of ancient Mars, as the crystallinity of ancient soils and soil-derived sediments appears to be highly variable in time and space. While strong signatures of crystalline phyllosilicates have been identified in possible ancient paleosols on Mars, Mars Science Laboratory rover investigations of diverse ancient sediments at Gale Crater has shown that they can contain very high abundances (40-50 wt%) of poorly crystalline phases. We hypothesize that these poorly crystalline phases could be the result of weathering by ice/snow melt, perhaps providing support for sustained cold climates on early Mars punctuated by more limited warm climates. Furthermore, such poorly crystalline soils could be highly fertile growth media for future human exploration and colonization on Mars. To test this hypothesis, we are currently using rover-like instrumentation to investigate the mineralogy and chemistry of weathering products generated by snow and ice melt in a Mars analog alpine environment: the glaciated Three Sisters volcanic complex in central Oregon. Alteration in this glacial environment generates high abundances of poorly crystalline phases, many of which have compositions distinct from those identified in previous terrestrial investigations, and perhaps more similar to poorly crystalline phases identified on Mars.

Horgan, Briony↗

Lessons Learned from Radiative Transfer Simulations of the Venus Atmosphere

The Venus atmosphere is extremely complex, and because of this the spectrum of Earths sister planet is likewise intricate and a challenge to model accurately. However, accurate modeling of Venus spectrum opens up multiple opportunities to better understand the planet next door, and even for understanding Venus-like planets beyond our solar system. Near-infrared (1-2.5 um, NIR) spectral windows observable on the Venus nigthside present the opportunity to probe beneath the Venusian cloud deck and measure thermal emission from the surface and lower atmosphere remotely from Earth or from orbit. These nigthside spectral windows were discovered by Allen and Crawford (1984) and have since been used measure trace gas abundances in the Venus lower atmosphere (less than 45 km), map surface emissivity varisions, and measure properties of the lower cloud deck. These windows sample radiation from below the cloud base at roughly 45 km, and pressures in this region range from roughly Earthlike (approx. 1 bar) up to 90 bars at the surface. Temperatures in this region are high: they range from about 400 K at the base of the cloud deck up to about 740 K at the surface. This high temperature and pressure presents several challenges to modelers attempting radiative transfer simulations of this region of the atmosphere, which we will review. Venus is also important to spectrally model to predict the remote observables of Venus-like exoplanets in anticipation of data from future observatories. Venus-like planets are likely one of the most common types of terrestrial planets and so simulations of them are valuable for planning observatory and detector properties of future telescopes being designed, as well as predicting the types of observations required to characterize them.

Arney, G.↗

Space Biology Meets Astrobiology: Critical Synergies and Concerns

The broad fields of space biology and astrobiology share much in common in terms of science questions, approaches, and goals. However, historical circumstances and funding agency practices have frequently resulted in a wide separation between the two related areas. Is this a good thing? We believe that it is not, and that much is to be gained in each field from sharing ideas, resources, and perhaps projects between investigators traditionally working in one discipline or the other. Some of the strengths that the Space Biology community offers include sophistication and experience in flying experiments on space missions. In turn, Astrobiology has focused heavily on ground-based and field research. Challenging physical and chemical conditions experienced in space and on other planets partially overlap, and much can be gleaned from the body of work of each community along these topical lines. A combination of these areas of expertise and experience could result in major advances to all involved. When possible, avoiding having to reinvent methods or approaches already used by a sister community can result in greater efficiencies of resource use. We will discuss some case studies where we believe there are significant overlaps including adaptation to a variety of environmental stresses, extremophiles as potential flight organisms, microfluidics as applied to planetary environment simulations, and others.

