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At least 91 records · Page 5

Resonance-enhanced compact nonlinear acoustic source of low frequency collimated beam for imaging applications in highly attenuating media

Acoustic signal sources include acoustic resonators that include acoustic nonlinear materials. Acoustic signals at higher frequencies are mixed in the nonlinear materials to produce a lower frequency acoustic signal. Resonance provides increased efficiency in producing acoustic signals at difference frequencies corresponding to resonance frequencies. Higher frequency acoustic signals used in nonlinear mixing are preferably at frequencies corresponding to resonance frequencies as well.

Pantea, Cristian↗

How do magnetized HED flows transition to collimated plasma jets? (Final Report)

We present results from a pulsed-power experiment designed to generate accretion-like flows in the laboratory that may be used to study the dynamics of astrophysical accretion-driven outflows. To emulate systems like Young Stellar Object (YSO) outflows, we create radially converging plasma flows in a short disk that transition into much longer bipolar outflows. Our experiment uses a ~1 MA pulsed-power driver to generate plasma from an array of thin aluminum wires mounted to a 3D-printed current path that controls the angular momentum and magnetic field topology. In this paper, we show that experimental data scale favorably to observed properties of YSO jets. This set of experiments tests the simplest version of our possible plasma dynamics, where outflows are generated without rotation or axial magnetic field present. The temperature, velocity and density of the disk and outflows are characterized using interferometry, gated optical and ultraviolet imaging, and Thomson scattering diagnostics. We discuss the Reynolds number, magnetic Reynolds number and Mach numbers calculated in three different stages of the experiment, and compare our results to 3D numerical simulations in the PERSEUS magnetohydrodynamics code. This report is a summary of the work done by the graduate students who were supported by the project.

70 PLASMA PHYSICS AND FUSION TECHNOLOGY↗

How to Turn Jets into Cylinders near Supermassive Black Holes in 3D General Relativistic Magnetohydrodynamic Simulations

Abstract Accreting supermassive black holes (SMBHs) produce highly magnetized relativistic jets that tend to collimate gradually as they propagate outward. However, recent radio interferometric observations of the 3C 84 galaxy reveal a stunning, cylindrical jet already at several hundred SMBH gravitational radii,r≳ 350r g . We explore how such extreme collimation emerges via a suite of 3D general relativistic magnetohydrodynamic simulations. We consider an SMBH surrounded by a magnetized torus immersed in a constant-density ambient medium that starts at the edge of the SMBH sphere of influence, chosen to be much larger than the SMBH gravitational radius,r B = 10 3 r g . We find that radiatively inefficient accretion flows (e.g., M87) produce winds that collimate the jets into parabolas near the black hole. After the disk winds stop collimating the jets atr≲r B , they turn conical. Once outsider B , the jets run into the ambient medium and form backflows that collimate the jets into cylinders some distance beyondr B . Interestingly, for radiatively efficient accretion, as in 3C 84, the radiative cooling saps the energy out of the disk winds; at early times, they cannot efficiently collimate the jets, which skip the initial parabolic collimation stage, start out conical near the SMBH, and turn into cylinders already atr≃ 300r g , as observed in 3C 84. Over time, the jet power remains approximately constant, whereas the mass accretion rate increases; the winds grow in strength and start to collimate the jets, which become quasi-parabolic near the base, and the transition point to a nearly cylindrical jet profile moves outward while remaining insider B .

