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At least 847 records · Page 47

Preliminary Evaluation of Commercial Off the Shelf (COTS) Packing Materials for Flight Medication Dispenser (FMD) Technology Development

With the advent of longer duration space missions, pharmaceutical use in space has increased. During the first 33 space shuttle missions, crew members took more than 500 individual doses of 31 different medications . Anecdotal reports from crew members described medications as generally "well tolerated" and "effective". However, reported use of increased medication doses and discrepancies in ground vs. flight efficacy may result from reduced potency or altered bioavailability due to changes in chemical and/or physical parameters of pharmaceutical stability. Based on preliminary results from a ground-based irradiation and an inflight study on pharmaceutical stability, three susceptible medications, Amoxicillin/Clavulanate and Sulfamethoxazole/trimethoprim antibiotics tablets and promethazine (PMZ), an antihistamine were selected for testing using two types of Oliver-Tolas bags, TPC-1475(Clear) and TPF-0599B (Foil) for radiation Shielding effectiveness. The material composition of the bags included aluminum coated Mylar sheathing coated with multifunctional nanocomposities based on polyethylene with dispersed boron-rich nanophases. Two bags of each medication were irradiated for different time intervals with 14.6 rad/min to achieve 0.1 Gy, 1 Gy and 10 Gy of cumulative radiation dose. Active pharmaceutical content (API) in each medication was determined and results analyzed. No significant difference in API content was observed between control and irradiated samples for both antibiotic tablets suggesting both types of bags may offer protection against gamma radiation; results with PMZ were inconclusive. These preliminary results suggest that Oliver-Tolas TPL-1475 and TPF-0599B materials may possess characteristics suitable for protection against ionizing radiation and can be considered for designing and further testing of FMD technology.

Du, Brian↗

SLS-SPEC-159 Cross-Program Design Specification for Natural Environments (DSNE) Revision D

This document is derived from the former National Aeronautics and Space Administration (NASA) Constellation Program (CxP) document CxP 70023, titled "The Design Specification for Natural Environments (DSNE), Revision C." The original document has been modified to represent updated Design Reference Missions (DRMs) for the NASA Exploration Systems Development (ESD) Programs. The DSNE completes environment-related specifications for architecture, system-level, and lower-tier documents by specifying the ranges of environmental conditions that must be accounted for by NASA ESD Programs. To assure clarity and consistency, and to prevent requirements documents from becoming cluttered with extensive amounts of technical material, natural environment specifications have been compiled into this document. The intent is to keep a unified specification for natural environments that each Program calls out for appropriate application. This document defines the natural environments parameter limits (maximum and minimum values, energy spectra, or precise model inputs, assumptions, model options, etc.), for all ESD Programs. These environments are developed by the NASA Marshall Space Flight Center (MSFC) Natural Environments Branch (MSFC organization code: EV44). Many of the parameter limits are based on experience with previous programs, such as the Space Shuttle Program. The parameter limits contain no margin and are meant to be evaluated individually to ensure they are reasonable (i.e., do not apply unrealistic extreme-on-extreme conditions). The natural environments specifications in this document should be accounted for by robust design of the flight vehicle and support systems. However, it is understood that in some cases the Programs will find it more effective to account for portions of the environment ranges by operational mitigation or acceptance of risk in accordance with an appropriate program risk management plan and/or hazard analysis process. The DSNE is not intended as a definition of operational models or operational constraints, nor is it adequate, alone, for ground facilities which may have additional requirements (for example, building codes and local environmental constraints). "Natural environments," as the term is used here, refers to the environments that are not the result of intended human activity or intervention. It consists of a variety of external environmental factors (most of natural origin and a few of human origin) which impose restrictions or otherwise impact the development or operation of flight vehicles and destination surface systems. These natural environments include the following types of environments: Terrestrial environments at launch, abort, and normal landing sites (winds, temperatures, pressures, surface roughness, sea conditions, etc.); Space environments (ionizing radiation, orbital debris, meteoroids, thermosphere density, plasma, solar, Earth, and lunar-emitted thermal radiation, etc.); Destination environments (Lunar surface and orbital, Mars atmosphere and surface, near Earth asteroids, etc.). Many of the environmental specifications in this document are based on models, data, and environment descriptions contained in the CxP 70044, Constellation Program Natural Environment Definition for Design (NEDD). The NEDD provides additional detailed environment data and model descriptions to support analytical studies for ESD Programs. For background information on specific environments and their effects on spacecraft design and operations, the environment models, and the data used to generate the specifications contained in the DSNE, the reader is referred to the NEDD paragraphs listed in each section of the DSNE. Also, most of the environmental specifications in this document are tied specifically to the ESD DRMs in ESD-10012, Revision B, Exploration Systems Development Concept of Operations (ConOps). Coordination between these environment specifications and the DRMs must be maintained. This document should be compatible with the current ESD DRMs, but updates to the mission definitions and variations in interpretation may require adjustments to the environment specifications.

