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Search indexed NASA NTRS and DOE OSTI research on propulsion, heat transfer, battery materials and energy systems. Follow report and document links to the original sources.

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At least 865 records · Page 48
All sourcesNASA NTRSDOE OSTI
NASA NTRS1988

The Advice Taker/Inquirer, a system for high-level acquisition of expert knowledge

The Advice Taker/Inquirer (AT/I) is a domain-independent program that is used to construct, monitor, and improve an expert system. In the learning phase, an expert teaches a strategy to the AT/I by providing it with declarative and procedural knowledge, expressed in the expert's domain-specific vocabulary. The expert can modify any advice given to the system earlier, and any advice dependent on the altered advice is reviewed automatically for syntactic and sematic soundness. Knowledge acquisition and methods for ensuring the integrity of the knowledge base in an expert system is discussed.

Cromp, Robert F.↗
DOE OSTI2022

A Novel DNA Repair Gene Signature for Immune Checkpoint Inhibitor-Based Therapy in Gastric Cancer

Gastric cancer is a heterogeneous group of diseases with only a fraction of patients responding to immunotherapy. The relationships between tumor DNA damage response, patient immune system and immunotherapy have recently attracted attention. Accumulating evidence suggests that DNA repair landscape is a significant factor in driving response to immune checkpoint blockade (ICB) therapy. In this study, to explore new prognostic and predictive biomarkers for gastric cancer patients who are sensitive and responsive to immunotherapies, we developed a novel 15-DNA repair gene signature (DRGS) and its related scoring system and evaluated the efficiency of the DRGS in discriminating different molecular and immune characteristics and therapeutic outcomes of patients with gastric adenocarcinoma, using publicly available datasets. The results demonstrated that DRGS high score patients showed significantly better therapeutic outcomes for ICB compared to DRGS low score patients (p < 0.001). Integrated analysis of multi-omics data demonstrated that the patients with high DRGS score were characteristic of high levels of anti-tumor lymphocyte infiltration, tumor mutation burden (TMB) and PD-L1 expression, and these patients exhibited a longer overall survival, as compared to the low-score patients. Results obtained from HPA and IHC supported significant dysregulation of the genes in DRGS in gastric cancer tissues, and a positive correlation in protein expression between DRGS and PD-L1. Therefore, the DRGS scoring system may have implications in tailoring immunotherapy in gastric cancers. A preprint has previously been published (Yuan et al., 2021).

60 APPLIED LIFE SCIENCES↗
NASA NTRS1977

Photometry of the Gallilean satellites

The dependence of the magnitudes and colors on both solar and orbital phase angles is derived from photometric observations of the Gallilean satellites. The rotational variations are best defined by the most recent observations; as a consequence of the complex albedo distributions on the satellites, the light curves cannot be represented by simple analytic expressions. The recent data also establish the mean magnitudes on the V photometric system to within + or - 0.02 magnitude and permit accurate geometric albedos to be derived. The dependence of magnitude on solar phase angle, and particularly at very small phase angles, is best shown by the extensive observations from 1926 and 1927. The determined rotational curves are used to reduce these data and express the phase effect in terms of a linear curve for phase angles greater than 6 deg and a quadratic curve for smaller angles. The phase dependence of these satellites is compared with that observed for other small bodies in the solar system; particularly interesting are the anomalously large phase coefficient and opposition effect of Io.

Morrison, D.↗
NASA NTRS2004

Generative Representations for Computer-Automated Design Systems

With the increasing computational power of Computers, software design systems are progressing from being tools for architects and designers to express their ideas to tools capable of creating designs under human guidance. One of the main limitations for these computer-automated design programs is the representation with which they encode designs. If the representation cannot encode a certain design, then the design program cannot produce it. Similarly, a poor representation makes some types of designs extremely unlikely to be created. Here we define generative representations as those representations which can create and reuse organizational units within a design and argue that reuse is necessary for design systems to scale to more complex and interesting designs. To support our argument we describe GENRE, an evolutionary design program that uses both a generative and a non-generative representation, and compare the results of evolving designs with both types of representations.

