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At least 865 records · Page 48

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NASA NTRS2001

Sympathetic restraint of respiratory sinus arrhythmia: implications for vagal-cardiac tone assessment in humans

Clinicians and experimentalists routinely estimate vagal-cardiac nerve traffic from respiratory sinus arrhythmia. However, evidence suggests that sympathetic mechanisms may also modulate respiratory sinus arrhythmia. Our study examined modulation of respiratory sinus arrhythmia by sympathetic outflow. We measured R-R interval spectral power in 10 volunteers that breathed sequentially at 13 frequencies, from 15 to 3 breaths/min, before and after beta-adrenergic blockade. We fitted changes of respiratory frequency R-R interval spectral power with a damped oscillator model: frequency-dependent oscillations with a resonant frequency, generated by driving forces and modified by damping influences. beta-Adrenergic blockade enhanced respiratory sinus arrhythmia at all frequencies (at some, fourfold). The damped oscillator model fit experimental data well (39 of 40 ramps; r = 0.86 +/- 0.02). beta-Adrenergic blockade increased respiratory sinus arrhythmia by amplifying respiration-related driving forces (P < 0.05), without altering resonant frequency or damping influences. Both spectral power data and the damped oscillator model indicate that cardiac sympathetic outflow markedly reduces heart period oscillations at all frequencies. This challenges the notion that respiratory sinus arrhythmia is mediated simply by vagal-cardiac nerve activity. These results have important implications for clinical and experimental estimation of human vagal cardiac tone.

NASA Discipline Cardiopulmonary↗

NASA NTRS2000

Mechanisms of blood pressure alterations in response to the Valsalva maneuver in postural tachycardia syndrome

The postural tachycardia syndrome (POTS) is characterized clinically by orthostatic lightheadedness and tachycardia. When these patients perform a Valsalva maneuver, there is an excessive blood pressure increment after cessation of the maneuver (phase IV) that is sometimes associated with headaches. It is not known whether excessive phase IV is due to excessive peripheral vascular tone (an alpha-adrenergic mechanism) or is a manifestation of increased beta-adrenergic tone (hyperadrenergic state). The authors undertook a pharmacologic study evaluating the effect of intravenous phentolamine (alpha-adrenergic antagonist) and propranolol (beta-adrenergic antagonist) on the different phases of the Valsalva maneuver in a group of patients with POTS and age-matched normal control subjects. Patients with POTS had mean phases, when compared with controls, that were characterized by more negative II_E (p = 0.07), smaller II_L (p = 0.04), and significantly larger phase IV (p = 0.001). The effect of phentolamine was qualitatively and quantitatively different in POTS when compared with controls. Ten mg phentolamine in controls resulted in a significant accentuation of phase II_E (p = 0.001), attenuation of phase II_L (p = 0.002), and increase of phase IV (57.6 vs 30.7 mm Hg; p = 0.025). These changes resembled those of patients with POTS at baseline. In patients with POTS, the phase II abnormalities, already present, were further accentuated (p <0.001), and phase IV became smaller (50.6 vs 73.8 mm Hg; p = 0.09). Propranolol had no significant effect on phases II_E and II_L, but significantly reduced phase IV in both controls (p <0.05) and in patients with POTS (p <0.001) and improved the headache symptoms, when present, during and after phase IV. The authors conclude that phase IV is mainly under beta-adrenergic regulation and that the exaggerated phase IV in POTS is a result of a hyperadrenergic state.

