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At least 883 records · Page 49

The Potential Outcome Model: Explaining Low-Dose Radiobiology through an Epidemiologic Lens

One of the major challenges in understanding space radiation-induced carcinogenesis is the uncertainty from translating radiobiological research in cellular and animal models to humans, especially at doses below 100 mSv. Biological studies have shown a host of potential outcomes at lowdoses in animal and cellular models. The existence of non-targeted effects as bystander and abscopal effects is well-documented from clinical research and basic science1,2,3. While some studies have shown increased effects at low doses, others have shown evidence of hormetic bystander effects, where radiation exposure may be beneficial4,5,6. Despite these varied and diverse findings, epidemiologic studies largely support the linear-no threshold (LNT) assumption used by radiation protection guidance7,8. Translational animal-to-human models have predominantly considered ratio values such as the relative biological effectiveness (RBE) and dose and dose-rate effectiveness factor (DDREF) that rely on the assumption of LNT rather than implementing specific dose-response shapes in the low-dose region, and translational cell-to-human models are uncommon. The sufficient component cause model presents an opportunity to examine biological findings at low doses from an epidemiological lens9. In this model, exposures “sufficient” to cause an outcome of interest are presented in pie charts, such that when all slices of a pie chart are fulfilled, the outcome will occur. Multiple pie charts may exist for a single outcome, illustrating individual differences9. In 1988,Greenland and Poole adapted the sufficient component cause model to incorporate interaction with other exposures (such as genetics or lifestyle factors)10. They show that a range of biological processes are possible in a population, but that an epidemiologic study will only reveal the mean outcome from the population at large10,11. Using this construct, the multiple outcomes presented in radiobiological models to date can be explained in the context of epidemiologic studies. This presentation aims to demonstrate a causal framework that can integrate radiobiological and epidemiological models to date. It is intended as a conversation starter to spur future research.

C M Milder↗

Simulation System for Training in Laparoscopic Surgery

A computer-based simulation system creates a visual and haptic virtual environment for training a medical practitioner in laparoscopic surgery. Heretofore, it has been common practice to perform training in partial laparoscopic surgical procedures by use of a laparoscopic training box that encloses a pair of laparoscopic tools, objects to be manipulated by the tools, and an endoscopic video camera. However, the surgical procedures simulated by use of a training box are usually poor imitations of the actual ones. The present computer-based system improves training by presenting a more realistic simulated environment to the trainee. The system includes a computer monitor that displays a real-time image of the affected interior region of the patient, showing laparoscopic instruments interacting with organs and tissues, as would be viewed by use of an endoscopic video camera and displayed to a surgeon during a laparoscopic operation. The system also includes laparoscopic tools that the trainee manipulates while observing the image on the computer monitor (see figure). The instrumentation on the tools consists of (1) position and orientation sensors that provide input data for the simulation and (2) actuators that provide force feedback to simulate the contact forces between the tools and tissues. The simulation software includes components that model the geometries of surgical tools, components that model the geometries and physical behaviors of soft tissues, and components that detect collisions between them. Using the measured positions and orientations of the tools, the software detects whether they are in contact with tissues. In the event of contact, the deformations of the tissues and contact forces are computed by use of the geometric and physical models. The image on the computer screen shows tissues deformed accordingly, while the actuators apply the corresponding forces to the distal ends of the tools. For the purpose of demonstration, the system has been set up to simulate the insertion of a flexible catheter in a bile duct. [As thus configured, the system can also be used to simulate other endoscopic procedures (e.g., bronchoscopy and colonoscopy) that include the insertion of flexible tubes into flexible ducts.] A hybrid approach has been followed in developing the software for real-time simulation of the visual and haptic interactions (1) between forceps and the catheter, (2) between the forceps and the duct, and (3) between the catheter and the duct. The deformations of the duct are simulated by finite-element and modalanalysis procedures, using only the most significant vibration modes of the duct for computing deformations and interaction forces. The catheter is modeled as a set of virtual particles uniformly distributed along the center line of the catheter and connected to each other via linear and torsional springs and damping elements. The interactions between the forceps and the duct as well as the catheter are simulated by use of a ray-based haptic-interaction- simulating technique in which the forceps are modeled as connected line segments.

Basdogan, Cagatay↗

Component mode synthesis for model order reduction of nonclassically damped systems

Based on a component mode synthesis approach, a model-order-reduction method for linear structures with arbitrary linear damping has been developed. Projection matrices are introduced to make the method applicable to systems having rigid-body freedom. To test the method, eigenvalues of a reduced-order model of a free-free beam with nonproportional damping were compared to exact eigenvalues and to eigenvalues obtained using two other model-reduction strategies. The present model-reduction strategy proved to be decidedly superior.

