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At least 865 records · Page 48
All sourcesNASA NTRSDOE OSTI
NASA NTRS2000

Recent Enhancements of the Phased Array Mirror Extendible Large Aperture (PAMELA) Telescope Testbed at MSFC

Recent incremental upgrades to the Phased Array Mirror Extendible Large Aperture (PAMELA) telescope testbed have enabled the demonstration of phasing (with a monochromatic source) of clusters of primary mirror segments down to the diffraction limit. PAMELA upgrades include an improved Shack-Hartmann wavefront sensor, passive viscoelastic damping treatments for the voice-coil actuators, mechanical improvement of mirror surface figures, and optical bench baffling. This report summarizes the recent PAMELA upgrades, discusses the lessons learned, and presents a status of this unique testbed for wavefront sensing and control. The Marshall Space Flight Center acquired the Phased Array Mirror Extendible Large Aperture (PAMELA) telescope in 1993 after Kaman Aerospace was unable to complete integration and testing under the limited SDIO and DARPA funding. The PAMELA is a 36-segment, half-meter aperture, adaptive telescope which utilizes a Shack-Hartmann wavefront sensor, inductive coil edge sensors, voice coil actuators, imaging CCD cameras and interferometry for figure alignment, wavefront sensing and control. MSFC originally obtained the PAMELA to supplement its research in the interactions of control systems with flexible structures. In August 1994, complete tip, tilt and piston control was successfully demonstrated using the Shack-Hartmann wavefront sensor and the inductive edge sensors.

Rakoczy, John↗
NASA NTRS1994

Pulsed Laser Illumination of Photovoltaic Cells

In future space missions, free electron lasers (FEL) may be used to illuminate photovoltaic array receivers to provide remote power. The induction FEL and the radio-frequency (RF) FEL both produce pulsed rather than continuous output. In this work, we investigate cell response to pulsed laser light which simulates the RF FEL format, producing 50 ps pulses at a frequency of 78 MHz. A variety of Si, GaAs, CaSb and CdInSe2 (CIS) solar cells are tested at average incident powers between 4 mW/sq cm and 425 mW/sq cm. The results indicate that if the pulse repetition is high, cell efficiencies are only slightly reduced by using a pulsed laser source compared to constant illumination at the same wavelength. Because the pulse separation is less than or approximately equal to the minority carrier lifetime, the illumination conditions are effectively those of a continuous wave laser. The time dependence of the voltage and current response of the cells are also measured using a sampling oscilloscope equipped with a high frequency voltage probe and current transformer. The frequency response of the cells is weak, with both voltage and current outputs essentially dc in nature. Comparison with previous experiments shows that the RF FEL pulse format yields much more efficient photovoltaic conversion of light than does an induction FEL pulse format.

Yater, Jane A.↗
NASA NTRS1999

Plasma Flow During RF Discharges in VASIMR

The Variable Specific Impulse Magnetoplasma Rocket (VASIMR) plasma source consists of a helical antenna, driven at frequencies of 4 to 19 MHz with powers up to 1 kW, in a magnetic field up to 3 kG. Helium is the current test gas, and future experiments with hydrogen are planned. Plasma density and temperature profiles were measured by a reciprocating Langmuir probe, and plasma flow profiles were measured with a reciprocating Mach probe. Both probes were located about 0.5 m downstream from the helical antenna. The plasma source operated in capacitive and inductive modes in addition to a helicon mode. During capacitive and inductive modes, densities were low and plasma flow was < 0.5 Cs. When the plasma operated in a helicon mode, the densities measured downstream from the source were higher [10(exp 12) / cubic cm ] and plasma flow along the magnetic field was of the order Mach 1. Details of the measurements will be shown.