Astronomy & Astrophysics↗

Bayesian optimization to design a novel x-ray shaping device

In radiation therapy, x-ray dose must be precisely sculpted to the tumor, while simultaneously avoiding surrounding organs at risk. This requires modulation of x-ray intensity in space and/or time. Typically, this is achieved using a multi leaf collimator (MLC) - a complex mechatronic device comprising over one hundred individually powered tungsten ‘leaves’ that move in or out of the radiation field as required. Here, an all-electronic x-ray collimation concept with no moving parts is presented, termed “SPHINX”: Scanning Pencil-beam High-speed Intensity-modulated X-ray source. SPHINX utilizes a spatially distributed bremsstrahlung target and collimator array in conjunction with magnetic scanning of a high energy electron beam to generate a plurality of small x-ray “beamlets.” A simulation framework was developed in Topas Monte Carlo incorporating a phase space electron source, transport through user defined magnetic fields, bremsstrahlung x-ray production, transport through a SPHINX collimator, and dose in water. This framework was completely parametric, meaning a simulation could be built and run for any supplied geometric parameters. This functionality was coupled with Bayesian optimization to find the best parameter set based on an objective function which included terms to maximize dose rate for a user defined beamlet width while constraining inter-channel cross talk and electron contamination. Designs for beamlet widths of 5, 7, and 10 mm 2 were generated. Each optimization was run for 300 iterations and took approximately 40 h on a 24-core computer. For the optimized 7-mm model, a simulation of all beamlets in water was carried out including a linear scanning magnet calibration simulation. Finally, a back-of-envelope dose rate formalism was developed and used to estimate dose rate under various conditions. The optimized 5–, 7–, and 10-mm models had beamlet widths of 5.1 , 7.2 , and 10.1 mm 2 and dose rates of 3574, 6351, and 10 015 Gy/C, respectively. The reduction in dose rate for smaller beamlet widths is a result of both increased collimation and source occlusion. For the simulation of all beamlets in water, the scanning magnet calibration reduced the offset between the collimator channels and beam centroids from 2.9 ±1.9 mm to 0.01 ±0.03 mm. A slight reduction in dose rate of approximately 2% per degree of scanning angle was observed. Based on a back-of-envelope dose rate formalism, SPHINX in conjunction with next-generation linear accelerators has the potential to achieve substantially higher dose rates than conventional MLC-based delivery, with delivery of an intensity modulated 100 x 100 mm 2 field achievable in 0.9 to 10.6 s depending on the beamlet widths used. Bayesian optimization was coupled with Monte Carlo modeling to generate SPHINX geometries for various beamlet widths. A complete Monte Carlo simulation for one of these designs was developed, including electron beam transport of all beamlets through scanning magnets, x-ray production and collimation, and dose in water. These results demonstrate that SPHINX is a promising candidate for sculpting radiation dose with no moving parts, and has the potential to vastly improve both the speed and robustness of radiotherapy delivery. A multi-beam SPHINX system may be a candidate for delivering magavoltage FLASH RT in humans.

62 RADIOLOGY AND NUCLEAR MEDICINE↗

Gamma Spectrometry Code Rodeo for Uranium Enrichment—FY 2021 Report

In FY22, the participating Department of Energy (DOE) laboratories continued the work on the project “Gamma Spectrometry Code Rodeo for Uranium Enrichment”. Oak Ridge National Laboratory (ORNL) and Lawrence Livermore National Laboratory (LLNL) continued their efforts to acquire spectra using uranium sources. A collimator (with side and back shields) was custom designed and constructed at ORNL. Spectra were acquired at ORNL using the uranium enrichment standards supplied by New Brunswick Laboratory (NBL) and the collimated M400 detector. Spectra were also acquired using steel absorbers of different thickness placed between the source and the collimated M400 detector. The plan was to ship the collimator to LLNL so that spectra could be acquired using the LLNL detector in collimated geometries. This activity was suspended since problems were noticed with the performance of the LLNL M400 detector. Also, it was brought to light to the project team that some of the aspects of the M400 detector had been updated by the vendor H3D in response to requests by the IAEA. In February 2021, the ORNL and LLNL M400 detectors were returned to the H3D factory in order to resolve the problems with the LLNL detector and to update ORNL and LLNL detectors to the same configuration as the M400 supplied to the IAEA. H3D repaired the LLNL M400 and performed the IAEA updates on both the ORNL and LLNL detectors. ORNL and LLNL received the detectors in April 2021. Data acquisition was continued using the upgraded detectors. ORNL re-collected the spectra using point sources and the NBL standards in uncollimated and collimated geometries. The collimator was shipped from ORNL to LLNL. Spectra were acquired at LLNL through Q4 of FY22. When the ORNL spectra were examined closely, it became apparent that there were spurious artifacts present in some of the spectra. This rendered suspect the ORNL spectra collected in June/July 2021 time frame. ORNL contacted H3D and per H3D’s advice, the M400 detector was returned to H3D for repairs in mid-August 2021. H3D diagnosed the problem and established that the root cause was the extra tight packaging that created a strain on the CZT crystals, causing one of them to break down. The repaired M400 was returned to ORNL in early September 2021. ORNL re-started data acquisition for the third time. Data was continued to be acquired at ORNL and LLNL through September 2021. The ORNL and LLNL data will be shared with the principal investigators from the analyzing laboratories. The GADRAS code and FRAM have been developed to have the capability to analyze the M400 spectra. Good quality spectra from FY21 have been analyzed using modified versions of GADRAS and FRAM. The spectra have also been analyzed using the GEM code. The analysis results from GADRAS, FRAM and GEM codes are presented and discussed in this report. Some preliminary results from FRAM and GEM analysis were presented in February 2021 at the U-Pu Isotopics Workshop sponsored by the IAEA. CZTU code is being modified to analyze M400 spectra. Data collection, code development and analysis will be continued in FY22 as per the FY22 Project Work Plan (PWP).

