Synthesis of N{sup 1},N{sup 1},N{sup 3},N{sup 3}-tetrasubstituted diethylenetriamines
Preparative procedures for the synthesis of N{sup 1},N{sup 1},N{sup 3},N{sup 3}-tetrasubstituted diethylenetriamines via aminoalkylation of N,N-disubstituted ethylenediamines with N,N-disubstituted 2-chloroethylamines were developed. Aminoalkylation of N,N-dimethylethylenediamine under heating gave simultaneously secondary N{sup 1},N{sup 1},N{sup 3},N{sup 3}-tetrasubstituted diethylenetriamines and quaternary ammonium salts, N-(2-aminoethyl)-N-(2-dialkylaminoethyl)-N,N-dimethylammonium chlorides. Structures of the synthesized compounds were established by IR spectroscopy, {sup 1}H and {sup 13}C NMR spectroscopy, and electrospray ionization mass spectrometry.