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At least 865 records · Page 48

Rejuvenation of Spent Media via Supported Emulsion Liquid Membranes

The overall goal of this project is to maximize the reuseability of spent fermentation media. Supported emulsion liquid membrane separation, a highly efficient extraction technique, is used to remove inhibitory byproducts during fermentation; thus, improving the yield while reducing the need for fresh water. The key objectives of this study are: Develop an emulsion liquid membrane system targeting low molecular weight organic acids which has minimal toxicity on a variety of microbial systems; Conduct mass transfer studies to allow proper modeling and design of a supported emulsion liquid membrane system; Investigate the effect of gravity on emulsion coalescence within the membrane unit; Access the effect of water re-use on fermentation yields in a model microbial system; Develop a perfusion-type fermentor utilizing a supported emulsion liquid membrane system to control inhibitory fermentation byproducts; Work for the coming year will focus on the determination of toxicity of various solvents, selection of the emulsifying agents, as well as characterizing the mass transfer of hollow-fiber contactors.

Wiencek, John M.↗

Physics of Reconnection and MMS Mission

Reconnection is the most important process driving the Earth's magnetosphere. Key to the success of the MMS science plan is the coupling of theory and observation. Determining the kinetic processes occurring in the diffusion region and physical parameters that control the rate of magnetic reconnection are among primary objectives of the MMS mission. Analysis of the role played by particle inertial effects in the diffusion region where the plasma is unmagnetized will be presented. The reconnection electric field in he diffusion region is supported primarily by particle non-gyrotropic effects. At the quasi-steady stage the reconnection electric field serves to accelerate and heat the incoming plasma population to maintain the current flow in the diffusion region the pressure balance. The primary mechanism controlling the dissipation in the vicinity of the reconnection site is incorporated into the fluid description in terms of non-gyrotropic corrections to the. induction and energy equations. The results of kinetic and fluid simulations illustrating the physics of magnetic reconnection will be presented. We will dem~:tistrate that kinetic nongyrotropic effects can significantly alter the global magnetosphere evolution and location of reconnection sites.

Kuznetsova, M. M.↗

Kinetic principles of interaction of components in complex biological systems

A biomathematical analysis of component interaction in biological systems is given. Two primary types of systems are discussed - open systems and closed systems. The applicability of these systems to life support equipment in spacecraft is analyzed and formulae are provided to demonstrate the effect (theoretical) of closed and open systems in life support systems.

Rubin, A. B.↗

Adaptive response of slow and fast skeletal muscle in the monkey to spaceflight

Experiments were designed to determine the effects of the absence of weight support on hindlimb muscles of the monkey: an ankle flexor (tibialis anterior, TA), two ankle extensors (medical gastrocnemius, MG and soleus, SOL), and a knee extensor (vastus lateralis, VL). These experiments will be performed as part of the BION mission. The original project proposed to assess the effects of weightlessness in adult Rhesus monkeys which were to be flown on the Space Shuttle as part of SLS-3. Feasibility studies were carried out and a series of experiments were performed at NASA/Ames Research Center to assess the effects of a 21-day restraint period in the ESOP on muscle properties. The results of these studies are summarized.

Bodine-Fowler, Sue↗

The desktop interface in intelligent tutoring systems

The interface between an Intelligent Tutoring System (ITS) and the person being tutored is critical to the success of the learning process. If the interface to the ITS is confusing or non-supportive of the tutored domain, the effectiveness of the instruction will be diminished or lost entirely. Consequently, the interface to an ITS should be highly integrated with the domain to provide a robust and semantically rich learning environment. In building an ITS for ZetaLISP on a LISP Machine, a Desktop Interface was designed to support a programming learning environment. Using the bitmapped display, windows, and mouse, three desktops were designed to support self-study and tutoring of ZetaLISP. Through organization, well-defined boundaries, and domain support facilities, the desktops provide substantial flexibility and power for the student and facilitate learning ZetaLISP programming while screening the student from the complex LISP Machine environment. The student can concentrate on learning ZetaLISP programming and not on how to operate the interface or a LISP Machine.

