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Search indexed NASA NTRS and DOE OSTI research on propulsion, heat transfer, battery materials and energy systems. Follow report and document links to the original sources.

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At least 91 records · Page 5
All sourcesNASA NTRSDOE OSTI
NASA NTRS2003

Improvement in diastolic intraventricular pressure gradients in patients with HOCM after ethanol septal reduction

We sought to validate measurement of intraventricular pressure gradients (IVPG) and analyze their change in patients with hypertrophic obstructive cardiomyopathy (HOCM) after ethanol septal reduction (ESR). Quantitative analysis of color M-mode Doppler (CMM) images may be used to estimate diastolic IVPG noninvasively. Noninvasive IVPG measurement was validated in 10 patients undergoing surgical myectomy. Echocardiograms were then analyzed in 19 patients at baseline and after ESR. Pulsed Doppler data through the mitral valve and pulmonary venous flow were obtained. CMM was used to obtain the flow propagation velocity (Vp) and to calculate IVPG off-line. Left atrial pressure was estimated with the use of previously validated Doppler equations. Data were compared before and after ESR. CMM-derived IVPG correlated well with invasive measurements obtained before and after surgical myectomy [r = 0.8, P < 0.01, Delta(CMM - invasive IVPG) = 0.09 +/- 0.45 mmHg]. ESR resulted in a decrease of resting LVOT systolic gradient from 62 +/- 10 to 29 +/- 5 mmHg (P < 0.001). There was a significant increase in the Vp and IVPG (from 48 +/- 5to 74 +/- 7 cm/s and from 1.5 +/- 0.2 to 2.6 +/- 0.3 mmHg, respectively, P < 0.001 for both). Estimated left atrial pressure decreased from 16.2 +/- 1.1 to 11.5 +/- 0.9 mmHg (P < 0.001). The increase in IVPG correlated with the reduction in the LVOT gradient (r = 0.6, P < 0.01). Reduction of LVOT obstruction after ESR is associated with an improvement in diastolic suction force. Noninvasive measurements of IVPG may be used as an indicator of diastolic function improvement in HOCM.

NASA Program Biomedical Research and Countermeasur↗
NASA NTRS2003

Polyomavirus JCV excretion and genotype analysis in HIV-infected patients receiving highly active antiretroviral therapy

OBJECTIVE: To assess the frequency of shedding of polyomavirus JC virus (JCV) genotypes in urine of HIV-infected patients receiving highly active antiretroviral therapy (HAART). METHODS: Single samples of urine and blood were collected prospectively from 70 adult HIV-infected patients and 68 uninfected volunteers. Inclusion criteria for HIV-infected patients included an HIV RNA viral load < 1000 copies, CD4 cell count of 200-700 x 106 cells/l, and stable HAART regimen. PCR assays and sequence analysis were carried out using JCV-specific primers against different regions of the virus genome. RESULTS: JCV excretion in urine was more common in HIV-positive patients but not significantly different from that of the HIV-negative group [22/70 (31%) versus 13/68 (19%); P = 0.09]. HIV-positive patients lost the age-related pattern of JCV shedding (P = 0.13) displayed by uninfected subjects (P = 0.01). Among HIV-infected patients significant differences in JCV shedding were related to CD4 cell counts (P = 0.03). Sequence analysis of the JCV regulatory region from both HIV-infected patients and uninfected volunteers revealed all to be JCV archetypal strains. JCV genotypes 1 (36%) and 4 (36%) were the most common among HIV-infected patients, whereas type 2 (77%) was the most frequently detected among HIV-uninfected volunteers. CONCLUSION: These results suggest that JCV shedding is enhanced by modest depressions in immune function during HIV infection. JCV shedding occurred in younger HIV-positive persons than in the healthy controls. As the common types of JCV excreted varied among ethnic groups, JCV genotypes associated with progressive multifocal leukoencephalopathy may reflect demographics of those infected patient populations.

