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Measuring Temperature Reading

There are two requirements for taking a measurement of something. The first is a tool for taking a measurement. The second is scale for making sense of the numbers of the measurement. For example, a ruler is often used to measure short lengths. It is the tool for measurement. On the ruler are one or more number scales with equally spaced numbers. These numbers can be compared with numbers from any other ruler that is accurately set to the same scale. Measuring length is far simpler than measuring temperature. While there is evidence of tools for measuring length at various times in human history, tools and scales for measuring temperature do not appear until more recent human history. Early thermometers, called thermoscopes, first appear in the 1500's. They were crude instruments that were not at all accurate. Most did not even have a number scale associated with them. This made them useless for most practical purposes. Gabriel Fahrenheit created the first accurate thermometer in 1714, and the Fahrenheit temperature scale followed it in 1724. The thermometer s accuracy was based on its use of mercury, a silver colored substance that remains liquid over a wide range of temperatures but expands or contracts in a standard, predictable way with changes in temperature. To set the scale, Fahrenheit created the coldest temperature that he could. He mixed equal parts of ice, water, and salt, and then used this as the zero point, 0 degrees, of his scale. He intended to make 30 degrees the freezing point of water and 90 degrees the temperature of the human body, but he had to later revise these temperatures to be 32 degrees and 96 degrees. In the final version of the scale, the temperature of the human body became 98.6 degrees. 19th century thermoscope

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Workshop on Exercise Prescription for Long-Duration Space Flight

The National Aeronautics and Space Administration has a dedicated history of ensuring human safety and productivity in flight. Working and living in space long term represents the challenge of the future. Our concern is in determining the effects on the human body of living in space. Space flight provides a powerful stimulus for adaptation, such as cardiovascular and musculoskeletal deconditioning. Extended-duration space flight will influence a great many systems in the human body. We must understand the process by which this adaptation occurs. The NASA is agressively involved in developing programs which will act as a foundation for this new field of space medicine. The hallmark of these programs deals with prevention of deconditioning, currently referred to as countermeasures to zero g. Exercise appears to be most effective in preventing the cardiovascular and musculoskeletal degradation of microgravity.

Harris, Bernard A., Jr.↗

Enabling Model Organism and Commercial Astronaut Data Access Through the NASA Open Science Data Repository

NASA’s Open Science Data Repository (OSDR) brings together omics data from NASA’s GeneLab project and non-omics data, including physiological, phenotypic, imaging, and behavioral data from NASA’s Ames Life Sciences Data Archive (ALSDA) collected from decades of space biology research, providing open and FAIR (findable, accessible, interoperable, and reusable) access of these precious data to scientists world-wide. This rich source of meticulously curated metadata and data from spaceflight and analog studies has been mined by the scientific community resulting in dozens of high impact scientific publications that reveals a complex network of molecular and physiological effects of spaceflight across living systems, from microbes to plants, to mammals. Understanding how these effects translate to the human condition is critical as we move deeper into the era of commercial space travel. However, the integration of data, specifically omics data, from astronauts is particularly challenging due to their sensitive nature. OSDR has risen to this challenge by developing a mechanism to control access to identifiable levels of omics data, such as raw sequence data, while enabling public access to processed, unidentifiable, data and associated metadata that will allow the scientific community to interrogate human astronaut data alongside data from model organisms to begin answering these critical questions. The 2021 SpaceX Inspiration4 (I4) mission collected a comprehensive atlas of biological measurements from four civilian astronauts, providing a wealth of data to characterize the effects of spaceflight on the human body. These data include both non-omics and omics assays such as direct RNA sequencing (RNA-seq), single nuclei ATAC-seq and RNA-seq, metagenomics, proteomics, and comprehensive metabolic and cytokine panels, all of which have been integrated into the OSDR system across no less than 9 studies. Each study has been carefully curated using community-backed OSDR standards for sample and assay level metadata ensuring these data are findable and accessible. In addition to hosting both raw and processed data from the principal investigator team for each assay type, the GeneLab team plans to re-process the I4 omics data using GeneLab’s standard processing pipelines. The GeneLab processed data outputs will allow for comparisons across studies on OSDR and enable visualization of these data through the OSDR data visualization platform thereby enabling data reusability and interoperability. Here we describe the robust privacy and security protocols implemented by OSDR to safeguard sensitive health data from astronauts while facilitating metadata and processed data sharing for research purposes. We further provide a road map for navigating the vast amount of data provided for each I4 study on the OSDR, including experimental design, associated experiments, payloads, and missions, data generation and analysis protocols, and associated scientific articles. Additionally, we illustrate how to interrogate the standardized metadata provided in the sample and assay tables as well as various means to download and access the data including programmatically through the GeneLab Open API (GLOpenAPI). The open access of datasets in NASA’s OSDR provides a unique opportunity for the scientific community, as well as citizen scientists and students, to continue using OSDR resources to further unlock profound insights into the consequences of space travel on the human body. Through implementation of security measures to protect sensitive human data, the OSDR seeks to strengthen the science exchange between the Biological and Physical Sciences Program and the Human Research Program, per recommendation 4-1 of the 2023-2032 Decadal Survey, and encourage further sharing and dissemination of astronaut data to provide the scientific community with the resources needed to lay the groundwork for developing targeted mitigation strategies to help withstand the rigors of long-duration spaceflight.