Baudendistel, Stephen↗

Size of tuber propagule influences injury of 'Kennebec' potato plants by constant light

Chlorosis and necrotic spotting develop on the foliage of particular cultivars of potato (Solanum tuberosum L.) when grown under constant light. 'Kennebec', a cultivar severely injured by constant light when propagated from tissue-cultured plantlets, also was injured when plants were propagated from small tuber pieces (approximately 1 g). However, plants did not develop injury when propagated from large tuber pieces (approximately 100 g). Plants from large tuber pieces grew more rapidly than plants from small tuber pieces. The role of plant vigor and carbohydrate translocation in controlling injury development is discussed.

NASA Discipline Life Support Systems↗

Pulse energy dependence of subcellular dissection by femtosecond laser pulses

Precise dissection of cells with ultrashort laser pulses requires a clear understanding of how the onset and extent of ablation (i.e., the removal of material) depends on pulse energy. We carried out a systematic study of the energy dependence of the plasma-mediated ablation of fluorescently-labeled subcellular structures in the cytoskeleton and nuclei of fixed endothelial cells using femtosecond, near-infrared laser pulses focused through a high-numerical aperture objective lens (1.4 NA). We find that the energy threshold for photobleaching lies between 0.9 and 1.7 nJ. By comparing the changes in fluorescence with the actual material loss determined by electron microscopy, we find that the threshold for true material ablation is about 20% higher than the photobleaching threshold. This information makes it possible to use the fluorescence to determine the onset of true material ablation without resorting to electron microscopy. We confirm the precision of this technique by severing a single microtubule without disrupting the neighboring microtubules, less than 1 micrometer away. c2005 Optical Society of America.

Non-NASA Center↗

Stability and transient motion of a plain journal mounted in flexible damped supports

Results are presented for an extensive study of the influence of damped flexible supports on the stability-threshold speed of a symmetric rotor mounted in nonlinear fluid-film bearings. A stability analysis is conducted by applying the Routh criteria and calculating the damped eigenvalues of the system. Stability maps are given in dimensionless form for a range of support stiffness, damping, and mass ratios. The effect of rotor imbalance on the stability of rotor systems is examined, and it is shown that time transient orbits of shaft and support motions clearly indicate their dynamic behavior for both stable and unstable operating speeds. Simple design criteria are proposed for choosing the support stiffness and damping on the basis of rotor weight and journal clearance to promote optimum stability. It is concluded that the use of a flexible damped support system may increase the stability threshold of a plain journal bearing and that damper supports should promote smoother and quieter machine operation by suppressing oil whirl and attenuating unbalanced rotational forces.

Kirk, R. G.↗

Evaluation of Human Research Facility Ultrasound With the ISS Video System

Most medical equipment on the International Space Station (ISS) is manifested as part of the U.S. or the Russian medical hardware systems. However, certain medical hardware is also available as part of the Human Research Facility. The HRF and the JSC Medical Operations Branch established a Memorandum of Agreement for joint use of certain medical hardware, including the HRF ultrasound system, the only diagnostic imaging device currently manifested to fly on ISS. The outcome of a medical contingency may be changed drastically, or an unnecessary evacuation may be prevented, if clinical decisions are supported by timely and objective diagnostic information. In many higher-probability medical scenarios, diagnostic ultrasound is a first-choice modality or provides significant diagnostic information. Accordingly, the Clinical Care Capability Development Project is evaluating the HRF ultrasound system for its utility in relevant clinical situations on board ISS. For effective management of these ultrasound-supported ISS medical scenarios, the resulting data should be available for viewing and interpretation on the ground, and bidirectional voice communication should be readily available to allow ground experts (sonographers, physicians) to provide guidance to the Crew Medical Officer. It may also be vitally important to have the capability of real-time guidance via video uplink to the CMO-operator during an exam to facilitate the diagnosis in a timely fashion. In this document, we strove to verify that the HRF ultrasound video output is compatible with the ISS video system, identify ISS video system field rates and resolutions that are acceptable for varying clinical scenaiios, and evaluate the HRF ultrasound video with a commercial, off-the-shelf video converter, and compare it with the ISS video system.

