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At least 91 records · Page 5
All sourcesNASA NTRSDOE OSTI
NASA NTRS1990

Industry liaison section implementation plan

The Industry Liaison Section is a new function of the Army/NASA Aircrew-Aircraft Integration (AAAI) Program that is intended to bridge an existing gap between Government developers (including contractors) and outside organizations who are potential users of products and services developed by the AAAI Program. Currently in its sixth year, the Program is experiencing considerable pull from industry and other government organizations to disseminate products. Since the AAAI Program's charter is exploratory and research in nature, and satisfying proper dissemination requirements is in conflict with the rapid prototyping approach utilized by the design team, the AAAI Program has elected to create an Industry Liaison Section (ILS) to serve as the Program's technology transfer focal point. The process by which the ILS may be established, organized and managed is described, including the baseline organizational structure, duties, functions, authority, responsibilities, relations and policies and procedures relevant to the conduct of the ILS.

Lakowske, Stephen↗
NASA NTRS1992

Effect of spaceflight on lymphocyte proliferation and interleukin-2 production

In this study, inguinal lymp node lymphocytes from rats flown on the Cosmos 2044 mission were tested for proliferation and interleukin-2 (IL-2) production. Cells cultured with mitogenic lectins, phorbol ester, and calcium ionophore, or T-cell mitogen and lymphokine, were assayed for DNA synthesis by (H-3) thymidine incorporation. Lymphocytes incubated with a T-cell mitogen alone also were tested for IL-2 production. Proliferation of lymphocytes from flight rats was not significantly different from controls for any of the mitogens tested. Furthermore, lymph node lymphocytes from control and flown rats produced similar amounts of IL-23. Thus microgravity may act on lymphocytes in a tissue-specific manner, a new finding that could impact on the evaluation of spaceflight effects on immunocompetence.

Nash, Patricia V.↗
NASA NTRS2003

Genetic models in applied physiology: selected contribution: effects of spaceflight on immunity in the C57BL/6 mouse. II. Activation, cytokines, erythrocytes, and platelets

This portion of the study quantified the effects of a 12-day space shuttle mission (Space Transport System-108/UF-1) on body and lymphoid organ masses, activation marker expression, cytokine secretion, and erythrocyte and thrombocyte characteristics in C57BL/6 mice. Animals in flight (Flt group) had 10-12% lower body mass compared with ground controls housed either in animal enclosure modules or under standard vivarium conditions (P < 0.001) and the smallest thymus and spleen masses. Percentages of CD25(+) lymphocytes, CD3(+)/CD25(+) T cells, and NK1.1(+)/CD25(+) natural killer cells from Flt mice were higher compared with both controls (P < 0.05). In contrast, CD71 expression was depressed in the Flt and animal enclosure module control mice compared with vivarium control animals (P < 0.001). Secretion of interferon-gamma, IL-2, and IL-4, but not tumor necrosis factor-alpha and IL-5, by splenocytes from Flt mice was decreased relative to either one or both ground controls (P < 0.05). Flt mice also had high red blood cell and thrombocyte counts compared with both sets of controls; low red blood cell volume and distribution width, percentage of reticulocytes, and platelet volume were also noted (P < 0.05) and were consistent with dehydration. These data indicate that relatively short exposure to the spaceflight environment can induce profound changes that may become significant during long-term space missions.

Flight Experiment↗
NASA NTRS1997

Induction of ceruloplasmin synthesis by IFN-gamma in human monocytic cells

Ceruloplasmin is a 132-kDa glycoprotein abundant in human plasma. It has multiple in vitro activities, including copper transport, lipid pro- and antioxidant activity, and oxidation of ferrous ion and aromatic amines; however, its physiologic role is uncertain. Although ceruloplasmin is synthesized primarily by the liver in adult humans, production by cells of monocytic origin has been reported. We here show that IFN-gamma is a potent inducer of ceruloplasmin synthesis by monocytic cells. Activation of human monoblastic leukemia U937 cells with IFN-gamma increased the production of ceruloplasmin by at least 20-fold. The identity of the protein was confirmed by plasmin fingerprinting. IFN-gamma also increased ceruloplasmin mRNA. Induction followed a 2- to 4-h lag and was partially blocked by cycloheximide, indicating a requirement for newly synthesized factors. Ceruloplasmin induction in monocytic cells was agonist specific, as IL-1, IL-4, IL-6, IFN-alpha, IFN-beta, TNF-alpha, and LPS were completely ineffective. The induction was also cell type specific, as IFN-gamma did not induce ceruloplasmin synthesis in endothelial or smooth muscle cells. In contrast, IFN-gamma was stimulatory in other monocytic cells, including THP-1 cells and human peripheral blood monocytes, and also in HepG2 cells. Ceruloplasmin secreted by IFN-gamma-stimulated U937 cells had ferroxidase activity and was, in fact, the only secreted protein with this activity. Monocytic cell-derived ceruloplasmin may contribute to defense responses via its ferroxidase activity, which may drive iron homeostasis in a direction unfavorable to invasive organisms.