11 NUCLEAR FUEL CYCLE AND FUEL MATERIALS↗

Machine Protection Studies of Fast Instability-Driven Beam Losses in the EIC Electron Storage Ring

Fast transverse beam instabilities represent one of the most challenging protection scenarios for the Electron-Ion Collider (EIC) electron storage ring (ESR). Coherent betatron oscillations driven by collective effects can grow rapidly and lead to substantial beam losses within only a few tens of turns, posing a threat to collimators, superconducting (SC) magnets, cryogenic systems, and detector components. A dedicated simulation framework based on distributed transverse excitations was developed to evaluate instability-driven beam losses in the ESR. A conservative instability rise time on the order of 10 turns was used to define a bounding protection scenario. Simulations show that the original two-collimator configuration is insufficient to localize losses under all operating conditions, whereas an optimized four-collimator configuration reduces loss leakage into protected regions by more than two orders of magnitude. Nevertheless, the most severe instability scenarios produce catastrophic beam impacts, with nearly half of the stored beam being intercepted by the collimators within a single turn, exceeding the preliminary estimated survivability limits of the baseline collimator design. The results demonstrate that collimation alone is insufficient to guarantee safe ESR operation and must be complemented by a fast machine-protection system. Dedicated turn-by-turn beam-position monitors and fast beam-loss monitors provide sufficient advance warning to detect instability growth and initiate a beam abort before equipment-damaging loss levels are reached. These findings establish quantitative requirements for the ESR machine-protection architecture and support the implementation of a multilayer protection strategy for both accelerator and detector systems.

43 PARTICLE ACCELERATORS↗

Phase Trombone Design in the Beam Transfer line for the Project PIP-II at Fermilab

PIP-II beam transfer line (BTL) to transport the beam from PIP-II Linac to the Booster ring at Fermilab. One crucial aspect of the BTL design involved the implementation of collimators. These collimators play a vital role in removing large amplitude particles from the beamline that might otherwise miss the horizontal and vertical edge of the foil at the point of the Booster injection. To ensure the effectiveness of these collimators, simulation was conducted to determine their optical placement within the BTL. The simulation revealed that the precise control of accumulated phase advances between the collimators and the foil was crucial. To achieve this control, a phase trombone is needed within the BTL. The phase trombone serves as an adjustment mechanism, allowing for the fine-tuning of the phase advance between the collimators and the foil, thus optimizing the performance of the collimation process. This paper discusses and presents the details of the design and implementation of the phase trombone within the PIP-II BTL.

43 PARTICLE ACCELERATORS↗

Optical design for the single crystal neutron diffractometer Pioneer

Pioneer is a single-crystal neutron diffractometer optimized for small-volume samples and weak signals at the Second Target Station at Oak Ridge National Laboratory. This paper presents the preliminary optical design progress, focusing on the rationale behind key design choices. It covers the T 0 and bandwidth disk choppers, guide and beam control system, incident-beam polarizer, scattering beam collimators, and additional strategies. The chopper locations are selected to maximize neutron transport while taking advantage of standardized shielding structures. To accommodate the maintenance shield, operational shutter, and polarizing V-cavity, the guide design includes significant gaps. When these optical components are moved out of the beam path, oversized collimators, rather than guides, will be translated in. Pioneer will utilize slit packages to control beam size and divergence and a translatable polarizing V-cavity. Absorbing panels are strategically placed near the end station to minimize background. An oscillating radial collimator, operating in a shift mode, will be used with the vertical cylindrical detector, while a fixed multi-cone collimator will be used with the bottom flat detector. In conclusion, these collimators will enable the detection of weak signals when complex sample environments are used.

