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DOE OSTI2026

LArCADe | Liquid Argon Charge Amplification Devices

The Liquid Argon Charge Amplification Devices (LArCADe) project is an R$\&$D effort aimed at developing instrumentation capable of lowering detection thresholds for ionization signatures in liquid and gaseous argon detectors and achieving O(100 $\mu$m) position resolution. The core concept is the use of sharp “tip arrays” that generate strong local electric-field enhancement, enabling charge amplification and collection with improved spatial resolution. A key physics motivation for this work is to enhance the experimental sensitivity of Coherent Elastic Neutrino-Nucleus Scattering (CEvNS) measurements to low-energy nuclear recoils by enabling spatially resolved charge reconstruction at reduced ionization thresholds, with the goal of achieving event-by-event energy reconstruction for interactions originating from localized accelerator or astrophysical neutrino sources. This poster will present the current status of the instrumentation R$\&$D, which leverages Fermilab’s Noble Liquid Test Facility and UC Santa Barbara’s Nanofabrication Facility, and will discuss the potential physics impact of this technology.

Antonakis, Alexander [UC, Santa Barbara]↗

DOE OSTI2024

Rapid detection of mexX in Pseudomonas aeruginosa based on CRISPR-Cas13a coupled with recombinase polymerase amplification

The principal pathogen responsible for chronic urinary tract infections, immunocompromised hosts, and cystic fibrosis patients is Pseudomonas aeruginosa , which is difficult to eradicate. Due to the extensive use of antibiotics, multidrug-resistant P. aeruginosa has evolved, complicating clinical therapy. Therefore, a rapid and efficient approach for detecting P. aeruginosa strains and their resistance genes is necessary for early clinical diagnosis and appropriate treatment. This study combines recombinase polymerase amplification (RPA) and clustered regularly interspaced short palindromic repeats-association protein 13a (CRISPR-Cas13a) to establish a one-tube and two-step reaction systems for detecting the mexX gene in P. aeruginosa . The test times for one-tube and two-step RPA-Cas13a methods were 5 and 40 min (including a 30 min RPA amplification reaction), respectively. Both methods outperform Quantitative Real-time Polymerase Chain Reactions (qRT-PCR) and traditional PCR. The limit of detection (LoD) of P. aeruginosa genome in one-tube and two-step RPA-Cas13a is 10 aM and 1 aM, respectively. Meanwhile, the designed primers have a high specificity for P. aeruginosa mexX gene. These two methods were also verified with actual samples isolated from industrial settings and demonstrated great accuracy. Furthermore, the results of the two-step RPA-Cas13a assay could also be visualized using a commercial lateral flow dipstick with a LoD of 10 fM, which is a useful adjunt to the gold-standard qRT-PCR assay in field detection. Taken together, the procedure developed in this study using RPA and CRISPR-Cas13a provides a simple and fast way for detecting resistance genes.

Zhu, Xiao-Xuan↗

DOE OSTI2022

Magnetic Field Amplification by a Plasma Cavitation Instability in Relativistic Shock Precursors

Abstract Plasma streaming instabilities play an important role in magnetic field amplification and particle acceleration in relativistic shocks and their environments. However, in the far shock precursor region where accelerated particles constitute a highly relativistic and dilute beam, streaming instabilities typically become inefficient and operate at very small scales when compared to the gyroradii of the beam particles. We report on a plasma cavitation instability that is driven by dilute relativistic beams and can increase both the magnetic field strength and coherence scale by orders of magnitude to reach near-equipartition values with the beam energy density. This instability grows after the development of the Weibel instability and is associated with the asymmetric response of background leptons and ions to the beam current. The resulting net inductive electric field drives a strong energy asymmetry between positively and negatively charged beam species. Large-scale particle-in-cell simulations are used to verify analytical predictions for the growth and saturation level of the instability and indicate that it is robust over a wide range of conditions, including those associated with pair-loaded plasmas. These results can have important implications for the magnetization and structure of shocks in gamma-ray bursts, and more generally for magnetic field amplification and asymmetric scattering of relativistic charged particles in plasma astrophysical environments.

70 PLASMA PHYSICS AND FUSION TECHNOLOGY↗

DOE OSTI2018

Current Status of Chirped-Pulse Amplification Technology and Its Applications

We survey current status of chirped-pulse amplification development and its applications. We start with the review of optical compressor and stretcher as well as the amplification techniques. The methods to control spatial and temporal profile of the laser pulse as well as the state-of-the-arts spatiotemporal control techniques and designs of high repetition-rate amplifiers are discussed. Examples of applications in medical and particle acceleration are introduced.

43 PARTICLE ACCELERATORS↗

NASA NTRS1972

Laser amplification in an inhomogeneous plasma

The propagation of an electromagnetic wave into an inhomogeneous plasma was studied. In a plasma with large density gradients a QTX mode propagating perpendicular to the magnetic field can encounter a resonance and a cutoff separated by a distance comparable to the incident wave length. In this region the wave is evanescent, and in general there will be a reflected and transmitted wave, and amplification will occur in the region near the resonance. The amplification is important for the study of nonlinear phenomena and for feedback stabilization applications.

