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At least 847 records · Page 47

Binder jet additive manufacturing of ceramic heat exchangers for concentrating solar power applications with thermal energy storage in molten chlorides

Triply periodic minimal surface (TPMS) geometries can only be fabricated by additive manufacturing methods and are of interest for heat exchangers. Ceramic TPMS heat exchangers can operate at higher temperatures and pressures with superior performance and increased operating efficiencies compared to metal heat exchangers. The properties of ultra-high temperature ceramic (UHTC) materials are also favorable for heat exchangers and potentially suited to concentrated solar power (CSP) systems, such as those based on a molten chloride salt thermal energy storage (TES) medium used to heat CO 2 in a closed-loop Brayton power cycle. We intended to demonstrate binder jet additive manufacturing feasibility of a UHTC-TPMS structure by printing and sintering a null candidate. We aimed to achieve parts with a relative density ≥ 92 % of theoretical and to provide a TPMS part demonstration. The target density indicates the transition from intermediate to final stage sintering, a requirement to inhibit gas permeability and for sintering complex near net shapes to full density with sinter-HIP technology. The goal of the TPMS part demonstration was to determine if printing and sintering parameters developed from test coupons apply to the complex geometries that will eventually be used in a heat exchanger design. Our objective was to print cubic TPMS parts with a 9 cm 3 volume and sinter it without distorting and cracking. We report we were able to sinter ZrB 2 -MoSi 2 composite parts based on the Schwarz-D TPMS and achieve isotropic shrinkage up to 60 % by volume, resulting in densities ranging from 92 % to 96 % of theoretical.

36 MATERIALS SCIENCE↗

Predicting spring phenology in deciduous broadleaf forests: NEON phenology forecasting community challenge

Accurate models are important to predict how global climate change will continue to alter plant phenology and near-term ecological forecasts can be used to iteratively improve models and evaluate predictions that are made a priori. The Ecological Forecasting Initiative's National Ecological Observatory Network (NEON) Forecasting Challenge, is an open challenge to the community to forecast daily greenness values, measured through digital images collected by the PhenoCam Network at NEON sites before the data are collected. For the first round of the challenge, which is presented here, we forecasted canopy greenness throughout the spring at eight deciduous broadleaf sites to investigate when, where, and for what model type phenology forecast skill is highest. A total of 192,536 predictions were submitted, representing eighteen models, including a persistence and a day of year mean null models. We found that overall forecast skill was highest when forecasting earlier in the greenup curve compared to the end, for shorter lead times, for sites that greened up earlier, and when submitting forecasts during times other than near budburst. The models based on day of year historical mean had the highest predictive skill across the challenge period. In this first round of the challenge, by synthesizing across forecasts, we started to elucidate what factors affect the predictive skill of near-term phenology forecasts.

54 ENVIRONMENTAL SCIENCES↗

Measurement of acoustic properties of microalgae and implications for the performance of ultrasonic harvesting systems

Microalgae are a promising feedstock for biofuel production, but difficulties associated with harvesting suspended cultures contribute to the high costs of algal feedstock production. Ultrasonic harvesting has been identified as a potential low-cost technique, but limited data are available on the response of microalgae cells in the presence of an acoustic field. The acoustic radiation force acting on a cell depends upon cell size and the acoustic contrast factor (ACF) of the cell in the media. The ACF depends upon the density and compressibility of the cell and the media. Cell size and ACF were measured for Microchloropsis gaditana, Nannochloropsis oculata, Phaeodactylum tricornutum, and Chlamydomonas reinhardtii. The average ACFs, which were determined by measuring the densities and sound velocities of suspensions containing varying concentrations of cells in growth media, were 0.04 (range = 0.03–0.05) for M. gaditana, 0.02 (range = 0.01–0.04) for N. oculata, 0.05 (range = 0.04–0.07) for P. tricornutum, and 0.05 (range = 0.049–0.053) for C. reinhardtii. The ratio of the acoustic radiation force to the drag force would be highest for C. reinhardtii cells due to their larger effective radius (5.6 μm compared to 1.9–2.7 μm for the other species). The effective ACF of C. reinhardtii was also evaluated by recording the motion of cells in the presence of an acoustic field, using particle tracking velocimetry, and then modeling the recorded motion using COMSOL Multiphysics software. The result (ACF = 0.04) demonstrated agreement with the density/sound velocity meter method. Experiments with starch null sta6 mutant C. reinhardtii cells demonstrated that the effective ACF can transition from positive to zero and eventually become negative as microalgae cells accumulate lipids. Furthermore, the dynamic nature of the ACF represents an opportunity and a challenge for acoustic harvesting of algal cells.