Melton, Shannon↗

Lunar Surface Reference Missions: A Description of Human and Robotic Surface Activities

Most medical equipment to the International Space Station (ISS) is manisfested as part of the U.S. or the Russian medical hardware systems. However, certain medical hardware is also available as part of the Human Research Facility. The HRF and the JSC Medical Operations Branch established a Memorandum of Agreement for joint use of certain medical hardware, including the HRF ultrasound system, the only diagnostic imaging device currently manifested to fly on ISS. The outcome of a medical contingency may be changed drastically, or an unnecessary evacuation may be prevented, if clinical decisions are supported by timely and objective diagnostic information. In many higher-probability medical scenarios, diagnostic ultrasound is a first-choice modality or provides significant diagnostic information. Accordingly, the Clinical Care Capability Development Project is evaluating the HRF ultrasound system for its utility in relevant clinical siruations on board ISS. For effective management of these ultrasound-supported ISS medical scenarios, the resulting data should be available for viewing and interpretation on the ground, and bidirectional voice communication should be readily available to allow ground experts (sonographers, physicians) to provide guidance to the Crew Medical Officer. It may also be vitally important to have the capability of real-time guidance via video uplink to the CMO-opertor during an exam to facilitate the diagnosis in a timely fashion.

Duke, Michael B.↗

In-Flight Aeroelastic Stability of the Thermal Protection System on the NASA HIAD, Part I: Linear Theory

Conical shell theory and piston theory aerodynamics are used to study the aeroelastic stability of the thermal protection system (TPS) on the NASA Hypersonic Inflatable Aerodynamic Decelerator (HIAD). Structural models of the TPS consist of single or multiple orthotropic conical shell systems resting on several circumferential linear elastic supports. The shells in each model may have pinned (simply-supported) or elastically-supported edges. The Lagrangian is formulated in terms of the generalized coordinates for all displacements and the Rayleigh-Ritz method is used to derive the equations of motion. The natural modes of vibration and aeroelastic stability boundaries are found by calculating the eigenvalues and eigenvectors of a large coefficient matrix. When the in-flight configuration of the TPS is approximated as a single shell without elastic supports, asymmetric flutter in many circumferential waves is observed. When the elastic supports are included, the shell flutters symmetrically in zero circumferential waves. Structural damping is found to be important in this case. Aeroelastic models that consider the individual TPS layers as separate shells tend to flutter asymmetrically at high dynamic pressures relative to the single shell models. Several parameter studies also examine the effects of tension, orthotropicity, and elastic support stiffness.

Goldman, Benjamin D.↗

Development of a mobile research flight test support capability

This paper presents the approach taken by the NASA Western Aeronautical Test Range (WATR) of the Ames Research Center to develop and utilize mobile systems to satisfy unique real-time research flight test requirements of research projects such as the advanced fighter technology integration (AFTI)F-16, YAV-8B Harrier, F-18 high-alpha research vehicle (HARV), XV-15, and the UH-60 Black Hawk. The approach taken is cost-effective, staff efficient, technologically current, and provides a safe and effective research flight test environment to support a highly complex set of real-time requirements including the areas of tracking and data acquisition, communications (audio and video) and real-time processing and display, postmission processing, and command uplink. The development of this capability has been in response to the need for rapid deployment at varied site locations with full real-time computations and display capability. This paper will discuss the requirements, implementation and growth plan for mobile systems development within the NASA Western Aeronautical Test Range.

