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At least 847 records · Page 47

Genelab: Scientific Partnerships and an Open-Access Database to Maximize Usage of Omics Data from Space Biology Experiments

NASA's mission includes expanding our understanding of biological systems to improve life on Earth and to enable long-duration human exploration of space. The GeneLab Data System (GLDS) is NASA's premier open-access omics data platform for biological experiments. GLDS houses standards-compliant, high-throughput sequencing and other omics data from spaceflight-relevant experiments. The GeneLab project at NASA-Ames Research Center is developing the database, and also partnering with spaceflight projects through sharing or augmentation of experiment samples to expand omics analyses on precious spaceflight samples. The partnerships ensure that the maximum amount of data is garnered from spaceflight experiments and made publically available as rapidly as possible via the GLDS. GLDS Version 1.0, went online in April 2015. Software updates and new data releases occur at least quarterly. As of October 2016, the GLDS contains 80 datasets and has search and download capabilities. Version 2.0 is slated for release in September of 2017 and will have expanded, integrated search capabilities leveraging other public omics databases (NCBI GEO, PRIDE, MG-RAST). Future versions in this multi-phase project will provide a collaborative platform for omics data analysis. Data from experiments that explore the biological effects of the spaceflight environment on a wide variety of model organisms are housed in the GLDS including data from rodents, invertebrates, plants and microbes. Human datasets are currently limited to those with anonymized data (e.g., from cultured cell lines). GeneLab ensures prompt release and open access to high-throughput genomics, transcriptomics, proteomics, and metabolomics data from spaceflight and ground-based simulations of microgravity, radiation or other space environment factors. The data are meticulously curated to assure that accurate experimental and sample processing metadata are included with each data set. GLDS download volumes indicate strong interest of the scientific community in these data. To date GeneLab has partnered with multiple experiments including two plant (Arabidopsis thaliana) experiments, two mice experiments, and several microbe experiments. GeneLab optimized protocols in the rodent partnerships for maximum yield of RNA, DNA and protein from tissues harvested and preserved during the SpaceX-4 mission, as well as from tissues from mice that were frozen intact during spaceflight and later dissected on the ground. Analysis of GeneLab data will contribute fundamental knowledge of how the space environment affects biological systems, and as well as yield terrestrial benefits resulting from mitigation strategies to prevent effects observed during exposure to space environments.

bioinformatics↗

Description of the insulation system for the Langley 0.3-Meter Transonic Cryogenic Tunnel

The thermal insulation system of the Langley 0.3 Meter Transonic Cryogenic Tunnel is described. The insulation system is designed to operate from room temperature down to about 77.4 K, the temperature of liquid nitrogen at 1 atmosphere. A detailed description is given of the primary insulation sytem consists of glass fiber mats, a three part vapor barrier, and a dry positive pressure purge system. Also described are several secondary insulation systems required for the test section, actuators, and tunnel supports. An appendix briefly describes the original insulation system which is considered inferior to the one presently in place. The time required for opening and closing portions of the insulation system for modification or repair to the tunnel has been reduced, typically, from a few days for the original thermal insulating system to a few hours for the present system.

Lawing, P. L.↗

Laser-photodetector timing station instruction and maintenance manual

A laser photodetector station is used for detecting the arrival of a projectile at a specific point along a ballistic range. The system can be employed on either an open or evacuated range, with small projectiles, and at hypervelocities. The setup procedures, maintenance, and system components are described.

Strader, E. A.↗

Data Management as a Cluster Middleware Centerpiece

Through earth and space modeling and the ongoing launches of satellites to gather data, NASA has become one of the largest producers of data in the world. These large data sets necessitated the creation of a Data Management System (DMS) to assist both the users and the administrators of the data. Halcyon Systems Inc. was contracted by the NASA Center for Computational Sciences (NCCS) to produce a Data Management System. The prototype of the DMS was produced by Halcyon Systems Inc. (Halcyon) for the Global Modeling and Assimilation Office (GMAO). The system, which was implemented and deployed within a relatively short period of time, has proven to be highly reliable and deployable. Following the prototype deployment, Halcyon was contacted by the NCCS to produce a production DMS version for their user community. The system is composed of several existing open source or government-sponsored components such as the San Diego Supercomputer Center s (SDSC) Storage Resource Broker (SRB), the Distributed Oceanographic Data System (DODS), and other components. Since Data Management is one of the foremost problems in cluster computing, the final package not only extends its capabilities as a Data Management System, but also to a cluster management system. This Cluster/Data Management System (CDMS) can be envisioned as the integration of existing packages.

