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At least 865 records · Page 48

Sequential computation of elementary modes and minimal cut sets in genome-scale metabolic networks using alternate integer linear programming

Elementary (flux) modes (EMs) have served as a valuable tool for investigating structural and functional properties of metabolic networks. Identification of the full set of EMs in genome-scale networks remains challenging due to combinatorial explosion of EMs in complex networks. It is often, however, that only a small subset of relevant EMs needs to be known, for which optimization-based sequential computation is a useful alternative. Most of the currently available methods along this line are based on the iterative use of mixed integer linear programming (MILP), the effectiveness of which significantly deteriorates as the number of iterations builds up. To alleviate the computational burden associated with the MILP implementation, we here present a novel optimization algorithm termed alternate integer linear programming (AILP). Results: Our algorithm was designed to iteratively solve a pair of integer programming (IP) and linear programming (LP) to compute EMs in a sequential manner. In each step, the IP identifies a minimal subset of reactions, the deletion of which disables all previously identified EMs. Thus, a subsequent LP solution subject to this reaction deletion constraint becomes a distinct EM. In cases where no feasible LP solution is available, IP-derived reaction deletion sets represent minimal cut sets (MCSs). Despite the additional computation of MCSs, AILP achieved significant time reduction in computing EMs by orders of magnitude. The proposed AILP algorithm not only offers a computational advantage in the EM analysis of genome-scale networks, but also improves the understanding of the linkage between EMs and MCSs.

59 BASIC BIOLOGICAL SCIENCES↗

Argobots: A Lightweight Low-Level Threading and Tasking Framework

In the past few decades, a number of user-level threading and tasking models have been proposed in the literature to address the shortcomings of OS-level threads, primarily with respect to cost and flexibility. Current state-of-the-art user-level threading and tasking models, however, are either too specific to applications or architectures or are not as powerful or flexible. In this paper, we present Argobots, a lightweight, low-level threading and tasking framework that is designed as a portable and performant substrate for high-level programming models or runtime systems. Argobots offers a carefully designed execution model that balances generality of functionality with providing a rich set of controls to allow specialization by the user or high-level programming model. We describe the design, implementation, and optimization of Argobots and present integrations with three example high-level models: OpenMP, MPI, and co-located I/O service. Evaluations show that (1) Argobots outperforms existing generic threading runtimes; (2) our OpenMP runtime offers more efficient interoperability capabilities than production OpenMP runtimes do; (3) when MPI interoperates with Argobots instead of Pthreads, it enjoys reduced synchronization costs and better latency hiding capabilities; and (4) I/O service with Argobots reduces interference with co-located applications, achieving performance competitive with that of the Pthreads version.

Seo, Sangmin (ORCID:0000000295159836)↗

Development of Data Acquisition System for nuclear thermal hydraulic out-of-pile facility using the graphical programming methods

This paper describes the design of data acquisition system (DAQ) that is connected to a PC and development of a feedback control system that maintains the coolant temperature of the process at a desired set point using a digital controller system based on the graphical programming language. The paper will provide details about the data acquisition unit, shows the implementation of the controller, and present test results. (authors)

42 ENGINEERING↗

Award ER25844: Minimizing System Noise Effects for Extreme-Scale Scientific Simulation Through Function Delegation

In software running on distributed computing clusters, time spent on communication between nodes in the cluster can be a significant portion of the overall computation time; background operating system tasks and other computational noise on the nodes of the system can have a significant impact on the amount of time this communication takes, especially on large systems. The research completed in this period has improved understanding of when such noise will have a significant impact. Specifically, it was demonstrated that not just noise on the nodes, but also noise on the network between nodes can have a significant impact on computation time. It was also demonstrated that noise patterns matter more than noise intensity: very regular noise can cause less disruption than lighter (on average) but less regular noise. It was also demonstrated that the effect of noise is more prominent as the speed of the network between nodes is increased. Furthermore, a tracing tool, Netgauge, was improved via our work, and a system simulator, LogGOPSim, was developed; they can be used by application developers to improve performance of their program and by system designers to mitigate the effects of noise by adjusting the noise characteristics of the operating system. Both have been made freely available as open source programs. In the course of developing these tools, we demonstrated weaknesses in existing methodologies for modeling communication, and we introduced a more detailed model, LogGOPS, for simulating systems. Not only were the deleterious effects of noise explored but we have also offered solutions. Our studies of simulations of system noise have led to specific recommendations on tuning systems to mitigate noise. We have also improved existing approaches to mitigating noise. Non-blocking collective communication avoids the effects of noise by letting communication continue simultaneously with computation (thus being non-blocking), so that the delays in communication introduced by noise have a smaller impact on overall computation time. Potentially, noise can be reduced much further by offloading communication tasks to a separate processing element than the operating system is using. We have improved our library LibNBC, which provides an implementation of non-blocking collectives, via this work. During this research, our proposal to include non-blocking collectives (which used LibNBC as a reference implementation) in the upcoming MPI-3 standard was accepted. As MPI is a ubiquitous and important standard for communication in parallel computing, this demonstrates a certain acceptance of the practicality and desirability of non-blocking collectives. Now that non-blocking collectives are a part of the standard we can expect to see optimized platform-specific implementations of non-blocking collectives. Also as part of this work we have also developed a language GOAL (Global Operation Assembly Language) that can be used as a starting point for defining languages to express optimized communication algorithms.