Rhea, Donald C.↗

Development of a mobile research flight test support capability

This paper presents the approach taken by the NASA Western Aeronautical Test Range (WATR) of the Ames Research Center (ARC) to develop and utilize mobile systems to satisfy unique real-time research flight test requirements of research projects such as the advanced fighter technology integration (AFTI) F-16, YAV-8B Harrier, F-18 high-alpha research vehicle (HARV), XV-15, and the UH-60 Black Hawk. The approach taken is cost-effective, staff efficient, technologically current, and provides a safe and effective research flight test environment to support a highly complex set of real-time requirements including the areas of tracking and data acquisition, communications (audio and video) and real-time processing and display, postmission processing, and command uplink. The development of this capability has been in response to the need for rapid deployment at varied site locations with full real-time comutation and display capability. This paper will discuss the requirements, implementation and growth plan for mobile systems development within the NASA Western Aeronautical Test Range.

Rhea, Donald C.↗

Developing Technologies for Biological Experiments in Deep Space

NASA Ames Research Center is the leader in developing autonomous nanosatellites or CubeSats to address strategic knowledge gaps about the effects of space travel on biological organisms, including GeneSat, PharmaSat, and EcAMSat. Now that NASA has set its sights on human exploration in deep space, such missions require significant technological and biomedical countermeasures to protect astronauts from chronic radiation exposure. CubeSats can inform these countermeasures by querying relevant space environments with model organisms and/or biosensors. BioSentinel will be the first interplanetary CubeSat to study the biological response to space radiation outside low Earth orbit in almost 50 years. BioSentinel is an autonomous platform able to support biology and to investigate the effects of space radiation on a model organism in interplanetary deep space. It will fly onboard Artemis-1, from which it will be deployed on a lunar fly-by trajectory and into a heliocentric orbit. BioSentinel, a 6U CubeSat (1U = 10-cm cube), will measure the DNA damage response to ambient space radiation in a model organism, which will be compared to information provided by an onboard radiation spectrometer and to data obtained on the ISS and on Earth. Even though the primary objective of the mission is to develop an autonomous spacecraft capable of conducting biological experiments in deep space, the 4U BioSensor science payload contained within the free-flyer is an adaptable instrument that can perform bio measurements with different microorganisms and in multiple space environments, including the ISS, lunar gateway, and on the surface of the Moon. Thus, nanosatellites like BioSentinel can be used to study the effects of both reduced gravity and space radiation and can house different organisms to answer specific science questions. In addition to their flexibility, nanosatellites also provide a low-cost alternative to more complex and larger missions, and require minimal crew support, if any

biosenses↗

Developing Technologies for Biological Experiments in Deep Space

NASA Ames Research Center is the leader in developing autonomous nanosatellites or CubeSats to address strategic knowledge gaps about the effects of space travel on biological organisms, including GeneSat, PharmaSat, and EcAMSat. Now that NASA has set its sights on human exploration in deep space, such missions require significant technological and biomedical countermeasures to protect astronauts from chronic radiation exposure. CubeSats can inform these countermeasures by querying relevant space environments with model organisms and/or biosensors. BioSentinel will be the first interplanetary CubeSat to study the biological response to space radiation outside low Earth orbit in almost 50 years. BioSentinel is an autonomous platform able to support biology and to investigate the effects of space radiation on a model organism in interplanetary deep space. It will fly onboard Artemis-1, from which it will be deployed on a lunar fly-by trajectory and into a heliocentric orbit. BioSentinel, a 6U CubeSat (1U = 10-cm cube), will measure the DNA damage response to ambient space radiation in a model organism, which will be compared to information provided by an onboard radiation spectrometer and to data obtained on the ISS and on Earth. Even though the primary objective of the mission is to develop an autonomous spacecraft capable of conducting biological experiments in deep space, the 4U BioSensor science payload contained within the free-flyer is an adaptable instrument that can perform bio measurements with different microorganisms and in multiple space environments, including the ISS, lunar gateway, and on the surface of the Moon. Thus, nanosatellites like BioSentinel can be used to study the effects of both reduced gravity and space radiation and can house different organisms to answer specific science questions. In addition to their flexibility, nanosatellites also provide a low-cost alternative to more complex and larger missions, and require minimal crew support, if any.

