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At least 865 records · Page 48

Severe Gastrointestinal Haemorrhage: Summary of a National Quality of Care Study with Focus on Radiological Services

Purpose of StudyTo identify the remediable factors in the quality of care provided to patients with severe gastrointestinal (GI) bleeding.MethodAll hospital admissions in the first four months of 2013 with ICD10 coding for GI bleeding who received a transfusion of 4 units or more of blood. Up to five cases/hospital randomly selected for structured case note peer review. National availability of GI bleeding services data derived from organisational questionnaire completed by all hospitals.Results4563/29,796 (15.3%) of GI bleeds received 4 or more units of blood with a mortality rate of 20.2% compared to 7.3% without blood transfusion. 30.8% of GI bleeds received a blood transfusion. 32% (60/185) of hospitals admitting acute GI bleeds lacked 24/7 endoscopy. 26% (48/185) had on-site embolisation 24/7 with a further 34% (64/185) accessing embolisation by transfer within a validated formal network. Blood product use was inappropriate in 20% (84/426). Improved management, principally earlier senior gastroenterologist review and/or endoscopy, would have reduced blood product use in 25% (113/457). 14.5% (90/618) had a CT scan which identified the site of bleeding in 32% (29/90). 7.8% (36/459) underwent an Interventional Radiology (IR) procedure but a further 6.3% (21/33) should have had IR. 6% (36/586) underwent surgery with 21/36 for uncontrolled bleeding. In 20/35 IR was not considered despite the majority being suitable for IR. Overall 44% (210/476) received an acceptable standard of care according to peer review.Conclusions26 recommendations were made to improve the quality of care in GI bleeding, with six principle recommendations.

62 RADIOLOGY AND NUCLEAR MEDICINE↗

Epigenetic regulation of hematopoietic stem cell aging

Aging is invariably associated with alterations of the hematopoietic stem cell (HSC) compartment, including loss of functional capacity, altered clonal composition, and changes in lineage contribution. Although accumulation of DNA damage occurs during HSC aging, it is unlikely such consistent aging phenotypes could be solely attributed to changes in DNA integrity. Another mechanism by which heritable traits could contribute to the changes in the functional potential of aged HSCs is through alterations in the epigenetic landscape of adult stem cells. Indeed, recent studies on hematopoietic stem cells have suggested that altered epigenetic profiles are associated with HSC aging and play a key role in modulating the functional potential of HSCs at different stages during ontogeny. Even small changes of the epigenetic landscape can lead to robustly altered expression patterns, either directly by loss of regulatory control or through indirect, additive effects, ultimately leading to transcriptional changes of the stem cells. Potential drivers of such changes in the epigenetic landscape of aged HSCs include proliferative history, DNA damage, and deregulation of key epigenetic enzymes and complexes. This review will focus largely on the two most characterized epigenetic marks – DNA methylation and histone modifications – but will also discuss the potential role of non-coding RNAs in regulating HSC function during aging.

60 APPLIED LIFE SCIENCES↗

Cross Section Generation Capability in Griffin

The Griffin code is a Multiphysics Object-Oriented Simulation Environment (MOOSE) based reactor multiphysics analysis application jointly developed by Idaho National Laboratory and Argonne National Laboratory. The code includes a variety of steady-state solvers for fixed-source, k-eigenvalue, adjoint, and subcritical multiplication, as well as transient solvers for point-kinetics, improved quasi-static, and spatial dynamics. The code reads multigroup cross sections in the ISOXML format generated from external deterministic or Monte Carlo cross section generation codes. The implementation of the cross section generation capability in Griffin was initiated last year by plugging in the cross section application programming interface (CSAPI) and reviewing the methodologies for treating particulate fuels. The focus this year was on improving the CSAPI integration and implementing advanced self-shielding methods for applications to advanced reactor problems with TRISO fuels. First, the process for cross section library generation was updated to accurately and rigorously produce isotopic cross section data. Second, the equivalent Dancoff factor cell method performing slowing down calculations on the fly for the resonance treatment was implemented in CSAPI to improve the accuracy of effective multigroup cross sections in the resonance energy range. Third, the iterative local spatial self-shielding method was implemented under the calculation framework of the equivalent Dancoff factor cell method to accurately deal with the double heterogeneity effect of particulate fuel. The updated CSAPI with the advanced self-shielding methods, together with the cross section libraries generated based on the improved process, were tested for pin-cell, unit-cell, and fuel assembly problems with various resonance self-shielding conditions based on very high temperature reactor, high temperature test reactor, and Empire benchmark cores, indicating that the updated CSAPI in Griffin is able to produce multigroup cross sections accurately and efficiently. We also showed that the methodology worked well for pebble bed fuel from HTR-10, but the capability still needs to be fully integrated into CSAPI. In the future, further benchmark tests will be performed for various thermal reactor core problems, including particulate fuel-based pebble bed reactors.