97 MATHEMATICS AND COMPUTING↗

Composting toilets as a sustainable alternative to urban sanitation – A review

Highlights: • Composting toilets can be an alternative to flush based sanitation. • Many different composting toilet designs are available. • Composting is affected by moisture content, temperature, carbon to nitrogen ratio. • There are many barriers to composting toilets. • Research is needed in science based design of composting toilets. - Abstract: In today’s flush based urban sanitation systems, toilets are connected to both the centralized water and wastewater infrastructures. This approach is not a sustainable use of our water and energy resources. In addition, in the U.S., there is a shortfall in funding for maintenance and upgrade of the water and wastewater infrastructures. The goal of this paper was to review the current knowledge on composting toilets since this technology is decentralized, requires no water, creates a value product (fertilizer) and can possibly reduce the burden on the current infrastructure as a sustainable sanitation approach. We found a large variety of composting toilet designs and categorized the different types of toilets as being self contained or central; single or multi chamber; waterless or with water/foam flush, electric or non-electric, and no-mix or combined collection. Factors reported as affecting the composting process and their optimum values were identified as; aeration, moisture content (50–60%), temperature (40–65 °C), carbon to nitrogen ratio (25–35), pH (5.5–8.0), and porosity (35–50%). Mass and energy balance models have been created for the composting process. However there is a literature gap in the use of this knowledge in design and operation of composting toilets. To evaluate the stability and safety of compost for use as fertilizer, various methods are available and the temperature–time criterion approach is the most common one used. There are many barriers to the use of composting toilets in urban settings including public acceptance, regulations, and lack of knowledge and experience in composting toilet design and operation and program operation.

12 MANAGEMENT OF RADIOACTIVE AND NON-RADIOACTIVE W↗

A Bi-Level Formulation And Solution Method For The Integration Of Process Design And Scheduling

Design and operation decisions of manufacturing plants can often be expressed within a hierarchical structure, where optimal decisions at lower operating level provide constraints for the decision raking at a higher decision level. In this work, we are addressing the case of a hierarchical design and scheduling optimization problem. The integration of design and scheduling decisions can play a big role in designing economically profitable plants and improving their operational performance. This problem can be expressed as a bi-level problem, where design related decisions occur at the upper level and operational scheduling decisions at the lower level. Since discrete decisions are involved in both optimization levels, the resulting formulation typically corresponds to bi-level mixed-integer programming problems (B-MIP). The solution of B-MIP problems is very challenging, and typically requires the use of global optimization techniques, with many algorithms not able to guarantee feasibility. To overcome the challenges in solving this class of problems we propose the use of a multi-parametric based algorithm for the solution of bi-level mixed-integer linear and quadratic programming problems, capable of providing the exact and global solution. The main idea of this approach is to treat the lower scheduling problem as a multi-parametric programming problem in which the design decisions are considered as parameters. Here, the resulting parametric solutions can then be substituted into the upper level design problem, which can be solved as a set of single-level deterministic programming problems. Through the developed formulation and algorithm we are able to supply the decision makers with the exact solution of the integrated design and scheduling problem.