Extremophiles↗

Addressing Human Error in International Space Station Flight Control Teams: Advances in Ground Training for Science Operators

In flight control, as with any human in the loop system, operator error is an inevitable reality. On the International Space Station (ISS) where crew time and physical resources are precious and often irreplaceable, operator errors can result in significant, irreversible consequences. Flight controllers at the Payload Operations Integration Center (POIC) located at NASA's Marshall Space Flight Center (MSFC) in Huntsville, Alabama know this reality well. At the POIC, operator errors can be caused by a variety of factors, from poor hardware or software design to environmental factors such as time pressure or fatigue. The most difficult errors to address, however, are those which result from ineffective teamwork. To address these teamwork errors, trainers at the POIC have drawn best practices from high reliability industries as well as from our sister ISS control center at the Johnson Space Center (JSC) in Houston, Texas, to develop and implement a new training program focused specifically on teamwork skills. This training program, called Team Skills Training, is inspired by modern and historical training programs developed by NASA and is specifically tailored to the needs of the payload operations flight control team at the POIC. The program consists of training for both certified and trainee flight controllers, and covers team skills topics such as situational awareness, leadership, and communication skills. To maximize effectiveness, the program uses novel instructional techniques which extend beyond the classroom to encourage students to apply what they have learned to their day to day work. Minimizing operator errors in flight control is an endeavor which requires constant vigilance and continuous improvement. At the POIC, Team Skills Training is an important step in this journey.

Harris, Samantha S.↗

Sediment Transport and Aqueous Alteration in a Mars-Analog Glacial System

The bulk of the Martian crust is basaltic with a wide variety of subsequently derived aqueous alteration phases. Study of analogue terrains is vital to better understand the weathering of such mafic bedrock at a range of surface temperatures. Moreover, climatic models have suggested that the early Martian climate was not warm and wet, but cold and icy, with some of the apparent fluvial and lacustrine features attributable to transient melting of ice sheets as opposed to persistent surface water. This study examines sediment samples from Collier glacial valley, Three Sisters, Oregon (OR), with the aim of better characterizing erosion, transport, and in situ aqueous alteration in a glaciated Mars-analogue terrain.

Bamber, E. R.↗

Simulating the Surface of Venus on Earth

The growing interest in comparative climatology among the terrestrial planets, the explosion of planets being discovered around other stars and the exciting results of recent orbital and remote observations of Venus provide evidence for a growing case to better understand Earths sister planet. The surface of Venus is quite unlike Earths surface conditions, and in fact is rather extreme. Science, technology, and planetary mission communities have a growing interest in the unique physiochemical properties and processes that occur under extreme temperature and pressure conditions in exotic and even hostile chemical environments such as Venus. The steadily growing catalog of exoplanets likely contains many examples of bodies with environments dramatically different than the surface of the Earth. Understanding these properties and processes will help us under-stand the history and present day state of inhospitable and even inaccessible regions of the Earth as well as other solar or extrasolar planets. Additionally, Venus and Saturn targets are prioritized in the current Planetary Decadal Survey, with reference missions that include in-situ investigations of these challenging environments. The fact that two of the five recent Discovery mission proposals selected by NASA for further development are Venus-focused adds additional priority and even urgency to laboratory-based extreme environment investigations. In addition to the importance of science-focused investigations, there is a current and future need for understanding the behavior of advanced technologies and materials in these extreme environments. The materials of course make up instruments and systems in missions and ultimately the success of planetary missions is dependent upon performance testing of instruments and systems in conditions that closely approximate those of the target. Until very recently, there was limited ability to accurately simulate Venus surface-like conditions, especially in vessels large enough to accommodate full-size instruments and components. This gap in capability is being addressed by NASA Glenn's Extreme Environment Rig, called GEER, located in Cleveland, Ohio. This large chamber allows for engineering tests of newly-developed as well as heritage instruments, while simultaneously affording opportunities for geochemical and materials-based science investigations.

Simulation↗

Addressing Human Error in International Space Station Flight Control Teams: Advances in Ground Training for Science Operators