Roberts, Barry C.↗

Micro cavity fission chamber radiation detection system

A radiation detector to monitor the neutron flux of a nuclear reactor or other high-radiation environment, that can withstand the high temperatures and radiation fields of such environment, is provided. A small dielectric substrate with a low neutron-activation cross section is provided. The substrate is coated with a neutron conversion material, such as uranium oxide or thorium oxide. One or more substrates form a micro-sized detection cavity that is filled with a detection gas. A voltage is provided across anode and cathode wires in the detection cavity. A neutron absorbed in the conversion material may release reaction products into the gas, causing ionization of the gas which then produces a current or voltage signal. The small detector volume minimizes energy deposition into the detection gas by competing particles such as gamma rays, fast electrons, and beta particles, and therefore minimizes false counts while retaining large signals from neutron interactions.

McGregor, Douglas S.↗

The X-Ray Reflection Spectrum of the Radio-Loud Quasar 4C 74.26

The relativistic jets created by some active galactic nuclei are important agents of AGN feedback. In spite of this, our understanding of what produces these jets is still incomplete. X-ray observations, which can probe the processes operating in the central regions in the immediate vicinity of the supermassive black hole, the presumed jet launching point, are potentially particularly valuable in illuminating the jet formation process. Here, we present the hard X-ray NuSTAR observations of the radio-loud quasar 4C 74.26 in a joint analysis with quasi-simultaneous, soft X-ray Swift observations. Our spectral analysis reveals a high-energy cutoff of -183+3551 keV and confirms the presence of ionized reflection in the source. From the average spectrum we detect that the accretion disk is mildly recessed, with an inner radius of Rin4180 Rg. However, no significant evolution of the inner radius is seen during the three months covered by our NuSTAR campaign. This lack of variation could mean that the jet formation in this radio-loud quasar differs from what is observed in broad-line radio galaxies.

black hole physics – galaxies: active – quasar↗

GPU-Accelerated Analytic Simulation of Sparse Ionization Signal Formation in Pixelated Projection Detector

This paper presents a GPU-accelerated simulation package, TRED, for next-generation neutrino detectors with pixelated charge readout, leveraging community-driven software ecosystems to ensure adaptability and extensibility. We introduce two generic contributions: (i) an effective-charge representation based on Gaussian quadrature rules, in which the linear- interpolation factors for the field response inside each voxel are absorbed into the effective charge, and (ii) a sparse, block- binned tensor representation that enables efficient FFT-based computation of induced signals on readout electrodes for sparsely activated detector volumes. The former captures structure inside a voxel without dense sampling, while the latter achieves low memory usage and scalable runtime, as demonstrated in bench- mark studies. The underlying data representation is applicable to large-scale detectors and to other computational problems involving sparse activity.

72 PHYSICS OF ELEMENTARY PARTICLES AND FIELDS↗

Fe XXV and Fe XXVI Diagnostics of the Black Hole and Accretion Disk in Active Galaxies: Chandra Time-Resolved Spectroscopy of NGC 7314