Non-NASA Center↗

NASA NTRS1992

Mechanisms of alpha 1-adrenergic vascular desensitization in conscious dogs

To investigate the mechanisms of alpha 1-adrenergic vascular desensitization, osmotic minipumps containing either saline (n = 9) or amidephrine mesylate (AMD) (n = 9), a selective alpha 1-adrenergic receptor agonist, were implanted subcutaneously in dogs with chronically implanted arterial and right atrial pressure catheters and aortic flow probes. After chronic alpha 1-adrenergic receptor stimulation, significant physiological desensitization to acute AMD challenges was observed, i.e., pressor and vasoconstrictor responses to the alpha 1-adrenergic agonist were significantly depressed (p < 0.01) compared with responses in the same dogs studied in the conscious state before pump implantation. However, physiological desensitization to acute challenges of the neurotransmitter norepinephrine (NE) (0.1 micrograms/kg per minute) in the presence of beta-adrenergic receptor blockade was not observed for either mean arterial pressure (MAP) (30 +/- 7 versus 28 +/- 5 mm Hg) or total peripheral resistance (TPR) (29.8 +/- 4.9 versus 28.9 +/- 7.3 mm Hg/l per minute). In the presence of beta-adrenergic receptor plus ganglionic blockade after AMD pump implantation, physiological desensitization to NE was unmasked since the control responses to NE (0.1 micrograms/kg per minute) before the AMD pumps were now greater (p < 0.01) than after chronic AMD administration for both MAP (66 +/- 5 versus 32 +/- 2 mm Hg) and TPR (42.6 +/- 10.3 versus 23.9 +/- 4.4 mm Hg/l per minute). In the presence of beta-adrenergic receptor, ganglionic, plus NE-uptake blockade after AMD pump implantation, desensitization was even more apparent, since NE (0.1 micrograms/kg per minute) induced even greater differences in MAP (33 +/- 5 versus 109 +/- 6 mm Hg) and TPR (28.1 +/- 1.8 versus 111.8 +/- 14.7 mm Hg/l per minute). The maximal force of contraction induced by NE in the presence or absence of endothelium was significantly decreased (p < 0.05) in vitro in mesenteric artery rings from AMD pump dogs compared with saline control dogs. Furthermore, alpha 1-adrenergic receptor density, as determined by [3H]prazosin binding in membrane preparations from vessels in the mesentery, was decreased (8.2 +/- 1.0 versus 18.4 +/- 1.4 fmol/mg protein, p < 0.001) without any change in Kd in the AMD pump dogs compared with the saline pump dogs.(ABSTRACT TRUNCATED AT 400 WORDS).

Non-NASA Center↗

NASA NTRS2023

Reconnection in a Pinch

A recently published analysis of current sheets has updated the classic Harris 1D static solution by considering multiple classes of charged particle trajectories in a generalized and dynamic current sheet. It uses a 1D PIC simulation to describe dynamic pinching and bifurcation of the current sheet. These 1D results strongly suggest that properties of the inflowing plasma, including the plasma beta, have an important effect on the equilibrium thickness of the pinched current sheet. Since 1D studies cannot describe magnetic reconnection, the time appears right to carry such 1D studies over to 2D or 3D simulations to explore current sheet thickness effects on reconnection. The Magnetospheric Multiscale Mission (MMS), with its well-resolved multipoint measurements of collisionless plasma and fields, has found that collisionless reconnection is accompanied by non-adiabatic motions of electrons that only occur in magnetic structures with a narrow scale comparable to electron inertial lengths (d e ). The recent 1D studies suggest that a plasma pinch to such scales may only occur for inflowing magnetized plasmas with relatively low plasma beta. We conclude that a parametric exploration of simulated and observed reconnection inflow conditions, particularly plasma beta, should shed light on the enablement of reconnection in collisionless plasmas.

reconnection↗

NASA NTRS1956

An Engineering Approach to the Variable Fluid Property Problem in Free Convection

An analysis is made for the variable fluid property problem for laminar free convection on an isothermal vertical flat plate. For a number of specific cases, solutions of the boundary layer equations appropriate to the variable property situation were carried out for gases and liquid mercury. Utilizing these findings, a simple and accurate shorthand procedure is presented for calculating free convection heat transfer under variable property conditions. This calculation method is well established in the heat transfer field. It involves the use of results which have been derived for constant property fluids, and of a set of rules (called reference temperatures) for extending these constant property results to variable property situations. For gases, the constant property heat transfer results are generalized to the variable property situation by replacing beta (expansion coefficient) by one over T sub infinity and evaluating the other properties at T sub r equals T sub w minus zero point thirty-eight (T sub w minus T sub infinity). For liquid mercury, the generalization may be accomplished by evaluating all the properties (including beta) at this same T sub r. It is worthwhile noting that for these fluids, the film temperature (with beta equals one over T sub infinity for gases) appears to serve as an adequate reference temperature for most applications. Results are also presented for boundary layer thickness and velocity parameters.

