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NASA NTRS1992

Autonomous support for microorganism research in space

A preliminary design for performing on-orbit, autonomous research on microorganisms and cultured cells/tissues is presented. An understanding of gravity and its effects on cells is crucial for space exploration as well as for terrestrial applications. The payload is designed to be compatible with the COMmercial Experiment Transported (COMET) launch vehicle, an orbiter middeck locker interface, and with Space Station Freedom. Uplink/downlink capabilities and sample return through controlled reentry are available for all carriers. Autonomous testing activities are preprogrammed with inflight reprogrammability. Sensors for monitoring temperature, pH, light, gravity levels, vibration, and radiation are provided for environmental regulation and experimental data collection. Additional experiment data acquisition includes optical density measurement, microscopy, video, and file photography. Onboard full data storage capabilities are provided. A fluid transfer mechanism is utilized for inoculation, sampling, and nutrient replenishment of experiment cultures. In addition to payload design, representative experiments were developed to ensure scientific objectives remained compatible with hardware capabilities. The project is defined to provide biological data pertinent to extended duration crewed space flight including crew health issues and development of a Controlled Ecological Life Support System (CELSS). In addition, opportunities are opened for investigations leading to commercial applications of space, such as pharmaceutical development, modeling of terrestrial diseases, and material processing.

Luttges, M. W.↗

NASA NTRS2018

Impacts of NASA's Earth Observations on Subseasonal and Seasonal Forecasts

NASA's suite of Earth-observing satellites provides a unique view of many processes on Earth, with relevance on timescales ranging from hours to weeks and even years. NASA's observations span all parts of the Earth system: atmospheric, ocean, land and cryosphere, and include physical, chemical and biological components. This presentation explores use of NASA observations in extended-range prediction, from many days to months, using the Goddard Earth Observing System (GEOS) assimilation and predictive modeling capabilities. The skill of a weather forecast is linked to the fidelity of the initialization process (data assimilation) and the realistic representation of "fast" physical processes in the model. At longer time horizons, the slower "feedback" processes in the Earth System begin to take a more prominent role in the accuracy of the forecast. Simultaneously, forecast-skill attribution transitions away from feature-based metrics that emphasize smaller scales (e.g., representations of fronts and vortices) to metrics that emphasize the statistical distributions of large-scale features (e.g., ENSO diagnostics and teleconnections). This presentation will summarize studies performed using the GEOS-S2S (subseasonal to seasonal) system that explore the impacts of NASA observations on the fidelity of the forecasts. The GEOS-S2S system is configured for the atmosphere-ocean-land-ice model and is initialized using in-situ and space-based observations, including atmospheric aerosols and ozone which are not typically analyzed in such systems. The GEOS-S2S model routinely includes aerosol feedbacks, which systematically impact the realism of the forecasts, providing a first example of how suitable NASA observations impact the performance of the GEOS-S2S system. Studies in which a stratospheric chemistry module is activated in the GEOS-S2S system allow the impacts of ozone radiative feedbacks to be isolated. Space-based observations of sea-surface temperature and altimetry are routinely analyzed for the initialization of the GEOS-S2S system; recent advances allow the use of NASA's sea-surface salinity data, which are shown to impact the long-range skill of the forecasts.

Pawson, Steven↗

NASA NTRS1994

From neural-based object recognition toward microelectronic eyes

Engineering neural network systems are best known for their abilities to adapt to the changing characteristics of the surrounding environment by adjusting system parameter values during the learning process. Rapid advances in analog current-mode design techniques have made possible the implementation of major neural network functions in custom VLSI chips. An electrically programmable analog synapse cell with large dynamic range can be realized in a compact silicon area. New designs of the synapse cells, neurons, and analog processor are presented. A synapse cell based on Gilbert multiplier structure can perform the linear multiplication for back-propagation networks. A double differential-pair synapse cell can perform the Gaussian function for radial-basis network. The synapse cells can be biased in the strong inversion region for high-speed operation or biased in the subthreshold region for low-power operation. The voltage gain of the sigmoid-function neurons is externally adjustable which greatly facilitates the search of optimal solutions in certain networks. Various building blocks can be intelligently connected to form useful industrial applications. Efficient data communication is a key system-level design issue for large-scale networks. We also present analog neural processors based on perceptron architecture and Hopfield network for communication applications. Biologically inspired neural networks have played an important role towards the creation of powerful intelligent machines. Accuracy, limitations, and prospects of analog current-mode design of the biologically inspired vision processing chips and cellular neural network chips are key design issues.