We report the detection of Fe xxv and Fe XXVI Ka emission lines from a Chandra High Energy Grating Spectrometer (HETGS) observation of the narrow-line Seyfert 1 galaxy NGC 7314, made simultaneously with RXTE. The lines are redshifted (cz approximately 1500 kilometers per second) relative to the systemic velocity and unresolved by the gratings. We argue that the lines originate in a near face-on (less than 7 deg) disk having a radial line emissivity flatter than r(exp -2). Line emission from ionization states of Fe in the range approximately Fe I a up to Fe XXVI is observed. The ionization balance of Fe responds to continuum variations on timescales less than 12.5 ks, supporting an origin of the lines close to the X-ray source. We present additional, detailed diagnostics from this rich data set. These results identify NGC 7314 as a key source to study in the future if we are to pursue reverberation mapping of space-time near black-hole event horizons. This is because it is first necessary to understand the ionization structure of accretion disks and the relation between the X-ray continuum and Fe Ka line emission. However, we also describe how our results are suggestive of a means of measuring black-hole spin without a knowledge of the relation between the continuum and line emission. Finally, these data emphasize that one can study strong gravity with narrow (as opposed to very broad) disk lines. In fact narrow lines offer higher precision, given sufficient energy resolution.

Yaqoob, Tahir↗

Estimating the Effects of Astronaut Career Ionizing Radiation Dose Limits on Manned Interplanetary Flight Programs

The Hybrid Inflatable DSH combined with electric propulsion and high power solar-electric power systems offer a near TRL-now solution to the space radiation crew dose problem that is an inevitable aspect of long term manned interplanetary flight. Spreading program development and launch costs over several years can lead to a spending plan that fits with NASA's current and future budgetary limitations, enabling early manned interplanetary operations with space radiation dose control, in the near future while biomedical research, nuclear electric propulsion and active shielding research and development proceed in parallel. Furthermore, future work should encompass laboratory validation of HZETRN calculations, as previous laboratory investigations have not considered large shielding thicknesses and the calculations presented at these thicknesses are currently performed via extrapolation.

Koontz, Steven L.↗

Quantitative nanoscale tracking of oxygen vacancy diffusion inside single ceria grains by in situ transmission electron microscopy

Oxygen vacancy formation and migration in ceria is critical to its electrochemical and catalytic properties in systems for chemical and energy transformation, but its quantification is rather challenging especially at atomic-scale because of disordered distribution. Here we report a rational approach to track oxygen vacancy diffusion in single grains of pure and Sm-doped ceria at -20 °C to 160 °C using in situ (scanning) transmission electron microscopy ((S)TEM). To create a gradient in oxygen vacancy concentration, a small region (~30 nm in diameter) inside a ceria grain is reduced to the C-type CeO 1.68 phase by the ionization or radiolysis effect of a high-energy electron beam. The evolution in oxygen vacancy concentration is then mapped through lattice expansion measurement using scanning nano-beam diffraction or 4D STEM at a spatial resolution better than 2 nm; this allows direct determination of local oxygen vacancy diffusion coefficients in a very small domain inside pure and Sm-doped ceria at different temperatures. Further, the activation energies for oxygen transport are determined to be 0.59, 0.66, 1.12, and 1.27 eV for pure CeO 2 , Ce 0.94 Sm 0.06 O 1.97 , Ce 0.89 Sm 0.11 O 1.945 , and Ce 0.8 Sm 0.2 O 1.9 , respectively, implying that activation energy increases due to impurity scattering. The results are qualitatively supported by density functional theory (DFT) calculations. In addition, our in situ TEM investigation reveals that dislocations impede oxygen vacancy diffusion by absorbing oxygen vacancies from the surrounding areas and pinning them locally. With more oxygen vacancies absorbed, dislocations show extended strain fields with local tensile zone sandwiched between the compressed ones. Therefore, dislocation density should be reduced in order to minimize the resistance to oxygen vacancy diffusion at low temperatures.

36 MATERIALS SCIENCE↗

Spectroscopic measurements of element abundances in the solar corona: Variations on the FIP theme

Solar wind and solar energetic particle (SEP) data yield systematic differences between elemental abundances in the corona and in the photosphere related to the first ionization potential (FIP) of the elements: low-FIP elements are preferentially enhanced relative to high-FIP elements by about a factor of four. Spectroscopic studies of the inner corona show that such a pattern may apply on average but not in detail for coronal loops: substantial abundance differences occur between different types of coronal structures, and variations have been found from flare to flare, from one active region to another, and over time in the same region; further, in some flares, anomalies such as enhanced Ne:O ratios, distinctly at odds with the FIP pattern, show that a competing element selection mechanism sometimes operates. Details of the observed abundance variability -- such as the magnitude of the variations, the relevant temporal and spatial scales, and correlations with other properties of the given coronal structure -- may give important clues to the processes which supply and heat the corona, or they may reflect the changing physical conditions or locations where those processes take place. However, many such details remain to be established definitively. At present, abundance variability is primarily a major complication to data analysis and interpretation. However, once it is better understood, it may provide a new diagnostic tool for probing the lower layers of the solar atmosphere.