Non-NASA Center↗
NASA NTRS1992

Potentiation of lymphocyte proliferative responses by nickel sulfide

Crystalline nickel sulfide (NiS) induced a spleen cell proliferation that resembles a mixed lymphocyte reaction (MLR). It depended on cell-cell interaction, induced high levels of interleukin-1 (IL-1) and interleukin-2 (IL-2) and the responding cell subpopulation was composed of CD4+ T lymphocytes. Furthermore, the proliferation was inhibited in a dose-dependent manner by magnesium. Crystalline NiS also increased significantly the spleen cell proliferative response to concanavalin A (Con A) and lipopolysaccharide (LPS) with magnesium potentiating the combined effects of crystalline NiS and mitogens. Interestingly, crystalline NiS did not show any effect on the induction of IL-2 by Con A. The results described herein suggest that crystalline NiS can potentiate both antigenic (MLR) and mitogenic (Con A and LPS) proliferative responses in vitro. Crystalline NiS appears to potentiate these responses by acting in the form of ionic nickel on several intracellular targets for which magnesium ions have different noncompetitive interactions. The effects of magnesium on the potentiating action of crystalline NiS are different depending upon the type of primary stimulatory signal for proliferation (mitogenic or antigenic).

NASA Discipline Cell Biology↗
NASA NTRS2009

Lunar Oxygen Production and Metals Extraction Using Ionic Liquids

Initial results indicate that ionic liquids are promising media for the extraction of oxygen from lunar regolith. IL acid systems can solubilize regolith and produce water with high efficiency. IL electrolytes are effective for water electrolysis, and the spent IL acid media are capable of regeneration.

Marone, Matthew↗
NASA NTRS2010

An Illumination Correction ALgorithm on Landsat-TM Data

In this paper, a new illumination correction model, the rotation model, is introduced. The model is based on the empirical correlation between reflectance and the illumination condition (IL). The model eliminates the dependency of reflectance on IL through rotating the data in IL-reflectance space. This model is compared with widely used cosine model and C model over a sample forest region. We found that the newly developed rotation model consistently performs best on both atmospheric uncorrected and corrected Landsat images. Index Terms Landsat, illumination correction, change detection, LEDAPS

Tan, Bin↗
NASA NTRS2017

Ionic Liquids Enabling Revolutionary Closed-Loop Life Support

Minimizing resupply from Earth is essential for future long duration manned missions. The current oxygen recovery system aboard the International Space Station is capable of recovering approximately 50% of the oxygen from metabolic carbon dioxide. For long duration manned missions, a minimum of 75% oxygen recovery is targeted with a goal of greater than 90%. Theoretically, the Bosch process can recover 100% of oxygen, making it a promising technology for oxygen recovery for long duration missions. However, the Bosch process produces elemental carbon which ultimately fouls the catalyst. Once the catalyst performance is compromised, it must be replaced resulting in undesired resupply mass. Based on the performance of a Bosch system designed by NASA in the 1990's, a three year Martian mission would require approximately 1315 kg (2850 lbs) of catalyst resupply. It may be possible to eliminate catalyst resupply with a fully regenerable system using an Ionic Liquid (IL)-based Bosch system. In 2016, we reported the feasibility of using ILs to produce an iron catalyst on a copper substrate and to regenerate the iron catalyst by extracting the iron from the copper substrate and product carbon. Additionally, we described a basic system concept for an IL-based Bosch. Here we report the results of efforts to scale catalyst preparation, catalyst regeneration, and to scale the carbon formation processing rate of a single reactor.

