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At least 865 records · Page 48
All sourcesNASA NTRSDOE OSTI
DOE OSTI2024

Associations between regional blood-brain barrier permeability, aging, and Alzheimer’s disease biomarkers in cognitively normal older adults

Background Increased blood-brain barrier permeability (BBBp) has been hypothesized as a feature of aging that may lead to the development of Alzheimer’s disease (AD). We sought to identify the brain regions most vulnerable to greater BBBp during aging and examine their regional relationship with neuroimaging biomarkers of AD. Methods We studied 31 cognitively normal older adults (OA) and 10 young adults (YA) from the Berkeley Aging Cohort Study (BACS). Both OA and YA received dynamic contrast-enhanced MRI (DCE-MRI) to quantify K trans values, as a measure of BBBp, in 37 brain regions across the cortex. The OA also received Pittsburgh compound B (PiB)-PET to create distribution volume ratios (DVR) images and flortaucipir (FTP)- PET to create partial volume corrected standardized uptake volume ratios (SUVR) images. Repeated measures ANOVA assessed the brain regions where OA showed greater BBBp than YA. In OA, K trans values were compared based on sex, Aβ positivity status, and APOE4carrier status within a composite region across the areas susceptible to aging. We used linear models and sparse canonical correlation analysis (SCCA) to examine the relationship between K trans and AD biomarkers. Results OA showed greater BBBp than YA predominately in the temporal lobe, with some involvement of parietal, occipital and frontal lobes. Within an averaged ROI of affected regions, there was no difference in K trans values based on sex or Aβ positivity, but OA who were APOE4carriers had significantly higher K trans values. There was no direct relationship between averaged K trans and global Aβ pathology, but there was a trend for an Ab status by tau interaction on K trans in this region. SCCA showed increased K trans was associated with increased PiB DVR, mainly in temporal and parietal brain regions. There was not a significant relationship between K trans and FTP SUVR. Discussion Our findings indicate that the BBB shows regional vulnerability during normal aging that overlaps considerably with the pattern of AD pathology. Greater BBBp in brain regions affected in aging is related to APOE genotype and may also be related to the pathological accumulation of Aβ.

Science & Technology - Other Topics↗
NASA NTRS1998

Wall effects observed in tissue-equivalent proportional counters from 1.05 GeV/nucleon iron-56 particles

Tissue-equivalent proportional counters (TEPCs) have been used to measure energy deposition in simulated volumes of tissue ranging in diameter from 0.1 to 10 microm. There has been some concern that the wall used to define the volume of interest could influence energy deposition within the sensitive volume because it has a density significantly greater than that of the cavity gas. These effects become important for high-velocity heavy ions. Measurements of energy deposition were made for 1 GeV/nucleon iron particles in a TEPC simulating a 1-microm-diameter sphere of tissue. The TEPC was nested within a particle spectrometer that provided identification and flight path of individual particles. Energy deposition was studied as a function of pathlength through the TEPC. Approximately 30% of the energy transfer along trajectories through the center of the detector escapes the sensitive volume. The response of the TEPC, for trajectories through the detector, is always larger than calculations for energy loss in a homogeneous medium. This enhancement is greatest for trajectories near the cavity/wall interface. An integration of the response indicates that charged-particle equilibrium is essentially achieved for a wall thickness of 2.54 mm. However, estimates of the linear energy transfer for the incident particles are influenced by these wall effects.

Non-NASA Center↗
NASA NTRS2002

Preliminary Evaluation of Polyarylate Dielectric Films for Cryogenic Applications

Polymeric materials are used extensively on spacecraft and satellites in electrical power and distribution systems, as thermal blankets and optical surface coatings, as well as mechanical support structures. The reliability of these systems when exposed to the harsh environment of space is very critical to the success of the mission and the safety of the crew in manned-flight ventures. In this work, polyarylate films were evaluated for potential use as capacitor dielectrics and wiring insulation for cryogenic applications. Two grades of the film were characterized in terms of their electrical and mechanical properties before and after exposure to liquid nitrogen (-196 C). The electrical characterization consisted of capacitance and dielectric loss measure Cents in the frequency range of 50 Hz to 100 kHz, and volume and surface resistivities. The mechanical measurements performed included changes in tensile (Young's modulus, elongation-at-break, and tensile strength) and structural properties (dimensional change, weight, and surface morphology). The preliminary results, which indicate good stability of the polymer after exposure to liquid nitrogen, are presented and discussed.

