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At least 91 records · Page 5
All sourcesNASA NTRSDOE OSTI
NASA NTRS1973

Effect of artificial gravity on thermoregulation, respiratory metabolism and intermediary metabolism of animals

Metabolic alterations in animals exposed to radial acceleration are reported. Temperatures in acutely stressed animals dropped profoundly in correlation with decreased food consumption. Repeated exposure of the acutely stressed animal caused a decrease in hypothermic response whereas deceleration or reduction of G load did not significantly change body temperatures. Adrenal corticosteroids affected significantly the animal's recovery rate. No changes occured in body temperature patterns of chronically centrifuged animals after full adaptation; their respiratory rate increased very significantly in terms of CO2 output as did their glucose uptake by muscle tissues and their insulin responsiveness or sensitivity.

Oyama, J.↗
NASA NTRS1978

Animal life support transporters for Shuttle/Spacelab

Two transporter devices have been developed by the NASA Ames Research Center, primarily for the purpose of stowing small vertebrates and primates in the mid-deck avionics bay of the Shuttle during launch and re-entry. These animals will be used in Life Science Spacelab experiments. Stowage in the mid-deck area will reduce animal exposure to the high noise levels existing in Spacelab during launch; further, the possible exposure of the animals to high temperatures in Spacelab during re-entry and post-landing will be eliminated. The transporters will provide experimenters more timely access to their animals during experiment-critical, pre-launch, and post-landing periods. Rechargeable batteries in the transporters will provide life support system functions for the animals during periods of transfer and during mission phases in which power is temporarily unavailable. The transporters have been successfully designed, fabricated, and tested. Integrated testing of the transporters was performed in the Space Mission Development III (SMD III) Simulation at the NASA Johnson Space Center.

Berry, W. E.↗
NASA NTRS1988

Animals in space

Animals are indispensable to the space program. Their continued use could have many significant results. Those who are opposed to using animals in space should remember that space animals are treated humanely; they are necessary because results can be obtained from them that would be unobtainable from humans; and results from animal experiments can be applied to human systems. Therefore, NASA should continue to use animals in space research.

White, Angela↗
NASA NTRS1989

The rodent research animal holding facility as a barrier to environmental contamination

The rodent Research Animal Holding Facility (RAHF), developed by NASA Ames Research Center (ARC) to separately house rodents in a Spacelab, was verified as a barrier to environmental contaminants during a 12-day biocompatibility test. Environmental contaminants considered were solid particulates, microorganisms, ammonia, and typical animal odors. The 12-day test conducted in August 1988 was designed to verify that the rodent RAHF system would adequately support and maintain animal specimens during normal system operations. Additional objectives of this test were to demonstrate that: (1) the system would capture typical particulate debris produced by the animal; (2) microorganisms would be contained; and (3) the passage of animal odors was adequately controlled. In addition, the amount of carbon dioxide exhausted by the RAHF system was to be quantified. Of primary importance during the test was the demonstration that the RAHF would contain particles greater than 150 micrometers. This was verified after analyzing collection plates placed under exhaust air ducts and rodent cages during cage maintenance operations, e.g., waste tray and feeder changeouts. Microbiological testing identified no additional organisms in the test environment that could be traced to the RAHF. Odor containment was demonstrated to be less than barely detectable. Ammonia could not be detected in the exhaust air from the RAHF system. Carbon dioxide levels were verified to be less than 0.35 percent.

Savage, P. D., Jr.↗
NASA NTRS1989

Engineering visualization utilizing advanced animation

Engineering visualization is the use of computer graphics to depict engineering analysis and simulation in visual form from project planning through documentation. Graphics displays let engineers see data represented dynamically which permits the quick evaluation of results. The current state of graphics hardware and software generally allows the creation of two types of 3D graphics. The use of animated video as an engineering visualization tool is presented. The engineering, animation, and videography aspects of animated video production are each discussed. Specific issues include the integration of staffing expertise, hardware, software, and the various production processes. A detailed explanation of the animation process reveals the capabilities of this unique engineering visualization method. Automation of animation and video production processes are covered and future directions are proposed.