In flight control, as with any human in the loop system, operator error is an inevitable reality. On the International Space Station (ISS) where crew time and physical resources are precious and often irreplaceable, operator errors can result in significant, irreversible consequences. Flight controllers at the Payload Operations Integration Center (POIC) located at NASA’s Marshall Space Flight Center (MSFC) in Huntsville, Alabama know this reality well. At the POIC, operator errors can be caused by a variety of factors, from poor hardware or software design to environmental factors such as time pressure or fatigue. The most difficult errors to address, however, are those which result from ineffective teamwork.Academic research in teamwork has resulted in the identification of many factors which make cross-functional teaming difficult, including leadership, trust building, and communication challenges. These factors, especially when combined with the challenging environmental factors flight control teams must contend with daily, make the goal of minimizing operator errors in payload operations challenging to achieve. To address such teamwork errors, trainers at the POIC have drawn best practices from high reliability industries such as commercial aviation, healthcare, and nuclear power plants, as well as from our sister ISS control center in Houston, Texas, to develop and institute a new training program focused specifically on teamwork skills.This training program, called the Team Skills Curriculum, is based on the concept of Crew Resource Management (CRM) which was developed by NASA in the 1970s for the commercial aviation industry in response to a series of aviation disasters resulting from ineffective teamwork. CRM was later tailored by the Johnson Space Center (JSC) for use in astronaut and flight control training. The result, called Space Flight Resource Management (SFRM) was formally introduced into manned spaceflight training in the late 90s. SFRM has evolved over the years, but the focus has remained on helping operators develop the skills needed to work as part of an effective team. Using these concepts as well as the latest research in cross-functional teaming and data on specific errors occurring at the POIC, trainers in the integrated flight control training branch created a custom training program for both new and certified payload operations specialists.

Harris, Samantha S.↗

Pioneer Odyssey: Encounter with a Giant

Ancient peoples, perhaps thousands of years ago, undoubtedly conceived the idea of "reaching out" to Jupiter, the largest and most brilliant of the "wandering stars." But for mankind to stretch across the half billion miles to the giant planet of the Solar System many advances in technical and organizational fields of human endeavor had to be made. Outreach to Jupiter did not become a serious possibility until the Pioneer F and G Project was formed by NASA early in 1968. And then man began to design an extension of his senses that would probe the environs of the giant of the Solar System, a truly pioneer odyssey into the virtually unknown regions beyond the orbit of Mars. In the ensuing year. a dedicated and cooperative effort of several thousand people in Govern­ment, university, and private industrial organiza­tions converted the idea into a reality. Less than twelve generations after Galileo first saw the banded disc of Jupiter and the flickering dots of its large satellites in the newly invented telescope, mankind sent a machine to make observations within that Jovian system. The two Pioneer spacecraft for the mission to Jupiter each weighed only about 570 pounds, yet carried eleven highly sophisticated instruments capable of operating unattended for many year in space. The spacecraft consumes less electrical power than a standard 100 watt lamp yet is able to accept instructions from Earth to control numerous operating modes of its scientific payload, process observations from these scientific instruments and format the observations into information usable on Earth. Even more remarkable. the space­craft transmits a radio signal of only 8 watts power - equal to a nightlight - yet the information carried by the radio signal is received back on Earth from a distance of several billion miles. The Pioneer mission could not have been a success without the special engineering, scientific and management organization created for its accomplishment. This organization was rather unique in that it first had to meet a launch date target relatively quickly and then had to function for an extremely long mission operational time, far longer than any previous mission to planets. The first task was thus to organize so that the mission could be planned and the spacecraft designed and fabricated to be ready for launch within a few weeks of a 30-month target for completion. The program also produced an organization that planned mission operations to such detail that more than 16,000 commands were transmitted flawlessly to the distant spacecraft during Jupiter encounter. And each command reached the spacecraft within one second of the planned time despite the more than 90 minutes required for the radio message to travel from Earth to the space­craft and for the spacecraft to return a confirma­tion to controllers back on Earth. The organization for Pioneer also determined the required flight path from Earth to Jupiter with such precision, and controlled the launch vehicle with such accuracy, that 21 months after launch the spacecraft was able to fly behind Jupiter's satellite lo, thereby providing the first measurement that indicated the possibility of a tenuous atmosphere about this large satellite. Finally, the Pioneer organization processed and analyzed each year sufficient information from the spacecraft to fill a book having about 3 million pages and reduced this avalanche of data from space into summaries of manageable size. And all this organization depended on people, consisted of people: the people who really made this whole mission possible. Pioneer has always depended on the dedication of many individuals from many organizations throughout the world to achieve its scientific objectives, and, as evidenced by the success of the Pioneer series, this dependence is completely justified. Relatively few individuals have an opportunity during their lives to participate in such a challenging, historic, pioneering effort; and still fewer are able to enjoy the rewards of such an activity. We who have worked on Pioneer 10 and its sister spacecraft, Pioneer 11, consider ourselves fortunate to be in both classes. For the opportunity we thank the people of the United States of America, who have supported our country's space effort and its spreading of human awareness of a vast and intriguing universe in which our own unique planet Earth is only one of myriads of worlds. This volume describing the mission to Jupiter and its results is one of the many rewards for our effort which we share with you, the reader.