Saba, J. L. R.↗

Calibration of the active radiation detector for Spacelab-One

The flight models of the active radiation detector (ARD) for the ENV-01 environmental monitor were calibrated using gamma radiation. Measured sensitivities of the ion chambers were 6.1 + or - 0.3 micron rad per count for ARD S/N1, and 10.4 + or - 0.5 micron rad per count for ARD S/N2. Both were linear over the measured range 0.10 to 500 m/rad hour. The particle counters (proportional counters) were set to respond to approximately 85% of minimum ionizing particles of unit charge passing through them. These counters were also calibrated in the gamma field.

Source record↗

A Detailed FLUKA-2005 Monte Carlo Simulation for the ATIC Detector

We have performed a detailed Monte Carlo (MC) calculation for the Advanced thin Ionization Calorimeter (ATIC) detector using the MC code FLUKA-2005 which is capable of simulating particles up to 10 PeV. The ATIC detector has completed two successful balloon flights from McMurdo, Antarctica lasting a total of more than 35 days. ATIC is designed as a multiple, long duration balloon Bight, investigation of the cosmic ray spectra from below 50 GeV to near 100 TeV total energy; using a fully active Bismuth Germanate @GO) calorimeter. It is equipped with a large mosaic of silicon detector pixels capable of charge identification and as a particle tracking system, three projective layers of x-y scintillator hodoscopes were employed, above, in the middle and below a 0.75 nuclear interaction length graphite target. Our calculations are part of an analysis package of both A- and energy-dependences of different nuclei interacting with the ATIC detector. The MC simulates the responses of different components of the detector such as the Simatrix, the scintillator hodoscopes and the BGO calorimeter to various nuclei. We also show comparisons of the FLUKA-2005 MC calculations with a GEANT calculation and data for protons, He and CNO.

Gunasingha, R. M.↗

Comparison of Fluka-2006 Monte Carlo Simulation and Flight Data for the ATIC Detector

We have performed a detailed Monte Carlo (MC) simulation for the Advanced Thin Ionization Calorimeter (ATIC) detector using the MC code FLUKA-2006 which is capable of simulating particles up to 10 PeV. The ATIC detector has completed two successful balloon flights from McMurdo, Antarctica lasting a total of more than 35 days. ATIC is designed as a multiple, long duration balloon flight, investigation of the cosmic ray spectra from below 50 GeV to near 100 TeV total energy; using a fully active Bismuth Germanate(BGO) calorimeter. It is equipped with a large mosaic of.silicon detector pixels capable of charge identification, and, for particle tracking, three projective layers of x-y scintillator hodoscopes, located above, in the middle and below a 0.75 nuclear interaction length graphite target. Our simulations are part of an analysis package of both nuclear (A) and energy dependences for different nuclei interacting in the ATIC detector. The MC simulates the response of different components of the detector such as the Si-matrix, the scintillator hodoscopes and the BGO calorimeter to various nuclei. We present comparisons of the FLUKA-2006 MC calculations with GEANT calculations and with the ATIC CERN data and ATIC flight data.

Gunasingha, R.M.↗

Operational Health Physics for Radiation Source Payloads

Spacecraft payloads processed at the Kennedy Space Center (KSC) frequently include ionizing and nonionizing radiation sources that require controls to protect the health of the workers involved in the ground operations. At KSC, a robust radiation protection program ensures that radiation hazards are identified, and appropriate controls are implemented using a radiation use authorization (RUA) process and Radiation Protection Committee review and approval. The Health Physics Office provides monitoring and oversight to ensure compliance. A brief overview of health physics activities in support of the Mars 2020 mission will be described to illustrate the overall management of radiation sources during payload ground processing.

