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At least 865 records · Page 48
All sourcesNASA NTRSDOE OSTI
NASA NTRS1976

Studies in neuroendocrine pharmacology

The expertise and facilities available within the Medical Sciences Program section on Pharmacology were used along with informational input from various NASA sources to study areas relevant to the manned space effort. Topics discussed include effects of drugs on deprivation-induced fluid consumption, brain biogenic amines, biochemical responses to stressful stimuli, biochemical and behavioral pharmacology of amphetamines, biochemical and pharmacological studies of analogues to biologically active indole compounds, chemical pharmacology: drug metabolism and disposition, toxicology, and chemical methodology. Appendices include a bibliography, and papers submitted for publication or already published.

Maickel, R. P.↗
NASA NTRS1977

Effects of interior aircraft noise on speech intelligibility and annoyance

Recordings of the aircraft ambiance from ten different types of aircraft were used in conjunction with four distinct speech interference tests as stimuli to determine the effects of interior aircraft background levels and speech intelligibility on perceived annoyance in 36 subjects. Both speech intelligibility and background level significantly affected judged annoyance. However, the interaction between the two variables showed that above an 85 db background level the speech intelligibility results had a minimal effect on annoyance ratings. Below this level, people rated the background as less annoying if there was adequate speech intelligibility.

Pearsons, K. S.↗
NASA NTRS1977

Model of aircraft noise adaptation

Development of an aircraft noise adaptation model, which would account for much of the variability in the responses of subjects participating in human response to noise experiments, was studied. A description of the model development is presented. The principal concept of the model, was the determination of an aircraft adaptation level which represents an annoyance calibration for each individual. Results showed a direct correlation between noise level of the stimuli and annoyance reactions. Attitude-personality variables were found to account for varying annoyance judgements.

Dempsey, T. K.↗
NASA NTRS1977

Validation of the Passenger Ride Quality Apparatus (PRQA) for simulation of aircraft motions for ride-quality research

The NASA passenger ride quality apparatus (PRQA), a ground based motion simulator, was compared to the total in flight simulator (TIFS). Tests were made on PRQA with varying stimuli: motions only; motions and noise; motions, noise, and visual; and motions and visual. Regression equations for the tests were obtained and subsequent t-testing of the slopes indicated that ground based simulator tests produced comfort change rates similar to actual flight data. It was recommended that PRQA be used in the ride quality program for aircraft and that it be validated for other transportation modes.

Bigler, W. B., II↗
NASA NTRS1977

Biorhythms and space experiments with nonhuman primates

Man's response to exposure to spaceflight and weightlessness is expressed in physiological adjustments which involve his health and ability to function. The amplitude and periodicity of fluctuations in biological processes affect various functions and responses to provocative stimuli. Primates and other species are subjected to tests to determine the consequences of an altered biorhythm on work and performance, emotional stability, biomedical evaluation in space, the ability to cope with the unexpected, and susceptibility to infection, toxicity, radiation, drugs, and stress. Factors in the environment or operational setup which can change the physiological baseline must be determined and controlled.

Winget, C. M.↗
NASA NTRS1977

Suprachiasmatic nuclei and Circadian rhythms. The role of suprachiasmatic nuclei on rhythmic activity of neurons in the lateral hypothalamic area, ventromedian nuclei and pineal gland

Unit activity of lateral hypothalamic area (LHA) and Ventromedian nuclei (VMN) was recorded in urethane anesthetized male rats. A 5 to 10 sec. a 3-5 min and a circadian rhythmicity were observed. In about 15% of all neurons, spontaneous activity of LHA and VMN showed reciprocal relationships. Subthreshold stimuli applied at a slow rate in the septum and the suprachiasmatic nuclei (SCN) suppressed the rhythms without changing firing rates. On the other hand, stimulation of the optic nerve at a rate of 5 to 10/sec increased firing rates in 1/3 of neurons of SCN. Iontophoretically applied acetylcholine increased 80% of tested neurons of SCN, whereas norepinephrine, dopamine and 5 HT inhibited 64, 60 and 75% of SCN neurons respectively. These inhibitions were much stronger in neurons, the activity of which was increased by optic nerve stimulation. Stimulation of the SCN inhibited the tonic activity in cervical sympathetic nerves.