Sabionski, Gunter R.↗
NASA NTRS1989

The rodent Research Animal Holding Facility as a barrier to environmental contamination

The rodent Research Animal Holding Facility (RAHF), developed by NASA Ames Research Center (ARC) to separately house rodents in a Spacelab, was verified as a barrier to environmental contaminants during a 12-day biocompatibility test. Environmental contaminants considered were solid particulates, microorganisms, ammonia, and typical animal odors. The 12-day test conducted in August 1988 was designed to verify that the rodent RAHF system would adequately support and maintain animal specimens during normal system operations. Additional objectives of this test were to demonstrate that: (1) the system would capture typical particulate debris produced by the animal; (2) microorganisms would be contained; and (3) the passage of animal odors was adequately controlled. In addition, the amount of carbon dioxide exhausted by the RAHF system was to be quantified. Of primary importance during the test was the demonstration that the RAHF would contain particles greater than 150 micrometers. This was verified after analyzing collection plates placed under exhaust air ducts and and rodent cages during cage maintenance operations, e.g., waste tray and feeder changeouts. Microbiological testing identified no additional organisms in the test environment that could be traced to the RAHF. Odor containment was demonstrated to be less than barely detectable. Ammonia could not be detected in the exhaust air from the RAHF system. Carbon dioxide levels were verified to be less than 0.35 percent.

Savage, P. D., Jr.↗
NASA NTRS1992

Animal research facility for Space Station Freedom

An integrated animal research facility is planned by NASA for Space Station Freedom which will permit long-term, man-tended experiments on the effects of space conditions on vertebrates. The key element in this facility is a standard type animal habitat which supports and maintains the animals under full bioisolation during transport and during the experiment. A holding unit accommodates the habitats with animals to be maintained at zero gravity; and a centrifuge, those to be maintained at artificial gravity for control purposes or for gravity threshold studies. A glovebox permits handling of the animals for experimental purposes and for transfer to a clean habitat. These facilities are described, and the aspects of environmental control, monitoring, and bioisolation are discussed.

Bonting, Sjoerd L.↗
NASA NTRS1991

Technology development activities for housing research animals on Space Station Freedom

The development and design of animal facilities are described in terms of the technological needs for NASA's Biological Flight Research Laboratory. Animal habitats are presented with illustrations which encompass waste-collection techniques for microgravity conditions that reduce the need for crew participation. The technology is intended to be highly compatible with animal morphology, and airflow is employed as the primary mechanism of waste control. The airflow can be utilized in the form of localized high-speed directed flow that simultaneously provides a clean animal habitat and low airflow rates. The design of an animal-habitat testbed is presented which capitalizes on contamination-control mechanisms and suitable materials for microgravity conditions. The developments in materials and technologies represent significant contributions for the design of the centrifuge facilities for the Space Station Freedom.

Jenner, Jeffrey W.↗
NASA NTRS1991

Facilities for animal research in space

The animal facilities used aboard or designed for various spacecraft research missions are described. Consideration is given to the configurations used in Cosmos-1514 (1983) and Cosmos-1887 (1987) missions; the reusable Biosatellite capsule flown three times by NASA between 1966 and 1969; the NASA's Lifesat spacecraft that is being currently designed; the Animal Enclosure Module flown on Shuttle missions in 1983 and 1984; the Research Animal Holding Facility developed for Shuttle-Spacelab missions; the Rhesus Research Facility developed for a Spacelab mission; and the Japanese Animal Holding Facility for the Space Station Freedom. Special attention is given to the designs of NASA's animal facilities developed for Space Station Freedom and the details of various subsystems of these facilities. The main characteristics of the rodent and the primate habitats provided by these various facilities are discussed.

Bonting, Sjoerd L.↗
NASA NTRS1998

GIF Animation of Mode Shapes and Other Data on the Internet

The World Wide Web abounds with animated cartoons and advertisements competing for our attention. Most of these figures are animated Graphics Interchange Format (GIF) files. These files contain a series of ordinary GIF images plus control information, and they provide an exceptionally simple, effective way to animate on the Internet. To date, however, this format has rarely been used for technical data, although there is no inherent reason not to do so. This paper describes a procedure for creating high-resolution animated GIFs of mode shapes and other types of structural dynamics data with readily available software. The paper shows three example applications using recent modal test data and video footage of a high-speed sled run. A fairly detailed summary of the GIF file format is provided in the appendix. All of the animations discussed in the paper are posted on the Internet available through the following address: http://sdb-www.larc.nasa.gov/.