Hornby, Gregory S.↗
DOE OSTI2025

Structural analysis of the NifL-NifA complex reveals the molecular basis of anti-activation of nitrogen fixation gene expression in Azotobacter vinelandii

Understanding the molecular basis of regulated nitrogen (N 2 ) fixation is essential for engineering N 2 -fixing bacteria that fulfill the demand of crop plants for fixed nitrogen, reducing our reliance on synthetic nitrogen fertilizers. In Azotobacter vinelandii and many other members of Proteobacteria, the two-component system comprising the anti-activator protein (NifL) and the Nif-specific transcriptional activator (NifA)controls the expression of nif genes, encoding the nitrogen fixation machinery. The NifL-NifA system evolved the ability to integrate several environmental cues, such as oxygen, nitrogen, and carbon availability. The nitrogen fixation machinery is thereby only activated under strictly favorable conditions, enabling diazotrophs to thrive in competitive environments. While genetic and biochemical studies have enlightened our understanding of how NifL represses NifA, the molecular basis of NifA sequestration by NifL depends on structural information on their interaction. Here, we present mechanistic insights into how nitrogen fixation is regulated by combining biochemical and genetic approaches with a low-resolution cryo-electron microscopy (cryo-EM) map of the oxidized NifL-NifA complex. Our findings define the interaction surface between NifL and NifA and reveal how this interaction can be manipulated to generate bacterial strains with increased nitrogen fixation rates able to secrete surplus nitrogen outside the cell, a crucial step in engineering improved nitrogen delivery to crop plants.

59 BASIC BIOLOGICAL SCIENCES↗
NASA NTRS2016

Network Security via Biometric Recognition of Patterns of Gene Expression

Molecular biology provides the ability to implement forms of information and network security completely outside the bounds of legacy security protocols and algorithms. This paper addresses an approach which instantiates the power of gene expression for security. Molecular biology provides a rich source of gene expression and regulation mechanisms, which can be adopted to use in the information and electronic communication domains. Conventional security protocols are becoming increasingly vulnerable due to more intensive, highly capable attacks on the underlying mathematics of cryptography. Security protocols are being undermined by social engineering and substandard implementations by IT (Information Technology) organizations. Molecular biology can provide countermeasures to these weak points with the current security approaches. Future advances in instruments for analyzing assays will also enable this protocol to advance from one of cryptographic algorithms to an integrated system of cryptographic algorithms and real-time assays of gene expression products.

cybersecurity↗
NASA NTRS2022

Towards Self-Adaptive Game Logic

Self-adaptive systems (SAS) can reconfigure at run time in response to changing situations to express acceptable behaviors in the face of uncertainty. With respect to game design, such situations may include user input, emergent behaviors, performance concerns, and combinations thereof. Typically an SAS is modeled as a feedback loop that functions within an existing system, with operations including monitoring, analyzing, planning, and executing (i.e., MAPE-K) to enable online reconfiguration. This paper presents a conceptual approach for extending software engineering artifacts to be self-adaptive within the context of game design. We have modified a game developed for creative coding education to include a MAPE-K self-adaptive feedback loop, comprising run-time adaptation capabilities and the software artifacts required to support adaptation.

Erik M. Fredericks↗
DOE OSTI2023

A Multi-Qubit Quantum Gate Using the Zeno Effect

The Zeno effect, in which repeated observation freezes the dynamics of a quantum system, stands as an iconic oddity of quantum mechanics. When a measurement is unable to distinguish between states in a subspace, the dynamics within that subspace can be profoundly altered, leading to non-trivial behavior. Here we show that such a measurement can turn a non-interacting system with only single-qubit control into a two- or multi-qubit entangling gate, which we call a Zeno gate. The gate works by imparting a geometric phase on the system, conditioned on it lying within a particular nonlocal subspace. We derive simple closed-form expressions for the gate fidelity under a number of non-idealities and show that the gate is viable for implementation in circuit and cavity QED systems. More specifically, we illustrate the functioning of the gate via dispersive readout in both the Markovian and non-Markovian readout regimes, and derive conditions for longitudinal readout to ideally realize the gate.