47 OTHER INSTRUMENTATION↗

Laboratory disruption of scaled astrophysical outflows by a misaligned magnetic field

The shaping of astrophysical outflows into bright, dense, and collimated jets due to magnetic pressure is here investigated using laboratory experiments. Here we look at the impact on jet collimation of a misalignment between the outflow, as it stems from the source, and the magnetic field. For small misalignments, a magnetic nozzle forms and redirects the outflow in a collimated jet. For growing misalignments, this nozzle becomes increasingly asymmetric, disrupting jet formation. Our results thus suggest outflow/magnetic field misalignment to be a plausible key process regulating jet collimation in a variety of objects from our Sun’s outflows to extragalatic jets. Furthermore, they provide a possible interpretation for the observed structuring of astrophysical jets. Jet modulation could be interpreted as the signature of changes over time in the outflow/ambient field angle, and the change in the direction of the jet could be the signature of changes in the direction of the ambient field.

70 PLASMA PHYSICS AND FUSION TECHNOLOGY↗

The evolution of gamma-ray burst jet opening angle through cosmic time

ABSTRACT Jet opening angles of long gamma-ray bursts (lGRBs) appear to evolve in cosmic time, with lGRBs at higher redshifts being on average more narrowly beamed than those at lower redshifts. We examine the nature of this anticorrelation in the context of collimation by the progenitor stellar envelope. First, we show that the data indicate a strong correlation between gamma-ray luminosity and jet opening angle, and suggest this is a natural selection effect – only the most luminous GRBs are able to successfully launch jets with large opening angles. Then, by considering progenitor properties expected to evolve through cosmic time, we show that denser stars lead to more collimated jets; we argue that the apparent anticorrelation between opening angle and redshift can be accounted for if lGRB massive star progenitors at high redshifts have higher average density compared to those at lower redshifts. This may be viable for an evolving initial mass function (IMF) – under the assumption that average density scales directly with mass, this relationship is consistent with the form of the IMF mass evolution suggested in the literature. The jet angle–redshift anticorrelation may also be explained if the lGRB progenitor population is dominated by massive stars at high redshift, while lower redshift lGRBs allow for a greater diversity of progenitor systems (that may fail to collimate the jet as acutely). Overall, however, we find both the jet angle–redshift anticorrelation and jet angle–luminosity correlation are consistent with the conditions of jet launch through, and collimation by, the envelope of a massive star progenitor.

Lloyd-Ronning, Nicole↗

Dark Field Proton Radiography (Los Alamos LDRD Report)

Proton radiography at LANL (pRad) takes advantage of the high flux, high proton energy, and flexible timing structure of LANSCE's 800-MeV proton beam to visualize dense, dynamic systems under extreme strain. With recent needs identified for the development of the W93, the pRad team has been actively searching for ways to increase the facility's radiographic capabilities. Recently, we discovered that utilizing two magnetic lenses (one upstream and one downstream of the object), and specific combinations of collimator choices within the two lenses, that the signal-to-noise ratio was improved by more than a factor of two. However, we did not fully understand the mechanism, and found that results did not match forward modeling predictions. This work specifically sought to implement an engineering solution to solve this problem, through the development of an actuated collimator that reduced the time required to swap collimator settings from a typical 4-8 hours, to less than 30 seconds. This allowed, in combination with a unique multi-material, multi-resolution stepwedge, to acquire an unprecedently enormous dataset, with in total 24 collimation combinations, and multiple diffuser settings and pulse patterns, equivalent to almost a full run cycle's worth of data in a few days. This massive dataset is currently being harnessed to make a fully-predictive, ultra-fast Python-based model of the system, to dial in specific settings for any future experiments that fully optimize that radiographic sensitivity to the material of interest.

46 INSTRUMENTATION RELATED TO NUCLEAR SCIENCE AND ↗

System and method for sub micron additive manufacturing

An apparatus is disclosed for performing an additive manufacturing operation to form a structure by processing a photopolymer resist material. The apparatus may incorporate a laser for generating a laser beam, and a tunable mask for receiving the laser beam which has an optically dispersive element. The mask splits the laser beam into a plurality of emergent beams each having a subplurality of beamlets of varying or identical intensity, with each beamlet emerging from a unique subsection of illuminated regions of the mask. A collimator collimates at least one of the emergent beams to form a collimated beam. One or more focusing elements focuses the collimated beam into a focused beam which is projected as a focused image plane on or within the resist material. The focused beam simultaneously illuminates a layer of the resist material to process an entire layer in a parallel fashion.

