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At least 883 records · Page 49

Human cardiovascular response to sympathomimetic agents during head-down bed rest: the effect of dietary sodium

Changes in sympathoadrenal function and cardiovascular deconditioning have long been recognized as a feature of the physiological adaptation to microgravity. The deconditioning process, coupled with altered hydration status, is thought to significantly contribute to orthostatic intolerance upon return to Earth gravity. The cardiovascular response to stimulation by sympathomimetic agents before, during, and after exposure to simulated microgravity was determined in healthy volunteers equilibrated on normal or high sodium diets in order to further the understanding of the deconditioning process.

NASA Discipline Number 18-10↗

Probing transmembrane mechanical coupling and cytomechanics using magnetic twisting cytometry

We recently developed a magnetic twisting cytometry technique that allows us to apply controlled mechanical stresses to specific cell surface receptors using ligand-coated ferromagnetic microbeads and to simultaneously measure the mechanical response in living cells. Using this technique, we have previously shown the following: (i) beta 1 integrin receptors mediate mechanical force transfer across the cell surface and to the cytoskeleton, whereas other transmembrane receptors (e.g., scavenger receptors) do not; (ii) cytoskeletal stiffness increases in direct proportion to the level of stress applied to integrins; and (iii) the slope of this linear stiffening response differs depending on the shape of the cell. We now show that different integrins (beta 1, alpha V beta 3, alpha V, alpha 5, alpha 2) and other transmembrane receptors (scavenger receptor, platelet endothelial cell adhesion molecule) differ in their ability to mediate force transfer across the cell surface. In addition, the linear stiffening behavior previously observed in endothelial cells was found to be shared by other cell types. Finally, we demonstrate that dynamic changes in cell shape that occur during both cell spreading and retraction are accompanied by coordinate changes in cytoskeletal stiffness. Taken together, these results suggest that the magnetic twisting cytometry technique may be a powerful and versatile tool for studies analyzing the molecular basis of transmembrane mechanical coupling to the cytoskeleton as well as dynamic relations between changes in cytoskeletal structure and alterations in cell form and function.

NASA Discipline Number 40-20↗

Nonlinear Reduced Order Random Response Analysis of Structures With Shallow Curvature

The goal of this investigation is to further develop nonlinear modal numerical simulation methods for application to geometrically nonlinear response of structures with shallow curvature under random loadings. For reduced order analysis, the modal basis selection must be capable of reflecting the coupling in both the linear and nonlinear stiffness. For the symmetric shallow arch under consideration, four categories of modal basis functions are defined. Those having symmetric transverse displacements (ST modes) can be designated as transverse dominated (ST-T) modes and in-plane dominated (ST-I) modes. Those having anti-symmetric transverse displacements (AT modes) can similarly be designated as transverse dominated (AT-T) modes and in-plane dominated (AT-I) modes. The response of an aluminum arch under a uniformly distributed transverse random loading is investigated. Results from nonlinear modal simulations made using various modal bases are compared with those obtained from a numerical simulation in physical degrees-of-freedom. While inclusion of ST-T modes is important for all response regimes, it is found that the ST-I modes become increasingly important in the nonlinear response regime, and that AT-T and AT-I modes are critical in the autoparametric regime.

Przekop, Adam↗

Quenching of Excited Na due to He Collisions

The quenching and elastic scattering of excited Sodium by collisions with Helium have been investigated for energies between 10(exp -13) eV and 10 eV. With the ab initio adiabatic potentials and nonadiabatic radial and rotational couplings obtained from multireference single- and double-excitation configuration interaction approach, we carried out scattering calculations by the quantum-mechanical molecular-orbital close-coupling method. Cross sections for quenching reactions and elastic collisions are presented. Quenching and elastic collisional rate coefficients as a function of temperature between 1 micro-K and 10,000 K are also obtained. The results are relevant to modeling non-LTE effects on Na D absorption lines in extrasolar planets and brown dwarfs.

Lin, C. Y.↗

High-speed dynamic domino circuit implemented with gaas mesfets

A dynamic logic circuit (AND or OR) utilizes one depletion-mode metal-semiconductor FET for precharging an internal node A, and a plurality of the same type of FETs in series, or a FET in parallel with one or more of the series connected FETs for implementing the logic function. A pair of FETs are connected to provide an output inverter with two series diodes for level shift. A coupling capacitor may be employed with a further FET to provide level shifting required between the inverter and the logic circuit output terminal. These circuits may be cascaded to form a domino chain.