Non-NASA Center↗
NASA NTRS1998

Prognostic significance of electrical alternans versus signal averaged electrocardiography in predicting the outcome of electrophysiological testing and arrhythmia-free survival

OBJECTIVE: To investigate the accuracy of signal averaged electrocardiography (SAECG) and measurement of microvolt level T wave alternans as predictors of susceptibility to ventricular arrhythmias. DESIGN: Analysis of new data from a previously published prospective investigation. SETTING: Electrophysiology laboratory of a major referral hospital. PATIENTS AND INTERVENTIONS: 43 patients, not on class I or class III antiarrhythmic drug treatment, undergoing invasive electrophysiological testing had SAECG and T wave alternans measurements. The SAECG was considered positive in the presence of one (SAECG-I) or two (SAECG-II) of three standard criteria. T wave alternans was considered positive if the alternans ratio exceeded 3.0. MAIN OUTCOME MEASURES: Inducibility of sustained ventricular tachycardia or fibrillation during electrophysiological testing, and 20 month arrhythmia-free survival. RESULTS: The accuracy of T wave alternans in predicting the outcome of electrophysiological testing was 84% (p < 0.0001). Neither SAECG-I (accuracy 60%; p < 0.29) nor SAECG-II (accuracy 71%; p < 0.10) was a statistically significant predictor of electrophysiological testing. SAECG, T wave alternans, electrophysiological testing, and follow up data were available in 36 patients while not on class I or III antiarrhythmic agents. The accuracy of T wave alternans in predicting the outcome of arrhythmia-free survival was 86% (p < 0.030). Neither SAECG-I (accuracy 65%; p < 0.21) nor SAECG-II (accuracy 71%; p < 0.48) was a statistically significant predictor of arrhythmia-free survival. CONCLUSIONS: T wave alternans was a highly significant predictor of the outcome of electrophysiological testing and arrhythmia-free survival, while SAECG was not a statistically significant predictor. Although these results need to be confirmed in prospective clinical studies, they suggest that T wave alternans may serve as a non-invasive probe for screening high risk populations for malignant ventricular arrhythmias.

Non-NASA Center↗
NASA NTRS2004

Month-to-month and year-to-year reproducibility of high frequency QRS ECG signals

High frequency electrocardiography analyzing the entire QRS complex in the frequency range of 150 to 250 Hz may prove useful in the detection of coronary artery disease, yet the long-term stability of these waveforms has not been fully characterized. Therefore, we prospectively investigated the reproducibility of the root mean squared voltage, kurtosis, and the presence versus absence of reduced amplitude zones in signal averaged 12-lead high frequency QRS recordings acquired in the supine position one month apart in 16 subjects and one year apart in 27 subjects. Reproducibility of root mean squared voltage and kurtosis was excellent over these time intervals in the limb leads, and acceptable in the precordial leads using both the V-lead and CR-lead derivations. The relative error of root mean squared voltage was 12% month-to-month and 16% year-to-year in the serial recordings when averaged over all 12 leads. Reduced amplitude zones were also reproducible up to a rate of 87% and 81%, respectively, for the month-to-month and year-to-year recordings. We conclude that 12-lead high frequency QRS electrocardiograms are sufficiently reproducible for clinical use.

Coronary Disease/diagnosis↗
NASA NTRS2008

Galaxies in the X-Ray Band

This talk will provide a brief review of progress an X-ray emission from normal (non-AGN) galaxy populations, including important constraints on the evolution of accreting binary populations over important cosmological timescales. We will also look to the future, anticipating constraints from near-term imaging hard X-ray missions such as NuSTAR, Simbol-X and NeXT and then the longer-term prospects for studying galaxies with the Generation-X mission,

Hornschemeier, Ann↗
NASA NTRS2008

Galaxies in the X-ray Band

This talk will provide a brief review of progress on X-ray emission from normal (non-AGN) galaxy populations, including important constraints on the evolution of accreting binary populations over important cosmological timescales. We will also look to the future, anticipating constraints from near-term imaging hard X-ray missions such as NuSTAR, Simbol-X and NeXT and then the longer-term prospects for studying galaxies with the Generation-X mission.