73 NUCLEAR PHYSICS AND RADIATION PHYSICS↗

Quantitative Assessment for Advanced Reactor Radioisotope Screening Utilizing a Heat Pipe Reactor Inventory

This report documents a method for the quantitative identification of radionuclides of potential interest for accident consequence analysis involving advanced nuclear reactors. Based on previous qualitative assessments of radionuclide inventories for advanced reactors coupled with the review of a radiological inventory developed for a heat pipe reactor, a 1 Ci activity airborne release was calculated for 137 radionuclides using the MACCS 4.1 code suite. Several assumptions regarding release conditions were made and discussed herein. The potential release of a heat pipe reactor inventory was also modeled following the same assumptions. Results provide an estimation of the relative EARLY and CHRONC phase dose contribution from advanced reactor radionuclides and are normalized to doses from equivalent releases of I-131 and Cs-137, respectively. Ultimately, a list of 69 radionuclides with EARLY or CHRONC dose contributions at least 1/100th that of I-131 or Cs-137, respectively – 48 of which are currently considered for LWR consequence analyses – was identified of being of potential importance for analyses involving a heat pipe reactor.

07 ISOTOPE AND RADIATION SOURCES↗

System Level Analysis Software Validation with Argonne's THETA Experimental Facility (Final CRADA Report)

Under this CRADA, the Contractor will be generating and collecting sodium-based experimental data with modern instrumentation. The Contractor will work symbiotically with the Participant to generate SAS4A/SASSYS-1 and SAM computational models of the THETA experimental facility for validation of the system-level analysis codes utilized by Oklo, Inc. This effort will be specifically focused on the design basis event space scoped by Chapter 15 of the NRC’s Standard Review Plan (NUREG-0800) with an emphasis on natural circulation and thermal stratification phenomena in a prototypic sodium-cooled fast reactor (SFR).

22 GENERAL STUDIES OF NUCLEAR REACTORS↗

Notice of Illegal Foreign Pesticides Entering the United States: Information Bulletin v.01

This information bulletin is intended to generate a heightened awareness of illicit pesticide importation, distribution, and use in the United States. This bulletin focuses on solid, fumigant materials which are primarily used in the production of marijuana growth and cultivation. Exposure to illicit pesticides, fumigant fumes, or residual materials may pose a public health and officer safety concern. Many illegal fumigant pesticide products have been seized and determined to consist of a mixture of several pesticides and is often in contrast with the pesticide labelling. This information bulletin is not a complete account of all illegal pesticides found in country; it serves to highlight frequently encountered materials and present patterns in product presentation, packaging, and shipment containment which are intended to aid in identification and intervention. Other varieties of illegal pesticide fumigants are known to exist, and additional variations are expected to be encountered in policing intervention. This bulletin includes information on the presentation of illegal pesticides, label review recommendations, a field reference guide, which includes example photographs of seized pesticide/fumigants and their labels, and related United States federal regulation information, including relevant tariff code information for reference.

