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Search indexed NASA NTRS and DOE OSTI research on propulsion, heat transfer, battery materials and energy systems. Follow report and document links to the original sources.

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At least 91 records · Page 5
All sourcesNASA NTRSDOE OSTI
DOE OSTI2026

Rapid T cell engineering to counter emerging threats (Full Technical Report)

Instead of genetic engineering, we sought to determine if a rapid method of membrane protein delivery could generate functional CAR-T cells in a rapid, safer, cost-effective manner. Using cell free protein synthesis, we generated CAR proteins embedded in a nanodisc, and thus effectively solubilized the protein. We demonstrated the first functional CAR proteins outside of a cellular context. We next tested uptake into immune cells and found extremely high uptake into T cells and multiple other populations of immune cells. We found some evidence of cytotoxicity in vitro conferred by the nanodisc delivered protein.

59 BASIC BIOLOGICAL SCIENCES↗
NASA NTRS1989

Automated generation of influence functions for planar crack problems

A numerical procedure for the generation of influence functions for Mode I planar problems is described. The resulting influence functions are in a form for convenient evaluation of stress-intensity factors for complex stress distributions. Crack surface displacements are obtained by a least-squares solution of the Williams eigenfunction expansion for displacements in a cracked body. Discrete values of the influence function, evaluated using the crack surface displacements, are curve fit using an assumed functional form. The assumed functional form includes appropriate limit-behavior terms for very deep and very shallow cracks. Continuous representation of the influence function provides a convenient means for evaluating stress-intensity factors for arbitrary stress distributions by numerical integration. The procedure is demonstrated for an edge-cracked strip and a radially cracked disk. Comparisons with available published results demonstrate the accuracy of the procedure.

Sire, Robert A.↗
DOE OSTI2026

Organo-catalyzed deamination of polystyrene sulfonamide for diverse post-polymerization modification of styrenic polymers

Post-polymerization modification allows for the incorporation of functional groups that would otherwise be incompatible with polymerization conditions, enhancing synthetic efficiency and facilitating the creation of complex polymer architectures for specialized applications, such as biomedical devices, electronics, and advanced coatings. Herein, we report a method inspired by late-stage functionalization of small molecules for the post-polymerization modification of aromatic polymers, specifically polystyrene (PS), under mild reaction conditions. First, PS was converted to polystyrene sulfonamide (PSSNH 2 ) with an 85% yield using established procedures. PSSNH 2 was subsequently transformed into a reactive sulfinate by deamination using an N-heterocyclic carbene (NHC) catalyst and benzaldehyde. The catalytic process was optimized by varying catalysts, solvents, bases, temperatures, and reaction times. The highest degree of deamination was 88% with a bicyclic NHC and K 2 CO 3 base in DMSO for 18 hours at 120 °C. The reactive sulfinate was then treated with various functional reagents, resulting in a library of aromatic polymers with different substituents with high degrees of functionalization ranging from 74% to 98%. Similarly, we modified expanded PS waste with trifluorobutyl iodide with a degree of functionalization of 72%, highlighting a new avenue for plastic upgrading. This approach could be used to rapidly generate functionalized polymers from PS with potential applications, including antibacterial properties and flame retardancy.

Shrestha, Tulaja [Univ. of Delaware, Newark, DE (U↗
NASA NTRS2009

Numerical Evaluation of the "Dual-Kernel Counter-flow" Matric Convolution Integral that Arises in Discrete/Continuous (D/C) Control Theory

Discrete/Continuous (D/C) control theory is a new generalized theory of discrete-time control that expands the concept of conventional (exact) discrete-time control to create a framework for design and implementation of discretetime control systems that include a continuous-time command function generator so that actuator commands need not be constant between control decisions, but can be more generally defined and implemented as functions that vary with time across sample period. Because the plant/control system construct contains two linear subsystems arranged in tandem, a novel dual-kernel counter-flow convolution integral appears in the formulation. As part of the D/C system design and implementation process, numerical evaluation of that integral over the sample period is required. Three fundamentally different evaluation methods and associated algorithms are derived for the constant-coefficient case. Numerical results are matched against three available examples that have closed-form solutions.

Nixon, Douglas D.↗
NASA NTRS1992

In-space operations for lunar and Mars space transfer vehicles

The in-space operations required to process the lunar and Mars mission vehicles foreseen in early studies for the SEI are discussed. Those studies that have examined the degree to which on-orbit operations alter as a function of the earth-to-orbit launch vehicle size, identified a common set of on-orbit vehicle processing tasks, and generated functional requirements for in-space processing nodes, are summarized. Attention is focused on the amount of time these processing operations might necessitate and how this time duration changes as a result of how the operation is executed and how the hardware is designed.