Kurt R Geber↗

Proton and Electron Threshold Energy Measurements for Extravehicular Activity Space Suits

Construction of ISS will require more than 1000 hours of EVA. Outside of ISS during EVA, astronauts and cosmonauts are likely to be exposed to a large fluence of electrons and protons. Development of radiation protection guidelines requires the determination of the minimum energy of electrons and protons that penetrate the suits at various locations. Measurements of the water-equivalent thickness of both US. and Russian EVA suits were obtained by performing CT scans. Specific regions of interest of the suits were further evaluated using a differential range shift technique. This technique involved measuring thickness ionization curves for 6-MeV electron and 155-MeV proton beams with ionization chambers using a constant source-to-detector distance. The thicknesses were obtained by stacking polystyrene slabs immediately upstream of the detector. The thicknesses of the 50% ionizations relative to the maximum ionizations were determined. The detectors were then placed within the suit and the stack thickness adjusted until the 50% ionization was reestablished. The difference in thickness between the 50% thicknesses was then used with standard range-energy tables to determine the threshold energy for penetration. This report provides a detailed description of the experimental arrangement and results.

Moyers, M. F.↗

Cobalt as a promising dopant for producing semi-insulating β-Ga 2 O 3 crystals: Charge state transition levels from experiment and theory

Optical absorption and photoconductivity measurements of Co-doped β-Ga 2 O 3 crystals reveal the photon energies of optically excited charge transfer between the Co related deep levels and the conduction or valence band. The corresponding photoionization cross sections are fitted by a phenomenological model considering electron–phonon coupling. The obtained fitting parameters: thermal ionization (zero-phonon transition) energy, Franck–Condon shift, and effective phonon energy are compared with corresponding values predicted by first principle calculations based on density functional theory. A (+/0) donor level ~0.85 eV above the valence band maximum and a (0/-) acceptor level ~2.1 eV below the conduction band minimum are consistently derived. Temperature-dependent electrical resistivity measurement at elevated temperatures (up to 1000 K) yields a thermal activation energy of 2.1 ± 0.1 eV, consistent with the position of the Co acceptor level. Furthermore, the results show that Co doping is promising for producing semi-insulating β-Ga 2 O 3 crystals.

Materials science↗

A search for a turbulent-free region in the solar transition zone

A search for a turbulence-free transition-zone region was conducted. The data used were spectra recorded by a slit spectrograph on Skylab. It was found that the nonthermal turbulent motions are smallest in certain active regions and quiescent prominences. The spectra of one such region, a quiescent prominence, are discussed. The nonthermal turbulence in the region is between about 2 and 7 km/s. Therefore, the widths of lines emitted by transition-zone ions are determined primarily by the ion temperature. To within the experimental error, temperatures derived from the line widths are equal to the temperatures of maximum emitting efficiency obtained using the ionization equilibrium calculations of Jordan (1969).

Feldman, U.↗

Chemical releases in the ionosphere

The study of the interaction between the atmosphere, ionosphere and magnetosphere is identified as a major task worthy of pursuit. The present review demonstrates the major contributions to this complex problem already made by active experiments involving the injection of chemicals and energetic electron beams into the atmosphere, ionosphere and magnetosphere. Through the use of chemical releases, it has been possible to investigate a number of quantities including high-altitude winds and electric fields, the detailed configurations of the geomagnetic field within the ionosphere and the magnetosphere, as well as the propagation of energetic particle beams and their interaction with natural neutral and ionized constituents of the high atmosphere. So far, virtually all of this effort has been accomplished using rockets. In the future, it is obvious that satellite platforms will play a greater role, both in making injections and in observing their effects.

Davis, T. N.↗

Collective capture of released lithium ions in the solar wind

The capture of newly ionized lithium ions in the solar wind by means of electromagnetic instabilities is investigated through linear analysis and computer simulation. Three instabilities, driven by a lithium velocity ring perpendicular to and drifting along the magnetic field, are considered. The capture time of the lithium by the solar wind is roughly 10 linear growth times, regardless of whether resonant or nonresonant modes dominate initially. Possible implications of the results for the Active Magnetosphere Particle Tracer Explorer (AMPTE) mission are discussed.

Winske, D.↗