Saha, Sourabh Kumar↗

A holistic approach to the optimization of neutron beam transport at the LANSCE facility

An advanced neutron beam collimation system has been developed as part of an effort to optimize neutron beam transport at the Weapons Neutron Research (WNR) Facility, located within the Los Alamos Neutron Science Center (LANSCE). The goal of this work was to develop and demonstrate techniques to tailor neutron delivery in order to provide maximum available flux on sample with a specific beam profile, while simultaneously reducing unwanted background. A holistic approach was taken, upgrading the facility spallation target, facility metrology infrastructure, and flight path shutter insert to support the implementation of this advanced collimation system. Here, modern instruments and software were employed to conduct facility surveys, characterization of as-built geometry of critical components, 3D ray tracing and neutron transport calculations. Beam images and flux measurements were acquired after installation to evaluate the performance of the collimation system and to demonstrate consistent agreement with MCNP simulations which showed an 87% increase of flux on sample while providing suppression of background neutron impingement on the sample frame by 10 3 .

46 INSTRUMENTATION RELATED TO NUCLEAR SCIENCE AND ↗

Application of radiochromic gel dosimetry to commissioning of a megavoltage research linear accelerator for small–field animal irradiation studies

To develop and implement an efficient and accurate commissioning procedure for small-field static beam animal irradiation studies on an MV research linear accelerator (Linatron-M9) using radiochromic gel dosimetry. The research linear accelerator (Linatron-M9) is a 9 MV linac with a static fixed collimator opening of 5.08 cm diameter. Lead collimators were manually placed to create smaller fields of 2 × 2 cm 2 , 1 × 1 cm 2 , and 0.5 × 0.5 cm 2 . Relative dosimetry measurements were performed, including profiles, percent depth dose (PDD) curves, beam divergence, and relative output factors using various dosimetry tools, including a small volume ionization chamber (A14), GAFCHROMIC™ EBT3 film, and Clearview gel dosimeters. The gel dosimeter was used to provide a 3D volumetric reference of the irradiated fields. The Linatron profiles and relative output factors were extracted at a reference depth of 2 cm with the output factor measured relative to the 2 × 2 cm 2 reference field. Absolute dosimetry was performed using A14 ionization chamber measurements, which were verified using a national standards laboratory remote dosimetry service. Absolute dosimetry measurements were confirmed within 1.4% (k = 2, 95% confidence = 5%). The relative output factor of the small fields measured with films and gels agreed with a maximum relative percent error difference between the two methods of 1.1 % for the 1 × 1 cm 2 field and 4.3 % for the 0.5 × 0.5 cm 2 field. These relative errors were primarily due to the variability in the collimator positioning. The measured beam profiles demonstrated excellent agreement for beam size (measured as FWHM), within approximately 0.8 mm (or less). Film measurements were more accurate in the penumbra region due to the film’s finer resolution compared with the gel dosimeter. Following the van Dyk criteria, the PDD values of the film and gel measurements agree within 11% in the buildup region starting from 0.5 cm depth and within 2.6 % beyond maximum dose and into the fall-off region for depths up to 5 cm. The 2D beam profile isodose lines agree within 0.5 mm in all regions for the 0.5 × 0.5 cm 2 and the 1 × 1 cm 2 fields and within 1 mm for the larger field of 2 × 2 cm 2 . The 2D PDD curves agree within approximately 2% of the maximum in the typical therapy region (1–4 cm) for the 1 × 1 cm 2 and 2 × 2 cm 2 and within 5% for the 0.5 × 0.5 cm 2 field. This work provides a commissioning process to measure the beam characteristics of a fixed beam MV accelerator with detailed dosimetric evaluation for its implementation in megavoltage small animal irradiation studies. Radiochromic gel dosimeters are efficient small-field relative dosimetry tools providing 3D dose measurements allowing for full representation of dose, dosimeter misalignment corrections and high reproducibility with low inter-dosimeter variability. Altogether, radiochromic gels are valuable for fast, full relative dosimetry commissioning in comparison to films for application in high-energy small-field animal irradiation studies.