Sheu, Bing J.↗

NASA NTRS2021

Physics and Chemistry of Te and HgTe-based Ternary Melts

Historically, the theoretical treatment of the liquid phases has always been more difficult and complicated than that for solid and gas phases. A liquid has no lattice structure as crystalline solids and the atoms/molecules in the liquid can migrate through it relatively rapidly. On the other hand, it is also interacting with many other atoms/molecules so that the simplifications of the kinetic theory of gases cannot be employed. For more complicated liquids, such as the liquids of high ionicity and those containing hydrogen bonds and electric dipoles, the understanding is far from complete. At the same time, accurate information on the physics and chemistry of semiconductor melts is needed for the quantitative descriptions of the process of crystal growth from melt. The pre-crystallization phenomena in the liquid phase are critical because the properties of the grown crystals depend on the state and structure of the melt as well as the thermal history of the melt during solidification process. However, the data on the liquid phase, such as thermophysical properties of semiconductor melts are scarce, especially for the HgTe-based II-VI ternary compound semiconductors because of their high vapor pressure and extreme toxicity. Analysis of the thermophysical properties of the melt can provide information about structural transitions of the melt during the solidification process. From a broader point of view, the structure of liquids is much more complicated than the crystalline solids, especially the relaxation behavior through different thermal histories. The theory of hetero-phase fluctuations of liquids is applicable to any many-body systems including condensed-matter physics, field theory, physics of nuclear-matter, cosmology, biology and even sociology. This book summarizes the physics and chemistry from the experimental measurements and theoretical analyses of phase diagram, thermodynamic properties, density, thermal conductivity, viscosity, and electrical conductivity on the binary, pseudo-binary and ternary melts of the most advanced IR-detector material systems of HgCdTe and HgZnTe as well as the analyses of these results. The main objectives of this study are: (1) to provide the phase diagrams and thermodynamic properties of Hg-Cd-Te and Hg-Zn-Te systems through quantitatively fitting the experimental data by assuming an associated solution model for the liquid phase, (2) to experimentally measure the thermophysical properties of the Hg-Cd-Te and Hg-Zn-Te melts, including density, viscosity, electrical conductivity and thermal conductivity as functions of temperature and composition and (3) to enhance the fundamental knowledge of hetero-phase fluctuations and relaxation phenomena in the melts and extend our understanding of the solidification process in order to interpret the experimental results of crystal growth so as to improve the melt growth processes of the compound semiconductor. The physics and chemistry of Te and HgTe-based ternary melts were explored through the studies of the structural transformation during melting, the supercooling during solidification, the relaxation phenomena after rapid cooling of the melts and the metal-semiconductor transition in the melts through the analyses of electrical conductivity and Lorenz number. An in-depth study on the thermophysical properties and their time-dependent structural dynamic processes taking place in the vicinity of the solid-liquid phase transition of the narrow homogeneity range HgTe-based ternary semiconductors as well as the analysis of the homogenization process in the melt will also be presented.