Jacobson, V. T.↗
NASA NTRS1999

[Radiation Anticarcinogenesis by Thiazolidine Pro-drug]

The original goal of this work was to determine the capacity of selected aminothiols to modulate radiation induced cytotoxicity, mutagenesis and carcinogenesis in a human mammary epithelial cell line. The conclusions from this work are that WR-1065 is the "gold standard" for protection against radiation induced cytotoxicity, mutagenesis and carcinogenesis. While a potent radiation protector, WR-1065 is cytotoxic in vitro and in vivo. Our rationale for a study of the thiazolidine pro-drugs was that these compounds are neither toxic in vitro or in vivo. The results obtained during this funding period indicate that the thiazolidine pro-drugs are as potent as WR-1065 as protectors against radiation induced mutation induction, and thus presumably against radiation induced carcinogenesis. Our results indicate that the thiazolidine prodrugs are excellent candidates to test as non-toxic anticarcinogens for protecting astronauts from cancer induction during space travel.

Warters, Raymond L.↗
NASA NTRS2000

Electromagnetic Propulsion

The design and development of an Electromagnetic Propulsion is discussed. Specific Electromagnetic Propulsion Topics discussed include: (1) Technology for Pulse Inductive Thruster (PIT), to design, develop, and test of a multirepetition rate pulsed inductive thruster, Solid-State Switch Technology, and Pulse Driver Network and Architecture; (2) Flight Weight Magnet Survey, to determine/develop light weight high performance magnetic materials for potential application Advanced Space Flight Systems as these systems develop; and (3) Magnetic Flux Compression, to enable rapid/robust/reliable omni-planetary space transportation within realistic development and operational costs constraints.

Schafer, Charles↗
NASA NTRS2001

Recent Enhancements of the Phased Array Mirror Extendible Large Aperture (PAMELA) Telescope Testbed at MSFC

Recent incremental upgrades to the Phased Array Mirror Extendible Large Aperture (PAMELA) telescope testbed have enabled the demonstration of phasing (with a monochromatic source) of clusters of primary mirror segments down to the diffraction limit. PAMELA upgrades include in improved Shack-Hartmann wavefront sensor, passive viscoelastic damping treatments for the voice-coil actuators, mechanical improvement of mirror surface figures, and optical bench baffling. This report summarizes the recent PAMELA upgrades, discusses the lessons learned, and presents a status of this unique testbed for wavefront sensing and control. The Marshall Space Flight Center acquired the Phased Array Mirror Extendible Large Aperture (PAMELA) telescope in 1993 after Kaman Aerospace was unable to complete integration and testing under the limited SDIO and DARPA funding. The PAMELA is a 36-segment, half-meter aperture, adaptive telescope which utilizes a Shack-Hartmann wavefront sensor, inductive coil edge sensors, voice coil actuators, imaging CCD cameras and interferometry for figure alignment, wavefront sensing and control. MSFC originally obtained the PAMELA to supplement its research in the interactions of control systems with flexible structures. In August 1994, complete tip, tilt and piston control was successfully demonstrated using the Shack-Hartmann wavefront sensor and the inductive edge sensors.

Rakoczy, John↗
NASA NTRS2002

Magnetic Microspheres for Therapeutical Applications

Hyperthermia is a well known cancer therapy and consists of heating a tumor region to the elevated temperatures in the range of 40-45 C for an extended period of time (2-8 hours). This leads to thermal inactivation of cell regulatory and growth processes with resulting widespread necrosis, carbonization and coagulation. Moreover, heat boosts the tumor response to other treatments such as radiation, chemotherapy or immunotherapy. Of particular importance is careful control of generated heat in the treated region and keeping it localized. Higher heating, to about 56 C can lead to tissue thermo-ablation. With accurate temperature control, hyperthermia has the advantage of having minimal side effects. Several heating techniques are utilized for this purpose, such as whole body hyperthermia, radio-frequency (RF) hyperthermia, ultrasound technique, inductive microwave antenna hyperthermia, inductive needles (thermoseeds), and magnetic fluid hyperthermia (MFH).MFH offers many advantages as targeting capability by applying magnets. However, this technology still suffers significant inefficiencies due to lack of thermal control. This paper will provide a review of the topic and outline the ongoing work in this area. The main emphasis is in devising ways to overcome the technical difficulty in hyperthermia therapy of achieving a uniform therapeutic temperature over the required region of the body and holding it steady. The basic obstacle of the present heating methods are non-uniform thermal properties of the tissue. Our approach is to develop a novel class of magnetic fluids which have inherent thermoregulating properties. We have identified a few magnetic alloys which can serve as a suitable nano-particle material. The objective is to synthesize, characterize and evaluate the efficacy of TRMF for hyperthermia therapy.