09 BIOMASS FUELS↗

Quantum information entropies for position-dependent mass Schrödinger problem

The Shannon entropy for the position-dependent Schrödinger equation for a particle with a nonuniform solitonic mass density is evaluated in the case of a trivial null potential. The position S{sub x} and momentum S{sub p} information entropies for the three lowest-lying states are calculated. In particular, for these states, we are able to derive analytical solutions for the S{sub x} entropy as well as for the Fourier transformed wave functions, while the S{sub p} quantity is calculated numerically. We notice the behavior of the S{sub x} entropy, namely, it decreases as the mass barrier width narrows and becomes negative beyond a particular width. The negative Shannon entropy exists for the probability densities that are highly localized. The mass barrier determines the stability of the system. The dependence of S{sub p} on the width is contrary to the one for S{sub x}. Some interesting features of the information entropy densities ρ{sub s}(x) and ρ{sub s}(p) are demonstrated. In addition, the Bialynicki-Birula–Mycielski (BBM) inequality is tested for a number of states and found to hold for all the cases.

71 CLASSICAL AND QUANTUM MECHANICS, GENERAL PHYSIC↗

The Kummer tensor density in electrodynamics and in gravity

Guided by results in the premetric electrodynamics of local and linear media, we introduce on 4-dimensional spacetime the new abstract notion of a Kummer tensor density of rank four, K{sup ijkl}. This tensor density is, by definition, a cubic algebraic functional of a tensor density of rank four T{sup ijkl}, which is antisymmetric in its first two and its last two indices: T{sup ijkl}=−T{sup jikl}=−T{sup ijlk}. Thus, K∼T{sup 3}, see Eq. (46). (i) If T is identified with the electromagnetic response tensor of local and linear media, the Kummer tensor density encompasses the generalized Fresnel wave surfaces for propagating light. In the reversible case, the wave surfaces turn out to be Kummer surfaces as defined in algebraic geometry (Bateman 1910). (ii) If T is identified with the curvature tensor R{sup ijkl} of a Riemann–Cartan spacetime, then K∼R{sup 3} and, in the special case of general relativity, K reduces to the Kummer tensor of Zund (1969). This K is related to the principal null directions of the curvature. We discuss the properties of the general Kummer tensor density. In particular, we decompose K irreducibly under the 4-dimensional linear group GL(4,R) and, subsequently, under the Lorentz group SO(1,3)

71 CLASSICAL AND QUANTUM MECHANICS, GENERAL PHYSIC↗

Geometric optics for a coupling model of electromagnetic and gravitational fields

The coupling between the electromagnetic and gravitational fields results in “faster than light” photons, and then the first and third laws of geometric optics are invalid in usual spacetime. By introducing an effective spacetime, we find that the wave vector can be casted into null and then it obeys the geodesic equation, the polarization vector is perpendicular to the rays, and the number of photons is conserved. That is to say, the laws of geometric optics are valid for the modified theory in the effective spacetime. We also show that the focusing theorem of light rays for the modified theory in the effective spacetime can be cast into the usual form.