37 INORGANIC, ORGANIC, PHYSICAL, AND ANALYTICAL CH↗

Cross Section Generation Capability in Griffin

The Griffin code is a Multiphysics Object-Oriented Simulation Environment (MOOSE) based reactor multiphysics analysis application jointly developed by Idaho National Laboratory and Argonne National Laboratory. The code includes a variety of steady-state solvers for fixed-source, k-eigenvalue, adjoint, and subcritical multiplication, as well as transient solvers for point-kinetics, improved quasi-static, and spatial dynamics. The code reads multigroup cross sections in the ISOXML format generated from external deterministic or Monte Carlo cross section generation codes. The implementation of the cross section generation capability in Griffin was initiated last year by plugging in the cross section application programming interface (CSAPI) and reviewing the methodologies for treating particulate fuels. The focus this year was on improving the CSAPI integration and implementing advanced self-shielding methods for applications to advanced reactor problems with TRISO fuels. First, the process for cross section library generation was updated to accurately and rigorously produce isotopic cross section data. Second, the on-the-fly slowing down method for the resonance treatment was implemented in CSAPI to improve the accuracy of effective multigroup cross sections in the resonance energy range. Among various on-the-fly slowing down methods, the equivalent Dancoff factor cell method was employed. Third, the iterative local spatial self-shielding method was implemented under the calculation framework of the equivalent Dancoff factor cell method to accurately deal with the double heterogeneity effect of particulate fuel. The updated CSAPI with the advanced self-shielding methods, together with the cross section libraries generated based on the improved process, were tested for the very high temperature reactor (VHTR), high temperature test reactor (HTTR), and Empire benchmark problems with various resonance self-shielding conditions, indicating that the updated CSAPI in Griffin is able to produce multigroup cross sections accurately and efficiently. We also show that the methodology works well for pebble bed fuel from HTR-10, but the capability still needs to be fully integrated into CSAPI. In the future, further benchmark tests will be performed for various thermal reactor core problems, including particulate fuel-based pebble bed reactors.

22 - GENERAL STUDIES OF NUCLEAR REACTORS↗

Report of the Technology and Test Panel

The state of technology relative to the Tethered Satellite System (TSS) was reviewed. The technology areas which could benefit from the TSS were defined. To support TSS design studies it is necessary to develop tether dynamic model computer codes for definition of mission and tether requirements. Present major codes are very elaborate, expensive to run, and not very user friendly. An additional technology concern was related to the manufacturing of tethers. The development of complex tethers (nonconducting-taper/double taper long 100 km, conducting-embedded conduction, fiber optics, and superconducting) and their applications to space stations requires the development of manufacturing capabilities for both Earth-based as well as space-based systems.

Siemers, P.↗

Recent advances in methods for numerical solution of O.D.E. initial value problems

In the mathematical modeling of physical systems, it is often necessary to solve an initial value problem (IVP), consisting of a system of ordinary differential equations (ODE). A typical program produces approximate solutions at certain mesh points. Almost all existing codes try to control the local truncation error, while the user is really interested in controlling the true or global error. The present investigation provides a review of recent advances regarding the solution of the IVP, giving particular attention to stiff systems. Stiff phenomena are customarily defined in terms of the eigenvalues of the Jacobian. There are, however, some difficulties connected with this approach. It is pointed out that an estimate of the Lipschitz constant proves to be a very practical way to determine the stiffness of a problem.

Bui, T. D.↗

Measurement Requirements for Improved Modeling of Arcjet Facility Flows

Current efforts to develop new reusable launch vehicles and to pursue low-cost robotic planetary missions have led to a renewed interest in understanding arc-jet flows. Part of this renewed interest is concerned with improving the understanding of arc-jet test results and the potential use of available computational-fluid- dynamic (CFD) codes to aid in this effort. These CFD codes have been extensively developed and tested for application to nonequilibrium, hypersonic flow modeling. It is envisioned, perhaps naively, that the application of these CFD codes to the simulation of arc-jet flows would serve two purposes: first. the codes would help to characterize the nonequilibrium nature of the arc-jet flows; and second. arc-jet experiments could potentially be used to validate the flow models. These two objectives are, to some extent, mutually exclusive. However, the purpose of the present discussion is to address what role CFD codes can play in the current arc-jet flow characterization effort, and whether or not the simulation of arc-jet facility tests can be used to eva1uate some of the modeling that is used to formu1ate these codes. This presentation is organized into several sections. In the introductory section, the development of large-scale, constricted-arc test facilities within NASA is reviewed, and the current state of flow diagnostics using conventional instrumentation is summarized. The motivation for using CFD to simulate arc-jet flows is addressed in the next section, and the basic requirements for CFD models that would be used for these simulations are briefly discussed. This section is followed by a more detailed description of experimental measurements that are needed to initiate credible simulations and to evaluate their fidelity in the different flow regions of an arc-jet facility. Observations from a recent combined computational and experiment.al investigation of shock-layer flows in a large-scale arc-jet facility are then used to illustrate the current state of development of diagnostic instrumentation, CFD simulations, and general knowledge in the field of arc-jet characterization. Finally, the main points are summarized and recommendations for future efforts are given.