Zero, Jose↗

Open Architecture Standard for NASA's Software-Defined Space Telecommunications Radio Systems

NASA is developing an architecture standard for software-defined radios used in space- and ground-based platforms to enable commonality among radio developments to enhance capability and services while reducing mission and programmatic risk. Transceivers (or transponders) with functionality primarily defined in software (e.g., firmware) have the ability to change their functional behavior through software alone. This radio architecture standard offers value by employing common waveform software interfaces, method of instantiation, operation, and testing among different compliant hardware and software products. These common interfaces within the architecture abstract application software from the underlying hardware to enable technology insertion independently at either the software or hardware layer. This paper presents the initial Space Telecommunications Radio System (STRS) Architecture for NASA missions to provide the desired software abstraction and flexibility while minimizing the resources necessary to support the architecture.

Reinhart, Richard C.↗

Gondola for High Altitude Planetary Science (GHAPS) Telescope Secondary Mirror Positioning Hexapod Issues and Alternatives

Active positioning of the GHAPS secondary telescope mirror is desired to correct for rigid body deflections due to temperature variations and gravity sag in the telescope structure that may impact optical performance. The current design concept for the secondary mirror mount uses a Commercial-Off -the-Shelf hexapod for mirror positioning and fine adjustment. The Hexapod specification states that motions as small as 0.1 microns along the optical axis and 2 microns perpendicular to the optical axis will cause optical aberrations that will require correction by repositioning the secondary mirror. In addition, the secondary mirror mount and positioning system must survive a 15g shock of parachute opening and landing during the instrument recovery operation. The secondary mirror positioning system must operate at a minimum specified temperature of -50 C. The telescope operates in the IR and the secondary mirror mount and positioning device is in the metering path between the primary and secondary mirrors. I2R losses in positioning system actuator devices, which may cause heating of the positioning system and secondary mirror, must be minimized due to the previously mentioned alignment sensitivity and the viewing spectrum of interest. The GHAPs project was cancelled on June 30, 2017. The purpose of this study is to address some of the issues identified with the hexapod secondary mirror positioning system and identify alternative approaches. This information may be used if the project is re-started at a later date.

Gondola Mirror Hexapo↗

System identification of the Large-Angle Magnetic Suspension Test Fixture (LAMSTF)

The Large-Angle Magnetic Suspension Test Fixture (LAMSTF), a laboratory-scale research project to demonstrate the magnetic suspension of objects over wide ranges of attitudes, has been developed. This system represents a scaled model of a planned Large-Gap Magnetic Suspension System (LGMSS). The LAMSTF consists of a small cylindrical permanent magnet suspended element which is levitated above a planar array of five electromagnets mounted in a circular configuration. The cylinder is a rigid body and can be controlled to move in five independent degrees of freedom. Six position variables are sensed indirectly by using infrared light-emitting diodes and light-receiving phototransistors. The motion of the suspended cylinder is in general nonlinear and hence only the linear, time-invariant perturbed motion about an equilibrium state is considered. One of the main challenges in this project is the control of the suspended element over a wide range of orientations. An accurate dynamic model plays an essential role in controller design. The analytical model is first derived and open-loop characteristics discussed. The system is shown to be highly unstable and requires feedback control for system identification. Projection filters are first proposed to identify the state space model from closed-loop input/output test data in the time domain. This method is then extended to identify linear systems from the frequency test data. A canonical transformation matrix is also derived to transform the identified state space model into the physical coordinate. The LAMSTF system is stabilized by using a linear quadratic regulator (LQR) feedback controller for closed-loop identification. The rate information is obtained by calculating the back difference of the sensed position signals. Only the closed-loop random input/output data are recorded. Preliminary results from numerical simulations demonstrate that the identified system model is fairly accurate from either time domain or frequency-domain data. Experiments will be performed to validate the proposed closed-loop identification algorithms.