Mazuruk, K.↗
NASA NTRS2002

Rapid Maturation of Edge Sensor Technology and Potential Application in Large Space Telescopes with Segmented Primary Mirrors

This paper explores the history and results of the last two year's efforts to transition inductive edge sensor technology from Technology Readiness Level 2 to Technology Readiness Level 6. Both technical and programmatic challenges were overcome in the design, fabrication, test, and installation of over a thousand sensors making up the Segment Alignment Maintenance System (SAMs) for the 91 segment, 9.2-meter. Hobby Eberly Telescope (HET). The integration of these sensors with the control system will be discussed along with serendipitous leverage they provided for both initialization alignment and operational maintenance. The experience gained important insights into the fundamental motion mechanics of large segmented mirrors, the relative importance of the variance sources of misalignment errors, the efficient conduct of a program to mature the technology to the higher levels. Unanticipated factors required the team to develop new implementation strategies for the edge sensor information which enabled major segmented mirror controller design simplifications. The resulting increase in the science efficiency of HET will be shown. Finally, the on-going effort to complete the maturation of inductive edge sensor by delivering space qualified versions for future IR (infrared radiation) space telescopes.

Montgomery, Edward E., IV↗
NASA NTRS2003

Magnetic Microspheres and Tissue Model Studies for Therapeutical Applications

Hyperthermia is a well known cancer therapy and consists of heating a tumor region to the elevated temperatures in the range of 40-45 C for an extended period of time (2-8 hours). This leads to thermal inactivation of cell regulatory and growth processes with resulting widespread necrosis, carbonization and coagulation. Moreover, heat boosts the tumor response to other treatments such as radiation, chemotherapy or immunotherapy. Of particular importance is careful control of generated heat in the treated region and keeping it localized. Higher heating, to about 56 C can lead to tissue thermo-ablation. With accurate temperature control, hyperthermia has the advantage of having minimal side effects. Several heating techniques are utilized for this purpose, such as whole body hyperthermia, radio-frequency (RF) hyperthermia, ultrasound technique, inductive microwave antenna hyperthermia, inductive needles (thermoseeds), and magnetic fluid hyperthermia (MFH).MFH offers many advantages as targeting capability by applying magnets. However, this technology still suffers significant inefficiencies due to lack of thermal control. This paper will provide a review of the topic and outline the ongoing work in this area. The main emphasis is in devising ways to overcome the technical difficulty in hyperthermia breast therapy of achieving a uniform therapeutic temperature over the required region of the body and holding it steady for an extended period (2-3 hours). The basic shortcomings of the presently utilized heating methods stem from the non-uniform thermal properties of the tissue and the point heating characteristics of the techniques without any thermal control. Our approach is to develop a novel class of magnetic fluids, which have inherent thermoregulating properties. We have identified a few magnetic alloys which can serve as suitable nano to micron-size particle material. The objective is to synthesize, characterize and evaluate the efficacy of Thermo Regulating Magnetic Fluids (TRMF) for hyperthermia therapy. The development of a tissue model and testing the fluid dynamics of particle motion, settling, distribution in the tissue matrix and heat generation will be discussed.