Fletcher, Douglas G.↗

Enhancing the Remote Variable Operations in NPSS/CCDK

Many scientific applications in aerodynamics and solid mechanics are written in Fortran. Refitting these legacy Fortran codes with distributed objects can increase the code reusability. The remote variable scheme provided in NPSS/CCDK helps programmers easily migrate the Fortran codes towards a client-server platform. This scheme gives the client the capability of accessing the variables at the server site. In this paper, we review and enhance the remote variable scheme by using the operator overloading features in C++. The enhancement enables NPSS programmers to use remote variables in much the same way as traditional variables. The remote variable scheme adopts the lazy update approach and the prefetch method. The design strategies and implementation techniques are described in details. Preliminary performance evaluation shows that communication overhead can be greatly reduced.

Sang, Janche↗

Statistical mechanics in biology: how ubiquitous are long-range correlations?

The purpose of this opening talk is to describe examples of recent progress in applying statistical mechanics to biological systems. We first briefly review several biological systems, and then focus on the fractal features characterized by the long-range correlations found recently in DNA sequences containing non-coding material. We discuss the evidence supporting the finding that for sequences containing only coding regions, there are no long-range correlations. We also discuss the recent finding that the exponent alpha characterizing the long-range correlations increases with evolution, and we discuss two related models, the insertion model and the insertion-deletion model, that may account for the presence of long-range correlations. Finally, we summarize the analysis of long-term data on human heartbeats (up to 10(4) heart beats) that supports the possibility that the successive increments in the cardiac beat-to-beat intervals of healthy subjects display scale-invariant, long-range "anti-correlations" (a tendency to beat faster is balanced by a tendency to beat slower later on). In contrast, for a group of subjects with severe heart disease, long-range correlations vanish. This finding suggests that the classical theory of homeostasis, according to which stable physiological processes seek to maintain "constancy," should be extended to account for this type of dynamical, far from equilibrium, behavior.

Non-NASA Center↗

Rover Sequencing and Visualization Program

The Rover Sequencing and Visualization Program (RSVP) is the software tool for use in the Mars Exploration Rover (MER) mission for planning rover operations and generating command sequences for accomplishing those operations. RSVP combines three-dimensional (3D) visualization for immersive exploration of the operations area, stereoscopic image display for high-resolution examination of the downlinked imagery, and a sophisticated command-sequence editing tool for analysis and completion of the sequences. RSVP is linked with actual flight-code modules for operations rehearsal to provide feedback on the expected behavior of the rover prior to committing to a particular sequence. Playback tools allow for review of both rehearsed rover behavior and downlinked results of actual rover operations. These can be displayed simultaneously for comparison of rehearsed and actual activities for verification. The primary inputs to RSVP are downlink data products from the Operations Storage Server (OSS) and activity plans generated by the science team. The activity plans are high-level goals for the next day s activities. The downlink data products include imagery, terrain models, and telemetered engineering data on rover activities and state. The Rover Sequence Editor (RoSE) component of RSVP performs activity expansion to command sequences, command creation and editing with setting of command parameters, and viewing and management of rover resources. The HyperDrive component of RSVP performs 2D and 3D visualization of the rover s environment, graphical and animated review of rover-predicted and telemetered state, and creation and editing of command sequences related to mobility and Instrument Deployment Device (IDD) operations. Additionally, RoSE and HyperDrive together evaluate command sequences for potential violations of flight and safety rules. The products of RSVP include command sequences for uplink that are stored in the Distributed Object Manager (DOM) and predicted rover state histories stored in the OSS for comparison and validation of downlinked telemetry. The majority of components comprising RSVP utilize the MER command and activity dictionaries to automatically customize the system for MER activities. Thus, RSVP, being highly data driven, may be tailored to other missions with minimal effort. In addition, RSVP uses a distributed, message-passing architecture to allow multitasking, and collaborative visualization and sequence development by scattered team members.