71 CLASSICAL AND QUANTUM MECHANICS, GENERAL PHYSIC↗

Strain induced novel quantum magnetotransport properties of topological insulators

Recent theoretical and experimental researches have revealed that the strained bulk HgTe can be regarded as a three-dimensional topological insulator (TI). Motivated by this, we explore the strain effects on the transport properties of the HgTe surface states, which are modulated by a weak 1D in-plane electrostatic periodic potential in the presence of a perpendicular magnetic field. We analytically derive the zero frequency (dc) diffusion conductivity for the case of quasielastic scattering in the Kubo formalism, and find that, in strong magnetic field regime, the Shubnikov–de Haas oscillations are superimposed on top of the Weiss oscillations due to the electric modulation for null and finite strain. Furthermore, the strain is shown to remove the degeneracy in inversion symmetric Dirac cones on the top and bottom surfaces. This accordingly gives rise to the splitting and mixture of Landau levels, and the asymmetric spectrum of the dc conductivity. These phenomena, not known in a conventional 2D electron gas and even in a strainless TI and graphene, are a consequence of the anomalous spectrum of surface states in a fully stained TI. These results should be valuable for electronic and spintronic applications of TIs, and thus we fully expect to see them in the further experiment. - Highlights: • The strain removes the degeneracy in inversion symmetric Dirac cones. • The strain gives rise to the splitting and mixture of the Landau levels. • The strain leads to the asymmetric spectrum of the dc conductivity. • Shubnikov de Haas oscillations are shown to be superimposed on Weiss oscillations. • Interplay between strain and electric field causes different occupancy of TI states.

71 CLASSICAL AND QUANTUM MECHANICS, GENERAL PHYSIC↗

Wormhole geometry and Noether symmetry in f(R) gravity

This paper investigates the geometry of static traversable wormhole through Noether symmetry approach in f(R) gravity. We take perfect fluid distribution and formulate symmetry generators with associated conserved quantities corresponding to general form, power-law and exponential f(R) models. In each case, we evaluate wormhole solutions using constant and variable red-shift functions. We analyze the behavior of shape function, viability of constructed f(R) model and stability of wormhole solutions graphically. The physical existence of wormhole solutions can be examined through null/weak energy conditions of perfect fluid and null energy condition of the effective energy–momentum tensor. The graphical interpretation of constructed wormhole solutions ensures the existence of physically viable and traversable wormholes for all models. It is concluded that the constructed wormholes are found to be stable in most of the cases.

71 CLASSICAL AND QUANTUM MECHANICS, GENERAL PHYSIC↗

Huygens triviality of the time-independent Schrödinger equation. Applications to atomic and high energy physics

Huygens triviality – a concept invented by Jacques Hadamard – describes an equivalence class connecting those 2nd order partial differential equations which are transformable into the wave equation. In this work it is demonstrated, that the Schrödinger equation with the time-independent Hamiltonian belongs to such an equivalence class. The wave equation is the equation for which Huygens’ principle (HP) holds. The HP was a subject of confusion in both physics and mathematics literature for a long time. Not surprisingly, the role of this principle was obscured from the beginnings of quantum mechanics causing some theoretical and experimental misunderstandings. The purpose of this work is to bring the full clarity into this topic. By doing so, we obtained a large amount of new results related to uses of Lie sphere geometry, of twistors, of Dupin cyclides, of null electromagnetic fields, of AdS-CFT correspondence, of Penrose limits, of geometric algebra, etc. in physical problems ranging from the atomic to high energy physics and cosmology.

71 CLASSICAL AND QUANTUM MECHANICS, GENERAL PHYSIC↗

Shadow of Schwarzschild–Tangherlini black holes

We study the shadow cast by the higher-dimensional Schwarzschild–Tangherlini black hole, and analytically calculate the influence of extra dimensions on the shadow of a black hole. A black hole casts a shadow as an optical appearance because of its strong gravitational field which is known to be a dark zone covered by a circle for a Schwarzschild black hole. We demonstrate that the null geodesic equation can be integrated by Hamilton–Jacobi approach, which enable us to investigate the shadow cast by the higher-dimensional Schwarzschild–Tangherlini black holes. Interestingly, it turns out that, for fixed values of the mass parameter, the shadow in higher-dimensional spacetimes are smaller when compared with four-dimensional Schwarzschild black hole. Further, the shadows of higher-dimensional Schwarzschild–Tangherlini black holes are concentric circles with radius of the circle decreases with increase in D. We visualize the photon regions and the shadows in various dimensions for different values of the parameters, and the energy emission rates are is also investigated. Our results, in the limit D=4, reduced exactly to vis-à-vis Schwarzschild black hole case.