42 ENGINEERING↗

Solar Living House Final Technical Report

The Solar Living House is a high-performance solar-powered dwelling designed by a team of faculty and students from the University of Florida, in collaboration with Santa Fe College, the National University of Singapore, and Alachua Habitat for Humanity. The project was designed in accordance with the Solar Decathlon 2015, a research, design, education, and outreach program developed by the U.S. Department of Energy (DOE). The Solar Living House is fundamentally a house for living, centered on people and the activities of daily life while quietly introducing advanced design, construction, and engineering technologies. The 993 square-foot two-bedroom one-bath home was designed to embrace and frame an exterior courtyard space. This courtyard acts as an extension of the interior living spaces, maximizing the spatial potentials of a modest building footprint and introducing natural light into the primary living spaces of the house. Research Outcomes: The Solar Living House advances work on high-performance buildings through three principal technological innovations: wet/dry modular construction, a building automation system, and solar dehumidification systems. Wet / Dry Modular Construction: The house is designed as a series of five modules, including one that is designated as the “wet core.” The wet core consolidates the mechanical systems and bathroom into a single module to reduce plumbing runs, efficiency losses, and on-site construction time. The other four modules are designed to eliminate interior load bearing walls to allow for maximum flexibility in the reconfiguring of the space over time. The modules are designed to meet the structural challenges of both Florida’s hurricanes and California’s earthquakes. Building Automation System: The house is equipped with an integrated building automation system, allowing the houses environmental systems, lights, security systems, and smoke detectors to be programmed, monitored, and controlled through any mobile or computing device. These systems allow for more precise calibrations of temperature/humidity/lighting to correspond with user needs and preferences, minimizing energy losses with economical night- or day-time setbacks. Solar Dehumidification System: The most significant technological innovation in the Solar Living House is the solar thermal dehumidification system. This system generates hot water through two rooftop-mounted evacuated tube solar thermal collectors. The hot water is used to continually dry a regenerative solid desiccant material, typically white silica gel. The solid desiccant is used to adsorb moisture and humidity from the air without additional mechanical cooling. This strategy allows humidity to be modulated independently of air temperature, providing greater thermal comfort and reducing the opportunity for the growth of mold spores within the house while also reducing the overall energy consumption of the HVAC system. Economic Feasibility: The team set aggressive goals for affordability, targeting a construction cost of $138,710. An independent professional cost estimator determined the overall project costs, as designed, would be $333,799, or $336.15 per square foot of finished floor area. This is more than 2.4 times the target construction cost. By comparison, the average construction cost for a home in the United States in 2015 was $289,415, or $103.29 per square foot of finished floor area. Following work on the Solar Living House, team leaders incorporated many of its objectives into a net-zero energy home on a site in Gainesville, Florida. This site-built home avoided many of the constraints and complications of modular construction necessitated by the Solar Decathlon, allowing it to be built for a much more modest budget. This two-bedroom two bath 1,800 square foot home was constructed for $135.39 per square foot, including active photovoltaic solar systems, careful attention to continuous air barriers, increased insulation levels, and permanent site constructions. This project suggest that high-performance buildings can be realized for more modest budgets. Public Benefits: Work on the Solar Living House and Solar Decathlon 2015 offered our student team unparalleled learning opportunities. Because of the duration of the project, a number of students participated at different points in their education, from first year undergraduates all the way through to advanced graduate students. The opportunity for collaboration with students and faculty from the National University of Singapore was also extraordinary, allowing for a sharing of technical knowledge and cultural exchange. The wider public has benefited from this work as its findings have been shared through public presentations and publications. It serves as a useful stepping stone along the path towards affordable, high-performance buildings.

14 SOLAR ENERGY↗

Visualization and Decision Making Design Under Uncertainty

This report documents the program and the outcomes of Dagstuhl Seminar 22331 "Visualization and Decision Making Design Under Uncertainty". The seminar brought together 33 researchers and practitioners from different domains concerned with visualization and decision making under uncertainty including visualization, visual analytics, human-computer interaction, artificial intelligence, climate research, geography and geology. The programme was organized in two parts: In the first part which lasted two days, participants gave short talks where they discussed current practices and the uncertainty visualization challenges they encountered in their own research. At the end of day two, participants brainstormed collectively around the main uncertainty visualization research challenges across domains and applications. In the second part, participants voted for the following three main challenges they wished to discuss for the remainder of the seminar (one and a half days): applications, human-centered uncertainty visualization, a design process for uncertainty visualization. Thus three break-out groups were formed to discuss these challenges. Abstracts for the individual talks and the break-out group activities are included in this report.