biosenses↗

Metrics in Space Life Support Technology Selection

Engineering metrics are useful in space life support technology selection, but they must be carefully used. Metrics are only part of a complete system trade-off. Metrics do harm if they cause neglect of other important technical, organizational, or intuitive decision factors. Two metrics have damaged space life support, closure and Equivalent Systems Mass (ESM). Closure measures the fraction of the required system inputs that are produced by recycling system outputs. Increasing closure produces diminishing returns and becomes increasingly expensive. Increasing closure does not directly contribute to providing better life support. ESM measures the total launch mass required to provide life support. ESM includes the mass of the system hardware and of its power, cooling, pressurized volume, spares, and logistics. ESM predicts launch costs, but recently launch costs have been reduced by a factor of 20 or more. System development cost for space hardware is often much greater than launch cost. The past nearly exclusive use of ESM has led to the neglect of Life Cycle Cost (LCC), reliability, cost, and the other engineering factors. Closure and ESM have misguided space life support technology selection for more than twenty years and have adversely affected the expenditure of 100’s of millions of dollars. Metrics can be effectively used three ways in space life support technology selection: 1. A small set of key engineering metrics for preliminary screening. 2. A full set of engineering to guide technical selection. 3. Combining engineering metrics with organizational, political, and intuitive decision factors to understand technology selection. The past emphasis on closure and ESM served to support recycling life support over resupply and built on the intuitive appeal of a human ecosystem in space.

Harry W Jones↗

Volatile-rich Crater Interior Deposits in the Polar Regions of Mars: Evidence for Ice Cap Advance and Retreat

Many craters on Mars are partially filled by distinctive material emplaced by post-impact processes. This crater fill material is an interior mound which is generally separated from the walls of the crater by a trough that may be continuous along the crater circumference (i.e. a ring-shaped trough), or which may only partially contact the crater walls (i.e. a crescent-shaped trough). The fill deposit is frequently offset from the crater center and may be asymmetric in plan view. Populations of such craters include those in the circum-south polar cap region, in Arabia Terra, associated with the Medusae Fossae Formation, and in the northern lowlands proximal to the north polar cap. We focus on those craters in circumpolar regions and assess their relationship to polar cap advance and retreat, especially the possibility that fill material represents remnants of a formerly larger contiguous cap. Volatile-rich deposits have the property of being modifiable by the local stability of the solid volatile, which is governed by local energy balance. Here we test the hypothesis that asymmetries in volatile fill shape, profile, and center-location within a crater result from asymmetries in local energy balance within the crater, due mainly to variation of solar insolation and radiative effects of the crater walls over the crater interior. Model profiles of crater fill are compared with MOLA topographic profiles to assess this hypothesis. If asymmetry in morphology and location of crater fill are consistent with radiative-dominated asymmetries in energy budget within the crater, then 1) the volatile-rich composition of the fill is supported (this process should not be effective at shaping volcanic or sedimentary deposits), and 2) the dominant factor determining the observed shape of volatile-rich crater fill is the local radiative energy budget (and erosive processes such as eolian deflation are secondary or unnecessary). We also use a geographic and energy model approach to specifically test the idea that material in partially filled craters around the south pole may once have been contiguous to the cap and may have been sustained and modified by radiative processes specific to the crater environment (as opposed to the surrounding plains) as the cap retreated.

Russell, Patrick S.↗

Effects of method of loading and specimen configuration on compressive strength of graphite/epoxy composite materials

Three test schemes were examined for testing graphite/epoxy (Narmco T300/5208) composite material specimens to failure in compression, including an adaptation of the IITRI "wedge grip" compression fixture, a face-supported-compression fixture, and an end-loaded-coupon fixture. The effects of specimen size, specimen support arrangement and method of load transfer on compressive behavior of graphite/epoxy were investigated. Compressive stress strain, strength, and modulus data obtained with the three fixtures are presented with evaluations showing the effects of all test parameters, including fiber orientation. The IITRI fixture has the potential to provide good stress/strain data to failure for unidirectional and quasi-isotropic laminates. The face supported fixture was found to be the most desirable for testing + or - 45 s laminates.

Clark, R. K.↗