Gregg, J. L.↗

NASA NTRS1972

Analysis of bioelectric records and fabrication of phototype sleep analysis equipment

A computer-analysis technique was used to evaluate the changes in the waking EEGs of 5 normal subjects which occurred during the oral administration of flurazepam hydrochloride (Dalmane). While the subjects were receiving the drug, there was an increase in the amount of beta (14-38 c/sec) activity in fronto-central EEG leads in all 5 subjects. This increase in beta activity was characterized by a highly consistent increase in the number of waves that occurred during an EEG recording interval of fixed duration and by a less consistent increase in average wave amplitude. There was no detectable change in mean EEG wavelength (frequency) within the beta frequency range. The EEG patterns reverted to their baseline condition during 2-3 weeks after withdrawal of the drug. Analysis of the alpha, theta and delta components of the EEG indicated no changes during or following administration of the drug. This study clearly illustrates the usefulness of specific computer-analysis techniques in the characterization and quantification of sleep-promoting drugs upon the EEG of the normal young adults in the waking state. Two preamplifiers and 150 EEG monitoring caps with electrodes were delivered to MSC.

Kellaway, P.↗

NASA NTRS1971

Uranium-bearing minerals of lunar rock 12013.

The U distribution in rock 12013 was studied by fission track and elemental mapping techniques. Major U-bearing phases are whitlockite, apatite, zircon, and phase beta, which is a Zr-Ti mineral rich in Fe, Nb, Y, REE, and containing up to 3.6% UO2, 4.7% ThO2 and 4.2% PbO. Calculated microprobe ages for phase beta average 4.0 b.y. and are in reasonable agreement with Rb-Sr and K-Ar ages. Phase beta plays a significant role in the U-Th-Pb systematics of rock 12012 and may play a similar role in the model ages of lunar soil.

Haines, E. L.↗

NASA NTRS1972

Some implications of satellite spin effects in cylindrical probe measurements.

Observation that in situ measurements of ambient electron densities with satellite-borne cylindrical probes exhibit periodic variations synchronous with the satellite spin cycle. Representing these fluctuations as a superposition of effects attributable to both the presence of the satellite wake and the geomagnetic field leads to a model of the modulations of accelerated electron current to cylindrical probes in which one modulation component displays current variations dependent on the probe velocity angle (psi), and the other displays variations dependent on the angle between the probe axis and the geomagnetic-field lines (beta). The modulations produce an electron current decrease whenever the probe axis rotates into the satellite wake or whenever the probe axis rotates toward alignment with the geomagnetic-field lines. As altitude increases, the modulation dependent on psi decreases, whereas the modulation dependent on beta increases. The psi-dependent modulation component can be associated with the presence of a wake structure, and the beta-dependent component can be associated with the magnetic influence on the transport properties of thermal electrons, assuming that the electron fluxes are predominant along the field lines. The analysis results imply that the most accurate determinations of atmospheric electron densities by satellite-borne cylindrical probes come from measurements taken out of the wake of the satellite when the probe axis is within 20 deg of being perpendicular to the geomagnetic-field lines.

Miller, N. J.↗

NASA NTRS1972

Auroral emissions and particle precipitation in the noon sector.

Comparison of airborne optical measurements during December 1969 with satellite particle measurements made earlier in 1969. The latitudinal distributions of H beta, 4278-A and 6300-A emissions during quiet periods are observed to agree with what would be expected from the latitudinal distribution of particle precipitation during similar conditions. In particular, there is a belt 200 to 500 km wide (at ionospheric heights) in which the magnetosheath plasma penetrates down to low altitudes through the cusps in the dayside magnetosphere and in which both H beta and 6300-A emissions are observed. There are brighter red arcs with green lower borders within this belt. It is suggested that these are produced by narrow regions of precipitation of slightly more energetic electrons embedded in the cusp fluxes. Poleward of this belt the flux of particles is low, and the atmospheric emissions are very weak, except for occasional narrow regions of electron precipitation (without measurable protons) and the corresponding polar-cap aurora (without the H beta emission).