71 CLASSICAL AND QUANTUM MECHANICS, GENERAL PHYSIC↗
NASA NTRS2003

STS-114 Crew Interviews Eileen Collins, CDR

Commander Eileen Collins of the STS-114 space mission is seen during a pre-launch interview. She answers questions about the primary goals of the mission which are to exchange the expedition six and expedition seven crews. Also, she says that a large amount of logistics will be taken up to the International Space Station. The primary payload on this mission include: 1) The Utilization and Logistics Flight-1 (ULF-1); 2) Raffaello Multi-Purpose Logistics Module (MPLM); and 3) External Stowage Platform (ESP-2) which are all explained in detail by the Commander. The Window Observational Research Facility (WORF) rack, Human Research Facility (HRF) rack, Minus Eighty Degree Laboratory Freezer (MELF) and EXPRESS rack are the Space Station equipment to be installed on the International Space Station (I.S.S.). Collins is the Intravehicular Activity (IVA) specialist for this mission who oversees the three Extravehicular Activity (EVA)'s performed by Mission Specialists Soichi Noguchi and Stephen Robinson. The three EVA's include an external camera installation, positioning devices for an ammonia system and the installation of Floating Potential Measuring Unit (FPMU). Commander Collins expresses that she wants to have a successful mission, and also wants to see the Earth from space.

Source record↗
DOE OSTI2020

Carbon fixation systems in plants and algae

Provided are methods for elevating cyclic electron transfer activity, improving carbon concentration, and enhancing carbon fixation in C3 and C4 plants, and algae, and producing biomass or other products from C3 or C4 plants, and algae, selected from among, for example, starches, oils, fatty acids, lipids, cellulose or other carbohydrates, alcohols, sugars, nutraceuticals, pharmaceuticals, fragrance and flavoring compounds, and organic acids, as well as transgenic plants produced thereby. These methods and transgenic plants and algae encompass the expression, or overexpression, of various combinations of genes that improve carbon concentrating systems in plants and algae, such as bicarbonate transport proteins, carbonic anhydrase, light driven proton pump, cyclic electron flow regulators, etc.

59 BASIC BIOLOGICAL SCIENCES↗
NASA NTRS1977

Photovoltaic, gravitationally-stabilized solid-state, satellite solar power station /GSS4PS/

The salient feature of a gravitationally-stabilized satellite solar power system (SSPS) for a photovoltaic system is that the large solar array is separated into smaller segments or subunits, joined together in a linear array oriented along the local vertical. Applicability of gravitational stabilization to the design of photovoltaic SSPS is demonstrated. Both actively controlled systems using multiple solar panels oriented to the sun and passively controlled systems requiring no sun orientation are considered and determined to be feasible. Expressions for gravity-gradient induced tension and restoring torques about the local vertical are assessed. Particular attention is directed to the applicability of solid-state approaches to the design of SSPS. It is shown that an all solid-state SSPS utilizing the LITOMIC (light-to-microwave conversion) concept is feasible but that a hybrid system employing a combination of both solid-state and cryogenic cooled low-voltage techniques to the design of the power management and distribution subsystem may also provide a solution.

Cantafio, L. J.↗
NASA NTRS1981

User's Manual: Thermal Radiation Analysis System TRASYS 2

A digital computer software system with generalized capability to solve the radiation related aspects of thermal analysis problems is presented. When used in conjunction with a generalized thermal analysis program such as the systems improved numerical differencing analyzer program, any thermal problem that can be expressed in terms of a lumped parameter R-C thermal network can be solved. The function of TRASYS is twofold. It provides: (a) Internode radiation interchange data; and (b) Incident and absorbed heat rate data from environmental radiant heat sources. Data of both types is provided in a format directly usable by the thermal analyzer programs. The system allows the user to write his own executive or driver program which organizes and directs the program library routines toward solution of each specific problem in the most expeditious manner. The user also may write his own output routines, thus the system data output can directly interface with any thermal analyzer using the R-C network concept.

Jensen, C. L.↗
NASA NTRS1988

Stability margins for Hurwitz polynomials

The authors treat the robust stability issue using the characteristic polynomial, for two different cases: first in coefficient space with respect to perturbations in the coefficient of the characteristic polynomial; and then for a control system containing perturbed parameters in the transfer function description of the plant. In coefficient space, a simple expression is first given for the l-(squared) stability margin for both the monic and nonmonic cases. Following this, a method is given to find the l(infinity) margin, and the method is extended to reveal much larger stability regions. In parameter space the authors consider all single-input (multi-output) or single-output (multi-input) systems with a fixed controller and a plant described by a set of transfer functions which are ratios of polynomials with variable coefficients. A procedure is presented to calculate the radius of the largest stability ball in the space of these variable parameters. The calculation serves as a stability margin for the control system. The formulas that result are quasi-closed-form expressions for the stability margin and are computationally efficient.