Patterson, Richard L.↗
DOE OSTI2025

Megahertz Rate Optical Diagnostics of Explosively Generated Soot

Detonation of a solid explosive produces a turbulent and luminous post‐detonation fireball containing condensed carbon soot. Diagnostics of soot dynamics are needed for model validation and to interpret emission signals. Diffuse back‐illumination extinction imaging (DBI‐EI) and laser‐induced incandescence (LII) are two common optical diagnostics for flame soot. This work extends both to measure time‐resolved soot dynamics from a 12 mm HMX hemisphere. DBI‐EI measured line‐of‐sight optical extinction exceeds 99% in some regions. Results are tomographically inverted to obtain a signal proportional to the soot volume fraction. Pulse‐burst LII measures are presented at 1 MHz. For the first time, LII results are combined with DBI‐EI extinction measurements to quantify and correct for signal trapping. Following this, spatially and temporally resolved DBI‐EI and LII measures are shown to be in reasonable agreement. Finally, experimental results are compared against recently developed simulations. Quantitative differences in the soot mixing dynamics are resolved. These findings motivate future model improvements and demonstrate ongoing needs for diagnostic advancements for heavily sooting environments.

diffuse back-illumination extinction imaging↗
NASA NTRS1988

Inflow Measurements Made with a Laser Velocimeter on a Helicopter Model in Forward Flight. Volume 1: Rectangular Planform Blades at an Advance Ration of 0.15

An experimental investigation was conducted in the 14- by 22-Foot Subsonic Tunnel at NASA Langley to measure the inflow into a scale model helicopter rotor in forward flight (microinf = 0.15). The measurements were made with a two component Laser Velocimeter (LV) one chord above the plane formed by the path of the rotor tips (tip path plane). A conditional sampling technique was employed to determine the azimuthal position of the rotor at the time each velocity measurement was made so that the azimuthal fluctuations in velocity could be determined. Measurements were made at a total of 147 separate locations in order to clearly define the inflow character. This data is presented without analysis. In order to increase the availability of the resulting data, both the mean and azimuthally dependent values are included as part of this report on two 5.25 inch floppy disks in Microsoft Corporation MS-DOS format.

Elliott, Joe W.↗
DOE OSTI2022

The CMS Magnetic Field Measuring and Monitoring Systems

This review article describes the performance of the magnetic field measuring and monitoring systems for the Compact Muon Solenoid (CMS) detector. To cross-check the magnetic flux distribution obtained with the CMS magnet model, four systems for measuring the magnetic flux density in the detector volume were used. The magnetic induction inside the 6 m diameter superconducting solenoid was measured and is currently monitored by four nuclear magnetic resonance (NMR) probes installed using special tubes outside the barrel hadron calorimeter. Two more NRM probes were installed at the faces of the tracking system. The field inside the superconducting solenoid was precisely measured in 2006 in a cylindrical volume of 3.448 m in diameter and 7 m in length using 10 three-dimensional (3D) B-sensors based on the Hall effect. These B-sensors were installed on each of the two propeller arms of an automated field-mapping machine. In addition to these measurement systems, a system for monitoring the magnetic field during the CMS detector operation has been developed. Inside the solenoid in the horizontal plane, 4 3D B-sensors were installed at the faces of the tracking detector. Twelve 3D B-sensors were installed on the surfaces of the flux-return yoke nose disks. Seventy 3D B-sensors were installed in the air gaps of the CMS magnet yoke. A specially developed flux loop technique was used for the most complex measurements of the magnetic flux density inside the steel blocks of the CMS magnet yoke. The flux loops are installed in 22 sections of the flux-return yoke blocks. The areas enclosed by these coils varied from 0.3 to 1.59 m$^{2}$ in the blocks of the barrel wheels and from 0.5 to 1.12 m$^{2}$ in the blocks of the yoke endcap disks. The development of these systems and the results of the magnetic flux density measurements across the CMS magnet are presented and discussed in this review article.