Hornschemeier, Ann↗
NASA NTRS2016

Neuromapping: Inflight Evaluation of Cognition and Adaptability

In consideration of the health and performance of crewmembers during flight and postflight, we are conducting a controlled prospective longitudinal study to investigate the effects of spaceflight on the extent, longevity and neural bases of sensorimotor, cognitive, and neural changes. Previous studies investigating sensorimotor adaptation to the microgravity environment longitudinally inflight have shown reduction in the ability to perform complex dual tasks. In this study we perform a series of tests investigating the longitudinal effects of adaptation to the microgravity environment and how it affects spatial cognition, manual visuo-motor adaption and dual tasking.

Kofman, I. S.↗
NASA NTRS1978

Status and future prospects of using numerical methods to study complex flows at High Reynolds numbers

The calculation of flow fields past aircraft configuration at flight Reynolds numbers is considered. Progress in devising accurate and efficient numerical methods, in understanding and modeling the physics of turbulence, and in developing reliable and powerful computer hardware is discussed. Emphasis is placed on efficient solutions to the Navier-Stokes equations.

Maccormack, R. W.↗
NASA NTRS2001

Neocytolysis on descent from altitude: a newly recognized mechanism for the control of red cell mass

BACKGROUND: Studies of space-flight anemia have uncovered a physiologic process, neocytolysis, by which young red blood cells are selectively hemolyzed, allowing rapid adaptation when red cell mass is excessive for a new environment. OBJECTIVES: 1) To confirm that neocytolysis occurs in another situation of acute plethora-when high-altitude dwellers with polycythemia descend to sea level; and 2) to clarify the role of erythropoietin suppression. DESIGN: Prospective observational and interventional study. SETTING: Cerro de Pasco (4380 m) and Lima (sea level), Peru. PARTICIPANTS: Nine volunteers with polycythemia. INTERVENTIONS: Volunteers were transported to sea level; three received low-dose erythropoietin. MEASUREMENTS: Changes in red cell mass, hematocrit, hemoglobin concentration, reticulocyte count, ferritin level, serum erythropoietin, and enrichment of administered(13)C in heme. RESULTS: In six participants, red cell mass decreased by 7% to 10% within a few days of descent; this decrease was mirrored by a rapid increase in serum ferritin level. Reticulocyte production did not decrease, a finding that establishes a hemolytic mechanism.(13)C changes in circulating heme were consistent with hemolysis of young cells. Erythropoietin was suppressed, and administration of exogenous erythropoietin prevented the changes in red cell mass, serum ferritin level, and(13)C-heme. CONCLUSIONS: Neocytolysis and the role of erythropoietin are confirmed in persons with polycythemia who descend from high altitude. This may have implications that extend beyond space and altitude medicine to renal disease and other situations of erythropoietin suppression, hemolysis, and polycythemia.

Non-NASA Center↗
NASA NTRS1985

Prospects for determining the cosmological helium-3 to helium-4 ratio via absorption-line studies of the local interstellar medium

The prospects for determining the interstellar (He-3)/(He-4) ratio via absorption-line studies in the extreme ultraviolet are considered. A high-resolution extreme-ultraviolet spectrometer fed by a 1-meter-class telescope similar to that discussed in the Far Ultraviolet Spectroscopic Explorer Report (1983) is assumed, and it is found that detection of He-3 may be possible with less than three days of observing time. To measure the (He-3)/(He-4) ratio with sufficient precision to determine the number of light neutrino species will require over 50 days of integration time for each object studied.

Hurwitz, M.↗
NASA NTRS1994

Theoretical Studies of PNC in Molecules: current Capabilites, Future Prospects, and Issues

The current capabilities of relativistic electronic structure codes for calculations on molecules such as TlF and YbF, which are of interest in the study of parity non-conservation, will be presented. The issues of basis set size and correlation methods will be discussed, and planned developments of the codes which would extend the range of their capabilities will be outlined. Issues of the sensitivity of the desired properties to the form of the nuclear potential and the flexibility of the wave function near the nucleus will be raised to stimulate discussion.