decision making↗

Optimization of the light detection system of the ICARUS detector

The Short Baseline Neutrino (SBN) Program at Fermilab is designed to investigate short-baseline neutrino oscillations and test the hypothesis of sterile neutrinos, motivated by several experimental anomalies observed over the past decades. Within this program, the ICARUS experiment plays a key role. It employs the world’s largest Liquid Argon Time Projection Chamber (LArTPC) and serves as the farthest and most sensitive SBN detector for studying muon and electron neutrino oscillations. A crucial subsystem of the ICARUS detector is the Light Detection System (LDS), which captures the prompt scintillation light produced by neutrino interactions in the 600-ton active liquid Argon volume. This system provides precise timing information that is essential for event reconstruction, the trigger system, and cosmic background rejection. The LDS is composed of 360 Hamamatsu R5912-MOD 8-inch photomultiplier tubes (PMTs), operating under cryogenic conditions ($\sim 87 \ K$) inside the detector’s cryostats. During the detector’s operation at FNAL, a degradation in PMT gain has been observed, attributed to aging under low-temperature conditions. In collaboration with ICARUS teams from INFN Pavia and Catania, I developed an experimental setup to study the temperature-dependent behavior of the PMTs, performing gain measurements both at room temperature and down to $-70°C$ using a climatic chamber at INFN Catania. The results indicate that while the PMTs maintain stable gain at room temperature, a significant and permanent gain reduction occurs at low temperatures. Although $-70°C$ is still warmer than liquid Argon temperatures, the findings clearly demonstrate a gain-dependent performance degradation. The thesis also discusses mitigation strategies implemented in the ICARUS detector to address this issue and presents a simplified model to describe and simulate the observed behavior.

Saia, Clara [Catania U.] (ORCID:0009000464102417)↗

Results of recent tests of GNS transport and storage casks for nuclear waste - 15285

State of the art dimensioning of casks for nuclear waste is changing rapidly in recent years. Therefore even established packages that serve the market for many years have to face new type testing programs that implements changes to its designs. The paper shows some of the recent testing programs for existing packages and provides an outlook to future casks solutions and its testing programs. (authors)

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WE-D-207-00: CT Lung Cancer Screening and the Medical Physicist: Moving Forward

In the United States, Lung Cancer is responsible for more cancer deaths than the next four cancers combined. In addition, the 5 year survival rate for lung cancer patients has not improved over the past 40 to 50 years. To combat this deadly disease, in 2002 the National Cancer Institute launched a very large Randomized Control Trial called the National Lung Screening Trial (NLST). This trial would randomize subjects who had substantial risk of lung cancer (due to age and smoking history) into either a Chest X-ray arm or a low dose CT arm. In November 2010, the National Cancer Institute announced that the NLST had demonstrated 20% fewer lung cancer deaths among those who were screened with low-dose CT than with chest X-ray. In December 2013, the US Preventive Services Task Force recommended the use of Lung Cancer Screening using low dose CT and a little over a year later (Feb. 2015), CMS announced that Medicare would also cover Lung Cancer Screening using low dose CT. Thus private and public insurers are required to provide Lung Cancer Screening programs using CT to the appropriate population(s). The purpose of this Symposium is to inform medical physicists and prepare them to support the implementation of Lung Screening programs. This Symposium will focus on the clinical aspects of lung cancer screening, requirements of a screening registry for systematically capturing and tracking screening patients and results (such as required Medicare data elements) as well as the role of the medical physicist in screening programs, including the development of low dose CT screening protocols. Learning Objectives: To understand the clinical basis and clinical components of a lung cancer screening program, including eligibility criteria and other requirements. To understand the data collection requirements, workflow, and informatics infrastructure needed to support the tracking and reporting components of a screening program. To understand the role of the medical physicist in implementing Lung Cancer Screening protocols for CT, including utilizing resources such as the AAPM Protocols and the ACR Designated Lung Screening Center program. UCLA Department of Radiology has an Institutional research agreement with Siemens Healthcare; Dr. McNitt-Gray has been a recipient of Research Support from Siemens Healthcare in the past. Dr. Aberle has been a Member of Advisory Boards for the LUNGevity Foundation (2011-present) and Siemens Medical Solutions. (2013)