Chapellat, Herve↗
DOE OSTI2025

Partners in root nodule symbiosis respond uniquely to heavy metal stresses in a host genotype-dependent manner

Abstract The mutualistic symbiosis between legume roots and soil rhizobia culminates in the formation of root nodules, where nitrogen is fixed. Root nodule symbiosis is inhibited by heavy metal stress. In this study, we investigated the relative responses of the symbiotic partners to a non-essential heavy metal cadmium (Cd) and an essential heavy metal zinc (Zn) stress and identified patterns in gene expression. We performed dual transcriptomics in nodules, using theMedicago truncatula-Sinorhizobium melilotisymbiotic system. Phenotypes were measured in the wild-typeMedicago truncatulaand a mutant in anABCtransporter gene (Mtabcg36), which showed compromised nodule formation in control conditions and further after heavy metal treatment. We observed that the rhizobia were particularly sensitive to Zn in mutant nodules. The greatest degree of differential gene expression in the host plant were observed under Cd and Zn treatments in wild-type nodules. Most Cd-regulated host genes were also differentially regulated by Zn, revealing little discernment between an essential and a non-essential ion under increased exposure. Furthermore, the host response to both the stresses affected auxin and iron homeostasis genes in a host genotype-dependent manner. Our results suggested impaired cadmium export from the mutant nodules. These results have potential implications in agricultural management systems and bioremediation strategies.

Science & Technology - Other Topics↗
NASA NTRS1974

Geophysical, geochemical, and geological investigations of the Dunes geothermal system, Imperial Valley, California

The Dunes anomaly is a water-dominated geothermal system in the alluvium of the Salton Trough, lacking any surface expression. It was discovered by shallow-temperature gradient measurements. A 612-meter-deep test well encountered several temperature-gradient reversals, with a maximum of 105 C at 114 meters. The program involves surface geophysics, including electrical, gravity, and seismic methods, down-hole geophysics and petrophysics of core samples, isotopic and chemical studies of water samples, and petrological and geochemical studies of the cores and cuttings. The aim is (1) to determine the source and temperature history of the brines, (2) to understand the interaction between the brines and rocks, and (3) to determine the areal extent, nature, origin, and history of the geothermal system. These studies are designed to provide better definition of exploration targets for hidden geothermal anomalies and to contribute to improved techniques of exploration and resource assessment.

Elders, W. A.↗
DOE OSTI2023

Expression quantitative trait loci mapping identified PtrXB38 as a key hub gene in adventitious root development in Populus

Summary Plant establishment requires the formation and development of an extensive root system with architecture modulated by complex genetic networks. Here, we report the identification of the PtrXB38 gene as an expression quantitative trait loci (eQTL) hotspot, mapped using 390 leaf and 444 xylem Populus trichocarpa transcriptomes. Among predicted targets of this trans ‐eQTL were genes involved in plant hormone responses and root development. Overexpression of PtrXB38 in Populus led to significant increases in callusing and formation of both stem‐born roots and base‐born adventitious roots. Omics studies revealed that genes and proteins controlling auxin transport and signaling were involved in PtrXB38‐mediated adventitious root formation. Protein–protein interaction assays indicated that PtrXB38 interacts with components of endosomal sorting complexes required for transport machinery, implying that PtrXB38‐regulated root development may be mediated by regulating endocytosis pathway. Taken together, this work identified a crucial root development regulator and sheds light on the discovery of other plant developmental regulators through combining eQTL mapping and omics approaches.

54 ENVIRONMENTAL SCIENCES↗
NASA NTRS1990

The impact of NRZ data asymmetry on the performance of a space telemetry system

The telemetry data asymmetry due to rising and falling voltage transitions can cause undesired spectral components at the output of a spacecraft transmitter. The performance of a space telemetry system can potentially degrade because of these undesired components. Here, an expression is derived for the power spectral density of an asymmetric nonreturn-to-zero (NRZ) data stream. This formula is then used to investigate how the data bandwidth varies with data asymmetry. At the receiver end, the threshold levels of undesired spectral components that fall into the carrier-tracking-loop bandwidth are determined by examining the derived spectral density. Further, based on this formula, a simple technique is developed for the computation of bit signal-to-noise ratio (SNR) degradation due to data asymmetry. The telemetry bit SNR degradations derived using this technique are compared with results obtained previously and with measurements by the Electronic Systems Test Laboratory (ESTL) at the Lyndon B. Johnson Space Center.

Nguyen, T. M.↗