Thermophysical properties↗

NASA NTRS1986

Controlled Ecological Life Support Systems (CELSS) conceptual design option study

Results are given of a study to explore options for the development of a Controlled Ecological Life Support System (CELSS) for a future Space Station. In addition, study results will benefit the design of other facilities such as the Life Sciences Research Facility, a ground-based CELSS demonstrator, and will be useful in planning longer range missions such as a lunar base or manned Mars mission. The objectives were to develop weight and cost estimates for one CELSS module selected from a set of preliminary plant growth unit (PGU) design options. Eleven Space Station CELSS module conceptual PGU designs were reviewed, components and subsystems identified and a sensitivity analysis performed. Areas where insufficient data is available were identified and divided into the categories of biological research, engineering research, and technology development. Topics which receive significant attention are lighting systems for the PGU, the use of automation within the CELSS system, and electric power requirements. Other areas examined include plant harvesting and processing, crop mix analysis, air circulation and atmosphere contaminant flow subsystems, thermal control considerations, utility routing including accessibility and maintenance, and nutrient subsystem design.

Oleson, Melvin↗

NASA NTRS2018

NASA's GeneLab: An Integrated Omics Data Commons and Workbench

GeneLab (http://genelab.nasa.gov) is a NASA initiative designed to accelerate “open science” biomedical research in support of the human exploration of space and the improvement of life on earth. The GeneLab Data Systems (GLDS) were developed to help investigators corroborate findings from “omics” (genomics, transcriptomics, proteomics, and metabolomics) assays and translate them into systems biology knowledge and, eventually, therapeutics, including countermeasures to support life in space. Phase I of the project (completed) emphasized developing key capabilities for submission, curation, storage, search, and retrieval of omics data from biomedical research in and of space environments. The development focus for Phase II (completed) was federated data search and retrieval of these kinds of data from other open-access repositories. The last phase of the project (in work) entails developing an omics analysis tool set, and a portal to visualize processed omics data, emphasizing integration with the data repository and search functions developed during the prior phases. The final product will be an open-access system where users can individually or collaboratively publish, search, integrate, analyze, and visualize omics data.

genome↗

NASA NTRS2018

NASA's GeneLab: An Integrated Omics Data Commons and Workbench

GeneLab (http://genelab.nasa.gov) is a NASA initiative designed to accelerate "open science" biomedical research in support of the human exploration of space and the improvement of life on earth. The GeneLab Data Systems (GLDS) were developed to help investigators corroborate findings from "omics" (genomics, transcriptomics, proteomics, and metabolomics) assays and translate them into systems biology knowledge and, eventually, therapeutics, including countermeasures to support life in space. Phase I of the project (completed) emphasized developing key capabilities for submission, curation, storage, search, and retrieval of omics data from biomedical research in and of space environments. The development focus for Phase II (completed) was federated data search and retrieval of these kinds of data from other open-access repositories. The last phase of the project (in work) entails developing an omics analysis tool set, and a portal to visualize processed omics data, emphasizing integration with the data repository and search functions developed during the prior phases. The final product will be an open-access system where users can individually or collaboratively publish, search, integrate, analyze, and visualize omics data.

genome↗

NASA NTRS2017

NASA's GeneLab: An Integrated Omics Data Commons and Workbench

Berrios, Daniel C.↗

NASA NTRS1975

Atmospheric corrections for satellite water quality studies

Variations in the relative value of the blue and green reflectances of a lake can be correlated with important optical and biological parameters measured from surface vessels. Measurement of the relative reflectance values from color film imagery requires removal of atmospheric effects. Data processing is particularly crucial because: (1) lakes are the darkest objects in a scene; (2) minor reflectance changes can correspond to important physical changes; (3) lake systems extend over broad areas in which atmospheric conditions may fluctuate; (4) seasonal changes are of importance; and, (5) effects of weather are important, precluding flights under only ideal weather conditions. Data processing can be accomplished through microdensitometry of scene shadow areas. Measurements of reflectance ratios can be made to an accuracy of plus or minus 12%, sufficient to permit monitoring of important eutrophication indices.