60 APPLIED LIFE SCIENCES↗

WE-D-207-01: Background and Clinical Implementation of a Screening Program

In the United States, Lung Cancer is responsible for more cancer deaths than the next four cancers combined. In addition, the 5 year survival rate for lung cancer patients has not improved over the past 40 to 50 years. To combat this deadly disease, in 2002 the National Cancer Institute launched a very large Randomized Control Trial called the National Lung Screening Trial (NLST). This trial would randomize subjects who had substantial risk of lung cancer (due to age and smoking history) into either a Chest X-ray arm or a low dose CT arm. In November 2010, the National Cancer Institute announced that the NLST had demonstrated 20% fewer lung cancer deaths among those who were screened with low-dose CT than with chest X-ray. In December 2013, the US Preventive Services Task Force recommended the use of Lung Cancer Screening using low dose CT and a little over a year later (Feb. 2015), CMS announced that Medicare would also cover Lung Cancer Screening using low dose CT. Thus private and public insurers are required to provide Lung Cancer Screening programs using CT to the appropriate population(s). The purpose of this Symposium is to inform medical physicists and prepare them to support the implementation of Lung Screening programs. This Symposium will focus on the clinical aspects of lung cancer screening, requirements of a screening registry for systematically capturing and tracking screening patients and results (such as required Medicare data elements) as well as the role of the medical physicist in screening programs, including the development of low dose CT screening protocols. Learning Objectives: To understand the clinical basis and clinical components of a lung cancer screening program, including eligibility criteria and other requirements. To understand the data collection requirements, workflow, and informatics infrastructure needed to support the tracking and reporting components of a screening program. To understand the role of the medical physicist in implementing Lung Cancer Screening protocols for CT, including utilizing resources such as the AAPM Protocols and the ACR Designated Lung Screening Center program. UCLA Department of Radiology has an Institutional research agreement with Siemens Healthcare; Dr. McNitt-Gray has been a recipient of Research Support from Siemens Healthcare in the past. Dr. Aberle has been a Member of Advisory Boards for the LUNGevity Foundation (2011-present) and Siemens Medical Solutions. (2013)

60 APPLIED LIFE SCIENCES↗

WE-D-207-02: Capturing Data Elements and the Role of Imaging Informatics

In the United States, Lung Cancer is responsible for more cancer deaths than the next four cancers combined. In addition, the 5 year survival rate for lung cancer patients has not improved over the past 40 to 50 years. To combat this deadly disease, in 2002 the National Cancer Institute launched a very large Randomized Control Trial called the National Lung Screening Trial (NLST). This trial would randomize subjects who had substantial risk of lung cancer (due to age and smoking history) into either a Chest X-ray arm or a low dose CT arm. In November 2010, the National Cancer Institute announced that the NLST had demonstrated 20% fewer lung cancer deaths among those who were screened with low-dose CT than with chest X-ray. In December 2013, the US Preventive Services Task Force recommended the use of Lung Cancer Screening using low dose CT and a little over a year later (Feb. 2015), CMS announced that Medicare would also cover Lung Cancer Screening using low dose CT. Thus private and public insurers are required to provide Lung Cancer Screening programs using CT to the appropriate population(s). The purpose of this Symposium is to inform medical physicists and prepare them to support the implementation of Lung Screening programs. This Symposium will focus on the clinical aspects of lung cancer screening, requirements of a screening registry for systematically capturing and tracking screening patients and results (such as required Medicare data elements) as well as the role of the medical physicist in screening programs, including the development of low dose CT screening protocols. Learning Objectives: To understand the clinical basis and clinical components of a lung cancer screening program, including eligibility criteria and other requirements. To understand the data collection requirements, workflow, and informatics infrastructure needed to support the tracking and reporting components of a screening program. To understand the role of the medical physicist in implementing Lung Cancer Screening protocols for CT, including utilizing resources such as the AAPM Protocols and the ACR Designated Lung Screening Center program. UCLA Department of Radiology has an Institutional research agreement with Siemens Healthcare; Dr. McNitt-Gray has been a recipient of Research Support from Siemens Healthcare in the past. Dr. Aberle has been a Member of Advisory Boards for the LUNGevity Foundation (2011-present) and Siemens Medical Solutions. (2013)

60 APPLIED LIFE SCIENCES↗

Effect of Gasoline Properties on Exhaust Emissions from Tier 2 Light-Duty Vehicles (Final Report: Phase 3)