Craig, Roy R., Jr.↗

Computer-aided operations engineering with integrated models of systems and operations

CONFIG 3 is a prototype software tool that supports integrated conceptual design evaluation from early in the product life cycle, by supporting isolated or integrated modeling, simulation, and analysis of the function, structure, behavior, failures and operation of system designs. Integration and reuse of models is supported in an object-oriented environment providing capabilities for graph analysis and discrete event simulation. Integration is supported among diverse modeling approaches (component view, configuration or flow path view, and procedure view) and diverse simulation and analysis approaches. Support is provided for integrated engineering in diverse design domains, including mechanical and electro-mechanical systems, distributed computer systems, and chemical processing and transport systems. CONFIG supports abstracted qualitative and symbolic modeling, for early conceptual design. System models are component structure models with operating modes, with embedded time-related behavior models. CONFIG supports failure modeling and modeling of state or configuration changes that result in dynamic changes in dependencies among components. Operations and procedure models are activity structure models that interact with system models. CONFIG is designed to support evaluation of system operability, diagnosability and fault tolerance, and analysis of the development of system effects of problems over time, including faults, failures, and procedural or environmental difficulties.

Malin, Jane T.↗

Model Development for Multi-Component Fuel Vaporization and Flash Boiling

The objectives of this project are to improve the multi-component fuel droplet and film vaporization models used in internal combustion engine simulation, and to develop a comprehensive model to predict the characteristics of multi-component flash boiling spray. This work explores two approaches to fuel composition treatment for modeling multi-component fuel vaporization: one based on discretization and surrogates, and the other based on continuous thermodynamic distribution of fuel properties. The experimental data collected for model validation are done under three fuel form factors: droplet, spray, and thin film. The study on sprays also include experimentation under non-flash and flash boiling conditions, a phenomenon that enhances fuel vaporization. The main goals of this work are: Design and develop a multi-component fuel droplet and wall film vaporization model using both discrete and continuous thermodynamics methods. Design and develop an analytical model for multi-component flash boiling. Integrate the multi-component droplet and film model into multi-dimensional engine calculations to predict the fuel vaporization process under engine operation condition. Conduct multi-component droplet and fuel film vaporization experiments in a non-combusting chamber to verify the proposed vaporization models. Characterize flash boiling phenomena of multi-component fuel sprays by optical and laser diagnostic techniques. This report will detail the experimental setup and the numerical basis for developing a model to achieve the main goals listed above. Key features of observed multi-component fuel vaporization will be summarized at the end of each experimental sections, and corresponding model performance evaluation will be presented at the end of each model development section.

33 ADVANCED PROPULSION SYSTEMS↗

The Application of New Software Technology to the Architecture of the National Cycle Program

As part of the Numerical Propulsion System Simulation (NPSS) effort of NASA Lewis in conjunction with the United States aeropropulsion industry, a new system simulation framework, the National Cycle Program (NCP), capable of combining existing empirical engine models with new detailed component-based computational models is being developed. The software architecture of the NCP program involves a generalized object- oriented framework and a base-set of engine component models along with supporting tool kits which will support engine simulation in a distributed environment. As the models are extended to contain two and three dimensions the computing load increases rapidly and it is intended that this load be distributed across multiple work stations executing concurrently in order to get acceptably fast results. The research carried out was directed toward performance analysis of the distributed object system. More specifically, the performance of the actor-based distributed object design I created earlier was desired. To this end, the research was directed toward the design and implementation of suitable performance-analysis techniques and software to demonstrate those techniques. There were three specific results which are reported in two separate reports submitted separately as NASA Technical Memoranda. The results are: (1) Design, implementation, and testing of a performance analysis program for a set of active objects (actor based objects) which allowed the individual actors to be assigned to arbitrary processes on an arbitrary set of machines. (2) The global-balance-equation approach has the fundamental limitation that the number of equations increases exponentially with the number of actors. Hence, unlike many approximate approaches to this problem, the nearest-neighbor approach allows checking of the solution and an estimate of the error. The technique was demonstrated in a prototype analysis program as part of this research. The results of the program were checked against the global-balance solution discussed above. Late during the grant, a much better approximation was developed and this is discussed in result below. As a consequence, a proposal was submitted to continue the research by developing the new approximation including development of a complete program from the prototype. (3) The source of approximation in the nearest-neighbor algorithm is the requirement for estimating some joint probabilities from some marginal distributions. A completely ad hoc estimate was used in the prototype.