Dyall, Kenneth G.↗
NASA NTRS1983

Structural considerations for a software life cycle dynamic simulation model

This paper presents the results of a preliminary study into the prospects for simulating the software implementation and maintenance life cycle process, with the aim of producing a computerized tool for use by management and software engineering personnel in project planning, tradeoff studies involving product, environmental, situational, and technological factors, and training. The approach taken is the modular application of a 'flow of resource' concept to the systems dynamics simulation modeling technique. The software life cycle process is represented as a number of stochastic, time-varying, interacting work tasks that each achieves one of the project milestones. Each task is characterized by the item produced, the personnel applied, and the budgetary profile.

Tausworthe, R. C.↗
DOE OSTI2025

Accelerating nuclear-integrated data center pursuits in the USA: SWOT analysis, power-thermal management strategies and demonstration plan

Here, this study explores the increasing interest in leveraging nuclear power to meet the escalating energy demands of data centers in the United States (U.S.) by focusing on key factors that contribute to accelerated deployment. The study highlights the importance of N+1/N+2 power supplies (where N is the required number of units), outlines research and innovations in nuclear-integrated data center thermal management and demonstration plan. It also provides updates about status and costing of various reactor system designs. A summarized strengths, weaknesses, opportunities, and threats (SWOT) analysis shows the potential options for grid connectivity, reactors, and site selection. Suitable site discussions consider land and water availability, grid access, and optical fiber connectivity, and the study presents graded prospects for Department of Energy (DOE) sites with a specific example. Community engagement and partnerships are emphasized, particularly the roles of local government, federal agencies, utilities, and data center industry partners, which are crucial for accelerating deployment, business outreach, and approvals. The study provides actionable insights for stakeholders to accelerate the deployment of nuclear-powered data centers.

21 - SPECIFIC NUCLEAR REACTORS AND ASSOCIATED PLAN↗
NASA NTRS1984

Polycrystalline silicon study: Low-cost silicon refining technology prospects and semiconductor-grade polycrystalline silicon availability through 1988

Photovoltaic arrays that convert solar energy into electrical energy can become a cost effective bulk energy generation alternative, provided that an adequate supply of low cost materials is available. One of the key requirements for economic photovoltaic cells is reasonably priced silicon. At present, the photovoltaic industry is dependent upon polycrystalline silicon refined by the Siemens process primarily for integrated circuits, power devices, and discrete semiconductor devices. This dependency is expected to continue until the DOE sponsored low cost silicon refining technology developments have matured to the point where they are in commercial use. The photovoltaic industry can then develop its own source of supply. Silicon material availability and market pricing projections through 1988 are updated based on data collected early in 1984. The silicon refining industry plans to meet the increasing demands of the semiconductor device and photovoltaic product industries are overviewed. In addition, the DOE sponsored technology research for producing low cost polycrystalline silicon, probabilistic cost analysis for the two most promising production processes for achieving the DOE cost goals, and the impacts of the DOE photovoltaics program silicon refining research upon the commercial polycrystalline silicon refining industry are addressed.

Costogue, E. N.↗
NASA NTRS2011

Stratospheric Collection of Dust from Comet 73P/Schwassmann-Wachmann 3

Interplanetary dust particles (IDPs) collected in the stratosphere are unique materials that are compositionally distinct from meteorites. Astronomical observations and dynamical models indicate that both asteroids and short-period comets are significant sources of IDPs. IDPs having fragile, porous structures, unequilibrated, anhydrous mineralogy, and high atmospheric entry velocities are thought to derive from comets, whereas asteroidal IDPs are identified by their compact structure, hydrated mineralogy and low atmospheric entry velocities. Uncertainty remains in the classification of asteroidal and cometary IDPs owing to our limited sampling of comets and the asteroid belt and the complex dynamical histories of most IDPs in space. Most IDPs spend thousands of years in space prior to being accreted by the Earth. During this time, dust particles undergo orbital evolution, including gradual reduction in their perihelion and eccentricity as a result of Poynting-Robertson drag. Planetary encounters may also significantly change their orbital parameters. Consequently, it is generally not possible to identify the specific parent body of a given IDP. However, it has been proposed that it is possible to identify dust from comets that have formed Earth-crossing dust trails. In this case, the dust particles have been in space for such a short period of time (a few decades or less) that their orbits have not significantly changed. Furthermore, these fresh IDPs could be identified in the laboratory from their short space-exposure histories (low solar noble gas abundance and lack of solar flare tracks). NASA flew several dedicated IDP collection missions attempting to collect dust from comet 26P/Grigg-Skjellerup, the best candidate identified. Remarkably, many particles from those collectors exhibit unusual properties, including low abundances of solar noble gases and high abundances of presolar grains. These observations are consistent with the dust particles originating from comet Grigg-Skjellerup (hereafter G-S). This study considers the prospects for collection of dust from comet 73P/Schwassmann-Wachmann 3 (hereafter SW3). SW3 is a small (2 km diameter) Jupiter family comet whose perihelion is close to and just inside the Earth's orbit. The orbit of SW3 is suitable for producing a low-velocity Earth-crossing dust stream and is the likely parent of the Tau Herculid meteor stream. This study complements a previously published model of the SW3 meteor stream that predicted a very low level of activity for grains 100 micron -- 100 mm in size.