Fimmel, Richard O.↗

Mineralogical Signatures of Cold and Icy Climates on Ancient and Modern Mars

Liquid water was abundant on early Mars, but whether the climate was warm and wet or cold and icy with punctuated periods of melting is still poorly understood. Modern climate models for Mars tend to predict a colder, icier early climate than previously imagined [e.g., 1]. However, any model for the early climate on Mars must be reconciled with the chemical record. We currently do not understand how alteration mineralogy formed in snow and ice dominated conditions compares to that of warmer climates, and it is unclear whether cold climate weathering could form all or any of the aqueous alteration phases expressed on early martian surfaces [2]. To help resolve this knowledge gap, we synthesize results from glacial Mars analog sites at the Three Sisters, Oregon and mafic regions of the Antarctic ice sheet, and compare them to the surface mineralogy of Mars. These sites provide the opportunity to investigate weathering in environments analogous to glacial environments on Mars throughout geologic time, including snowpacks or smaller wet-based or polythermal glaciers [3, 4] as well as the proposed extensive ice sheets of the late Noachian icy highlands model

Scudder, N. A.↗

Long Duration Venus Probes and Landers

Planetary probes have long been a tool used by scientists to gain early clues on environments and systems of new planetary targets. This not only fueled the scientific process but also helped prepare for future missions, such as landers, and helped ensure their success. Venus, Earth's sister planet, has been the target of more probes and landers than any other body in our solar system except for Earth and yet many fundamental questions are unanswered. Challenge for Venus Surface Science: This lack of knowledge is a result of the challenging Venus environments. Remote sensing of the surface and portions of the atmosphere is difficult at best due to the thick layers of sulfuric acid clouds and the high pressure supercritical CO2 atmosphere below those clouds. This has hampered the ability of orbiting missions to provide us insight into surface features and processes and thus hides potential clues on interior process from our view. Surface probes and landers face an even more daunting challenge, which is the extreme temperature, pressure and unfriendly chemical composition of the near surface atmosphere. Over 10 assets have landed on the surface yet the longest surviving asset Venera-13 lasted only 127 minutes before succumbing to the extreme temperature. While this and other landers provided valuable new data, the short life impacted ability to understand any temporal processes, for example meteorology, seismic active, and therefore very little is known about the interior and surface atmosphere interactions. New Capability Offering Potential Solutions: Re-cent developments by NASA are offering hope of overcoming the technical challenges of surface operations and life with the use of high temperature electronics and systems. Wide band gap, SiC based electronics have been demonstrated to function successfully for extended periods of time both at 500C, Venus surface temperatures as well as when temperature is combined with the reactive chemistry of the surface atmosphere and the high pressures (over 90 bar pressure at the surface). In addition to electronics a number of other subsystems are in development including power in the form of high temperature batteries and power management devices, communications including antennas, transmitters and other components, materials, and structures and mechanisms. These are all activities under NASA's Long Lived In situ Solar System Exploration (LLISSE) project. Other activities are also funded under NASA's HOTTech program.

Kremic, T.↗

High-Resolution Spectroscopy of Titan with SOFIA/EXES

We present the first observation of Titan with the high resolution Echelon cross-Echelle Spectrograph(EXES) instrument on the Stratospheric Observatory for Infrared Astronomy (SOFIA, Fig. 1). These show clear detection of multiple spectral lines in the R-branch of the acetylene vibrational band at 13 m. These are compared to similar observations with the ground-based sister instrument TEXES (Texas Echelon cross-Echelle Spectrograph) on the IRTF(Infrared Telescope Facility), showing that EXES will have access to an enlarged spectral range as expected, through reduced atmospheric opacity. In future EXES will be used to complement TEXES for spectral line searches on Titan, geared to detect new molecular species, focusing on spectral regions that are inaccessible from the ground.