Ramachandran, N.↗
NASA NTRS2003

Megawatt Electromagnetic Plasma Propulsion

The NASA Glenn Research Center program in megawatt level electric propulsion is centered on electromagnetic acceleration of quasi-neutral plasmas. Specific concepts currently being examined are the Magnetoplasmadynamic (MPD) thruster and the Pulsed Inductive Thruster (PIT). In the case of the MPD thruster, a multifaceted approach of experiments, computational modeling, and systems-level models of self field MPD thrusters is underway. The MPD thruster experimental research consists of a 1-10 MWe, 2 ms pulse-forming-network, a vacuum chamber with two 32 diffusion pumps, and voltage, current, mass flow rate, and thrust stand diagnostics. Current focus is on obtaining repeatable thrust measurements of a Princeton Benchmark type self field thruster operating at 0.5-1 gls of argon. Operation with hydrogen is the ultimate goal to realize the increased efficiency anticipated using the lighter gas. Computational modeling is done using the MACH2 MHD code, which can include real gas effects for propellants of interest to MPD operation. The MACH2 code has been benchmarked against other MPD thruster data, and has been used to create a point design for a 3000 second specific impulse (Isp) MPD thruster. This design is awaiting testing in the experimental facility. For the PIT, a computational investigation using MACH2 has been initiated, with experiments awaiting further funding. Although the calculated results have been found to be sensitive to the initial ionization assumptions, recent results have agreed well with experimental data. Finally, a systems level self-field MPD thruster model has been developed that allows for a mission planner or system designer to input Isp and power level into the model equations and obtain values for efficiency, mass flow rate, and input current and voltage. This model emphasizes algebraic simplicity to allow its incorporation into larger trajectory or system optimization codes. The systems level approach will be extended to the pulsed inductive thruster and other electrodeless thrusters at a future date.

Gilland, James↗
NASA NTRS2003

L-C Measurement Acquisition Method for Aerospace Systems

This paper describes a measurement acquisition method for aerospace systems that eliminates the need for sensors to have physical connection to a power source (i.e., no lead wires) or to data acquisition equipment. Furthermore, the method does not require the sensors to be in proximity to any form of acquisition hardware. Multiple sensors can be interrogated using this method. The sensors consist of a capacitor, C(p), whose capacitance changes with changes to a physical property, p, electrically connected to an inductor, L. The method uses an antenna to broadcast electromagnetic energy that electrically excites one or more inductive-capacitive sensors via Faraday induction. This method facilitates measurements that were not previously possible because there was no practical means of providing power and data acquisition electrical connections to a sensor. Unlike traditional sensors, which measure only a single physical property, the manner in which the sensing element is interrogated simultaneously allows measurement of at least two unrelated physical properties (e.g., displacement rate and fluid level) by using each constituent of the L-C element. The key to using the method for aerospace applications is to increase the distance between the L-C elements and interrogating antenna; develop all key components to be non-obtrusive and to develop sensing elements that can easily be implemented. Techniques that have resulted in increased distance between antenna and sensor will be presented. Fluid-level measurements and pressure measurements using the acquisition method are demonstrated in the paper.

Woodard, Stanley E.↗
NASA NTRS2003

In Vitro Studies on Space Radiation-Induced Delayed Genetic Responses: Shielding Effects

Understanding the radiation risks involved in spaceflight is of considerable importance, especially with the long-term occupation of ISS and the planned crewed exploration missions. Several independent causes may contribute to the overall risk to astronauts exposed to the complex space environment, such as exposure to GCR as well as SPES. Protons and high-Z energetic particles comprise the GCR spectrum and may exert considerable biological effects even at low fluence. There are also considerable uncertainties associated with secondary particle effects (e.g. HZE fragments, neutrons etc.). The interaction of protons and high-LET particles with biological materials at all levels of biological organization needs to be investigated fully in order to establish a scientific basis for risk assessment. The results of these types of investigation will foster the development of appropriately directed countermeasures. In this study, we compared the biological responses to proton irradiation presented to the target cells as a monoenergetic beam of particles of complex composition delivered to cells outside or inside a tissue phantom head placed in the United States EVA space suit helmet. Measurements of chromosome aberrations, apoptosis, and the induction of key proteins were made in bone marrow from CBA/CaJ and C57BL/6 mice at early and late times post exposure to radiation at 0, 0.5, 1 and 2 Gy while inside or outside of the helmet. The data showed that proton irradiation induced transmissible chromosomal/genomic instability in haematopoietic stem cells in both strains of mice under both irradiation conditions and especially at low doses. Although differences were noted between the mouse strains in the degree and kinetics of transforming growth factor-beta 1 and tumor necrosis factor-alpha secretion, there were no significant differences observed in the level of the induced instability under either radiation condition, or for both strains of mice. Consequently, when normalized to physical dose, the monoenergetic proton field present inside the helmet-protected phantom produced equivalent biological responses, when compared to unshielded cells, as measured by the induction of delayed genetic effects in murine haematopoietic stem cells.