Pappa, Richard S.↗
NASA NTRS1995

Sound For Animation And Virtual Reality

Sound is an integral part of the experience in computer animation and virtual reality. In this course, we will present some of the important technical issues in sound modeling, rendering, and synchronization as well as the "art" and business of sound that are being applied in animations, feature films, and virtual reality. The central theme is to bring leading researchers and practitioners from various disciplines to share their experiences in this interdisciplinary field. The course will give the participants an understanding of the problems and techniques involved in producing and synchronizing sounds, sound effects, dialogue, and music. The problem spans a number of domains including computer animation and virtual reality. Since sound has been an integral part of animations and films much longer than for computer-related domains, we have much to learn from traditional animation and film production. By bringing leading researchers and practitioners from a wide variety of disciplines, the course seeks to give the audience a rich mixture of experiences. It is expected that the audience will be able to apply what they have learned from this course in their research or production.

Hahn, James K.↗
NASA NTRS2014

Visualizing Flutter Mechanism as Traveling Wave Through Animation of Simulation Results for the Semi-Span Super-Sonic Transport Wind-Tunnel Model

It has long been recognized that frequency and phasing of structural modes in the presence of airflow play a fundamental role in the occurrence of flutter. Animation of simulation results for the long, slender Semi-Span Super-Sonic Transport (S4T) wind-tunnel model demonstrates that, for the case of mass-ballasted nacelles, the flutter mode can be described as a traveling wave propagating downstream. Such a characterization provides certain insights, such as (1) describing the means by which energy is transferred from the airflow to the structure, (2) identifying airspeed as an upper limit for speed of wave propagation, (3) providing an interpretation for a companion mode that coalesces in frequency with the flutter mode but becomes very well damped, (4) providing an explanation for bursts of response to uniform turbulence, and (5) providing an explanation for loss of low frequency (lead) phase margin with increases in dynamic pressure (at constant Mach number) for feedback systems that use sensors located upstream from active control surfaces. Results from simulation animation, simplified modeling, and wind-tunnel testing are presented for comparison. The simulation animation was generated using double time-integration in Simulink of vertical accelerometer signals distributed over wing and fuselage, along with time histories for actuated control surfaces. Crossing points for a zero-elevation reference plane were tracked along a network of lines connecting the accelerometer locations. Accelerometer signals were used in preference to modal displacement state variables in anticipation that the technique could be used to animate motion of the actual wind-tunnel model using data acquired during testing. Double integration of wind-tunnel accelerometer signals introduced severe drift even with removal of both position and rate biases such that the technique does not currently work. Using wind-tunnel data to drive a Kalman filter based upon fitting coefficients to analytical mode shapes might provide a better means to animate the wind tunnel data.

Christhilf, David M.↗
NASA NTRS2021

A Systematic Review and Meta-analysis of the Potential Non-human Animal Reservoirs and Arthropod Vectors of the Mayaro Virus

Improving our understanding of Mayaro virus (MAYV) ecology is critical to guide surveillance and risk assessment. We conducted a PRISMA-adherent systematic review of the published and grey literature to identify potential arthropod vectors and non-human animal reservoirs of MAYV. We searched PubMed/MEDLINE, Embase, Web of Science, SciELO and grey-literature sources including PAHO databases and dissertation repositories. Studies were included if they assessed MAYV virological/immunological measured occurrence in field-caught, domestic, or sentinel animals or in field-caught arthropods. We conducted an animal seroprevalence meta-analysis using a random effects model. We compiled granular georeferenced maps of non-human MAYV occurrence and graded the quality of the studies using a customized framework. Overall, 57 studies were eligible out of 1523 screened, published between the years 1961 and 2020. Seventeen studies reported MAYV positivity in wild mammals, birds, or reptiles and five studies reported MAYV positivity in domestic animals. MAYV positivity was reported in 12 orders of wild-caught vertebrates, most frequently in the orders Charadriiformes and Primate. Sixteen studies detected MAYV in wild-caught mosquito genera including Haemagogus, Aedes, Culex, Psorophora, Coquillettidia, and Sabethes. Vertebrate animals or arthropods with MAYV were detected in Brazil, Panama, Peru, French Guiana, Colombia, Trinidad, Venezuela, Argentina, and Paraguay. Among non-human vertebrates, the Primate order had the highest pooled seroprevalence