Nixon, Conor A.↗

Long-Duration Venus Lander Development

One of the most intriguing planets in our solar system for both solar system and extra-solar system science is Venus. Venus is the planet most similar to Earth in several key ways and many believe Venus-like planets are more common around other suns than are Earth-like planets. Therefore scientific understanding of our sister planet is a high priority. However, the hostile environmental conditions at the surface coupled with thick acid clouds and dense atmosphere have made understanding this planet very challenging. Remote sensing of surface features and near surface environments is very limited. The hostile environment has also limited the ability of landers to survive, in fact the longest living asset survived just over two hours. Even after over 50 years of attempts to explore Venus, many key measurements, especially near the surface, are still in the future. NASA has begun to undertake steps to overcome the technical challenges and is developing the capability for sustained operations and science return from this important body. For example, recent technology advances in high temperature sensors, electronics, power, and other systems have been funded and this, combined with the new capabilities to replicate Venus conditions on Earth, are changing the outlook for Venus surface exploration.

Kremic, Tibor↗

Freeze-Thaw Cycling as a Chemical Weathering Agent on a Cold and Icy Mars

Liquid water was abundant on early Mars, but whether the climate was warm and wet or cold and icy with punctuated periods of melting is still poorly understood. Modern climate models for Mars tend to predict a colder, icier early climate than previously imagined. In addition, ice and glaciation have been major geologic agents throughout the later Hesperian and Amazonian eras. One process that can act in such climates is repeated freezing and thawing of water on the surface and in the subsurface, and is significant because it can occur anywhere with an active layer and could have persisted for a time after liquid water was no longer stable on Mars’ surface. As freeze-thaw is the dominant mechanical weathering process in most glacial/periglacial terrains, it was likely a significant geomorphologic driver at local to regional scales during past climates, and would potentially have been most active when day-average surface temperatures exceeded 0 °C for part of the year. Indeed, freeze-thaw involving liquid water in the Amazonian is evidenced by abundant geomorphic features including polygonal ground and solifluction lobes requiring seasonal thawing. In addition to physical modification, freezing can drive solutions towards supersaturation and force dissolved solutes out as precipitates. In Mars-like terrains, dissolved solutes are typically dominated by silica. In polar regions on Earth, freeze-thaw cycles have been shown to promote deposition of silica, and freeze-thaw experiments on synthetic solutions found stable amorphous silica that built up over multiple cycles. Freeze-thaw may therefore be an important but overlooked chemical weathering process on Mars. However, our ability to assess its impact on alteration of martian terrains is majorly limited by the current lack of understanding of the alteration phases produced (and formation rates) under controlled freeze-thaw weathering of Mars-relevant materials. To address this knowledge gap, we report results from (1) freeze-thaw weathering products found at a glacial Mars analog site at the Three Sisters, Oregon, and (2) new controlled freeze-thaw experiments on basaltic material.

Scudder, N. A.↗

Lessons learned from replicating services for flood prediction and monitoring in Asia to the assessment of hurricane impacts in Central America

In October and November 2020, two dangerous back-to-back hurricanes, Eta and Iota, made landfall in Central America. The SERVIR program - a joint effort of NASA and the U.S. Agency for International Development, and whose motto is “connecting space to village” was able to leverage two tools originally developed for use in other regions for predicting and assessing the flood impacts of the hurricanes. The GEOGLoWS Streamflow Prediction tool - originally implemented in the Hindu Kush Himalayan region - was used for predicting potential flooding ahead of landfall by Eta and Iota. In conjunction, the Hydrologic Remote Sensing Analysis for Floods (HYDRAFloods) framework - originally developed along with SERVIR-Mekong - was used for post-event flood mapping, leveraging its ability to map floods in cloud-covered areas using synthetic aperture radar (SAR) imagery from the Copernicus program. Both tools were used in support of disaster coordination efforts being led by the Central American Regional Disaster Prevention Center (CEPREDENAC), in conjunction with its sister agency, the Regional Water Resources Committee (CRRH). The support provided to regional entities - and to their stakeholder national governments - served as an example of rapid generation of Earth observation products for disaster response. Feedback on those products was also provided, especially in terms of the implications of (i) calibration of predicted river volumes, and (ii) the latency of the input Earth observation imagery and attempts to map the floods’ maximum extents. An upcoming NASA DEVELOP project will also seek to strengthen the capability of CEPREDENAC and CRRH to apply HYDRAFloods for future extreme events. The application of the tools also provides a useful case study on capacity building, in terms of how Earth observation data and models can be replicated across regions.