Kadhim, Munira A.↗
NASA NTRS2004

Magnetic and Langmuir Probe Measurements on the Plasmoid Thruster Experiment (PTX)

The Plasmoid Thruster Experiment (PTX) operates by inductively producing plasmoids in a conical theta-pinch coil and subsequently ejecting them at high velocity. An overview of PTX is described in a companion paper. The shape and magnetic field structure of the translating plasmoids will be measured with of an array of inductive magnetic field probes. Six sets of two B-dot probes (for a total of twelve probes) have been constructed for measuring B(sub z) and B(sub theta), the axial and azimuthal components of the magnetic field. The probes were calibrated with a Helmholtz coil, driven alternately by a high-voltage pulser or a signal generator. The probes are wound on a G-10 form, and have an average (calibrated) NA of 9.37 x 10(exp -5) square meters, where N is the number of turns and A is cross-sectional area. The frequency response of the probes was measured over the range from 1 kHz to 10 MHZ. The electron number density n(sub e), electron temperature T(sub e) and velocity v will be determined from measurements taken with a quadruple Langmuir probe, situated in the exhaust chamber. Three of the four probes on the quadruple probe sample the current-voltage characteristic, and from this yield measurements of T(sub e) and n(sub e). The fourth probe provides a measurement of plasma flow velocity. A 6-inch long alumina rod, hollowed with four holes to house the probe wires, is being used to construct the quadruple probe. A variety of propellants will be used, including hydrogen, nitrogen and argon. From the measurements of the plasmoid mass, density, temperature, and velocity, the basic propulsion characteristics of PTX will be evaluated.

Koelfgen, Syri J.↗
NASA NTRS2003

Biological countermeasures in space radiation health

Exposure to the types of ionizing radiation encountered during space travel may cause a number of health-related problems, but the primary concern is related to the increased risk of cancer induction in astronauts. The major types of radiation considered to be of importance during space travel are protons and particles of high atomic number and high energy (HZE particles). It is now clear that biological countermeasures can be used to prevent or reduce the levels of biological consequences resulting from exposure to protons or HZE particles, including the induction of cancer, immunosuppression and neurological defects caused by these types of ionizing radiation. Research related to the dietary additions of agents to minimize the risks of developing health-related problems which can result from exposure to space radiations is reviewed.

NASA Discipline Radiation Health↗
NASA NTRS2003

Are chromosomal instabilities induced by exposure of cultured normal human cells to low- or high-LET radiation?

Radiation-induced genomic instability has been proposed as a very early, if not an initiating, step in radiation carcinogenesis. Numerous studies have established the occurrence of radiation-induced chromosomal instability in various cells of both human and rodent origin. In many of these studies, however, the cells were not "normal" initially, and in many cases they involved tumor-derived cell lines. The phenomenon clearly would be of even greater interest if it were shown to occur generally in cells that are normal at the outset, rather than cells that may have been "selected" because of a pre-existing susceptibility to induced instability. As a test of the generality of the phenomenon, we studied low-passage normal diploid human fibroblasts (AG1521A) to determine whether they are susceptible to the induction of chromosomal instability in the progeny of surviving cells after exposure in G(0) to low- and high-LET radiation. Cytogenetic assays for instability were performed on both mixed populations of cells and clones of cells surviving exposure. We found no evidence for the induction of such instability as a result of radiation exposure, though we observed a senescence-related chromosomal instability in the progeny of both irradiated and unirradiated cell populations. Copyright 2003 by Radiation Research Society.