Piech, K. R.↗

NASA NTRS2000

Salient Characteristics for Terrestrial Analog Engineering Test Sites

The use of terrestrial analog sites is an essential component of the development process for systems that are planned for lunar and planetary surfaces. These sites can also be valuable for training personnel who are expected to operate those systems. The fact that the site is an integral element, capable of influencing data and impacting test results, must not be overlooked. For tests performed in analog environments to be truly valid it is essential that the relevant characteristics of the employed sites be thoroughly understood. It is also critical that a comparative evaluation be made to assess the similarity of the analog sites to target planetary sites. Examples of relevant characteristics include terrain, soil properties, meteorology, geologic features, biological history, and remoteness. The importance of each of the characteristics varies with the type of extraterrestrial activity to be conducted. As a result, a site that is ideal for one purpose may be totally inadequate for another. It may also be appropriate to utilize multiple sites of increasing fidelity as the development process evolves. For example, early in the development process, the use of lower-fidelity sites may be elected - especially if they are available for a lower cost. Later, it may be necessary to employ higher-fidelity sites to capture greater realism, even if there is an associated increased cost. Finally, when interpreting the results of field tests, it is necessary to understand the sensitivity of the results to the relevant conditions. Knowledge of characteristics and sensitivity of results is particularly important when using field test results to validate analytical model predictions. This is especially true for activities that involve physical interaction with the site. Examples would include tests of rovers or other vehicles and associated trafficability modeling, spacesuit mobility tests, and tests associated with system deployment operations.

Watson, J.K.↗

NASA NTRS2000

The Urban Fabric of the City as Its Affects Thermal Energy Responses Derived from Remote Sensing Data

The physical geography of the city affects numerous aspects of its interlinked biophysical, social, and land-atmosphere characteristics - those attributes that come together to form the total urban environment. One approach to studying the multitude of interactions that occur as a result of urbanization is to view the city from a systems ecology perspective, where energy and material cycle into and out of the urban milieu. Thus, the urban ecosystem is synergistic in linking land, air, water, and living organisms in a vast network of interrelated physical, human, and biological process. Given the number and the shear complexity of the exchanges and, ultimately, their effects, that occur within the urban environment, we are focusing our research on looking at how the morphology or urban fabric of the city, drives thermal energy exchanges across the urban landscape. The study of thermal energy attributes for different cities provides insight into how thermal fluxes and characteristics are partitioned across the city landscape in response to each city's morphology. We are using thermal infrared remote sensing data obtained at a high spatial resolution from aircraft, along with satellite data, to identify and quantify thermal energy characteristics for 4 U.S. cities: Atlanta, GA, Baton Rouge, LA, Salt Lake City, UT, and Sacramento, CA. Analysis of how thermal energy is spatially distributed across the urban landscapes for these cities provides a unique perspective for understanding how the differing morphology of cities forces land-atmosphere exchanges, such as the urban heat island effect, as well as related meteorological and air quality interactions. Keyword: urban ecosystems, remote sensing, urban heat island

Quattrochi, Dale A.↗

NASA NTRS1987

Calcium messenger system in plants

The purpose of this review is to delineate the ubiquitous and pivotal role of Ca2+ in diverse physiological processes. Emphasis will be given to the role of Ca2+ in stimulus-response coupling. In addition to reviewing the present status of research, our intention is to critically evaluate the existing data and describe the newly developing areas of Ca2+ research in plants.

NASA Discipline Number 40-30↗

NASA NTRS2016

Light Microscopy Module: International Space Station Premier Automated Microscope

The Light Microscopy Module (LMM) was launched to the International Space Station (ISS) in 2009 and began hardware operations in 2010. It continues to support Physical and Biological scientific research on ISS. During 2016, if all goes as planned, three experiments will be completed: [1] Advanced Colloids Experiments with Heated base-2 (ACE-H2) and [2] Advanced Colloids Experiments with Temperature control (ACE-T1). Preliminary results, along with an overview of present and future LMM capabilities will be presented; this includes details on the planned data imaging processing and storage system, along with the confocal upgrade to the core microscope. [1] a consortium of universities from the State of Kentucky working through the Experimental Program to Stimulate Competitive Research (EPSCoR): Stuart Williams, Gerold Willing, Hemali Rathnayake, et al. and [2] from Chungnam National University, Daejeon, S. Korea: Chang-Soo Lee, et al.