Brown, Brittany R.↗
NASA NTRS2017

Ionic Liquids Enabling Revolutionary Closed-Loop Life Support

Minimizing resupply from Earth is essential for future long duration manned missions. The current oxygen recovery system aboard the International Space Station is capable of recovering approximately 50% of the oxygen from metabolic carbon dioxide. For long duration manned missions, a minimum of 75% oxygen recovery is targeted with a goal of greater than 90%. Theoretically, the Bosch process can recover 100% of oxygen, making it a promising technology for oxygen recovery for long duration missions. However, the Bosch process produces elemental carbon which ultimately fouls the catalyst. Once the catalyst performance is compromised, it must be replaced resulting in undesired resupply mass. Based on the performance of a Bosch system designed by NASA in the 1990's, a three year Martian mission would require approximately 1315 kg (2850 lbs) of catalyst resupply. It may be possible to eliminate catalyst resupply with a fully regenerable system using an Ionic Liquid (IL)-based Bosch system. In 2016, we reported the feasibility of using ILs to produce an iron catalyst on a copper substrate and to regenerate the iron catalyst by extracting the iron from the copper substrate and product carbon. Additionally, we described a basic system concept for an IL-based Bosch. Here we report the results of efforts to scale catalyst preparation, to scale catalyst regeneration, and to scale the carbon formation processing rate of a single reactor.

Brown, Brittany R.↗
NASA NTRSDate not supplied

Analysis of Interlaminar Damage in Refractory Composites by In-Situ Micro-X-Ray Computed Tomography

Refractory composites are relevant for hot-structure applications on re-entry vehicles. To develop optimized high-performance hot structures, accurate material property data is required. Material properties that often limit design in two-dimensional (2-D) composites are interlaminar strengths. A better understanding of the failure mechanisms for interlaminar shear (ILS), interlaminar tension (ILT), and curved-beam interlaminar tension (CB-ILT) tests can provide insight on improving the design and fabrication of refractory composites. In-situ tests were performed to capture the progressive failure in American Society for Testing and Materials (ASTM) sized ILS (ASTM D3846), ILT (ASTM D7291), and CB-ILT (ASTM D6415) specimens. The present study investigates the change in material behavior by examining the macro porosity change in in-situ ILS tests, the mesoscale and inter-ply porosity changes in flatwise in-situ ILT tests and the change in per-ply delamination in in-situ CB-ILT tests.

In-situ Damage Characterization↗
NASA NTRS1972

Flight evaluation of three-dimensional area navigation for jet transport noise abatement.

The NASA, working with American Airlines, has completed the first phase of research to evaluate the operational feasibility of two-segment approaches for noise abatement. For these tests, area navigation was used to establish the upper glide slope and an ILS was used to establish the lower. The flight director was modified to provide command information during the entire approach. Twenty-eight pilots representing the airlines, professional pilot associations, FAA, and NASA participated. With an ILS approach for comparison, the procedure gave a noise reduction of 18 EPNdB at the outer marker and 8 EPNdB 1.1 n. mi. from touchdown.

Denery, D. G.↗
NASA NTRS1974

Noise measurements obtained during engineering evaluation of two-segment approaches in a 727-200 aircraft

A series of noise measurements were made during engineering evaluation tests of two-segment approaches in a 727-200 aircraft equipped with acoustically treated nacelles. A two-segment approach having a 6-degree upper glide slope angle intercepting the Instrument Landing System (ILS) 2.9-degree glide slope at an altitude of 690 feet gave a 5-EPNdB decrease in measured noise at distances greater than 3 nautical miles from the runway threshold when compared with a normal ILS approach. Several of the noise measurements were taken under adverse weather conditions which were outside the specified limits of FAR Part 36. This may introduce uncertainties into the data from several approaches.

Tanner, C. S.↗
NASA NTRS1973

Noise measurements at Stockton Airport obtained during engineering evaluation of two-segment approaches in a 727-222 aircraft

The results of acoustic measurements made on a 727-222 aircraft during standard ILS and two-segment approaches are presented. The aircraft was equipped with a special purpose glide slope computer to provide the capability of making two-segment noise abatement approaches. For upper segment computations, the computer used barometric-corrected pressure altitude and the slant range to a DME transmitter which was colocated with the glide slope transmitter. The computer used the ILS glide slope deviation for lower segment computations. Additional measurements were made on 737 revenue aircraft using the Stockton Airport. The purpose of the acoustical portion of the test was to measure and identify the noise levels during the various approaches.