Amanda Marie Saravia-butler↗

Microbial Extremophiles in Aspect of Limits of Life

During Earth's evolution accompanied by geophysical and climatic changes a number of ecosystems have been formed. These ecosystems differ by the broad variety of physicochemical and biological factors composing our environment. Traditionally, pH and salinity are considered as geochemical extremes, as opposed to the temperature, pressure and radiation that are referred to as physical extremes (Van den Burg, 2003). Life inhabits all possible places on Earth interacting with the environment and within itself (cross species relations). In nature it is very rare when an ecotope is inhabited by a single species. As a rule, most ecosystems contain the functionally related and evolutionarily adjusted communities (consortia and populations). In contrast to the multicellular structure of eukaryotes (tissues, organs, systems of organs, whole organism), the highest organized form of prokaryotic life in nature is the benthic colonization in biofilms and microbial mats. In these complex structures all microbial cells of different species are distributed in space and time according to their functions and to physicochemical gradients that allow more effective system support, self-protection, and energy distribution. In vitro, of course, the most primitive organized structure for bacterial and archaeal cultures is the colony, the size, shape, color, consistency, and other characteristics of which could carry varies specifics on species or subspecies levels. In table 1 all known types of microbial communities are shown (Pikuta et a]., 2005). In deep underground (lithospheric) and deep-sea ecosystems an additional factor - pressure, and irradiation - could also be included in the list of microbial communities. Currently the beststudied ecosystems are: human body (due to the medical importance), and fresh water and marine ecosystems (due to the reason of an environmental safety). For a long time, extremophiles were terra incognita, since the environments with aggressive parameters (compared to the human body temperature, pH, mineralization, and pressure) were considered a priori as a dead zone.

Pikuta, Elena V.↗

Advanced Liquid-Cooling Garment Using Highly Thermally Conductive Sheets

This design of the liquid-cooling garment for NASA spacesuits allows the suit to remove metabolic heat from the human body more effectively, thereby increasing comfort and performance while reducing system mass. The garment is also more flexible, with fewer restrictions on body motion, and more effectively transfers thermal energy from the crewmember s body to the external cooling unit. This improves the garment s performance in terms of the maximum environment temperature in which it can keep a crewmember comfortable. The garment uses flexible, highly thermally conductive sheet material (such as graphite), coupled with cooling water lines of improved thermal conductivity to transfer the thermal energy from the body to the liquid cooling lines more effectively. The conductive sheets can be layered differently, depending upon the heat loads, in order to provide flexibility, exceptional in-plane heat transfer, and good through-plane heat transfer. A metal foil, most likely aluminum, can be put between the graphite sheets and the external heat source/sink in order to both maximize through-plane heat transfer at the contact points, and to serve as a protection to the highly conductive sheets. Use of a wicking layer draws excess sweat away from the crewmember s skin and the use of an outer elastic fabric ensures good thermal contact of the highly conductive underlayers with the skin. This allows the current state of the art to be improved by having cooling lines that can be more widely spaced to improve suit flexibility and to reduce weight. Also, cooling liquid does not have to be as cold to achieve the same level of cooling. Specific areas on the human body can easily be targeted for greater or lesser cooling to match human physiology, a warmer external environment can be tolerated, and spatial uniformity of the cooling garment can be improved to reduce vasoconstriction limits. Elements of this innovation can be applied to other embodiments to provide effective heat transfer over a flexible and surface-conformable fashion without the limitation of fluid freeze points.