Yang, Long↗

Nonlinear Reduced Order Random Response Analysis of Structures with Shallow Curvature

The goal of this investigation is to further develop nonlinear modal numerical simulation methods for application to geometrically nonlinear response of structures with shallow curvature under random loadings. For reduced order analysis, the modal basis selection must be capable of reflecting the coupling in both the linear and nonlinear stiffness. For the symmetric shallow arch under consideration, four categories of modal basis functions are defined. Those having symmetric transverse displacements (ST modes) can be designated as transverse dominated (ST-T) modes and in-plane dominated (ST-I) modes. Those having anti-symmetric transverse displacements (AT modes) can similarly be designated as transverse dominated (AT-T) modes and in-plane dominated (AT-I) modes. The response of an aluminum arch under a uniformly distributed transverse random loading is investigated. Results from nonlinear modal simulations made using various modal bases are compared with those obtained from a numerical simulation in physical degrees-of-freedom. While inclusion of ST-T modes is important for all response regimes, it is found that the ST-I modes become increasingly important in the nonlinear response regime, and that AT-T and AT-I modes are critical in the autoparametric regime.

Przekop, Adam↗

Methane on Mars: New Insights into the Sensitivity of CH4 with the NOMAD/ExoMars Spectrometer Through Its First In-Flight Calibration

The Nadir and Occultation for MArs Discovery instrument (NOMAD), onboard the ExoMars Trace Gas Orbiter (TGO) spacecraft was conceived to observe Mars in solar occultation, nadir, and limb geometries, and will be able to produce an outstanding amount of diverse data, mostly focused on properties of the atmosphere. The infrared channels of the instrument operate by combining an echelle grating spectrometer with an Acousto- Optical Tunable Filter (AOTF). Using in-flight data, we characterized the instrument performance and parameterized its calibration. In particular: an accurate frequency calibration was achieved, together with its variability due to thermal effects on the grating. The AOTF properties and transfer function were also quantified, and we developed and tested a realistic method to compute the spectral continuum transmitted through the coupled grating and AOTF system. The calibration results enabled unprecedented insights into the important problem of the sensitivity of NOMAD to methane abundances in the atmosphere. We also deeply characterized its performance under realistic conditions of varying aerosol abundances, diverse albedos and changing illumination conditions as foreseen over the nominal mission. The results show that, in low aerosol conditions, NOMAD single spectrum, 1σ sensitivity to CH4 is around 0.33 ppbv at 20 km of altitude when performing solar occultation's, and better than 1 ppbv below 30 km. In dusty conditions, we show that the sensitivity drops to 0 below 10 km. In Nadir geometry, results demonstrate that NOMAD will be able to produce seasonal maps of CH4 with a sensitivity around 5 ppbv over most of planet's surface with spatial integration over 5×5° bins. Results show also that such numbers can be improved by a factor of ~10 to ~30 by data binning. Overall, our results quantify NOMAD's capability to address the variable aspects of Martian climate.

Liuzzi, Giuliano↗

Overview of the Optical Communications Demonstrator

The Optical Communications Demonstrator is a laboratory-based lasercom demonstration instrument designed to validate effective beacon acquisition, high bandwidth tracking, precision beam pointing, and point ahead compensation functions. The instrument is designed using an array detector for both spatial acquisition and high bandwidth tracking, and a fiber coupled laser transmitter. The array detector tracking concept provides wide field of view acquisition as well as high update rate using a single output channel device. At the same time, it permits effective platform jitter compensation and point ahead control using only one steering mirror. The use of fiber coupled transmitter further modularizes transmitter design and de-couples the thermal management problem. The reduction in design complexity can lead to a reduced system cost and an improved system reliability. Furthermore, it can permit the implementation of a new generation of lasercom instruments capable of realizing the inherent advantages of optical frequency communication systems.

laser↗

A Lack of Spin-Orbit Signal in the Morphology of Mercury's Large Craters

The spatial structure of Mercury's thermal lithosphere depends on the balance between internal heat and surface temperature as controlled by solar insolation. For bodies not in a spin-orbital resonance, observed spatial temperature variations are due to internal heating variations. However, for Mercury's present 3:2 spin-orbit coupling a notable difference of ~150 K exists for the sub-skin depth temperature of the crust as a function of longitude (Fig 1B.; [1,2]). Mercury's longitudinal "hot poles" and "cold poles", in addition to the standard poles (i.e. North and South), have large temperature contrasts that could lead to systematic differences in crater size, morphology, or morphometry, especially for large impacts.