Mayaro virus↗
DOE OSTI2017

Established patterns of animal study design undermine translation of disease-modifying therapies for Parkinson’s disease

Translation of disease-modifying therapies in neurodegenerative disease has been disappointing. Parkinson’s disease (PD) was used to compare patterns of preclinical study design for symptomatic and potentially disease-modifying interventions. We examined the relationship of model, intervention type and timing, outcomes and outcome measures in 543 animal and human studies (1973–2015) across a contemporary cohort of animal and human interventional studies (n = 445), animal studies for approved interventions (n = 28), animal and human studies for those that failed to translate (n = 70). Detailed study design data were collected for 216 studies in non-human primate (NHP) and rodent toxin-induced models. Species-specific patterns of study design prevailed regardless of whether interventions were symptomatic or potentially disease-modifying. In humans and NHPs, interventions were typically given to both sexes well after the PD phenotype was established, and clinical outcome measures were collected at single (symptomatic) or multiple (disease-modifying) time-points. In rodents, interventions often preceded induction of the model, acute toxic protocols were common, usually given to young males, clinical outcome measures were used less commonly, and outcomes were less commonly assessed at multiple time points. These patterns were more prevalent in mice than rats. In contrast, study design factors such as randomization and blinding did not differ appreciably across symptomatic and disease-modifying intervention categories. The translational gap for potentially disease-modifying interventions in PD in part results from study designs, particularly in mice, that fail to model the progressive nature and relatively late intervention characteristic of PD, or that anchor mechanistic and neuropathologic data to longitudinal clinical outcomes. Even if measures to improve reproducibility are broadly adopted, perpetuation of these norms will continue to impede effective translation.

59 BASIC BIOLOGICAL SCIENCES↗
DOE OSTI2026

Observations of marine animal interactions with a small tidal turbine

The risk of collisions between animals and operating tidal turbines remains a concern in the scientific and regulatory communities. A sensor package including optical cameras was deployed to monitor animal interactions with a small-scale (1 m 2 ) cross-flow tidal turbine. The turbine was deployed in Washington State, USA for 141 days at a site with peak flow speeds of 2.5 m/s. We analyze optical camera imagery spanning 109 days of turbine operation. The analyzed images contain 1044 observations of fish, fish schools, seabirds, or seals in the vicinity of the turbine. No instances of collision with seabirds or seals were observed. Seabirds were only observed during daylight hours and while the turbine was stationary. Both seals and fish were observed during both day and night and while the turbine was stationary and rotating. Four fish were observed colliding with the moving turbine and in all but one case the animals swam away following the collision. Over the same period of time, over fifty times more fish (224 individual fish and 5 fish schools) were observed passing the moving turbine without collision. Fish encounters were likely under counted due to the difficulty in discerning small fish from plant matter in the water column. These observations represent the first optical camera imagery showing fish, bird, and marine mammal interactions with a tidal turbine in North America. In addition to quantitative and qualitative discussion of the implications of our observations for collision risk, we discuss lessons learned on sampling schemes and deployment of machine learning for detection of animals to inform future data collection strategies in future monitoring campaigns.