Huang, Jen-Kuang↗

Carbon Dioxide Reduction Technology Trade Study

For long-term human missions, a closed-loop atmosphere revitalization system (ARS) is essential to minimize consumables. A carbon dioxide (CO2) reduction technology is used to reclaim oxygen (O2) from metabolic CO2 and is vital to reduce the delivery mass of metabolic O2. A key step in closing the loop for ARS will include a proper CO2 reduction subsystem that is reliable and with low equivalent system mass (ESM). Sabatier and Bosch CO2 reduction are two traditional CO2 reduction subsystems (CRS). Although a Sabatier CRS has been delivered to International Space Station (ISS) and is an important step toward closing the ISS ARS loop, it recovers only 50% of the available O2 in CO2. A Bosch CRS is able to reclaim all O2 in CO2. However, due to continuous carbon deposition on the catalyst surface, the penalties of replacing spent catalysts and reactors and crew time in a Bosch CRS are significant. Recently, technologies have been developed for recovering hydrogen (H2) from Sabatier-product methane (CH4). These include methane pyrolysis using a microwave plasma, catalytic thermal pyrolysis of CH4 and thermal pyrolysis of CH4. Further, development in Sabatier reactor designs based on microchannel and microlith technology could open up opportunities in reducing system mass and enhancing system control. Improvements in Bosch CRS conversion have also been reported. In addition, co-electrolysis of steam and CO2 is a new technology that integrates oxygen generation and CO2 reduction functions in a single system. A co-electrolysis unit followed by either a Sabatier or a carbon formation reactor based on Bosch chemistry could improve the overall competitiveness of an integrated O2 generation and CO2 reduction subsystem. This study evaluates all these CO2 reduction technologies, conducts water mass balances for required external supply of water for 1-, 5- and 10-yr missions, evaluates mass, volume, power, cooling and resupply requirements of various technologies. A system analysis and comparison among the technologies was made based on ESM, technology readiness level and reliability. Those technologies with potential were recommended for development.

Jeng, Frank F.↗

STELAR: An experiment in the electronic distribution of astronomical literature

STELAR (Study of Electronic Literature for Astronomical Research) is a Goddard-based project designed to test methods of delivering technical literature in machine readable form. To that end, we have scanned a five year span of the ApJ, ApJ Supp, AJ and PASP, and have obtained abstracts for eight leading academic journals from NASA/STI CASI, which also makes these abstracts available through the NASA RECON system. We have also obtained machine readable versions of some journal volumes from the publishers, although in many instances, the final typeset versions are no longer available. The fundamental data object for the STELAR database is the article, a collection of items associated with a scientific paper - abstract, scanned pages (in a variety of formats), figures, OCR extractions, forward and backward references, errata and versions of the paper in various formats (e.g., TEX, SGML, PostScript, DVI). Articles are uniquely referenced in the database by journal name, volume number and page number. The selection and delivery of articles is accomplished through the WAIS (Wide Area Information Server) client/server models requiring only an Internet connection. Modest modifications to the server code have made it capable of delivering the multiple data types required by STELAR. WAIS is a platform independent and fully open multi-disciplinary delivery system, originally developed by Thinking Machines Corp. and made available free of charge. It is based on the ISO Z39.50 standard communications protocol. WAIS servers run under both UNIX and VMS. WAIS clients run on a wide variety of machines, from UNIX-based Xwindows systems to MS-DOS and macintosh microcomputers. The WAIS system includes full-test indexing and searching of documents, network interface and easy access to a variety of document viewers. ASCII versions of the CASI abstracts have been formatted for display and the full test of the abstracts has been indexed. The entire WAIS database of abstracts is now available for use by the astronomical community. Enhancements of the search and retrieval system are under investigation to include specialized searches (by reference, author or keyword, as opposed to full test searches), improved handling of word stems, improvements in relevancy criteria and other retrieval techniques, such as factor spaces. The STELAR project has been assisted by the full cooperation of the AAS, the ASP, the publishers of the academic journals, librarians from GSFC, NRAO and STScI, the Library of Congress, and the University of North Carolina at Chapel Hill.