White, R.↗

NASA NTRS1973

Cyclotron resonance wave amplification in the magnetosphere and energetic particle stability

Detailed electron distribution measurements in the outer magnetosphere now available indicate that the energetic electron anisotropy may be very energy dependent, there being positive anisotropies near the magnetic equator for low-energy particles and negative anisotropies in this region for high-energy particles. Previous wave growth calculations assuming the energetic particle anisotropy to be independent of energy are inaccurate at high energies. The net one-hop whistler mode wave amplification is calculated as a function of frequency for a measured electron distribution at L = 7 for a number of assumed equatorial plasma densities. It is found that an increase in cold plasma density results in a change from a net wave damping to significant wave amplification.

Lucas, C.↗

NASA NTRS1975

Amplification, attenuation, and dispersion of sound in inhomogeneous flows

First order effects of gradients in nonuniform potential flows of a compressible gas are included in a dispersion relation for sound waves. Three nondimensional numbers, the ratio of the change in the kinetic energy in one wavelength to the thermal energy of the gas, the ratio of the change in the total energy in one wavelength to the thermal energy, and the ratio of the dillatation frequency (the rate of expansion per unit volume) to the acoustic frequency, play a role in the separation of the effects of flow gradients into isotropic and anisotropic effects. Dispersion and attenuation (or amplification) of sound are found to be proportional to the wavelength for small wavelength, and depend on the direction of wave propagation relative to flow gradients. Modification of ray acoustics for the effects of flow gradients is suggested, and conditions for amplification and attenuation of sound are discussed.

Kentzer, C. P.↗

NASA NTRS1975

Amplification, attenuation, and dispersion of sound in inhomogeneous flows

First order effects of gradients in nonuniform potential flows of a compressible gas are included in a dispersion relation for sound waves. Three nondimensional numbers, the ratio of the change in the kinetic energy in one wavelength to the thermal energy of the gas, the ratio of the change in the total energy in one wavelength to the thermal energy, and the ratio of the dilatation frequency (the rate of expansion per unit volume) to the acoustic frequency, play the dominant role permitting the separation of the effects of flow gradients into isotropic and anisotropic effects. Dispersion and attenuation (or amplification) of sound are proportional to the wavelength for small wavelength and depend on the direction of wave propagation relative to flow gradients. Modification of ray acoustics for the effects of flow gradients is suggested and conditions for amplification and attenuation of sound are discussed.

Kentzer, C. P.↗

NASA NTRS1977

Parametric amplification and oscillation at 36 GHz using a point-contact Josephson junction

The paper reports observation of doubly degenerate parametric amplification and oscillation at 36 GHz from a single point-contact Josephson junction. The experimental results agree qualitatively with theoretical calculations based on the resistively shunted junction model. The estimated noise temperature of an amplifier with 11 dB net gain is consistent with zero, but has an upper limit of 50 K. Attempts to observe parametric amplification in the singly degenerate mode with a pump frequency of 72 GHz were not successful.

Taur, Y.↗

NASA NTRS1978

Laser amplification of incoherent radiation

The amplification of noise in a laser amplifier is treated theoretically. The model for the active medium and its description using density-matrix techniques, are taken from the theory of laser operation. The spectral behavior of the radiation in the nonlinear regime is studied and the formalism is written from the onset in the frequency domain. The statistics of the light are gradually modified by the nonlinear amplification process, and expressions are derived for the rate of change of fluctuations in intensity as a measure of statistical changes. In addition, the range of validity of Litvak's Gaussian-statistics approximation is discussed. In the homogeneous-broadening case, the evolution of initially broadband Gaussian radiation toward quasimonochromatic oscillations with laserlike statistics is explored in several numerical examples. The connections of this study with the time-domain work on self-pulsing in a ring-laser configuration, are established. Finally, spectral-narrowing and -rebroadening effects in Doppler-broadened media are discussed both analytically and with numerical examples. These examples show the distinct contribution of pulsations in the population ('Raman-type terms'), and saturation phenomena.

Menegozzi, L. N.↗

NASA NTRS1980

High-energy subnanosecond pulse amplification in XeCl

Pulse slicing and two-pass amplification are investigated as a means of producing high-energy subnanosecond pulses in the near ultraviolet. A simple laboratory-scale XeCl oscillator-Pockels cell pulse slicer-amplifier system is used to produce 50-mJ pulses of subnanosecond duration at 308 nm. Comparison of multinanosecond and subnanosecond pulse amplification allows estimation of the amplifier energy storage time to be 5 ns and demonstrates nearly complete extraction of available stored energy by the subnanosecond pulse.