16 TIDAL AND WAVE POWER↗
DOE OSTI2019

Amelioration of Alzheimer’s disease pathology and cognitive deficits by immunomodulatory agents in animal models of Alzheimer’s disease

The most common age-related neurodegenerative disease is Alzheimer’s disease (AD) characterized by aggregated amyloid-β (Aβ) peptides in extracellular plaques and aggregated hyperphosphorylated tau protein in intraneuronal neurofibrillary tangles, together with loss of cholinergic neurons, synaptic alterations, and chronic inflammation within the brain. These lead to progressive impairment of cognitive function. There is evidence of innate immune activation in AD with microgliosis. Classically-activated microglia (M1 state) secrete inflammatory and neurotoxic mediators, and peripheral immune cells are recruited to inflammation sites in the brain. The few drugs approved by the US FDA for the treatment of AD improve symptoms but do not change the course of disease progression and may cause some undesirable effects. Translation of active and passive immunotherapy targeting Aβ in AD animal model trials had limited success in clinical trials. Treatment with immunomodulatory/anti-inflammatory agents early in the disease process, while not preventive, is able to inhibit the inflammatory consequences of both Aβ and tau aggregation. The studies described in this review have identified several agents with immunomodulatory properties that alleviated AD pathology and cognitive impairment in animal models of AD. The majority of the animal studies reviewed had used transgenic models of early-onset AD. More effort needs to be given to create models of late-onset AD. The effects of a combinational therapy involving two or more of the tested pharmaceutical agents, or one of these agents given in conjunction with one of the cell-based therapies, in an aged animal model of AD would warrant investigation.

60 APPLIED LIFE SCIENCES↗
NASA NTRS1992

Vestibular short latency responses to pulsed linear acceleration in unanesthetized animals

Linear acceleration transients were used to elicit vestibular compound action potentials in non-invasively prepared, unanesthetized animals for the first time (chicks, Gallus domesticus, n = 33). Responses were composed of a series of up to 8 dominant peaks occurring within 8 msec of the stimulus. Response amplitudes for 1.0 g stimulus ranged from 1 to 10 microV. A late, slow, triphasic, anesthesia-labile component was identified as a dominant response feature in unanesthetized animals. Amplitudes increased and latencies decreased as stimulus intensity was increased (MANOVA P less than 0.05). Linear regression slope ranges were: amplitudes = 1.0-5.0 microV/g; latencies = -300 to -1100 microseconds/g. Thresholds for single polarity stimuli (0.035 +/- 0.022 g, n = 11) were significantly lower than those of alternating polarity (0.074 +/- 0.028 g, n = 18, P less than 0.001). Bilateral labyrinthectomy eliminated responses whereas bilateral extirpation of cochleae did not significantly change response thresholds. Intense acoustic masking (100/104 dB SL) produced no effect in 2 animals, but did produce small to moderate effects on response amplitudes in 7 others. Changes were attributed to effects on vestibular end organs. Results of unilateral labyrinth blockade (tetrodotoxin) suggest that P1 and N1 preferentially reflect ipsilateral eighth nerve compound action potentials whereas components beyond approximately 2 msec reflect activity from vestibular neurons that depend on both labyrinths. The results demonstrate that short latency vestibular compound action potentials can be measured in unanesthetized, non-invasively prepared animals.

NASA Discipline Neuroscience↗
DOE OSTI2019

A Chaos Theoretic Approach to Animal Activity Recognition

Animal activity is a descriptor that can be potentially used to track the health and well-being, which is obviously very important to improve the management process and productivity of farms. This paper deals with an animal behavior recognition problem using a chaos theory approach where we adopt such a technique for automatic classification of calves behavioral states. Two main mutually exclusive behaviors are of interest, namely, lying and standing/walking with six possible activities: feeding, drinking water, drinking milk, playing, rumination, and neutral. The time series generated by ear-tags with a 3D-accelerometer after a wavelet denoising transformation and frequency stabilization are treated as representations of the nonlinear dynamical system. The dynamical system of a certain animal state exhibits specific strange attractor in a phase space. A characterization of such an attractor is performed through metric, dynamic, and topological invariants including Lyapunov exponent, correlation dimension, length of a phase trajectory, sum of edges forming a convex hull and others. These measures are used as a feature vector for the subsequent classification. In a cross validation scheme, six classifiers are built on each training set, and the hyper-parameters are optimized using an inner validation set. The classifier that reaches the highest accuracy on the inner validation set is used to classify the outer validation set. It is shown that this approach can be useful at predicting activity states as an alternative methodology for the animal behavior state recognition problem with acceptable classification accuracy. Furthermore it is possible to include this procedure as part of an ensemble method in machine learning where a combination of different models is used.

97 MATHEMATICS AND COMPUTING↗