Messenger, Scott R.↗
NASA NTRS2004

Solar Spicules: Prospects for Breakthroughs in Understanding with Solar-B

Spicules densely populate the lower solar atmosphere; any image or movie of the chromosphere shows a plethora of them or their "cousins," such as mottles or fibrils. Yet despite several decades of effort we still do not know the mechanism that generates them, or how important their contribution is to the material and energy balance of the overall solar atmosphere. Solar-B will provide exciting new chromospheric observations at high time- and spatial-resolution, along with associated quality magnetic field data, that promise to open doors to revolutionary breakthroughs in spicule research. In this presentation we will review the current observational and theoretical status of spicule studies, and discuss prospects for advances in spicule understanding during the Solar-B era.

Sterling, A. C.↗
DOE OSTI2024

Gulf of Mexico Miocene CO2 Site Characterization Mega Transect

The project Gulf of Mexico Miocene CO2 Site Characterization Mega Transect is one of 9 site characterization projects that were implemented as part of ARRA (American Recovery and Reinvestment Act). Data from this project was used to improve resolution of data in NATCARB in the area of study. Data related to this study has already been incorporated in NATCARB Atlas. The University of Texas at Austin study focused on (1) collecting high-resolution, 3-D (HR3D) seismic datasets of the shallow geologic section to evaluate the capacity of potential reservoirs and the sealing capacity of the confining system, and (2) producing a regional CO2 atlas of Miocene age units of the upper Texas coast submerged lands (southeast Texas). The goal of the study was to evaluate the capability of the Miocene age geologic section of Texas submerged lands to permanently store large volumes of anthropogenic CO2. The geographic locations of three HR3D, “P-Cable” seismic surveys collected in the near-shore waters of southeast Texas offers a vertical and horizontal view (data “cube”) example from the second survey. The dataset's high quality allowed for defining recognizable geologic morphologies (shapes) and possible fluid content, which are important for determining an area’s prospects for geologic storage. The regional CO2 atlas of Miocene age units highlights several topics, including: (1) a regional analyses of petroleum systems as analogs for CO2 storage; (2) petrography, petrology, and extent of confining systems of the Miocene section; (3) static capacity estimate; and (4) examples of characterization methodologies of prospect areas. The HR3D datasets and regional analyses within the CO2 atlas of the offshore Texas Miocene provide a sound basis for a future generation of specific CO2 prospects in the study area.

.las↗
NASA NTRS1979

Compact galactic X-ray sources; Proceedings of the Workshop, Washington, D.C., April 20, 21, 1979

The current status and future prospects regarding the study of compact galactic X-ray sources are reviewed; key questions addressable by X-ray observations are outlined, and various proposed types of missions are evaluated in terms of their ability to address these questions. Subjects discussed include degenerate dwarfs and cataclysmic variables, bursters, neutron stars, black holes, and erratic variables, transients, and patrol programs. Specific topics include future X-ray observations of magnetic binaries, the thermonuclear-flash model for X-ray burst sources, neutron star X-ray sources, prospects for experimental research on black holes in binary systems, and compact X-ray source observations after Explorer with the LAMAR.

Lamb, F.↗