Nishino, H.↗
NASA NTRS1977

Certain aspects of the vestibular problem in space medicine

Vestibulovegetative disorders on manned space flights are discussed. A study relating to the vestibular stimuli in respiration, diaphoresis cardiac rhythm and a broad complex of hemodynamic indices was conducted. Certain tests for astronaut candidates are discussed.

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NASA NTRS1978

A maximal chromatic expansion method of mapping multichannel imagery into color space

The author has identified the following significant results. A color film generation method that maximally expands the chromaticity and aligns Kauth brightness with the gray axis was presented. In comparison with the current LACIE film product, the new color film product has more contrast and more colors and appears to be brighter. The field boundaries in the new product were more pronounced than in the current LACIE product. The speckle effect was one problem in the new product. The yellowness speckle can be treated using an equation. This equation can be used to eliminate any speckle introduced by the greenness. This product leads logically toward another that will employ quantitative colorimetry which will account for some of the eye's perception of color stimuli.

Juday, R. D.↗
NASA NTRS1978

Influence of central venous pressure upon sinus node responses to arterial baroreflex stimulation in man

Measurements were made of sinus node responses to arterial baroreceptor stimulation with phenylephrine injection or neck suction, before and during changes of central venous pressure provoked by lower body negative pressure or leg and lower truck elevation. Variations of central venous pressure between 1.1 and 9.0 mm Hg did not influence arterial baroreflex mediated bradycardia. Baroreflex sinus node responses were augmented by intravenous propranolol, but the level of responses after propranolol was comparable during the control state, lower body negative pressure, and leg and trunk elevation. Sinus node responses to very brief baroreceptor stimuli applied during the transitions of central venous pressure also were comparable in the three states. The authors conclude that physiological variations of central venous pressure do not influence sinus node responses to arterial baroreceptor stimulation in man.

Mark, A. L.↗
NASA NTRS1978

Evaluation of postural mechanisms under dynamic conditions

A stimulus delivery and data acquisition system for assessment of human posture was developed based on a digital computer and a translating platform. The movement of the platform acts to displace the subject's base of support while the computer tracks the corrections which are made by the subject to maintain balance. Various stimuli are used ranging from fast transients to sine waves.

Anderson, D. J.↗
NASA NTRS1978

Evaluation of the annoyance due to helicopter rotor noise

A program was conducted in which 25 test subjects adjusted the levels of various helicopter rotor spectra until the combination of the harmonic noise and a broadband background noise was judged equally annoying as a higher level of the same broadband noise spectrum. The subjective measure of added harmonic noise was equated to the difference in the two levels of broadband noise. The test participants also made subjective evaluations of the rotor noise signatures which they created. The test stimuli consisted of three degrees of rotor impulsiveness, each presented at four blade passage rates. Each of these 12 harmonic sounds was combined with three broadband spectra and was adjusted to match the annoyance of three different sound pressure levels of broadband noise. Analysis of variance indicated that the important variables were level and impulsiveness. Regression analyses indicated that inclusion of crest factor improved correlation between the subjective measures and various objective or physical measures.

Sternfeld, H., Jr.↗
NASA NTRS1978

A pilot evaluation of two G-seat cueing schemes

A comparison was made of two contrasting G-seat cueing schemes. The G-seat, an aircraft simulation subsystem, creates aircraft acceleration cues via seat contour changes. Of the two cueing schemes tested, one was designed to create skin pressure cues and the other was designed to create body position cues. Each cueing scheme was tested and evaluated subjectively by five pilots regarding its ability to cue the appropriate accelerations in each of four simple maneuvers: a pullout, a pushover, an S-turn maneuver, and a thrusting maneuver. A divergence of pilot opinion occurred, revealing that the perception and acceptance of G-seat stimuli is a highly individualistic phenomena. The creation of one acceptable G-seat cueing scheme was, therefore, deemed to be quite difficult.