Schoeffler, James D.↗

Geochemistry of grain-size fractions of soils from the Taurus-Littrow valley floor

Results are presented for a study in which high-precision instrumental neutron activation analysis was applied to determine the abundances of seven rare-earth and nine other elements in two grain-size fractions (90 to 150 microns and less than 20 microns) of eight soils from the Taurus-Littrow Valley floor and one Apollo 11 bulk-soil fraction with grain sizes of less than 1 mm. Compositional differences between the two size fractions of two valley-floor soils are examined, and mixing of soil components is investigated. It is found that a five-component mixing model describes very adequately the chemical composition of bulk soils with grain sizes of less than 1 mm as mixtures of local Apollo 17 rock types (basalt, anorthositic gabbro, noritic breccia), orange glass, and meteorites, but does not describe well the chemical compositions of the other two size fractions. A ten-component model is used to show that the compositions of those two size fractions can be well represented as mixtures of the five components if the mineralogy and chemical composition of the basalt component are allowed to vary in the size fractions.

Korotev, R. L.↗

Evaluation of CMIP6 Model Simulations of PM 2.5 and its Components Over China

Earth system models (ESMs) participating in the latest Coupled Model Intercomparison Project Phase 6 (CMIP6) simulate various components of fine particulate matter (PM 2.5 ) as major climate forcers. Yet the model performance for PM 2.5 components remains little evaluated due in part to a lack of observational data. Here, we evaluate near-surface concentrations of PM 2.5 and its five main components over China as simulated by 14 CMIP6 models, including organic carbon (OC; available in 14 models), black carbon (BC; 14 models), sulfate (14 models), nitrate (4 models), and ammonium (5 models). For this purpose, we collect observational data between 2000 and 2014 from a satellite-based dataset for total PM2.5 and from 2469 measurement records in the literature for PM 2.5 components. Seven models output total PM 2.5 concentrations, and they all underestimate the observed total PM 2.5 over eastern China, with GFDL-ESM4 (−1.5 %) and MPI-ESM-1-2-HAM (−1.1 %) exhibiting the smallest biases averaged over the whole country. The other seven models, for which we recalculate total PM 2.5 from the available component output, underestimate the total PM 2.5 concentrations partly because of the missing model representations of nitrate and ammonium. Concentrations of the five individual components are underestimated in almost all models, except that sulfate is overestimated in MPI-ESM-1-2-HAM by 12.6 % and in MRI-ESM2-0 by 24.5 %. The underestimation is the largest for OC (by −71.2 % to −37.8 % across the 14 models) and the smallest for BC (−47.9 % to −12.1 %). The multi-model mean (MMM) reproduces the observed spatial pattern for OC (R = 0.51), sulfate (R = 0.57), nitrate (R = 0.70) and ammonium (R = 0.74) fairly well, yet the agreement is poorer for BC (R = 0.39). The varying performances of ESMs on total PM 2.5 and its components have important implications for the modeled magnitude and spatial pattern of aerosol radiative forcing.

CMIP6↗

Flight service evaluation of composite components on the Bell helicopter model 206L, flight service report

The flight service components for the Bell Model 206L JetRanger helicopter are examined. The components were placed in service in the Continental United States, Canada, and Alaska. The status of 34 sets of components is discussed. Approximately 27,500 flight hours were accumulated on the components as of 1 August 1983. Three sets of components and one-fifth of the exposure coupons were returned and tested. The results are given. The overall behavior of the components and associated problems are discussed.

Zinberg, H.↗

PORFLOW Implementation of Vadose Zone Conceptual Model for Naval Reactor Component Disposal Area in the E-Area Low Level Waste Facility Performance Assessment

PORFLOW models have been developed to implement the proposed conceptual models for the two Naval Reactor Component Disposal Areas (NRCDAs), 643-7E and 643-26E, for the purpose of evaluating dose impacts and producing disposal limits for the E-Area Low-Level Facility (LLWF). New NRCDA conceptual models were proposed by Wohlwend and Butcher (2019) for two areas within/adjacent to the E-Area LLWF used as storage/disposal sites for reactor components from the U.S. Navy since 1987. Naval Reactor (NR) waste is comprised of highly radioactive components consisting of activated corrosion-resistant metal alloy contained within welded thick-walled steel casks, and auxiliary equipment primarily contaminated with lower levels of Activated Corrosion Products (ACPs) residing on the metal surfaces and contained within thinner-walled bolted containers.