This report covers work the Southwest Research Institute (SwRI) Office of Automotive Engineering has conducted for the U.S. Environmental Protection Agency (EPA), the National Renewable Energy Laboratory (NREL), and the Coordinating Research Council (CRC) in support of the Energy Policy Act of 2005 (EPAct). Section 1506 of EPAct requires EPA to produce an updated fuel effects model representing the 2007 light - duty gasoline fleet, including determination of the emissions impacts of increased renewable fuel use. This report covers the exhaust emissions testing of 15 light-duty vehicles with 27 E0 through E20 test fuels, and 4 light-duty flexible fuel vehicles (FFVs) on an E85 fuel, as part of the EPAct Gasoline Light-Duty Exhaust Fuel Effects Test Program. This program will also be referred to as the EPAct/V2/E-89 Program based on the designations used for it by the EPA, NREL, and CRC, respectively. It is expected that this report will be an attachment or a chapter in the overall EPAct/V2/E-89 Program report prepared by EPA and NREL.

02 PETROLEUM↗

CMM Sequential Analysis Program

This report documents a design agency (DA) method to evaluate coordinate measuring machine (CMM) data by constructing an algorithm that is equivalent to the production agency (PA) algorithm for processing the raw CMM data. Several refinements of the CMM analyses were implemented at both the PA and the DA to process inherent limitations of the raw data, such as the absence of measurements at the exact ends of the connector-adapter assembly (CAA) and the recovery from these limitations through (worst-case) adjustments to the the positional errors. Also, inherent errors of the CMM measurements were accommodated by introducing a guard band, which effectively lowered the tolerance so that the CMM code could not pass bad parts. The DA and the PA showed remarkable agreement in all areas of analysis. The ultimate comparison is shown in Figures 13a and 13b, where the effect of using a guard band and end adjustments to the CMM measurements were clearly shown.

42 ENGINEERING↗

Advanced Materials Program Summary

Materials solutions - enabling design, construction, and operation of licensable Advanced Nuclear Material, design, fabrication, installation, examination, testing, overpressure protection, inspection, stamping, and certification

11 NUCLEAR FUEL CYCLE AND FUEL MATERIALS↗

AN INFORMATION-THEORETIC APPROACH TO OPTIMIZE JWST OBSERVATIONS AND RETRIEVALS OF TRANSITING EXOPLANET ATMOSPHERES

We provide an example of an analysis to explore the optimization of observations of transiting hot Jupiters with the James Webb Space Telescope ( JWST ) to characterize their atmospheres based on a simple three-parameter forward model. We construct expansive forward model sets for 11 hot Jupiters, 10 of which are relatively well characterized, exploring a range of parameters such as equilibrium temperature and metallicity, as well as considering host stars over a wide range in brightness. We compute posterior distributions of our model parameters for each planet with all of the available JWST spectroscopic modes and several programs of combined observations and compute their effectiveness using the metric of estimated mutual information per degree of freedom. From these simulations, clear trends emerge that provide guidelines for designing a JWST observing program. We demonstrate that these guidelines apply over a wide range of planet parameters and target brightnesses for our simple forward model.

79 ASTRONOMY AND ASTROPHYSICS↗

Co-design optimization of combined heat and power-based microgrids

With the emergent need for clean and reliable energy resources, hybrid energy systems, such as the microgrid, are widely adopted in the United States. A microgrid can consist of various distributed energy resources, for instance, combined heat and power (CHP) systems. Here, the CHP module is a distributed cogeneration technology that produces electricity and recaptures heat generated as a by-product. It is an energy-efficient technology converting heat that would otherwise be wasted to valuable thermal energy. For an optimal system configuration, this study develops a novel co-design optimization framework for CHP-based cogeneration microgrids. The framework provides the stakeholder with a method to optimize investments and attain resilient operations. The proposed co-design framework has a mixed integer programming (MIP) model that outputs decisions for both plant designs and operating controls. The microgrid considered in this study contains six components: the CHP, boiler, heat recovery unit, thermal storage system, power storage system, and photovoltaic plant. After solving the MIP model, the optimal design parameters of each component can be found to minimize the total installation cost of all components in the microgrid. Furthermore, the online costs from energy production, operation, maintenance, machine startup, and disruption-induced unsatisfied loads are minimized by solving the optimal control decisions for operations. Case studies based on designing a CHP-based microgrid with empirical data are conducted. Moreover, we consider both nominal and disruptive operational scenarios to validate the performance of the proposed co-design framework in terms of a cost-effective, resilient system.

42 ENGINEERING↗