Ruemmele, Warren P.↗

Simulating Humans as Integral Parts of Spacecraft Missions

The Collaborative-Virtual Environment Simulation Tool (C-VEST) software was developed for use in a NASA project entitled "3-D Interactive Digital Virtual Human." The project is oriented toward the use of a comprehensive suite of advanced software tools in computational simulations for the purposes of human-centered design of spacecraft missions and of the spacecraft, space suits, and other equipment to be used on the missions. The C-VEST software affords an unprecedented suite of capabilities for three-dimensional virtual-environment simulations with plug-in interfaces for physiological data, haptic interfaces, plug-and-play software, realtime control, and/or playback control. Mathematical models of the mechanics of the human body and of the aforementioned equipment are implemented in software and integrated to simulate forces exerted on and by astronauts as they work. The computational results can then support the iterative processes of design, building, and testing in applied systems engineering and integration. The results of the simulations provide guidance for devising measures to counteract effects of microgravity on the human body and for the rapid development of virtual (that is, simulated) prototypes of advanced space suits, cockpits, and robots to enhance the productivity, comfort, and safety of astronauts. The unique ability to implement human-in-the-loop immersion also makes the C-VEST software potentially valuable for use in commercial and academic settings beyond the original space-mission setting.

Bruins, Anthony C.↗

Piezoelectric Charging and Wireless Communication

Modern medicine is undergoing a revolution in the application of new sensor capabilities for aiding in diagnosis of specific conditions and monitoring a variety of informative vital signs. In the past, many of the measurements were limited by what could be accomplished externally. A shift toward in-vivo monitoring for both diagnostic and therapeutic sensing and actuation [1] has created a need for low power electronics, high energy density batteries and methods to successfully power devices embedded in the body. For a review of the field and sensing capabilities see [2]. Recent studies suggest that charging with ultrasound is more efficient at longer transmission distance (> 10cm) than inductive charging [3]. In this manuscript, we discuss the modeling and experimentation that we have accomplished and demonstrate in ultrasonic charging of sensors having the form and fit of in-vivo sensors. The task goal has been to use piezoelectric transducers for wireless communication and powering of sensors internal to the human body with a goal to transmit power levels of 100 W a receiver with receiving area of 3x3 mm2 over a distance of 16 cm equivalent to human body interior. The results suggest that we can transmit power levels that exceed this baseline requirement.

Jackson, Shannon↗

STS-40 Spacelab Life Sciences 1 (SLS-1): The first dedicated spacelab life sciences mission

Successful exploration of space depends on the health and well-being of people who travel and work there. For this reason, the National Aeronautics and Space Administration (NASA) has dedicated several Space Shuttle missions to examine how living and working in space affects the human body. Spacelab Life Sciences 1 (SLS-1) is the first of these missions. The main purpose of the SLS-1 mission is to study the mechanisms, magnitudes, and time courses of certain physiological changes that occur during space flight and to investigate the consequences of the body's adaptation to microgravity and readjustment to gravity upon return to Earth. How does space flight influence the heart and circulatory system, metabolic processes, the muscles and bones, and the cells? If responses to weightlessness are undesirable, how can they be prevented or controlled? Will the human body maintain its physical and chemical equilibrium during months aboard a space station and years-long missions to Mars? When crews return to Earth, what can they expect to experience as their bodies readjust to Earth's gravity? With the SLS-1 experiments, NASA is addressing some of these questions. Various aspects of the SLS-1 are discussed.

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Proton tissue dose for the blood forming organ in human geometry: Isotropic radiation

A computer program is described which calculates doses averaged within five major segments of the blood forming organ in the human body taking into account selfshielding of the detailed body geometry and nuclear star effects for proton radiation of arbitrary energy spectrum (energy less than 1 GeV) and isotropic angular distribution. The dose calculation includes the first term of an asymptotic series expansion of transport theory which is known to converge rapidly for most points in the human body. The result is always a conservative estimate of dose and is given as physical dose (rad) and dose equivalent (rem).