Microgravity Biology Research↗

NASA NTRS2016

Using the Light Microscopy Module (LMM) on the International Space Station (ISS), The Advanced Colloids Experiment (ACE) and MacroMolecular Biophysics (MMB)

The Light Microscopy Module (LMM) was launched to the International Space Station (ISS) in 2009 and began science operations in 2010. It continues to support Physical and Biological scientific research on ISS. During 2016, if all goes as planned, three experiments will be completed: [1] Advanced Colloids Experiments with Heated base-2 (ACE-H2) and [2] Advanced Colloids Experiments with Temperature control (ACE-T1). Preliminary results, along with an overview of present and future LMM capabilities will be presented; this includes details on the planned data imaging processing and storage system, along with the confocal upgrade to the core microscope. [1] a consortium of universities from the State of Kentucky working through the Experimental Program to Stimulate Competitive Research (EPSCoR): Stuart Williams, Gerold Willing, Hemali Rathnayake, et al. and [2] from Chungnam National University, Daejeon, S. Korea: Chang-Soo Lee, et al.

Microgravity Biology Research↗

NASA NTRS2001

Predictability of the California Current System

The physical and biological oceanography of the Southern California Bight (SCB), a highly productive subregion of the California Current System (CCS) that extends from Point Conception, California, south to Ensenada, Mexico, continues to be extensively studied. For example, the California Cooperative Oceanic Fisheries Investigations (CalCOFI) program has sampled this region for over 50 years, providing an unparalleled time series of physical and biological data. However, our understanding of what physical processes control the large-scale and mesoscale variations in these properties is incomplete. In particular, the non-synoptic and relatively coarse spatial sampling (70km) of the hydrographic grid does not completely resolve the mesoscale eddy field (Figure 1a). Moreover, these unresolved physical variations exert a dominant influence on the evolution of the ecosystem. In recent years, additional datasets that partially sample the SCB have become available. Acoustic Doppler Current Profiler (ADCP) measurements, which now sample upper-ocean velocity between stations, and sea level observations along TOPEX tracks give a more complete picture of the mesoscale variability. However, both TOPEX and ADCP are well-sampled only along the cruise or orbit tracks and coarsely sampled in time and between tracks. Surface Lagrangian drifters also sample the region, although irregularly in time and space. SeaWiFS provides estimates of upper-ocean chlorophyll-a (chl-alpha), usually giving nearly complete coverage for week-long intervals, depending on cloud coverage. Historical ocean color data from the Coastal Zone Color Scanner (CZCS) has been used extensively to determine phytoplankton patterns and variability, characterize the primary production across the SCB coastal fronts, and describe the seasonal and interannual variability in pigment concentrations. As in CalCOFI, these studies described much of the observed structures and their variability over relatively large space and time scales.