Cooper, Brian↗

Update on Rover Sequencing and Visualization Program

The Rover Sequencing and Visualization Program (RSVP) has been updated. RSVP was reported in Rover Sequencing and Visualization Program (NPO-30845), NASA Tech Briefs, Vol. 29, No. 4 (April 2005), page 38. To recapitulate: The Rover Sequencing and Visualization Program (RSVP) is the software tool to be used in the Mars Exploration Rover (MER) mission for planning rover operations and generating command sequences for accomplishing those operations. RSVP combines three-dimensional (3D) visualization for immersive exploration of the operations area, stereoscopic image display for high-resolution examination of the downlinked imagery, and a sophisticated command-sequence editing tool for analysis and completion of the sequences. RSVP is linked with actual flight code modules for operations rehearsal to provide feedback on the expected behavior of the rover prior to committing to a particular sequence. Playback tools allow for review of both rehearsed rover behavior and downlinked results of actual rover operations. These can be displayed simultaneously for comparison of rehearsed and actual activities for verification. The primary inputs to RSVP are downlink data products from the Operations Storage Server (OSS) and activity plans generated by the science team. The activity plans are high-level goals for the next day s activities. The downlink data products include imagery, terrain models, and telemetered engineering data on rover activities and state. The Rover Sequence Editor (RoSE) component of RSVP performs activity expansion to command sequences, command creation and editing with setting of command parameters, and viewing and management of rover resources. The HyperDrive component of RSVP performs 2D and 3D visualization of the rover s environment, graphical and animated review of rover predicted and telemetered state, and creation and editing of command sequences related to mobility and Instrument Deployment Device (robotic arm) operations. Additionally, RoSE and HyperDrive together evaluate command sequences for potential violations of flight and safety rules. The products of RSVP include command sequences for uplink that are stored in the Distributed Object Manager (DOM) and predicted rover state histories stored in the OSS for comparison and validation of downlinked telemetry. The majority of components comprising RSVP utilize the MER command and activity dictionaries to automatically customize the system for MER activities.

Cooper, Brian↗

Simscape Modeling Verification in the Simulink Development Environment

The purpose of the Simulation Product Group of the Control and Data Systems division of the NASA Engineering branch at Kennedy Space Center is to provide a realtime model and simulation of the Ground Subsystems participating in vehicle launching activities. The simulation software is part of the Spaceport Command and Control System (SCCS) and is designed to support integrated launch operation software verification, and console operator training. Using Mathworks Simulink tools, modeling engineers currently build models from the custom-built blocks to accurately represent ground hardware. This is time consuming and costly due to required rigorous testing and peer reviews to be conducted for each custom-built block. Using Mathworks Simscape tools, modeling time can be reduced since there would be no custom-code developed. After careful research, the group came to the conclusion it is feasible to use Simscape's blocks in MatLab's Simulink. My project this fall was to verify the accuracy of the Crew Access Arm model developed using Simscape tools running in the Simulink development environment.

SIMSCAPE↗

Validation of MCNP Critical Benchmarks Models of Highly Enriched Uranium Cylinders

A new centralized repository of high-quality MCNP models of critical benchmark experiments is currently under development at Los Alamos National Laboratory (LANL). The benchmark experiments are described in the International Criticality Safety Benchmark Evaluation Project (ICSBEP) Handbook, and the initial set of benchmark models are derived from the Whisper Suite provided with MCNP6.2. This effort is a collaboration among the Nuclear Criticality Safety, Nuclear Data, and Monte Carlo code development/application organization at LANL. The objective is to create a current single LANL benchmark collection that includes the latest ICSBEP revision that has a formal review and revision process, is contained in an open- source repository, and utilizes new Python tools for improved input and output file review.