Mercury↗

Electrified Aircraft Propulsion Systems: Potential Failure Modes and Failure Mitigation Strategies

Electrified aircraft propulsion (EAP) systems hold great potential for the reduction of aircraft fuel burn, emissions, and noise. Currently, NASA and other organizations are actively working to identify and mature technologies necessary to bring EAP designs to reality. A requirement for the development of any civil aircraft and its systems is to ensure that potential hazards in the design are identified and appropriately mitigated to ensure that the system is safe. During aircraft development, a system safety assessment that consists of a functional hazard assessment is conducted to identify all potential failure conditions of each function, and classify those failures according to the severity of their effects on the aircraft or its occupants. The more severe a function's failure condition classification, the greater the development assurance level required for the function to ensure that the probability of the hazard is acceptably low. Today, aircraft engines and their control systems receive type certificate approval as a stand-alone system to signify their airworthiness. However, the complex coupling and distributed nature of EAP designs are expected to place added challenges on the certification of these systems. This presentation will provide an initial high-level review of the potential failure modes and hazards posed by a generic EAP system along with potential mitigation strategies for those failures. The EAP system is assumed to be a hybrid design consisting of gas turbine engines, mechanical drives, electric machines, power electronics and distribution systems, energy storage devices, and motor driven propulsors. The functionality provided by each of these EAP subsystems will be discussed along with the potential failure modes they may encounter. This will include a discussion of coupled failure effects, where a fault in one EAP subsystem effects the operation of other subsystems in the architecture. Next, potential failure mitigation strategies are discussed including both software-based and hardware-based mitigation strategies. The presentation will conclude with an example evaluation of the potential failure modes and mitigation strategies for a concept EAP system proposed by NASA.

Simon, Donald L.↗

Phase linearity of the 914H coupled-cavity traveling wave tube

Tests of phase deviation from linearity were made on two 914H coupled-cavity traveling wave tubes (TWT). One tube had a voltage standing wave ratio (VSWR) of 2.4 and the other 1.4. The data showed that phase deviation is primarily a function of the amplitude and shape of the output VSWR. It was predicted that the low-VSWR tube would give a better system performance than the tube with a high VSWR. This prediction was confirmed by the Advanced Communications Technology Satellite (ACTS) system tests performed at the NASA Lewis Research Center. A possible improvement in the construction and stability of coupled-cavity TWT's is discussed.

Kavanagh, Frank E.↗

An alternative formulation of the global sensitivity equations

To optimize the performance of any system, the sensitivity derivatives of the system's output variables with respect to its input variables must be readily available. It is also desirable that these derivatives be inexpensive to calculate as the optimization process requires many evaluations of the output variables and their derivatives. Optimization methods that have been developed for use in automated structural design programs may not be extended for use in integrated multidisciplinary design programs until adequate means of calculating accurate sensitivity derivatives of complex, internally coupled systems have been developed. Until the development of the Global Sensitivity Equations (GSE), the only method of determining the sensitivity derivatives of coupled systems has been by using finite differences. Analytical or semi-analytical derivatives do not exist as there is no analytical solution to the coupled problem. Also, difficulties arise because the finite difference method is expensive as the system has to iterate to a converged solution for each incremental input variable. The method may not be accurate, and the choice of the input variable increment may cause the difference in the output variable to be insignificant compared to computer numerical error if the choice is too small, or the process may not predict the true value of the output variable if the increment is too large. The GSE allow the system's sensitivity derivatives to be calculated as functions of the component subsystem's (local) sensitivity derivatives. These local sensitivity derivatives are calculated from specifically decoupled subsystems, whereas the GSE account for total system coupling. Since the subsystems are decoupled, it may be possible for the local derivatives to be calculated by analytical or semi-analytical methods, which generally reduce cost and improve accuracy. Several academic problems have been solved using GSE and have demonstrated encouraging results.