62 RADIOLOGY AND NUCLEAR MEDICINE↗

Accelerated radiation transport modeling techniques for pencil beam computed tomography using gamma rays

Monte Carlo radiation transport modeling studies were performed for a compact, and high-resolution gamma-ray computed tomography system designed for imaging irradiated nuclear fuel. The system comprises a 60 Co source – chosen for its highly penetrating 1173 keV and 1332 keV gamma rays – a pair of high-aspect-ratio pencil beam collimators, and an inorganic scintillator detector. Here two acceleration methods are proposed to rapidly model a transmission type gamma-ray tomography system. The first, a variance reduction technique, is based on performing Monte Carlo simulations with a monodirectionally-biased source, sampled from a characteristic sub-volume of the full source volume. The second acceleration method is based on the deterministic calculations using the Beer–Lambert law and detector response characteristics. Comparison of simulations using acceleration approaches with analog simulations of the fully isotropic, full-volume equivalent, show that the Monte Carlo variance reduction technique gives quantitatively accurate predictions for large collimator aspect ratios while the deterministic calculations are semi-quantitative but converge close to the correct result as the collimator aspect ratio increases. As such, these techniques can be used to reduce the computational cost in generating simulated radiographs and tomographs by several orders of magnitude. Experimental validation efforts are currently underway and will be demonstrated in future work.

11 NUCLEAR FUEL CYCLE AND FUEL MATERIALS↗

Spatially resolved x-ray detection with photonic crystal scintillators

We study the self-collimation phenomenon in photonic crystals (PhC) of wide bandgap materials for ultra-fast and high spatial resolution x-ray detection. We work on various heavy inorganic scintillators: BaF 2 , GaN, ZnO, CsI:Tl, NaI:Tl, LYSO, WO 4 compounds, and plastic scintillators. Conventional scintillator detectors do not rely on a direct detection mechanism; hence, they require intricate design and fabrication processes. We offer a PhC design to observe self-collimation phenomena and overcome the ongoing spatial resolution challenges with these types of materials. We investigate the photonic band diagrams and iso-frequency contours. Fourier transforms based on finite-difference time-domain and frequency domain simulations are done for verifying and analyzing the self-collimation with the selected material. Light extraction efficiency at the PhC–air interface, depending on the truncation distance from the excitation point, is measured. Beam divergence values are calculated at 1 mm propagation distance. The vertical field profiles are obtained to observe the confinement. For the spatial resolution analysis, cross-sectional beam profiles have been examined. Furthermore, Gaussian envelopes are fitted to beam profiles for a consistent data analysis, and full-width-at-half-maximum values are considered. As a result, we theoretically prove and demonstrate the spatially resolved x-ray detection at the sub-micrometer level for a wide range of scintillator materials.

36 MATERIALS SCIENCE↗

A TOPAS model for lens-based proton radiography

Abstract Objective. Proton Radiography can be used in conjunction with proton therapy for patient positioning, real-time estimates of stopping power, and adaptive therapy in regions with motion. The modeling capability shown here can be used to evaluate lens-based radiography as an instantaneous proton-based radiographic technique. The utilization of user-friendly Monte Carlo program TOPAS enables collaborators and other users to easily conduct medical- and therapy- based simulations of the Los Alamos Neutron Science Center (LANSCE). The resulting transport model is an open-source Monte Carlo package for simulations of proton and heavy ion therapy treatments and concurrent particle imaging. Approach. The four-quadrupole, magnetic lens system of the 800-MeV proton beamline at LANSCE is modeled in TOPAS. Several imaging and contrast objects were modelled to assess transmission at energies from 230–930 MeV and different levels of particle collimation. At different proton energies, the strength of the magnetic field was scaled according to βγ, the inverse product of particle relativistic velocity and particle momentum. Main results. Materials with high atomic number, Z, (gold, gallium, bone-equivalent) generated more contrast than materials with low-Z (water, lung-equivalent, adipose-equivalent). A 5-mrad collimator was beneficial for tissue-to-contrast agent contrast, while a 10-mrad collimator was best to distinguish between different high-Z materials. Assessment with a step-wedge phantom showed water-equivalent path length did not scale directly according to predicted values but could be mapped more accurately with calibration. Poor image quality was observed at low energies (230 MeV), but improved as proton energy increased, with sub-mm resolution at 630 MeV. Significance. Proton radiography becomes viable for shallow bone structures at 330 MeV, and for deeper structures at 630 MeV. Visibility improves with use of high-Z contrast agents. This modality may be particularly viable at carbon therapy centers with accelerators capable of delivering high energy protons and could be performed with carbon therapy.

60 APPLIED LIFE SCIENCES↗