Heikkila, W. J.↗

NASA NTRS1973

A study of B 6 stars.

Because detailed information about the spectra of normal late B type stars is deficient, a study of the spectrum of zeta-Draconis, beta-Sextantis, and alpha-Leonis was undertaken to fill this lack and to provide data for comparison with observations of Bp stars, many of which are of late B spectral type. The study was made from high dispersion spectrograms which cover the spectral region 3100 to 6700 A, and from OAO-II spectral scans covering the spectral region 1100 to 3600 A. Profiles, equivalent widths, and central intensities of many lines in the spectrum of zeta-Draconis and of the major lines of beta-Sextantis are presented. The star alpha-Leonis rotates too rapidly for these measurements to be made from high resolution spectrograms. The star beta-Sextantis is the most massive and hottest of the three stars studied.

Underhill, A. B.↗

NASA NTRS1974

Results of transonic wind tunnel tests on an 0.015-scale space shuttle mated vehicle model (67-ots) in the LaRC 8 foot TPT (IA41)

Wind tunnel tests were conducted to obtain aerodynamic force data for Mach numbers from 0.60 to 1.20. Data were obtained for an alpha range of -10 deg to +10 deg (beta = 0 deg beta = 5 deg) and beta range of -10 deg to +10 deg (alpha = 0 deg). Longitudinal and lateral-directional stability and control data were obtained for tank alone, tank plus SRB's, tank plus Orbiter, and mated configuration of tank + Orbiter + SRB's. Also, single-component rudder hinge moment data were obtained at rudder deflections of 0 and -20 deg for each Mach number tested. Plots of aerodynamic coefficients vs. Mach number are presented, using data from both test IA41 and tests LRC-UPWT-1056, 1073 (IA42A/B) for Mach numbers of 1.60 to 4.63. The model tested in IA42A/B was the same model as tested in IA41.

Hardin, R.↗

NASA NTRS1974

Effects of anisotropic electron-ion interactions in atomic photoelectron angular distributions

The photoelectron asymmetry parameter beta in LS-coupling is obtained as an expansion into contributions from alternative angular momentum transfers j sub t. The physical significance of this expansion of beta is shown to be that: (1) the electric dipole interaction transfers to the atom a charcteristic single angular momentum j sub t = sub o, where sub o is the photoelectron's initial orbital momentum; and (2) angular momentum transfers indicate the presence of anisotropic interaction of the outgoing photoelectron with the residual ion. For open shell atoms the photoelectron-ion interaction is generally anisotropic; photoelectron phase shifts and electric dipole matrix elements depend on both the multiplet term of the residual ion and the total orbital momentum of the ion-photoelectron final state channel. Consequently beta depends on the term levels of the residual ion and contains contributions from all allowed values of j sub t. Numerical calculations of the asymmetry parameters and partial cross sections for photoionization of atomic sulfur are presented.

Dill, D.↗

NASA NTRS1974

The effect of microstructure on the fracture toughness of titanium alloys

The microstructure of the alpha titanium alloy Ti-5Al-2.5Sn and the metastable beta titanium alloy Beta 3 was examined. The material was from normal and extra low interstitial grade plates which were either air-cooled or furnace-cooled from an annealing treatment. Beta 3 was studied in alpha-aged and omega-aged plates which were heat treated to similar strength levels. Tensile and plane strain fracture toughness tests were conducted at room temperature on the alpha-aged material. The microstructure and fracture mechanisms of alloys were studied using optical metallography, electron microscopy, microprobe analyses, and texture pole figures. Future experiments are described.