Non-NASA Center↗
NASA NTRS2002

Techniques for measurement of thoracoabdominal asynchrony

Respiratory motion measured by respiratory inductance plethysmography often deviates from the sinusoidal pattern assumed in the traditional Lissajous figure (loop) analysis used to determine thoraco-abdominal asynchrony, or phase angle phi. We investigated six different time-domain methods of measuring phi, using simulated data with sinusoidal and triangular waveforms, phase shifts of 0-135 degrees, and 10% noise. The techniques were then used on data from 11 lightly anesthetized rhesus monkeys (Macaca mulatta; 7.6 +/- 0.8 kg; 5.7 +/- 0.5 years old), instrumented with a respiratory inductive plethysmograph, and subjected to increasing levels of inspiratory resistive loading ranging from 5-1,000 cmH(2)O. L(-1). sec(-1).The best results were obtained from cross-correlation and maximum linear correlation, with errors less than approximately 5 degrees from the actual phase angle in the simulated data. The worst performance was produced by the loop analysis, which in some cases was in error by more than 30 degrees. Compared to correlation, other analysis techniques performed at an intermediate level. Maximum linear correlation and cross-correlation produced similar results on the data collected from monkeys (SD of the difference, 4.1 degrees ) but all other techniques had a high SD of the difference compared to the correlation techniques.We conclude that phase angles are best measured using cross-correlation or maximum linear correlation, techniques that are independent of waveform shape, and robust in the presence of noise. Copyright 2002 Wiley-Liss, Inc.

Non-NASA Center↗
NASA NTRS2000

Induced phenylpropanoid metabolism during suberization and lignification: a comparative analysis

Induction of the biosynthesis of phenylpropanoids was monitored at the enzyme level through measurement of the temporal change in the activity of two marker enzymes of phenylpropanoid metabolism, phenylalanine ammonia-lyase, (PAL, E.C. 4.1.3.5) and 4-coumaryl-CoA ligase (4-CL, E.C. 6.2.1.12) and two marker enzymes for hydroxycinnamyl alcohol biosynthesis, cinnamoyl-CoA:NADP+ oxidoreductase (CCR, E.C. 1.2.1.44) and cinnamyl alcohol dehydrogenase (CAD, E.C. 1.1.1.195) in both suberizing potato (Solanum tuberosum) tubers and lignifying loblolly pine (Pinus taeda) cell cultures. While measurable activities of PAL, 4-CL and CAD increased upon initiation of suberization in potato tubers, that of CCR did not. By contrast, all four enzymes were induced upon initiation of lignification in pine cell cultures. The lack of CCR induction in potato by wound treatment is consistent with the channelling of hydroxycinnamoyl-CoA derivatives away from monolignol formation and toward other hydroxycinnamoyl derivatives such as those that accumulate during suberization.

Non-NASA Center↗
NASA NTRS2002

Enhanced animal growth via ligand-regulated GHRH myogenic-injectable vectors

Regulated animal growth occurred following a single electroporated injection of a mixture of two plasmids (10 microg of DNA), one expressing the GeneSwitch regulator protein, the other an inducible growth hormone releasing hormone (GHRH) gene, into the tibialis anterior muscles of adult SCID mice. Administration of the ligand mifepristone (MFP) up-regulated GHRH expression, as shown by elevations of IGF-I levels, and when MFP dosing was withdrawn, IGF-I returned to baseline levels. Five cycles of IGF-I induction were observed during a five-month period. Chronic MFP dosing for 25 days increased lean body mass, weight gain, and bone mineral density significantly compared with non-MFP treated controls. In summary, long-term drug-regulated GHRH expression was achieved following plasmid-based gene therapy, and chronic induction of GHRH expression in adult animals led to improvements in weight gain and body composition.

NASA Discipline Musculoskeletal↗