11 NUCLEAR FUEL CYCLE AND FUEL MATERIALS↗

Innovative Solutions To Solve Complex Radioactive Waste Management Problems In The U.S. - 2017 Richard S. Hodes, M.D. Honor Lecture Award - 17609

Ever since Wilhelm Roentgen, Henri Becquerel, and Marie Curie discovered x-rays, radioactivity, and radium, respectively, at the turn of the nineteenth century, nuclear technologies have continued to evolve and significantly enrich the quality of life for mankind. The evolution of such technologies has enabled our society to diagnose medical illnesses without the need for invasive surgeries, treat cancers, conduct research, develop new kinds of pharmaceuticals, preserve our food supply, and generate over 20% of our nation's electricity from commercial nuclear power plants. While these life-changing technologies have significantly enriched our quality of life and advanced our understanding of the sciences, they also generate radioactive waste that must be managed responsibly in a manner that protects public health. Over the past several decades, decision makers have developed a patchwork of policies to safely manage radioactive wastes-policies that are not necessarily based on the risk posed to public health, but more often on the origins of the waste and the manner in which they are defined in federal legislation. However, in the past several years, much progress has been made to better risk-inform the practices of managing Low-Level Radioactive Waste (LLW) in the United States. In 2012, the nation's first regional commercial facility for disposing of Class A, B, and C LLW since the U.S. Congress enacted the Low-Level Radioactive Waste Policy Act of 1980, as amended in 1985, was opened in Andrews County, Texas. Since then, other innovative LLW management solutions have emerged, ranging from cost-effective disposal options for wastes with very low levels of radioactivity to depleted uranium, and perhaps ultimately, for waste exceeding the concentration-based limits for Class C LLW (i.e., Greater Than Class C LLW) as specified in Title 10 of the Code of Federal Regulations (CFR), chap. 61.55. Most recently, a license application for a consolidated interim storage facility for Spent Nuclear Fuel (SNF) is currently under review by the U.S. Nuclear Regulatory Commission (NRC). Should the NRC approve the license application, SNF currently located at 12 shutdown and decommissioned nuclear reactors could be placed into interim storage in Texas. Approval of this license application would facilitate the complete decommissioning of nuclear power plants, returning them to green-fields, and allowing the local communities to re-purpose the lands for further economic development. Over the next decade, many of these waste management challenges that once seemed insurmountable may soon be transformed into a reality. As will be discussed at the award lecture, achieving such possibilities clearly aligns with the vision of creating innovative radioactive waste management solutions for our nation that were championed by the late physician and statesman, Dr. Richard S. Hodes. (authors)

12 MANAGEMENT OF RADIOACTIVE AND NON-RADIOACTIVE W↗

Codes and Standards Update: February 2019

The goal of the DOE OE Energy Storage System Safety Roadmap is to foster confidence in the safety and reliability of energy storage systems. There are three interrelated objectives to support the realization of that goal: research, codes and standards(C/S)and communication/coordination. The objective focused on C/S is "To apply research and development to support efforts that refocused on ensuring that codes and standards are available to enable the safe implementation of energy storage systems in a comprehensive, non-discriminatory and science-based manner." The following activities support that objective and realization of the goal: (a.) Review and assess C/S which affect the design, installation, and operation of energy storage systems(ESS). (b.) Identify gaps in knowledge that require research and analysis that can serve as a basis for criteria in those C/S. (c.) Identify areas in C/S that are potentially in need of revision or enhancement and can benefit from activities conducted under research and development. (d.) Develop input for new or revisions to existing C/S through individual stakeholders, facilitated task forces, or through laboratory staff supporting these efforts. The purpose of this Codes and Standards Update is to support the above activities by providing information on efforts being conducted by U.S. standards developing organizations(SDOs)and other entities that are focused on ESS safety. The information is organized relative to the scope of each document in relation to ESS from the "macro to the micro"(e.g., from overarching covering considerable scope ,to installation specific, to ESS and then ESS components). Note that more macro documents are also likely to adopt by reference more micro documents.

25 ENERGY STORAGE↗