Vanstone, R. H.↗

NASA NTRS1974

Study of ceramic products and processing techniques in space

An analysis of the solidification kinetics of beta alumina in a zero-gravity environment was carried out, using computer-simulation techniques, in order to assess the feasibility of producing high-quality single crystals of this material in space. The two coupled transport processes included were movement of the solid-liquid interface and diffusion of sodium atoms in the melt. Results of the simulation indicate that appreciable crystal-growth rates can be attained in space. Considerations were also made of the advantages offered by high-quality single crystals of beta alumina for use as a solid electrolyte; these clearly indicate that space-grown materials are superior in many respects to analogous terrestrially-grown crystals. Likewise, economic considerations, based on the rapidly expanding technological applications for beta alumina and related fast ionic conductors, reveal that the many superior qualities of space-grown material justify the added expense and experimental detail associated with space processing.

Markworth, A. J.↗

NASA NTRS1976

Space processing float zone thermal analysis

Thermal analysis (BETA) computer program adaptations were prepared to analyze phase change histories in crystal specimens. The first program (BETA-CYL) treats right circular cylinder configurations and the second, more general, program (BETA-BOR) treats a generalized body-of-revolution configuration. A series of computer runs were made for silicon material to determine boundary conditions which produce flat solidification interfaces while, at the same time, minimizing peak temperatures in the molten zone. Flat solidification interfaces are a goal believed by some investigators to be required to produce high quality semiconductor materials. The thermal effects of convection in a molten zone were examined and found to be negligible in comparison to the conduction heat transfer of the melt.

Pogson, J. T.↗

NASA NTRS1978

Modulational instability of finite-amplitude, circularly polarized Alfven waves

The simple theory of the decay instability of Alfven waves is strictly applicable only to a small-amplitude parent wave in a low-beta plasma, but, if the parent wave is circularly polarized, it is possible to analyze the situation without either of these restrictions. Results show that a large-amplitude circularly polarized wave is unstable with respect to decay into three waves, one longitudinal and one transverse wave propagating parallel to the parent wave and one transverse wave propagating antiparallel. The transverse decay products appear at frequencies which are the sum and difference of the frequencies of the parent wave and the longitudinal wave. The decay products are not familiar MHD modes except in the limit of small beta and small amplitude of the parent wave, in which case the decay products are a forward-propagating sound wave and a backward-propagating circularly polarized wave. In this limit the other transverse wave disappears. The effect of finite beta is to reduce the linear growth rate of the instability from the value suggested by the simple theory. Possible applications of these results to the theory of the solar wind are briefly touched upon.

Derby, N. F., Jr.↗

NASA NTRS1979

Kinetics of the phase transformation in a Ti-15Mo-5Zr-3Al alloy as studied by X-ray diffraction

The purpose of the study is to make the T-T-T diagram available and to describe the X-ray diffraction techniques used to determine the fraction of transformed phase in the Ti-15Mo-5Zr-3Al metastable beta-alloy which decomposes into the hexagonal alpha-phase and the bcc beta-phase of a higher Mo concentration. The sheet material studied for this study is not ideal for an X-ray examination because of both a rolling and annealing texture as well as grain size problems. These difficulties are overcome using special X-ray techniques. Equations are given that indicate the approximations to be accepted if pole figure data are disregarded. Lattice parameter data from the beta phase enables one to obtain an approximate phase diagram.

Rao, V. B.↗

NASA NTRS1979

The spectrum of the Becklin-Neugebauer source in Orion from 3.3 to 5.5 microns

Spectra of the Becklin-Neugebauer source in Orion and the associated nebula are presented covering the complete range from 3.3-5.5 microns with a resolution of 1.2 kaysers. The data were taken in December 1976 and February 1978. Atomic hydrogen emission lines of Brackett-alpha and Pfund-beta are seen, as well as molecular CO absorptions. No other features intrinsic to BN were detected. The December 1976 data show an anomalously high intensity for Pfund-beta line. Theoretical considerations are presented which suggest that Pfund-beta radiation arises in a small dense region, with the transition possibly lasing.

Smith, H. A.↗