Raper, James L., Sr.↗
NASA NTRS1993

In-space operations for lunar and Mars space transfer vehicles

The objective of this paper is to discuss the in-space operations required to process the lunar and Mars mission vehicles envisioned for the Space Exploration Initiative (SEI). Recent studies, which have examined the degree to which on-orbit operations change as a function of the Earth-to-orbit (ETO) launch vehicle size, identified a common set of on-orbit vehicle processing tasks, and generated functional requirements for in-space processing nodes are summarized in this paper. Timelines for on-orbit processing of two different lunar transfer vehicles (LTV's) were developed to compare a 'current practice,' labor-intensive EVA approach to ones utilizing telerobotics and advanced automation. LTV aerobrake concepts ranging from simple deployment to considerable assembly are compared. Similar timelines for the on-orbit processing of a nuclear Mars transfer vehicle (MTV) are also presented. Aerobrakes can be processed in a timely manner and should not be ruled out for SEI missions. The 'tall pole' time interval for on-orbit vehicle initial processing is the delivery of elements to orbit, not the processing tasks.

Raper, James L., Sr.↗
NASA NTRS1991

Techniques in processing multi-frequency multi-polarization spaceborne SAR data

This paper presents the algorithm design of the SIR-C ground data processor, with emphasis on the unique elements involved in the production of registered multifrequency polarimetric data products. A quick-look processing algorithm used for generation of low-resolution browse image products and estimation of echo signal parameters is also presented. Specifically the discussion covers: (1) azimuth reference function generation to produce registered polarimetric imagery; (2) geometric rectification to accommondate cross-track and along-track Doppler drifts; (3) multilook filtering designed to generate output imagery with a uniform resolution; and (4) efficient coding to compress the polarimetric image data for distribution.

Curlander, John C.↗
NASA NTRS1990

Recognition and characterization of hierarchical interstellar structure. I - Correlation function

The problem of the quantitative description of multiscale structure in interstellar cloud complexes and gravitational collapse calculations is considered, emphasizing the recognition and characterization of hierarchical fragmentation structure. The response of the two-point correlation function to a variety of analytical models for density structure is discussed for simple clustering of pointlike clouds to more complex models involving clouds with a distribution of sizes and densities and hierarchical substructure. By expressing the density distribution as the superposition of individual clouds, it is shown that the correlation function generates two types of terms: those involving each cloud's density convolved with itself and those involving pairs of different clouds. Major distortion of the correlation function are introduced by the presence of any image features with size scales a significant fraction of the image size.

Houlahan, Padraig↗
NASA NTRS2013

Transfer Function Identification Using Orthogonal Fourier Transform Modeling Functions

A method for transfer function identification, including both model structure determination and parameter estimation, was developed and demonstrated. The approach uses orthogonal modeling functions generated from frequency domain data obtained by Fourier transformation of time series data. The method was applied to simulation data to identify continuous-time transfer function models and unsteady aerodynamic models. Model fit error, estimated model parameters, and the associated uncertainties were used to show the effectiveness of the method for identifying accurate transfer function models from noisy data.

Morelli, Eugene A.↗
DOE OSTI2025

Exclusive $J/ψ$ photoproduction on nuclei

Motivated by the recent experimental developments, the Pom-CQM model of the γ+N → J/ψ+N reaction of Lee et al. [Eur. Phys. J. A. 58, 252 (2022)] and Sakinah et al. [Phys. Rev. C. 109, 065204 (2024)] has been applied to predict the exclusive J/ψ photo-production on nuclei (A). Within the multiple scattering theory, the calculations have been performed by including the impulse amplitude $T^{\textrm{IMP}}_{J/ψA,γA}$ and the J/ψ-nucleus final state interaction (FSI) amplitude $T^{\textrm{FSI}}_{J/ψA,γA}$. For the deuteron target, $T^{\textrm{IMP}}_{J/ψd,γd}$ is calculated exactly using the wave function generated from the realistic nucleon-nucleon potentials. Here, it is found that, near the threshold region, the J/ψ photoproduction cross sections depend sensitively on the d-state of the deuteron wave function. The FSI amplitude $T^{\textrm{FSI}}_{J/ψA,γA}$ is calculated using the first-order optical potential constructed from the J/ψ-N scattering amplitude generated from the employed Pom-CQM model. It turns out that the FSI has significant effects in the large momentum-transfer region. By using the conventional fixed scatter approximation (FSA) and the nuclear form factors from the variational Monte-Carlo (VMC) calculations of Lonardoni et al. [Phys. Rev.C. 96, 024326 (2017)], the cross sections of the J/ψ photo-production on 4 He, 16 O, and 40 Ca are also predicted for future experimental investigations at JLab and EIC.