Warnock, A.↗

SolSTUS: Solar Source Thermal Upper Stage

This paper was written by members of the Utah State University (USU) Space Systems Design class, fall quarter 1993. The class is funded by NASA and administered by the University Space Research Association (USRA). The focus of the class is to give students some experience in design of space systems and as a source of original ideas for NASA. This paper is a summary of the work done by members of the Space Systems Design class during the opening phase of the course. The class was divided into groups to work on different areas of the Solar Thermal Rocket (STR) booster in order to produce a design reference mission that would identify the key design issues. The design reference mission focused upon a small satellite mission to Mars. There are several critical components in a Solar Thermal Rocket. STR's produce a very low thrust, but have a high specific impulse, meaning that they take longer to reach the desired orbit, but use a lot less fuel in doing it. The complexity of the rocket is discussed in this paper. Some of the more critical design problems discussed are: (1) the structural and optical complexity of collecting and focusing sunlight onto a specific point, (2) long term storage of fuel (liquid hydrogen), (3) attitude control while thrusting in an elliptical orbit and orienting the mirrors to collect sunlight, and (4) power and communications for the rocket and it's internal systems. The design reference mission discussed here is a very general mission to Mars. A first order trajectory design has been done and a possible basic science payload for Mars has been suggested. This paper summarizes the design reference mission (DRM) formulated by the USU students during fall quarter and identifies major design challenges that will confront the design team during the next two quarters here at USU.

Source record↗

Toward a New Generation of Agricultural System Data, Models, and Knowledge Products: State of Agricultural Systems Science

We review the current state of agricultural systems science, focusing in particular on the capabilities and limitations of agricultural systems models. We discuss the state of models relative to five different Use Cases spanning field, farm, landscape, regional, and global spatial scales and engaging questions in past, current, and future time periods. Contributions from multiple disciplines have made major advances relevant to a wide range of agricultural system model applications at various spatial and temporal scales. Although current agricultural systems models have features that are needed for the Use Cases, we found that all of them have limitations and need to be improved. We identified common limitations across all Use Cases, namely 1) a scarcity of data for developing, evaluating, and applying agricultural system models and 2) inadequate knowledge systems that effectively communicate model results to society. We argue that these limitations are greater obstacles to progress than gaps in conceptual theory or available methods for using system models. New initiatives on open data show promise for addressing the data problem, but there also needs to be a cultural change among agricultural researchers to ensure that data for addressing the range of Use Cases are available for future model improvements and applications. We conclude that multiple platforms and multiple models are needed for model applications for different purposes. The Use Cases provide a useful framework for considering capabilities and limitations of existing models and data.

Livestock models↗

Software Productivity of Field Experiments Using the Mobile Agents Open Architecture with Workflow Interoperability

We analyzed a series of ten systematically developed surface exploration systems that integrated a variety of hardware and software components. Design, development, and testing data suggest that incremental buildup of an exploration system for long-duration capabilities is facilitated by an open architecture with appropriate-level APIs, specifically designed to facilitate integration of new components. This improves software productivity by reducing changes required for reconfiguring an existing system.

Clancey, William J.↗

Credibility Assessment and Evaluation of the Astronaut Musculoskeletal Boot/Ankle Injury Scenario Using Open SIM(TM) Computational Modeling

The musculoskeletal system of astronauts is subject to physiological changes, potentially leading to injuries due to the exposure to different gravitational environments experienced during spaceflight. These injuries can occur while an astronaut is performing an extravehicular activity (EVA) in space, on lunar or planetary surfaces or while wearing a spacesuit during terrestrial training for an EVA. One area of concern are injuries occurring at the feet and ankles due to a poor fit of the spacesuit boot. These injuries can occur if the boot does not support the ankle sufficiently and the astronaut steps awkwardly, twisting the ankle or foot, during an EVA. The OpenSimTM software can assess EVA induced musculoskeletal injuries for muscle strains, ligament injuries and joint injuries. A modeling and simulation credibility assessment of the OpenSim musculoskeletal modeling and simulation procedures, applied to the boot/ankle injury scenario injury mechanisms that may occur while carrying out tasks in these environments, is performed. These modeling and simulation credibility assessments give information on the credibility of the model’s use in simulating foot/ankle related injury mechanisms.

C A Gallo↗

State space representation of the open-loop dynamics of the Space Shuttle Main Engine

A parameter and structure estimation technique for multivariable systems is used to obtain state space representation of open loop dynamics of the Space Shuttle Main Engine (SSME). The parameterization being used is both minimal and unique. The simplified linear models may be used for fault detection studies and control system design and development.