Khandelwal, G. S.↗

Space Physiology and Operational Space Medicine

The objectives of this slide presentation are to teach a level of familiarity with: the effects of short and long duration space flight on the human body, the major medical concerns regarding future long duration missions, the environmental issues that have potential medical impact on the crew, the role and capabilities of the Space Medicine Flight Surgeon and the environmental impacts experienced by the Apollo crews. The main physiological effects of space flight on the human body reviewed in this presentation are: space motion sickness (SMS), neurovestibular, cardiovascular, musculoskeletal, immune/hematopoietic system and behavioral/psycho-social. Some countermeasures are discussed to these effects.

Scheuring, Richard A.↗

A Parametric Model of Shoulder Articulation for Virtual Assessment of Space Suit Fit

Goal of space human factors analyses: Place the highly variable human body within these restrictive physical environments to ensure that the entire anticipated population can live, work, and interact. Space suits are a very restrictive space and if not properly sized can result in pain or injury. The highly dynamic motions performed while wearing a space suit often make it difficult to model. Limited human body models do not have much allowance for customization of anthropometry and representation of the population that may wear a space suit.

Young, Karen↗

Heavy-ion fragmentation studies in thick water absorbers

Proposed long-term space missions could expose crewmembers to significant fluxes of galactic cosmic radiation (GCR) particles and secondary particles created from nuclear collisions. An assessment of radiobiological risks is dependent upon an accurate description of the charged-particle radiation field inside the human body. As shield thickness increases and the incident ions are slowed, the production of secondary particles contributes an increasingly significant fraction of the total dose until eventually secondary particles become more important than the primary particles. The nuclear mean free path of the GCR ions (which usually have nuclear charge between 1 (protons) and 26 (iron), both inclusive) are comparable with thicknesses typical of spacecraft structures and the human body. Collisions in these media will create projectile and target fragments with charge less than that of the primary particle, and each interaction event can have a multiplicity of more than one emerging interaction product. Projectile fragments usually continue on with very nearly the velocity of the primary ion (the so-called straightahead approximation). Having sufficient energy, the fragments may collide with atomic nuclei in thick shields and create a second generation of fragments, and so on. Target fragments are emitted from a struck nucleus, usually with much lower energy than projectile fragments and nearly isotropically in the rest frame of the absorbing medium. The resulting spectrum of particles and their energy loss rates will be very different from that in the unshielded environment, will determine the radiobiological impact on exposed living tissues -- whether in space or in ground-based radiobiology experiments -- and will play an important role in radiation effects on microelectronics.

Shavers, M. R.↗

An overview of Space Shuttle anthropometry and biomechanics research with emphasis on STS/Mir recumbent seat system design

The Anthropometry and Biomechanics Laboratory (ABL) at JSC conducts multi-disciplinary research focusing on maximizing astronaut intravehicular (IVA) and extravehicular (EVA) capabilities to provide the most effective work conditions for manned space flight and exploration missions. Biomechanics involves the measurement and modeling of the strength characteristics of the human body. Current research for the Space Shuttle Program includes the measurement of torque wrench capability during weightlessness, optimization of foot restraint, and hand hold placement, measurements of the strength and dexterity of the pressure gloved hand to improve glove design, quantification of the ability to move and manipulate heavy masses (6672 N or 1500 lb) in weightlessness, and verification of the capability of EVA crewmembers to perform Hubble Space Telescope repair tasks. Anthropometry is the measurement and modeling of the dimensions of the human body. Current research for the Space Shuttle Program includes the measurement of 14 anthropometric parameters of every astronaut candidate, identification of EVA finger entrapment hazards by measuring the dimensions of the gloved hand, definition of flight deck reach envelopes during launch and landing accelerations, and measurement of anthropometric design parameters for the recumbent seat system required for the Shuttle/Mir mission (STS-71, Spacelab M) scheduled for Jun. 1995.