12 MANAGEMENT OF RADIOACTIVE AND NON-RADIOACTIVE W↗

PORFLOW Implementation of Vadose Zone Conceptual Model for Naval Reactor Component Disposal Areas in the E-Area Low Level Waste Facility Performance Assessment

PORFLOW models have been developed to implement the proposed conceptual models for the two Naval Reactor Component Disposal Areas (NRCDAs), 643-7E and 643-26E, for the purpose of evaluating dose impacts and producing disposal limits for the E-Area Low-Level Facility (LLWF). New NRCDA conceptual models were proposed by Wohlwend and Butcher (2019) for two areas within/adjacent to the E-Area LLWF used as storage/disposal sites for reactor components from the U.S. Navy since 1987. Naval Reactor (NR) waste is comprised of highly radioactive components consisting of activated corrosion-resistant metal alloy contained within welded thick-walled steel casks, and auxiliary equipment primarily contaminated with lower levels of Activated Corrosion Products (ACPs) residing on the metal surfaces and contained within thinner-walled bolted containers.

12 MANAGEMENT OF RADIOACTIVE AND NON-RADIOACTIVE W↗

On the Origin and Evolution of Stellar Chromospheres, Coronae and Winds

This grant was awarded by NASA to The University of Alabama in Huntsville (UAH) to construct state-of-the-art, theoretical, two-component, chromospheric models for single stars of different spectral types and different evolutionary status. In our proposal, we suggested to use these models to predict the level of the "basal flux", the observed range of variation of chromospheric activity for a given spectral type, and the decrease of this activity with stellar age. In addition, for red giants and supergiants, we also proposed to construct self-consistent, purely theoretical wind models, and used these models to investigate the origin of "dividing lines" in the H-R diagram. In the following, we describe our completed work. We have accomplished the first main goal of our proposal by constructing first purely theoretical, time-dependent and two-component models of stellar chromospheres.1 The models require specifying only three basic stellar parameters, namely, the effective temperature, gravity and rotation rate, and they take into account non-magnetic and magnetic regions in stellar chromospheres. The non-magnetic regions are heated by acoustic waves generated by the turbulent convection in the stellar subphotospheric layers. The magnetic regions are identified with magnetic flux tubes uniformly distributed over the entire stellar surface and they are heated by longitudinal tube waves generated by turbulent motions in the subphotospheric and photospheric layers. The coverage of stellar surface by magnetic regions (the so-called filling factor) is estimated for a given rotation rate from an observational relationship. The constructed models are time-dependent and are based on the energy balance between the amount of mechanical energy supplied by waves and radiative losses in strong Ca II and Mg II emission lines. To calculate the amount of wave energy in the non-magnetic regions, we have used the Lighthill-Stein theory for sound generation.

Musielak, Z. E.↗

NASTRAN Modeling of Flight Test Components for UH-60A Airloads Program Test Configuration

Based upon the recommendations of the UH-60A Airloads Program Review Committee, work towards a NASTRAN remodeling effort has been conducted. This effort modeled and added the necessary structural/mass components to the existing UH-60A baseline NASTRAN model to reflect the addition of flight test components currently in place on the UH-60A Airloads Program Test Configuration used in NASA-Ames Research Center's Modern Technology Rotor Airloads Program. These components include necessary flight hardware such as instrument booms, movable ballast cart, equipment mounting racks, etc. Recent modeling revisions have also been included in the analyses to reflect the inclusion of new and updated primary and secondary structural components (i.e., tail rotor shaft service cover, tail rotor pylon) and improvements to the existing finite element mesh (i.e., revisions of material property estimates). Mode frequency and shape results have shown that components such as the Trimmable Ballast System baseplate and its respective payload ballast have caused a significant frequency change in a limited number of modes while only small percent changes in mode frequency are brought about with the addition of the other MTRAP flight components. With the addition of the MTRAP flight components, update of the primary and secondary structural model, and imposition of the final MTRAP weight distribution, modal results are computed representative of the 'best' model presently available.