Duyar, Ahmet↗

3D Imaging with a Single-Aperture 3-mm Objective Lens: Concept, Fabrication and Test

There are many advantages to minimally invasive surgery (MIS). An endoscope is the optical system of choice by the surgeon for MIS. The smaller the incision or opening made to perform the surgery, the smaller the optical system needed. For minimally invasive neurological and skull base surgeries the openings are typically 10-mm in diameter (dime sized) or less. The largest outside diameter (OD) endoscope used is 4mm. A significant drawback to endoscopic MIS is that it only provides a monocular view of the surgical site thereby lacking depth information for the surgeon. A stereo view would provide the surgeon instantaneous depth information of the surroundings within the field of view, a significant advantage especially during brain surgery. Providing 3D imaging in an endoscopic objective lens system presents significant challenges because of the tight packaging constraints. This paper presents a promising new technique for endoscopic 3D imaging that uses a single lens system with complementary multi-bandpass filters (CMBFs), and describes the proof-of-concept demonstrations performed to date validating the technique. These demonstrations of the technique have utilized many commercial off-the-shelf (COTS) components including the ones used in the endoscope objective.

surgery↗

An Examination of Issues Related to a Europa Subsurface Component for the JIMO Mission

The Galileo Europa data set served to revolutionize our view of Europa. In particular the strong evidence of a large, cold, salty Ocean beneath 5-30 km of ice has profoundly altered the significance of Europa in our thinking, especially of context of habitability in the solar system. While much remains to be learned from spacecraft observations of several sorts, there are significant questions answerable only by in-situ techniques; these relate to the formation of Europa, the nature of its ocean, and the prospects for life in its ocean, sediments, and ice. We feel that wide-ranging discussion of an in-situ subsurface mission to Europa, as part of JIMO, should proceed. The science objective of the mission is to characterize the icy shell of Europa to resolve its provenance, estimate the composition of brine of the Europa ocean, and search for evidence of Earth-like life. Probably anyone would agree that an in-situ mission to Europa would be of great value, but he or she would also immediately take the position that such a mission is utterly impractical. We take the position here of defining the least complex mission that can nonetheless justify its cost and to argue that such a mission is realistic enough that it should be seriously considered. Our mission thinking has been: 1) Soft landing. A soft lander is required on a site sufficiently flat to offer a stable platform; no further site selectivity is required. 2) Subsurface exploration. The Europa subsurface must be examined. Surficial processes on Europa arguably have exposed the upper 200 m of shell to chemical effects from the Jovian radiation belts as well as cometary infall, etc; to examine native ice we must descend below that point to, for discussion, 300 m. At that depth we argue that the ice is characteristic of ice at depth and possibly is effectively sea ice. 3) Science data. A few simple measurements at various depths and at 300 m constitute a scientifically successful mission. Measurements would include analysis of meltwater for a few inorganic ions and amino acids and an optical examination of the borehole wall. 4) Communication. Transmission of data to an orbiter is essential, but we will constrain the landed mission to a daily communication over a few days. 5) Subsurface access. Drilling to 300 m is a significant challenge; it can be addressed by several means: Thermal Probe (Cryobot) which permits water to refreeze above the vehicle. This is our tentative choice with plutonium as the fuel to generate thermal energy for drilling and electrical power for operations. Open Hole Drill, a thermal system in which the meltwater is removed for greater thermal efficiency. Meltwater removal on Europa is both a complexity and a risk, but analysis is improved. Mechanical Drilling in which cutting or grinding generates ice chips which are removed. This is too complex at Europa temperatures. The measurement objectives for the mission will be: Obj. 1: Determine the concentration of simple inorganic salts in the Europa Ice Shell and, by extrapolation, of the ocean. These data will also validate spaceborne sensors. Obj. 2: Determine the nature and abundance of amino acids in the ice such that cometary infall material in the upper ice can be compared to material at depth. Obj. 3: Optically examine the ice to resolve inclusion structure, particulate content, and stratification. Access to 300 m depth is a significant if not audacious plan; we are aware that this has not been done on any planetary body. Our approach is the use of a plutonium heat source; to overcome Europa's surface temperature and to melt ice a significant amount of plutonium is needed, and significant shielding and other protective steps will be required. The quantity of plutonium is a key concern. The mission will require subsurface collection and processing of samples for in situ analysis, calling for a miniature, high pressure micro-sampling system designed to meet needs of instruments that require low presses for operation. The inlet system itself collects a micro-sample in the external high pressure environment, then transfers it into a protected low pressure environment for analysis.

Carsey, F. D.↗