Klute, Glenn K.↗

Spaceflight Validation of Hzetrn Code

HZETRN is being developed as a fast deterministic radiation transport code applicable to neutrons, protons, and multiply charged ions in the space environment. It was recently applied to 50 hours of IMP8 data measured during the August 4, 1972 solar event to map the hourly exposures within the human body under several shield configurations. This calculation required only 18 hours on a VAX 4000 machine. A similar calculation using the Monte Carlo method would have required two years of dedicated computer time. The code has been benchmarked against well documented and tested Monte Carlo proton transport codes with good success. The code will allow important trade studies to be made with relative ease due to the computational speed and will be useful in assessing design alternatives in an integrated system software environment. Since there are no well tested Monte Carlo codes for HZE particles, we have been engaged in flight validation of the HZETRN results. To date we have made comparison with TEPC, CR-39, charge particle telescopes, and Bonner spheres. This broad range of detectors allows us to test a number of functions related to differing physical processes which add to the complicated radiation fields within a spacecraft or the human body, which functions can be calculated by the HZETRN code system. In the present report we will review these results.

Wilson, J. W.↗

Human-like agents with posture planning ability

Human body models are geometric structures which may be ultimately controlled by kinematically manipulating their joints, but for animation, it is desirable to control them in terms of task-level goals. We address a fundamental problem in achieving task-level postural goals: controlling massively redundant degrees of freedom. We reduce the degrees of freedom by introducing significant control points and vectors, e.g., pelvis forward vector, palm up vector, and torso up vector, etc. This reduced set of parameters are used to enumerate primitive motions and motion dependencies among them, and thus to select from a small set of alternative postures (e.g., bend vs. squat to lower shoulder height). A plan for a given goal is found by incrementally constructing a goal/constraint set based on the given goal, motion dependencies, collision avoidance requirements, and discovered failures. Global postures satisfying a given goal/constraint set are determined with the help of incremental mental simulation which uses a robust inverse kinematics algorithm. The contributions of the present work are: (1) There is no need to specify beforehand the final goal configuration, which is unrealistic for the human body, and (2) the degrees of freedom problem becomes easier by representing body configurations in terms of 'lumped' control parameters, that is, control points and vectors.

Jung, Moon R.↗

Development of a Neutron Spectrometer to Assess Biological Radiation Damage Behind Spacecraft Materials

Astronauts who spend months and years traveling long distances in spacecraft and working on other planets will be subjected to high energy radiation of galactic and solar origin without the protection of the Earth's thick (one writer has called it buff) atmosphere and magnetic field. The lack of natural protection will allow high energy cosmic ray particles and solar protons to crash directly into relatively thin spacecraft walls and planetary atmospheres producing energetic secondary particles in these collisions. A substantial fraction of these secondaries will be neutrons that carry no electric charge and, consequently, are difficult to detect. At sea level on Earth the remaining neutrons are the result of many generations (approximately 10) of collisions, have very low energies (scientists call them thermal neutrons), and do not penetrate deeply into the human body. They do contribute to the natural background radiation seen by humans on Earth, but much of the dose is only at the surface or skin of the body. In the International Space Station or on the surface of Mars, the secondary neutrons will be the result of only one or two generations of interaction due to the thinner (about a factor of 20 compared to the Earth's atmosphere) walls or atmosphere, have considerably more energy and penetrate deeply into the human body. In addition, neutrons are substantially moderated by hydrogenous material such as water. A significant fraction of the water exists in the astronaut's body. Therefore, the neutron can not only penetrate more deeply into the body, but also be stopped there and deposit all or most of its radiation dose in organs such as the liver, spleen, kidney, etc. We hypothesize that the risk of serious cancers will be increased for the exposed humans. The portable, real time neutron spectrometer being developed by our team will monitor the environment inside spacecraft structures and on planetary surfaces. Activities supported by this grant will evaluate the neutron environment inside several candidate spacecraft materials at accelerator facilities. These experiments will enable engineers to choose the structure materials that minimize the production of secondary neutrons. With the information that the neutron energy spectrometer produces, scientists and doctors will be able to assess the increased risk of cancer and develop countermeasures. The instrument itself will include an alarm system to warn astronauts when high radiation fluxes are occurring so that they can seek shelter immediately.

Maurer, R. H.↗