79 ASTRONOMY AND ASTROPHYSICS↗

Geodesic motion around hairy black holes

In a recent paper Ovalle et al. (2021) it has been obtained new static black hole solutions with primary hairs by the Gravitational Decoupling. In this work we either study the geodesic motion of massive and massless particles around those solutions and restrict the values of the primary hairs by observational data. In particular, we obtain the effective potential, the innermost stable circular orbits, the marginally bounded orbit, and the periastron advance for time-like geodesics. In order to restrict the values taken by the primary hairs we explore their relationship with the rotation parameter of the Kerr black hole giving the same innermost stable circular orbit radius and give the numerical values for the supermassive black holes at Ark 564 and NGC 1365. The photon sphere and the impact parameter associated to null geodesics are also discussed.

71 CLASSICAL AND QUANTUM MECHANICS, GENERAL PHYSIC↗

A surrogate-model-based approach for estimating the first and second-order moments of offshore wind power

Power curve, the functional relationship that governs the process of converting a set of weather variables experienced by a wind turbine into electric power, is widely used in the wind industry to estimate power output for planning and operational purposes. Existing methods for power curve estimation have three main limitations: (i) they mostly rely on wind speed as the sole input, thus ignoring the secondary, yet possibly significant effects of other environmental factors, (ii) they largely overlook the complex marine environment in which offshore turbines operate, potentially compromising their value in offshore wind energy applications, and (ii) they solely focus on the first-order properties of wind power, with little (or null) information about the variation around the mean behavior, which is important for ensuring reliable grid integration, asset health monitoring, and energy storage, among others. In light of that, this study investigates the impact of several wind-and wave-related factors on offshore wind power variability, with the ultimate goal of accurately predicting its first two moments. Further, our approach couples OpenFAST—a multi-physics wind turbine simulator—with Gaussian Process (GP) regression to reveal the underlying relationships governing offshore weather-to-power conversion. We first find that a multi-input power curve which captures the combined impact of wind speed, direction, and air density, can provide double-digit improvements, in terms of prediction accuracy, relative to univariate methods which rely on wind speed as the sole explanatory variable (e.g. the standard method of bins). Wave-related variables are found not important for predicting the average power output, but interestingly, appear to be extremely relevant in describing the fluctuation of the offshore power around its mean. Tested on real-world data collected at the New York/New Jersey bight, our proposed multi-input models demonstrate a high explanatory power in predicting the first two moments of offshore wind generation, testifying their potential value to the offshore wind industry.

17 WIND ENERGY↗

Immunization with FSHβ fusion protein antigen prevents bone loss in a rat ovariectomy-induced osteoporosis model

Highlights: •A GST-FSH fusion protein was successfully expressed in E. coli. •Immunization with GST-FSH antigen can raise high-titer anti-FSH polyclonal sera. •Anti-FSH polyclonal sera can neutralize osteoclastogenic effect of FSH in vitro. •FSH immunization can prevent bone loss in a rat osteoporosis model. -- Abstract: Osteoporosis, a metabolic bone disease, threatens postmenopausal women globally. Hormone replacement therapy (HTR), especially estrogen replacement therapy (ERT), is used widely in the clinic because it has been generally accepted that postmenopausal osteoporosis is caused by estrogen deficiency. However, hypogonadal α and β estrogen receptor null mice were only mildly osteopenic, and mice with either receptor deleted had normal bone mass, indicating that estrogen may not be the only mediator that induces osteoporosis. Recently, follicle-stimulating hormone (FSH), the serum concentration of which increases from the very beginning of menopause, has been found to play a key role in postmenopausal osteoporosis by promoting osteoclastogenesis. In this article, we confirmed that exogenous FSH can enhance osteoclast differentiation in vitro and that this effect can be neutralized by either an anti-FSH monoclonal antibody or anti-FSH polyclonal sera raised by immunizing animals with a recombinant GST-FSHβ fusion protein antigen. Moreover, immunizing ovariectomized rats with the GST-FSHβ antigen does significantly prevent trabecular bone loss and thereby enhance the bone strength, indicating that a FSH-based vaccine may be a promising therapeutic strategy to slow down bone loss in postmenopausal women.