James, Benjamin B.↗

Resonance line transfer calculations by doubling thin layers. I - Comparison with other techniques. II - The use of the R-parallel redistribution function

A versatile and efficient technique for the solution of the resonance line scattering problem with frequency redistribution in planetary atmospheres is introduced. Similar to the doubling approach commonly used in monochromatic scattering problems, the technique has been extended to include the frequency dependence of the radiation field. Methods for solving problems with external or internal sources and coupled spectral lines are presented, along with comparison of some sample calculations with results from Monte Carlo and Feautrier techniques. The doubling technique has also been applied to the solution of resonance line scattering problems where the R-parallel redistribution function is appropriate, both neglecting and including polarization as developed by Yelle and Wallace (1989). With the constraint that the atmosphere is illuminated from the zenith, the only difficulty of consequence is that of performing precise frequency integrations over the line profiles. With that problem solved, it is no longer necessary to use the Monte Carlo method to solve this class of problem.

Yelle, Roger V.↗

Discharge transient coupling in large space power systems

Experiments have shown that plasma environments can induce discharges in solar arrays. These plasmas simulate the environments found in low earth orbits where current plans call for operation of very large power systems. The discharges could be large enough to couple into the power system and possibly disrupt operations. Here, the general concepts of the discharge mechanism and the techniques of coupling are discussed. Data from both ground and flight experiments are reviewed to obtain an expected basis for the interactions. These concepts were applied to the Space Station solar array and distribution system as an example of the large space power system. The effect of discharges was found to be a function of the discharge site. For most sites in the array discharges would not seriously impact performance. One location at the negative end of the array was identified as a position where discharges could couple to charge stored in system capacitors. This latter case could impact performance.

Stevens, N. John↗

Impacts in Ice: Commissions of Solar System Crater Populations

The classical phases of cratering are compression, excavation, and modification. Recent theory, however, supports and alternative sequence of physical events: (1) coupling - energy and momentum are transferred, and the cratering flow field is set up; (2) power-law-growth the flow field expands, with transient cavity dimensions expressible as a simple power law function of time; and (3) late phase - some combination of gravity, strength, and viscosity limits cavity growth, initially causing a deviation from power-law behavior and eventually determining the size and shape of the final (transient) crater. The dominant mechanism that limits cavity growth defines a cratering regime and a single variable, the coupling parameter, determines the scaling laws in the various regimes. The coupling parameter is intermediate in dimensionality between energy and momentum and its exact form is determined. For simple materials with rate and scale independent strength, the transition crater diameter between the strength and gravity regimes is, within reasonable bounds, independent of velocity. Even the smallest craters observed by Voyager appear to be gravity dominated.

Mckinnon, W. B.↗

Dynamics and control of instrumented harmonic drives

Since torque in harmonic drives is transmitted by a pure couple, harmonic drives do not generate radial forces and therefore can be instrumented with torque sensors without interference from radial forces. The installation of torque sensors on the stationary component of harmonic drives (the Flexipline cup in this research work) produce backdrivability needed for robotic and telerobotic compliant maneuvers. Backdrivability of a harmonic drive, when used as torque increaser, means that the output shaft can be rotated via finite amount of torque. A high ratio harmonic drive is non-backdrivable because its output shaft cannot be turned by applying a torque on it. This article first develops the dynamic behavior of a harmonic drive, in particular the non-backdrivability, in terms of a sensitivity transfer function. The instrumentation of the harmonic drive with torque sensor is then described. This leads to a description of the control architecture which allows modulation of the sensitivity transfer function within the limits established by the closed-loop stability. A set of experiments on an active hand controller, powered by a DC motor coupled to an instrumented harmonic drive, is given to exhibit this method's limitations.

NASA Discipline Space Human Factors↗

A numerically exact full wave packet approach to molecule-surface scattering

A numerically exact spectral method for solving the time-dependent Schroedinger equation in spherical coordinates is described. The angular dependence of the wave function is represented on a two-dimensional grid of evenly spaced points. The fast Fourier transform algorithm is used to transform between the angle space representation of the wave function and its conjugate representation in momentum space. The time propagation of the wave function is evaluated using an expansion of the time evolution operator as a series of Chebyshev polynomials. Calculations performed for a model system representing H2 scattering from a rectangular corrugated surface yield transition probabilities that are in excellent agreement with those obtained using the close-coupling wave packet (CCWP) method. However, the new method is found to require substantially more computation time than the CCWP method because of the large number of grid points needed to represent the angular dependence of the wave function and the variation in the number of terms required in the Chebyshev representation of the time evolution operator.

Mowrey, R. C.↗