46 INSTRUMENTATION RELATED TO NUCLEAR SCIENCE AND ↗
NASA NTRS1980

The dielectric behaviour of snow: A study versus liquid water content

Snow is treated as a heterogeneous dielectric material consisting of ice, air, and water. The greater difference in the high frequency relative permittivity of dry snow and water allows to determine the liquid water content by measurements of the relative permittivity of snow. A plate condenser with a volume of about 1000 cv cm was used to measure the average liquid water content in a snow volume. Calibration was carried out using a freezing calorimeter. In order to measure the liquid water content in thin snow layers, a comb-shaped condenser was developed, which is the two dimensional analogon of the plate condenser. With this moisture meter the liquid water content was measured in layers of a few millimeters in thickness, whereby the effective depth of measurement is given by the penetration depth of electric field lines which is controlled by the spacing of the strip lines. Results of field measurements with both moisture meters, the plate condenser and the comb-shaped condenser, are given.

Ambach, W.↗
NASA NTRS1991

The analysis of a rocket tomography measurement of the N2+3914A emission and N2 ionization rates in an auroral arc

Techniques were developed for recovering two-dimensional distributions of auroral volume emission rates from rocket photometer measurements made in a tomographic spin scan mode. These tomographic inversion procedures are based upon an algebraic reconstruction technique (ART) and utilize two different iterative relaxation techniques for solving the problems associated with noise in the observational data. One of the inversion algorithms is based upon a least squares method and the other on a maximum probability approach. The performance of the inversion algorithms, and the limitations of the rocket tomography technique, were critically assessed using various factors such as (1) statistical and non-statistical noise in the observational data, (2) rocket penetration of the auroral form, (3) background sources of emission, (4) smearing due to the photometer field of view, and (5) temporal variations in the auroral form. These tests show that the inversion procedures may be successfully applied to rocket observations made in medium intensity aurora with standard rocket photometer instruments. The inversion procedures have been used to recover two-dimensional distributions of auroral emission rates and ionization rates from an existing set of N2+3914A rocket photometer measurements which were made in a tomographic spin scan mode during the ARIES auroral campaign. The two-dimensional distributions of the 3914A volume emission rates recoverd from the inversion of the rocket data compare very well with the distributions that were inferred from ground-based measurements using triangulation-tomography techniques and the N2 ionization rates derived from the rocket tomography results are in very good agreement with the in situ particle measurements that were made during the flight. Three pre-prints describing the tomographic inversion techniques and the tomographic analysis of the ARIES rocket data are included as appendices.

Mcdade, Ian C.↗
DOE OSTI2024

3013 Fire Test 2020: Post-Test Volumes

Sandia National Laboratory conducted fire tests on ten 3013 containers with varying amounts of water. The containers plastically deformed during the fire tests. The plastic deformation increased the free-gas volume within the containers. The amount of plastic deformation is measured and post-test free gas volumes at 25°C is reported.

36 MATERIALS SCIENCE↗
NASA NTRS1976

Static and wind tunnel near-field/far field jet noise measurements from model scale single-flow baseline and suppressor nozzles. Volume 2: Forward speed effects

A model scale flight effects test was conducted in the 40 by 80 foot wind tunnel to investigate the effect of aircraft forward speed on single flow jet noise characteristics. The models tested included a 15.24 cm baseline round convergent nozzle, a 20-lobe and annular nozzle with and without lined ejector shroud, and a 57-tube nozzle with a lined ejector shroud. Nozzle operating conditions covered jet velocities from 412 to 640 m/s at a total temperature of 844 K. Wind tunnel speeds were varied from near zero to 91.5 m/s. Measurements were analyzed to (1) determine apparent jet noise source location including effects of ambient velocity; (2) verify a technique for extrapolating near field jet noise measurements into the far field; (3) determine flight effects in the near and far field for baseline and suppressor nozzles; and (4) establish the wind tunnel as a means of accurately defining flight effects for model nozzles and full scale engines.

Jaeck, C. L.↗
NASA NTRS1992

Calculation of area-averaged vertical profiles of the horizontal wind velocity from volume-imaging lidar data

Area-averaged horizontal wind measurements are derived from the motion of spatial inhomogeneities in aerosol backscattering observed with a volume-imaging lidar. Spatial averaging provides high precision, reducing sample variations of wind measurements well below the level of turbulent fluctuations, even under conditions of very light mean winds and strong convection or under the difficult conditions represented by roll convection. Wind velocities are measured using the two-dimensional spatial cross correlation computed between successive horizontal plane maps of aerosol backscattering, assembled from three-dimensional lidar scans. Prior to calculation of the correlation function, three crucial steps are performed: (1) the scans are corrected for image distortion by the wind during a finite scan time; (2) a temporal high pass median filtering is applied to eliminate structures that do not move with the wind; and (3) a histogram equalization is employed to reduce biases to the brightest features.