Idosor, Florentino R.↗

Geothermal Operational Optimization with Machine Learning

The Geothermal Operational Optimization with Machine Learning (GOOML) project has developed a generic and extensible component-based system modeling framework to study complex geothermal fields using a data-driven approach. Through building a digital twin of a geothermal steam field with the GOOML modeling framework, operators can analyze historical and forecasted power production, explore possible steam field configurations, and optimize real world operations, all in a cost-effective digital environment. The GOOML modeling software is based on a historical data-assimilation framework that uses first-principal thermodynamics to model steam field components using historical data, and a forecast framework that uses machine-learning-driven models of steam field components to predict future operations. This modeling framework creates countless new opportunities for digital exploration of steam field design and operations. To date, digital twins have been developed for several steam fields in New Zealand and the United States. These digital twins have been validated by comparing hindcast predictions against historical production data. Field design and operations have been explored using genetic optimization and reinforcement learning. Initial results show compelling and often surprising opportunities for improved design and operation of fields with 2 to 5 percent improvements in annual energy production. GOOML is driving a step-change in geothermal operations by applying state-of-the-art machine learning algorithms, comprehensive data analytics, and a first-of-its-kind intelligent geothermal systems model.

40 EE - Geothermal Technologies Office (EE-4G)↗

Numerical simulation of the beam self-cleaning process in a multimode graded-index fibre during propagation of a pump wave and a Stokes component

A model of coupled modes is proposed, which makes it possible to describe the propagation of a pump wave and a Stokes component in a multimode graded-index fibre. A decrease in the depression in the centre of the profile of the pump wave intensity distribution as a result of the influence of Kerr effects and random linear coupling of modes is demonstrated. (paper)

72 PHYSICS OF ELEMENTARY PARTICLES AND FIELDS↗

Spectral variability of Cygnus X-2 - Structure in the circumsource material

Cygnus X-2 was observed during 13 separate pointings in the course of 1 yr by the Einstein monitor proportional counter. During one of these pointings the objective grating spectrometer was also used. It is found that the data from these observations are well fitted by single-component thermal bremsstrahlung models with temperatures ranging from 4-12 keV; however, two-component models, where one component is a blackbody, are not excluded. The X-ray light curve appears to be correlated with the 9.843 day optical period, possibly implying a partial eclipse of the X-ray source. During the high states there are irregular dips of up to 30 percent in intensity that last for 300-700 s. The high spectra resolution grating data were taken during one of the high states when these dips occurred, and it is possible to distinguish variable variable emission and absorption features due to Fe, O, and Ne. The picture of Cygnus X-2 is consistent with an intrinsic thermal source surrounded by a hot accretion disk corona. This model can be used to explain the high and low X-ray states, the variability within the states, and the intensity dips which occur in the high states.

Vrtilek, S. D.↗

RSRM and ETM03 Internal Flow Simulations and Comparisons

ETM03 (Engineering Test Motor-03) is an extended length RSRM (Reusable Solid Rocket Motor) designed to increase motor performance and create more severe internal environments compared with the standard four-segment RSRM motor configuration. This is achieved primarily through three unique design features. First is the incorporation of an additional RSRM center segment, second is a slight increase in throat diameter, and third is the use of an Extended Aft Exit Cone (EAEC). As a result of these design features, parameters such as web time, action time, head end pressure, web time average pressure, maximum thrust, mass flow rate, centerline Mach number, pressure and thrust integrals have all increased compared with nominal RSRM values. In some cases these increases are substantial. The primary objective of the ETM03 test program is to provide a platform for RSRM component margin testing. Test results will not only provide direct data concerning component performance under more adverse conditions, but serve as a second design data point for developing, validating and enhancing component analytical modeling techniques. To help component designers assess how the changes in motor environment will affect performance, internal flow simulations for both the nominal RSRM and ETM03 motor designs were completed to obtain comparisons of aero-thermal boundary conditions and system loads. Full geometries for both motors were characterized with two-dimensional axi-symmetric models at burn times of 1, 20, 54, 67 and 80-seconds. A sixth set considered burn times of 110 and 117-seconds for RSRM and ETM03, respectively. The simulations were performed using the computational fluid dynamics (CFD) commercial code FLUENT (trademark). Of particular interest were any differences between the two motor environments that could lead to a significant increase in system loads, or in internal insulation and/or nozzle component charring and erosion in ETM03 compared with RSRM. Based on these comparative analyses conducted in this study, the objective of ETM03 will be achieved by providing a more adverse operating environment for motor components than the nominal RSRM environment. For example: Higher chamber pressure drop in ETM03 than in RSRM; higher centerline Mach numbers approaching the nozzle in ETM03 than in RSRM; higher heat transfer rates for the internal insulation and nozzle components in ETM03 than in RSRM; and higher levels of droplet impingement and slag accumulation in ETM03 than in the RSRM.

Ahmad, R. A.↗