60 APPLIED LIFE SCIENCES↗

Prolyl oligopeptidase inhibition-induced growth arrest of human gastric cancer cells

Highlights: •We examined the effects of prolyl oligopeptidase (POP) inhibition on p53 null gastric cancer cell growth. •POP inhibition-induced cell growth suppression was associated with an increase in a quiescent G{sub 0} state. •POP might regulate the exit from and/or reentry into the cell cycle. -- Abstract: Prolyl oligopeptidase (POP) is a serine endopeptidase that hydrolyzes post-proline peptide bonds in peptides that are <30 amino acids in length. We recently reported that POP inhibition suppressed the growth of human neuroblastoma cells. The growth suppression was associated with pronounced G{sub 0}/G{sub 1} cell cycle arrest and increased levels of the CDK inhibitor p27{sup kip1} and the tumor suppressor p53. In this study, we investigated the mechanism of POP inhibition-induced cell growth arrest using a human gastric cancer cell line, KATO III cells, which had a p53 gene deletion. POP specific inhibitors, 3-((4-[2-(E)-styrylphenoxy]butanoyl)-L-4-hydroxyprolyl)-thiazolidine (SUAM-14746) and benzyloxycarbonyl-thioprolyl-thioprolinal, or RNAi-mediated POP knockdown inhibited the growth of KATO III cells irrespective of their p53 status. SUAM-14746-induced growth inhibition was associated with G{sub 0}/G{sub 1} cell cycle phase arrest and increased levels of p27{sup kip1} in the nuclei and the pRb2/p130 protein expression. Moreover, SUAM-14746-mediated cell cycle arrest of KATO III cells was associated with an increase in the quiescent G{sub 0} state, defined by low level staining for the proliferation marker, Ki-67. These results indicate that POP may be a positive regulator of cell cycle progression by regulating the exit from and/or reentry into the cell cycle by KATO III cells.

60 APPLIED LIFE SCIENCES↗

NHE1 deficiency in liver: Implications for non-alcoholic fatty liver disease

Highlights: • FXR, PGC1α and PPARγ levels are upregulated in NHE1 deficient livers. • NHE1 deficiency downregulates expression of pro-lipogenic genes in liver. • Chronic exposure to high-fat diet upregulates hepatic NHE1 expression. • Loss of NHE1 better preserves hepatic insulin signaling in high-fat diet-fed mice. - Abstract: Non-alcoholic fatty liver disease NAFLD is closely associated with the dysregulation of lipid homeostasis. Diet-induced hepatic steatosis, which can initiate NAFLD progression, has been shown to be dramatically reduced in mice lacking the electroneutral Na{sup +}/H{sup +} exchanger NHE1 (Slc9a1). In this study, we investigated if NHE1 deficiency had effects in liver that could contribute to the apparent protection against aberrant lipid accumulation. RT-PCR and immunoblot analyses of wild-type and NHE1-null livers revealed an expression profile that strongly suggested attenuation of both de novo lipogenesis and hepatic stellate cell activation, which is implicated in liver fibrosis. This included upregulation of the farnesoid X receptor FXR, peroxisome proliferator-activated receptor PPARγ, its co-activator PGC1α, and sestrin 2, an antioxidant protein involved in hepatic metabolic homeostasis. Furthermore, expression levels of the pro-lipogenic liver X receptor LXRα, and acetyl CoA carboxylases 1 and 2 were downregulated. These changes were associated with evidence of reduced cellular stress, which persisted even upon exposure to a high-fat diet, and the better preservation of insulin signaling, as evidenced by protein kinase B/Akt phosphorylation (Ser473). These results indicate that NHE1 deficiency may protect against NAFLD pathogenesis, which is significant given the availability of highly specific NHE1 inhibitors.