Glass, R. E.↗
NASA NTRS1974

Flight evaluation of advanced control systems and displays on a general aviation airplane

A flight-test program was conducted to determine the effect of advanced flight control systems and displays on the handling qualities of a light twin-engined airplane. A flight-director display and an attitude-command control system, used separately and in combination, transformed a vehicle with poor handling qualities during ILS approaches in turbulent air into a vehicle with good handling qualities. The attitude-command control system also improved the ride qualities of the airplane. A rate-command control system made only small improvements to the airplane's ILS handling qualities in turbulence. Both the rate- and the attitude-command control systems reduced stall warning in the test airplane, increasing the likelihood of inadvertent stalls. The final approach to the point of flare was improved by both the rate- and the attitude-command control systems. However, the small control wheel deflections necessary to flare were unnatural and tended to cause overcontrolling during flare. Airplane handling qualities are summarized for each control-system and display configuration.

Loschke, P. C.↗
NASA NTRS1975

Models for estimating runway landing capacity with Microwave Landing System (MLS)

A model is developed which is capable of computing the ultimate landing runway capacity, under ILS and MLS conditions, when aircraft population characteristics and air traffic control separation rules are given. This model can be applied in situations when only a horizontal separation between aircraft approaching a runway is allowed, as well as when both vertical and horizontal separations are possible. It is assumed that the system is free of errors, that is that aircraft arrive at specified points along the prescribed flight path precisely when the controllers intend for them to arrive at these points. Although in the real world there is no such thing as an error-free system, the assumption is adequate for a qualitative comparison of MLS with ILS. Results suggest that an increase in runway landing capacity, caused by introducing the MLS multiple approach paths, is to be expected only when an aircraft population consists of aircraft with significantly differing approach speeds and particularly in situations when vertical separation can be applied. Vertical separation can only be applied if one of the types of aircraft in the mix has a very steep descent angle.

Tosic, V.↗
NASA NTRS1976

Energy management - The delayed flap approach

Flight test evaluation of a Delayed Flap approach procedure intended to provide reductions in noise and fuel consumption is underway using the NASA CV-990 test aircraft. Approach is initiated at a high airspeed (240 kt) and in a drag configuration that allows for low thrust. The aircraft is flown along the conventional ILS glide slope. A Fast/Slow message display signals the pilot when to extend approach flaps, landing gear, and land flaps. Implementation of the procedure in commercial service may require the addition of a DME navigation aid co-located with the ILS glide slope transmitter. The Delayed Flap approach saves 250 lb of fuel over the Reduced Flap approach, with a 95 EPNdB noise contour only 43% as large.

Bull, J. S.↗
NASA NTRS1976

Effect of multiple path approach procedures on runway landing capacity

When using the Instrument Landing System (ILS) all aircraft must follow a straight line approach path before landing. The Microwave Landing System (MLS) will allow use of differing curved approach paths. The objective of this research is to find out whether the introduction of MLS and consequently multiple approach paths can bring an increase in runway landing capacity. A model is developed which is capable of computing the expected ultimate landing runway capacity, under ILS and MLS conditions, when aircraft population characteristics and Air Traffic Control separation rules are given. This model can be applied in situations when only a horizontal separation between aircraft approaching a runway is allowed, as well as when both vertical and horizontal separations are possible. Results suggest that an increase in runway landing capacity, caused by introducing the MLS-described multiple approach paths, is to be expected only when an aircraft population consists of aircraft with significantly differing approach velocities and particularly in situations when a vertical separation can be applied.

Tosic, V.↗
NASA NTRS1980

Simulator study of conventional general aviation instrument displays in path-following tasks with emphasis on pilot-induced oscillations

A study of the use of conventional general aviation instruments by general aviation pilots in a six degree of freedom, fixed base simulator was conducted. The tasks performed were tracking a VOR radial and making an ILS approach to landing. A special feature of the tests was that the sensitivity of the displacement indicating instruments (the RMI, CDI, and HSI) was kept constant at values corresponding to 5 n. mi. and 1.25 n. mi. from the station. Both statistical and pilot model analyses of the data were made. The results show that performance in path following improved with increases in display sensitivity up to the highest sensitivity tested. At this maximum test sensitivity, which corresponds to the sensitivity existing at 1.25 n. mi. for the ILS glide slope transmitter, tracking accuracy was no better than it was at 5 n. mi. from the station and the pilot aircraft system exhibited a marked reduction in damping. In some cases, a pilot induced, long period unstable oscillation occurred.

Adams, J. J.↗