Schols, J. L.↗
NASA NTRS1988

Inflow measurement made with a laser velocimeter on a helicopter model in forward flight. Volume 2: Rectangular planform blades at an advance ratio of 0.23

An experimental investigation was conducted in the 14- by 22-Foot Subsonic Tunnel at NASA Langley Research Center to measure the inflow into a scale model helicopter rotor in forward flight (mu sub infinity = 0.23). The measurements were made with a two-component Laser Velocimeter (LV) one chord above the plane formed by the path of the rotor tips (tip path plane). A conditional sampling technique was employed to determine the azimuthal position of the rotor at the time that each velocity measurement was made so that the azimuthal fluctuations in velocity could be determined. Measurements were made at a total of 180 separate locations in order to clearly define the inflow character. This data is presented without analysis.

Elliott, Joe W.↗
NASA NTRS1988

Inflow measurement made with a laser velocimeter on a helicopter model in forward flight. Volume 3: Rectangular planform blades at an advance ratio of 0.30

An experimental investigation was conducted in the 14- by 22-Foot Subsonic Tunnel at NASA Langley Research Center to measure the inflow into a scale model helicopter rotor in forward flight (micron sub infinity = 0.30). The measurements were made with a two component Laser Velocimeter (LV) one chord above the plane formed by the path of the rotor tips (tip path plane). A conditional sampling technique was employed to determine the azimuthal position of the rotor at the time that each velocity measurement was made so that the azimuthal fluctuations in velocity could be determined. Measurements were made at a total of 180 separate locations in order to clearly define the inflow character. These data are presented without analysis.

Elliott, Joe W.↗
NASA NTRS1988

Inflow measurements made with a laser velocimeter on a helicopter model in forward flight. Volume 4: Tapered planform blades at an advance ratio of 0.15

An experimental investigation was conducted in the 14- by 22-Foot Subsonic Tunnel at NASA Langley Research Center to measure the inflow into the scale model helicopter rotor in forward flight (mu sub infinity = 0.15). The measurements were made with a two-component Laser Velocimeter (LV) one chord above the plane formed by the path of the rotor tips (tip path plane). A conditional sampling technique was employed to determine the position of the rotor at the time that each velocity measurement was made so that the azimuthal fluctuations in velocity could be determined. Measurements were made at a total of 146 separate locations in order to clearly define the inflow character. This data is presented herein without analysis. In order to increase the availability of the resulting data, both the mean and azimuthally dependent values are included as part of this report on two 5.25 inch floppy disks in MS-DOS format.

Althoff, Susan L.↗
NASA NTRS1988

Inflow measurement made with a laser velocimeter on a helicopter model in forward flight. Volume 5: Tapered planform blades at an advance ratio of 0.23

An experimental investigation was conducted in the 14- by 22-Foot Subsonic tunnel at NASA Langley Research Center to measure the inflow into a scale model helicopter rotor in forward flight (mu sub inf = 0.23). The measurements were made with a two component Laser Velocimeter (LV) one chord above the plane formed by the path of the blade tips. A conditional sampling technique was employed to determine the position of the rotor at the time that each velocity measurement was made so that the azimuthal fluctuations in velocity could be determined. Measurements were made at a total of 168 separate locations in order to clearly define the inflow character. This data is presented without analysis. In order to increase the availability of the resulting data, both the mean and azimuthally dependenet values are included as part of this report on two 5.25 inch floppy disks in Microsoft Corporation MS-DOS format.