Pacala, T. J.↗

NASA NTRS1981

Experiments on the abiotic amplification of optical activity

Experiments concerning the physical mechanisms for the abiotic generation and chemical mechanisms for the amplification of optical activity in biological compounds are reviewed. Attention is given to experiments involving the determination of the differential adsorption of racemic amino acids on d- and l-quartz, the asymmetric photolysis of racemic amino acids by circularly polarized light, and the asymmetric radiolysis of solid amino acids by longitudinally polarized electrons, and the enantiomeric enrichments thus obtained are noted. Further experiments on the amplification of the chirality in the polymerization of D, L-amino acid mixtures and the hydrolysis of D-, L-, and D, L-polypeptides are discussed. It is suggested that a repetitive cycle of partial polymerization-hydrolyses may account for the abiotic genesis of optically enriched polypeptides on the primitive earth.

Bonner, W. A.↗

NASA NTRS1982

Turbulence amplification in shock-wave boundary-layer interaction

Attention is directed to the acoustics research of the 1950s and 1960s for guidance in understanding and quantizing the turbulence amplification that can occur in regions of shock-wave boundary-layer interaction. Three primary turbulence amplifier-generator mechanisms are identified and shown, by linear analysis, to be responsible for turbulence amplification across a shock wave in excess of 100% of the incident turbulence intensity.

Anyiwo, J. C.↗

NASA NTRS1986

Optimal coherent image amplification by two-wave coupling in photorefractive BaTiO3

Coherent image amplification by two-wave coupling in a crystal of photorefractive BaTiO3 is analyzed. This amplifier is optimized with respect to such operational characteristics as gain versus amplified image quality and space-bandwidth product. Experimental results that demonstrate coherent image amplification of 4000, space-bandwidth product of 1,000,000, and gray-level dynamic range of greater than 100 are presented.

Fainman, Y.↗

NASA NTRS1990

Amplification of a high-frequency electromagnetic wave by a relativistic plasma

The amplification of a high-frequency transverse electromagnetic wave by a relativistic plasma component, via the synchrotron maser process, is studied. The background plasma that supports the transverse wave is considered to be cold, and the energetic component whose density is much smaller than that of the background component has a loss-cone feature in the perpendicular momentum space and a finite field-aligned drift speed. The ratio of the background plasma frequency squared to the electron gyrofrequency squared is taken to be sufficiently larger than unity. Such a parameter regime is relevant to many space and astrophysical situations. A detailed study of the amplification process is carried out over a wide range of physical parameters including the loss-cone index, the ratio of the electron mass energy to the temperature of the energetic component, the field-aligned drift speed, the normalized density, and the wave propagation angle.

Yoon, Peter H.↗

NASA NTRS1990

Perturbation amplification in the entry region of a transitional pipe flow

The forced transition due to the application of large disturbances in the entry region of a pipe flow is considered. The disturbances are not large enough to cause a puff-type transition which is peculiar to a pipe low; they cause a slug-type transition which is akin to a flate turbulence spot. The perturbation amplifications with Reynolds number have been measured at the entrance and also soon after the mean turbulent flow has become fully developed. At the entrance, all dominant frequencies amplify in a nearly universal manner which is exponential in part of the Reynolds number range. Further-more, the nonlinear process undergoes a change at Reynolds numbers of 4930 to 6020, and again at 8120 to 10060. At the downstream station, an almost saturated amplification rate has been reached and, in the background of a higher turbulence level, the trend is qualitatively similar to that in peak-valley splitting.

Bandyopadhyay, Promode R.↗

NASA NTRS1996

Parametric Amplification For Detecting Weak Optical Signals

Optical-communication receivers of proposed type implement high-sensitivity scheme of optical parametric amplification followed by direct detection for reception of extremely weak signals. Incorporates both optical parametric amplification and direct detection into optimized design enhancing effective signal-to-noise ratios during reception in photon-starved (photon-counting) regime. Eliminates need for complexity of heterodyne detection scheme and partly overcomes limitations imposed on older direct-detection schemes by noise generated in receivers and by limits on quantum efficiencies of photodetectors.

Hemmati, Hamid↗

NASA NTRS1998

Acoustic Amplification in the Far Infrared Focal Plane Assembly of the Composite Infrared Spectrometer (CIRS) for the Cassini Mission to Saturn

The Composite Infrared Spectrometer (CIRS) of the Cassini mission to Saturn has two interferometers covering the far infrared FIR and mid infrared, MIR wavelength region. The FIR is a polarizing Michelson interferometer which presents a collimated output beam to the FIR focal plane. The focal plane consists of a parabolic focus mirror and an analyzer grid, which splits the output beams into transmitted and reflected components. The two polarizations are focussed onto two thermopile detectors; each consisting of a gold black foil welded to the top of two bismuth pyramids. The gold black is 30 microns thick, and the weld area is approximately 2 microns in diameter. The detectors are extremely fragile and the weld can be broken with a miniscule amount of airflow. The detectors consistently passed acoustic testing to qualification levels that simulated the launch environment of the Titan IV launch vehicle. However, they experienced a 50% failure rate when installed in the focal plane assembly during instrument level acoustic tests. A test focal plane was developed with small pressure transducers in the nominal detector locations. These tests indicated over 10 dB of acoustic amplification in the focal plane within the instrument during testing. New techniques were developed to allow testing of the focal plane without over testing the instrument, and modifications were made the focal plane assembly to successfully attenuate the amplification.

Hagopian, John G.↗