Capacity building↗

Open Science for Life in Space: Data Sharing and Tools for Knowledge Discovery

The next era in human space exploration is rapidly approaching and will require the use of countermeasures to deep space health hazards. The development of countermeasures (or, the re-purposing of existing agents) will be highly dependent on our understanding of basic biological responses to space stressors (e.g. ionizing radiation, altered gravitational fields, altered day-night cycles, confinement, isolation, hostile-closed environments, distance-duration from Earth, exposure to celestial regolith, etc.). The fast-growing array of space biological data, which in the past was simply archived after minimal analysis, holds great potential if it can be reorganized and formatted for Open Science. Organizing the data for such analysis is a challenge because of its diverse nature (molecular, cellular, tissue, imaging, whole organism and behavior). We will discuss here several strategies that NASA’s Biological and Physical Science Division has put in place to maximize the return on investment for spaceflight bioscience data. Open Science, as a scientific philosophy, is the concept that the more people who have access to the data, the more knowledge will be gained from it. This guiding principle led NASA to develop GeneLab in 2015. GeneLab houses spaceflight and relevant ground-based multi-omics data, and has grown to ~400 transcriptomic, proteomic, metabolomic and epigenomic datasets from plant, rodent, small animal, and microbial space experiments. GeneLab provides users with various tools for data analysis and a visualization portal that allows users to interact with gene expression data from space-related ‘omics experiments. Open Science is also about building scientific communities, and with this spirit in mind, GeneLab has spawned several Analysis Working Groups (AWGs), comprised of more than 200 volunteer scientists. The AWGs initially provided feedback on the processing pipeline and metadata ‘omics standards for GeneLab. Over the last few years, they have become a community-driven science enterprise, engaging in large meta-analysis of GeneLab datasets, resulting in 10 publications (beyond the originally submitted research). Overall, the Open Science nature of GeneLab has resulted in a high degree of data re-use, resulting in 38 additional publications derived from the original 67 publication over the past four years. The enormous success and knowledge gained from GeneLab has led to a collection of sister NASA “Open Science Data Repositories (OSDR)” and research support groups. These include the NASA Ames Life Sciences Data Archive (ALSDA), the NASA Biological Institutional Scientific Collection (NBISC), and the Biospecimen Sharing Program (BSP). All are adopting the GeneLab data architecture system to maximize open-access, find-ability, accessibility, interoperability, and reusability (FAIR). ALSDA collects and curates phenotypic-physiological bioimaging-behavioral data from space and space-relevant non-human experiments, oftentimes coming from the same omics-associated experimental datasets found in GeneLab. Since 2021, a community of ~100 researchers have rallied around ALSDA, to provide feedback in a new ALSDA AWG focused on phenotypic-physiological investigation-sample-assay metadata standards (e.g., Micro-Computed Tomography, Light/Fluorescence Microscopy, Western Blot, Flow Cytometry, Novel Object Recognition, Elevated Plus Maze, etc. of ~50 assays collected). These standards are part of a new single point-of-entry data submission portal for all non-human Space Biology and Human Research Program principal investigators, to submit, curate, and share their research data. With open-access space biological data now collected and curated together with rich metadata, and with the potential for linkage to “big data” from the international biological and medical communities (NIH, EBI, etc.), the artificial intelligence and machine learning (AI/ML) era has started for Space Biology. Several other talks will cover these topics in this conference.

life sciences↗