Miller, Arthur J.↗

NASA NTRS2007

Advanced Systems for Monitoring Underwater Sounds

The term "Passive Acoustic Monitoring System" (PAMS) describes a developmental sensing-and-data-acquisition system for recording underwater sounds. The sounds (more precisely, digitized and preprocessed versions from acoustic transducers) are subsequently analyzed by a combination of data processing and interpretation to identify and/or, in some cases, to locate the sources of those sounds. PAMS was originally designed to locate the sources such as fish of species that one knows or seeks to identify. The PAMS unit could also be used to locate other sources, for example, marine life, human divers, and/or vessels. The underlying principles of passive acoustic sensing and analyzing acoustic-signal data in conjunction with temperature and salinity data are not new and not unique to PAMS. Part of the uniqueness of the PAMS design is that it is the first deep-sea instrumentation design to provide a capability for studying soniferous marine animals (especially fish) over the wide depth range described below. The uniqueness of PAMS also lies partly in a synergistic combination of advanced sensing, packaging, and data-processing design features with features adapted from proven marine instrumentation systems. This combination affords a versatility that enables adaptation to a variety of undersea missions using a variety of sensors. The interpretation of acoustic data can include visual inspection of power-spectrum plots for identification of spectral signatures of known biological species or artificial sources. Alternatively or in addition, data analysis could include determination of relative times of arrival of signals at different acoustic sensors arrayed at known locations. From these times of arrival, locations of acoustic sources (and errors in those locations) can be estimated. Estimates of relative locations of sources and sensors can be refined through analysis of the attenuation of sound in the intervening water in combination with water-temperature and salinity data acquired by instrumentation systems other than PAMS. A PAMS is packaged as a battery-powered unit, mated with external sensors, that can operate in the ocean at any depth from 2 m to 1 km. A PAMS includes a pressure housing, a deep-sea battery, a hydrophone (which is one of the mating external sensors), and an external monitor and keyboard box. In addition to acoustic transducers, external sensors can include temperature probes and, potentially, underwater cameras. The pressure housing contains a computer that includes a hard drive, DC-to- DC power converters, a post-amplifier board, a sound card, and a universal serial bus (USB) 4-port hub.

Lane, Michael↗

NASA NTRSDate not supplied

Creating Benchmark Data for Artificial Intelligence and Machine Learning Space Biology Research

To identify an appropriate AI/ML approach for a specific problem, the best practice is to measure algorithm performance through the benchmarking process. A scientific benchmark consists of an AI-ready dataset and a reference implementation on a specific scientific question. The NASA Science Mission Directorate (SMD) has started the “Benchmark Initiative for AI/ML to create scientific benchmark datasets in three applications: 1) scientific benchmarking, which finds the best algorithm for a specific problem; 2) application benchmarking, which measures algorithm performance against a set of parameters; and 3) system benchmarking, which evaluates performance of hardware and software architecture. Currently, there are no standardized datasets available to benchmark AI/ML algorithms in the domain of space biology. In this work, we constructed two AI/ML-ready biological datasets from experiments in space-flown mice: cellular imaging and RNA-seq. First, radiation-exposed immune cells harbor DNA damage foci that can be fluorescently marked to visualize the amount of damage following exposure to ionizing radiation. However, such large datasets are difficult to analyze visually, due to imaging inconsistencies and human bias, and classical image processing approaches can fail on imaging artifacts. AI/ML are therefore exciting alternative, providing the speed of machines and the accuracy of humans. We have made this dataset available at https://registry.opendata.aws/bps_microscopy/. Second, high-throughput nucleic acid sequencing (DNA-seq, RNA-seq) has become widespread in biomedical research due to the growing availability and affordability of these assays. However, most sequencing datasets suffer from high dimensionality and low sample count. In this work, we used a generative adversarial network to synthesize a standardized, AI-ready, publicly available benchmark dataset for space biology RNA-seq data with sufficient space-flown and ground control mouse liver samples from NASA GeneLab. This dataset is available at https://registry.opendata.aws/bps_rnaseq/. These datasets are now fully open the Space Biology community to test their favorite AI/ML approaches.

James Casaletto↗

NASA NTRS2003

MODIS Validation, Data Merger and Other Activities Accomplished by the SIMBIOS Project: 2002-2003

The purpose of this technical report is to provide current documentation of the Sensor Intercomparison and Merger for Biological and Interdisciplinary Oceanic Studies (SIMBIOS) Project activities, satellite data processing, and data product validation. This documentation is necessary to ensure that critical information is related to the scientific community and NASA management. This critical information includes the technical difficulties and challenges of validating and combining ocean color data from an array of independent satellite systems to form consistent and accurate global bio-optical time series products. This technical report focuses on the SIMBIOS Project s efforts in support of the Moderate-Resolution Imaging Spectroradiometer (MODIS) on the Earth Observing System (EOS) Terra platform (similar evaluations of MODIS/Aqua are underway). This technical report is not meant as a substitute for scientific literature. Instead, it will provide a ready and responsive vehicle for the multitude of technical reports issued by an operational project.

Fargion, Giulietta S.↗