60 APPLIED LIFE SCIENCES↗

Suppression of atherosclerosis by synthetic REV-ERB agonist

The nuclear receptors for heme, REV-ERBα and REV-ERBβ, play important roles in the regulation of metabolism and inflammation. Recently it was demonstrated that reduced REV-ERBα expression in hematopoetic cells in LDL receptor null mice led to increased atherosclerosis. We sought to determine if synthetic REV-ERB agonists that we have developed might have the ability to suppress atherosclerosis in this model. A previously characterized synthetic REV-ERB agonist, SR9009, was used to determine if activation of REV-ERB activity would affect atherosclerosis in LDL receptor deficient mice. Atherosclerotic plaque size was significantly reduced (p < 0.05) in mice administered SR9009 (100 mg/kg) for seven weeks compared to control mice (n = 10 per group). SR9009 treatment of bone marrow-derived mouse macrophages (BMDM) reduced the polarization of BMDMs to proinflammatory M1 macrophage while increasing the polarization of BMDMs to anti-inflammatory M2 macrophages. Our results suggest that pharmacological targeting of REV-ERBs may be a viable therapeutic option for treatment of atherosclerosis. - Highlights: • Synthetic REV-ERB agonist treatment reduced atherosclerosis in a mouse model. • Pharmacological activation of REV-ERB decreased M1 macrophage polarization. • Pharmacological activation of REV-ERB increased M2 macrophage polarization.

60 APPLIED LIFE SCIENCES↗

Hypermethylation of MST1 in IgG4-related autoimmune pancreatitis and rheumatoid arthritis

The serine/threonine kinase Mst1 plays important roles in the control of immune cell trafficking, proliferation, and differentiation. Previously, we reported that Mst1 was required for thymocyte selection and regulatory T-cell functions, thereby the prevention of autoimmunity in mice. In humans, MST1 null mutations cause T-cell immunodeficiency and hypergammaglobulinemia with autoantibody production. RASSF5C(RAPL) is an activator of MST1 and it is frequently methylated in some tumors. Herein, we investigated methylation of the promoter regions of MST1 and RASSF5C(RAPL) in leukocytes from patients with IgG4-related autoimmune pancreatitis (AIP) and rheumatoid arthritis (RA). Increased number of CpG methylation in the 5′ region of MST1 was detected in AIP patients with extrapancreatic lesions, whereas AIP patients without extrapancreatic lesions were similar to controls. In RA patients, we detected a slight increased CpG methylation in MST1, although the overall number of methylation sites was lower than that of AIP patients with extrapancreatic lesions. There were no significant changes of the methylation levels of the CpG islands in the 5′ region of RASSF5C(RAPL) in leukocytes from AIP and RA patients. Consistently, we found a significantly down-regulated expression of MST1 in regulatory T cells of AIP patients. Our results suggest that the decreased expression of MST1 in regulatory T cells due to hypermethylation of the promoter contributes to the pathogenesis of IgG4-related AIP. - Highlights: • Mst1 controls immune cells trafficking, cell proliferation and differentiation. • Autoimmune pancreatitis (AIP) is an idiopathic pancreatitis affecting multiple organs. • Decreased MST1 expression and increased CpG methylation of promoter of MST1 in AIP. • Slight increased CpG methylation of MST1 in rheumatoid arthritis patients. • MST1 contributes pathogenesis of IgG4-related AIP.

60 APPLIED LIFE SCIENCES↗