Showalter, T. W.↗
NASA NTRS1977

The effects of cockpit environment on long-term pilot performance

A fixed-base helicopter simulator was used to examine pilot performance as influenced by noise, vibration, and fatigue. Subjects flew the simulator for periods ranging between three and eight hours while exposed to vibrations (at 17 Hz) ranging from 0.1 to 0.3 g, and noise stimuli varying between 74 (ambient) and 100 dB. Despite reports of extreme fatigue on these long flights, subject performance did not degrade. Within the limits of this study, performance tended to improve as environmental stress increased. However, subjects did suffer from lapses resulting in abnormally poor performance. These lapses are probably of short duration (seconds) and occur at unpredictable times. If such lapses occur in actual flight, they could provide an explanation for many so-called 'pilot error' accidents.

Stave, A. M.↗
NASA NTRS1977

Adaptation to delayed auditory feedback

Delayed auditory feedback disrupts the production of speech, causing an increase in speech duration as well as many articulatory errors. To determine whether prolonged exposure to delayed auditory feedback (DAF) leads to adaptive compensations in speech production, 10 subjects were exposed in separate experimental sessions to both incremental and constant-delay exposure conditions. Significant adaptation occurred for syntactically structured stimuli in the form of increased speaking rates. After DAF was removed, aftereffects were apparent for all stimulus types in terms of increased speech rates. A carry-over effect from the first to the second experimental session was evident as long as 29 days after the first session. The use of strategies to overcome DAF and the differences between adaptation to DAF and adaptation to visual rearrangement are discussed.

Katz, D. I.↗
NASA NTRS1977

Ride quality criteria

Ride quality refers to the interior or passenger environment of a transportation system as well as the passenger response to the environment. Ride quality factors are illustrated with the aid of a diagram presenting inputs to vehicle, the vehicle transfer function, the ride environment, the passenger response function, and the passenger ride response. The reported investigation considers the ride environment as measured on a variety of air and surface vehicles, the passenger response to the environment as determined from laboratory and field surveys, and criteria/standards for vibration, noise, and combined stimuli. Attention is given to the vertical vibration characteristics in cruise for aircraft and automobile, the aircraft vibration levels for various operating regimes, comparative noise levels during cruise, the discomfort level for a 9 Hz sinusoidal vibration, equal discomfort contours for vertical vibration, subjective response to noise in a speech situation, and noise and vibration levels for constant discomfort contours.

Stephens, D. G.↗
NASA NTRS1974

Development of techniques to enhance man/machine communication

A four-state random stimulus generator, considered to function as an ESP teaching machine was used to investigate an approach to facilitating interactions between man and machines. A subject tries to guess in which of four states the machine is. The machine offers the user feedback and reinforcement as to the correctness of his choice. Using this machine, 148 volunteer subjects were screened under various protocols. Several whose learning slope and/or mean score departed significantly from chance expectation were identified. Direct physiological evidence of perception of remote stimuli not presented to any known sense of the percipient using electroencephalographic (EEG) output when a light was flashed in a distant room was also studied.

Targ, R.↗
NASA NTRS1978

Directional errors of movements and their correction in a discrete tracking task

Subjects can correct their own errors of movement more quickly than they can react to external stimuli by using three general categories of feedback: (1) knowledge of results, primarily visually mediated; (2) proprioceptive or kinaesthetic such as from muscle spindles and joint receptors, and (3) corollary discharge or efference copy within the central nervous system. The effects of these feedbacks on simple reaction time, choice reaction time, and error correction time were studied in four normal human subjects. The movement used was plantarflexion and dorsiflexion of the ankle joint. The feedback loops were modified, by changing the sign of the visual display to alter the subject's perception of results, and by applying vibration at 100 Hz simultaneously to both the agonist and antagonist muscles of the ankle joint. The central processing was interfered with when the subjects were given moderate doses of alcohol (blood alcohol concentration levels of up to 0.07%). Vibration and alcohol increase both the simple and choice reaction times but not the error correction time.

Jaeger, R. J.↗
NASA NTRS1978

NASA-UK STAP: A technology applications program to aid government and industry in Kentucky

There is a need for a well-defined partnership between universities, and the business and industrial community to promote the transfer of technology. In an effort to foster such a partnership, the Space Systems Program, administered by NASA, has established information dissemination centers in cooperation with various universities throughout the country. As a result of limited success in the transfer of technology to state and local units of government NASA felt that new stimuli and new approaches were needed in the public sector area. NASA selected the University of Kentucky, a land grant institution with a significant research dissemination and service role, as the site for the new program. An annual report of this program at the University of Kentucky is presented.

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