Kim, Sang-Ho [Soongsil University, Seoul (Korea, R↗
NASA NTRS1986

External calibration of SIR-B Imagery with area-extended and point targets

Data collected by the Shuttle Imaging Radar-B (SIR-B) on two ascending orbits over a site in west-central Illinois were used to establish end-to-end transfer functions for conversion of the digital numbers on the eight-bit image to values of the radar backscattering coefficient, sigma(0). The transfer function for each data take was defined by the SIR response to an array of six calibrated point targets of known radar cross section and to a large number of area-extended targets, also with a known cross section, as measured by externally calibrated, truck-mounted scatterometers. In spite of variance in the SIR transmit power, end-to-end transfer functions generated from either point targets or area-extended targets were found to yield close agreement for a given pass, indicating that targets of known radar cross section can be used to provide transfer functions for orbital SAR. Although the use of area-extended targets yielded the most satisfactory results, the use of point targets is far simpler and may be the preferred alternative for many situations.

Dobson, M. C.↗
NASA NTRS1994

Dynamic Stability Instrumentation System (DSIS). Volume 1: Hardware description

This paper is a hardware description manual for the Dynamic Stability Instrumentation System that is used in specific NASA Langley wind tunnels. The instrumentation system performs either a synchronous demodulation or a fast Fourier transform on dynamic balance strain gage signals, and ultimately computes aerodynamic coefficients. The DSIS consists of a double rack of instruments, a remote motor-generator set, two special stings each with motor driven shafts, and specially designed balances. The major components in the instrumentation rack include a personal computer, digital signal processor microcomputers, computer-controlled signal conditioners, function generator, digital multimeter, and an optional fast Fourier transform analyzer.

Jordan, T. L.↗
NASA NTRS1977

Line strengths, collision strengths and excitation rates for multiply-charged silicon ions

In the present paper, the line strengths, collision strengths, and rate coefficients are calculated for a variety of transitions in multiply charged silicon ions from Si(VI) to Si(XIV). The line strengths are obtained by using Clementi wave functions for the ground-state configuration, and excited-state wave functions generated by a semiempirical method. The collision strengths are calculated in an LS coupling scheme in the distorted-wave approximation, neglecting exchange except for the helium-like transitions. These results are then integrated over a Maxwellian velocity distribution function to yield rate coefficients. The rates are presented graphically and also in terms of a two-parameter fit.

Davis, J.↗
NASA NTRS1990

A triangular property of the associated Legendre functions

A mathematical formula is introduced and proved which relates the associated Legendre functions with given nonnegative integral indices. The application of this formula in simplifying the calculation of collisional electron-atom cross sections higher than the dipole is mentioned. A proof of the stated identity using the Gegenbauer polynomials and their generating function is given.

Fineschi, S.↗
DOE OSTI2024

Simultaneous enhancement of multiple functional properties using evolution-informed protein design

Abstract A major challenge in protein design is to augment existing functional proteins with multiple property enhancements. Altering several properties likely necessitates numerous primary sequence changes, and novel methods are needed to accurately predict combinations of mutations that maintain or enhance function. Models of sequence co-variation (e.g., EVcouplings), which leverage extensive information about various protein properties and activities from homologous protein sequences, have proven effective for many applications including structure determination and mutation effect prediction. We apply EVcouplings to computationally design variants of the model protein TEM-1 β -lactamase. Nearly all the 14 experimentally characterized designs were functional, including one with 84 mutations from the nearest natural homolog. The designs also had large increases in thermostability, increased activity on multiple substrates, and nearly identical structure to the wild type enzyme. This study highlights the efficacy of evolutionary models in guiding large sequence alterations to generate functional diversity for protein design applications.

59 BASIC BIOLOGICAL SCIENCES↗
DOE OSTI2024

RGM: Random Geological Model Generation Package

This Fortran code is to accompany a manuscript to be submitted to Computers & Geosciences, a high-impact, peer-reviewed journal in computer methods for geosciences research. This Fortran code focuses on generation of synthetic geological models using a multi-randomization strategy. Generating high-fidelity synthetic geological models, including realistic seismic reflector migration images, faults, salt bodies, and relative geological time images, is the key for many supervised machine learning methods that aim to delineate faults and other geological properties of interest from seismic migration images. Our package contains two major functionalities: generating 2D synthetic random geological models and generating 3D synthetic random geological models. In each step of the generation process, we set random values for key properties of a geological model to improve the fidelity of the resulting geological model. The package also includes example codes on how to use the random geological model generation subroutines. We name this package RGM – Random Geological Model generation package.

Gao, Kai↗