Althoff, Susan L.↗
DOE OSTI2021

Using bursty announcements for detecting BGP routing anomalies

Despite the robust structure of the Internet, it is still susceptible to disruptive routing updates that prevent network traffic from reaching its destination. Our research shows that BGP announcements that are associated with disruptive updates tend to occur in groups of relatively high frequency, followed by periods of infrequent activity. We hypothesize that we may use these bursty characteristics to detect anomalous routing incidents. In this work, we use manually verified ground truth metadata and volume of announcements as a baseline measure, and propose a burstiness measure that detects prior anomalous incidents with high recall and better precision than the volume baseline. We quantify the burstiness of inter-arrival times around the date and times of four large-scale incidents: the Indosat hijacking event in April 2014, the Telecom Malaysia leak in June 2015, the Bharti Airtel Ltd. hijack in November 2015, and the MainOne leak in November 2018; and three smaller scale incidents that led to traffic interception: the Belarusian traffic direction in February 2013, the Icelandic traffic direction in July 2013, and the Russian telecom that hijacked financial services in April 2017. Our method leverages the burstiness of disruptive update messages to detect these incidents. We describe limitations, open challenges, and how this method can be used for routing anomaly detection.

97 MATHEMATICS AND COMPUTING↗
NASA NTRS2000

CLUST - EVAP Monte Carlo Simulation Applications for Determining Effective Energy Deposition in Silicon by High Energy Protons

The CLUST-EVAP is a Monte Carlo simulation of the interaction of high energy (25 - 400 MeV) protons with silicon nuclei. The initial nuclear cascade stage is modeled using the CLUST model developed by Indiana University over 30 years ago. The second stage, in which the excited nucleus evaporates particles in random directions, is modeled according to the evaporation algorithm provided by H. H. K. Tang of IBM. Using the CLUST-EVAP code to model fragment produ6tion and the Vavilov-Landau theory to model fluctuations in direct ionization in thin silicon layers, we have predicted energy deposition in silicon components for various geometrical configurations. We have compared actual measurements with model predictions for geometry's such as single, thin silicon particle detectors, telescopic particle detectors flown in space to measure the environment, and thin sensitive volumes of modern micro-electronic components. We have recently compared the model predictions with actual measurements made by the DOSTEL spectrometer flown in the Shuttle payload bay on STS-84. The model faithfully reproduces the features and aids in interpretation of flight results of this instrument. We have also applied the CLUST-EVAP model to determine energy deposition in the thin sensitive volumes of modern micro-electronic components. We have accessed the ability of high energy (200 MeV) protons to induce latch-up in certain devices that are known to latch up in heavy ion environments. However, some devices are not nearly as susceptible to proton induced latch-up as expected according to their measured heavy ion latch-up cross sections. The discrepancy is believed to be caused by the limited range of the proton-silicon interaction fragments. The CLUST-EV AP model was used to determine a distribution of these fragments and their range and this is compared to knowledge of the ranges required based on the known device structure. This information is especially useful in accessing the risk to on-orbit perfonnance in a heavy ion environment based on testing performed with only protons.

ONeill, Pat M.↗
DOE OSTI2022

Unveiling four decades of intensifying precipitation from tropical cyclones using satellite measurements

Increases in precipitation rates and volumes from tropical cyclones (TCs) caused by anthropogenic warming are predicted by climate modeling studies and have been identified in several high intensity storms occurring over the last half decade. However, it has been difficult to detect historical trends in TC precipitation at time scales long enough to overcome natural climate variability because of limitations in existing precipitation observations. We introduce an experimental global high-resolution climate data record of precipitation produced using infrared satellite imagery and corrected at the monthly scale by a gauge-derived product that shows generally good performance during two hurricane case studies but estimates higher mean precipitation rates in the tropics than the evaluation datasets. General increases in mean and extreme rainfall rates during the study period of 1980–2019 are identified, culminating in a 12–18%/40-year increase in global rainfall rates. Overall, all basins have experienced intensification in precipitation rates. Increases in rainfall rates have boosted the mean precipitation volume of global TCs by 7–15% over 40 years, with the starkest rises seen in the North Atlantic, South Indian, and South Pacific basins (maximum 59–64% over 40 years). In terms of inland rainfall totals, year-by-year trends are generally positive due to increasing TC frequency, slower decay over land, and more intense rainfall, with an alarming increase of 81–85% seen from the strongest global TCs. As the global trend in precipitation rates follows expectations from warming sea surface temperatures (11.1%/°C), we hypothesize that the observed trends could be a result of anthropogenic warming creating greater concentrations of water vapor in the atmosphere, though retrospective studies of TC dynamics over the period are needed to confirm.

54 ENVIRONMENTAL SCIENCES↗