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At least 847 records · Page 47

Electric Fields at Breast Cancer and Cancer Cell Collective Galvanotaxis

Cancer growth interferes with local ionic environments, membrane potentials, and transepithelial potentials, resulting in small electrical changes in the tumor microenvironment. Electrical fields (EFs) have significant effects on cancer cell migration (galvanotaxis/electrotaxis), however, their role as a regulator of cancer progression and metastasis is poorly understood. Here, we employed unique probe systems to characterize the electrical properties of cancer cells and their migratory ability under an EF. Subcutaneous tumors were established from a triple-negative murine breast cancer cell line (4T1), electric currents and potentials of tumors were measured using vibrating probe and glass microelectrodes, respectively. Steady outward and inward currents could be detected at different positions on the tumor surface and magnitudes of the electric currents on the tumor surface strongly correlated with tumor weights. Potential measurements also showed the non-homogeneous intratumor electric potentials. Cancer cell migration was then surveyed in the presence of EFs in vitro. Parental 4T1 cells and metastatic sublines in isolation showed random migration in EFs of physiological strength, whereas cells in monolayer migrated collectively to the anode. Our data contribute to an improved understanding of breast cancer metastasis, providing new evidence in support of an electrical mechanism that promotes this phenomenon.

59 BASIC BIOLOGICAL SCIENCES↗

Inclusive cross section measurements in final states with and without protons for charged-current ν μ -Ar scattering in MicroBooNE

A detailed understanding of inclusive muon neutrino charged-current interactions on argon is crucial to the study of neutrino oscillations in current and future experiments using liquid argon time projection chambers. To that end, we report a comprehensive set of differential cross section measurements for this channel that simultaneously probe the leptonic and hadronic systems by dividing the channel into final states with and without protons. Measurements of the proton kinematics and proton multiplicity of the final state are also presented. For these measurements, we utilize data collected with the MicroBooNE detector from 6.4 × 10 20 protons on target from the Fermilab booster neutrino beam at a mean neutrino energy of approximately 0.8 GeV. We present in detail the cross section extraction procedure, including the unfolding, and model validation that uses data to model comparisons and the conditional constraint formalism to detect mismodeling that may introduce biases to extracted cross sections that are larger than their uncertainties. The validation exposes insufficiencies in the overall model, motivating the inclusion of an additional data-driven reweighting systematic to ensure the accuracy of the unfolding. The extracted results are compared to a number of event generators and their performance is discussed with a focus on the regions of phase space that indicate the greatest need for modeling improvements. Published by the American Physical Society 2024

72 PHYSICS OF ELEMENTARY PARTICLES AND FIELDS↗

A Hydrogen Iron Flow Battery with High Current Density and Long Cyclability Enabled Through Circular Water Management

The hydrogen‐iron (HyFe) flow cell has great potential for long‐duration energy storage by capitalizing on the advantages of both electrolyzers and flow batteries. However, its operation at high current density (high power) and over continuous cycling testing has yet to be demonstrated. In this paper, we discuss our design and demonstration of a water management strategy that supports high current and long cycling performance of a HyFe flow cell. Water molecules associated with the movement of protons from the iron electrode to the hydrogen electrode are sufficient to hydrate the membrane and electrode at a low current density of 100 mA cm −2 during the charge process. At higher charge current density, more aggressive measures must be taken to counter back‐diffusion driven by the acid concentration gradient between the iron and hydrogen electrodes. Our water management approach is based on water vapor feeding in the hydrogen electrode, and water evaporation in the iron electrode, thus enabling the high current density operation of 300 mA cm −2 .

25 ENERGY STORAGE↗

Ultimate Precision on Sin^2 Theta_23 With the Numi Experiments

There were two major goals to this proposal: the study of the discrepancy between data and MC in the NuMI Medium Energy neutrino beam and the incorporation of the MINOS and NOVA neutrino oscillation datasets. The first topic was approached via development of a simulation of the NuMI beam monitoring instrumentation suite. Initially, the Horn-Off current data sets were used to measure a set of hadron production parameters which improved the data/MC agreement in a way which was independent of the focusing parameters. The peak position discrepancy was only explained by a large (10kA) reduction in the horn current. A full simulation of the muon monitors was developed to attempt to make an independent measurement of the horn current by means of differential data taken by those monitors. While only at the 5kA level, the result corroborated the former findings. The second goal has not yet been completed but progress has focused on understanding how to modify the MINOS MC to take into account the MEC contribution which is missing from the underlying NEUGEN MC. A number of improvements to the MINOS reconstruction have been necessary. The framework to run the fits on the combined data has been completed.

72 PHYSICS OF ELEMENTARY PARTICLES AND FIELDS↗

Testing for pair density wave order in La 1.875 Ba 0.125 CuO 4

We report charge order is commonly believed to compete with superconducting order. An intertwined form of a superconducting wave function, known as pair density wave (PDW) order, has been proposed; however, direct evidence, theoretical or experimental, that it forms the ground state of any cuprate superconductor is lacking. As a test case, we consider La 2-x Ba x CuO 4 with x = 1/8, where charge and spin stripe orders within the CuO 2 planes compete with three-dimensional superconducting order. We report measurements of the superconducting critical current perpendicular to the planes in the presence of an in-plane magnetic field. The variation of the critical current with orientation of the field is inconsistent with a theoretical prediction specific to the PDW model. It appears, instead, that the orientation dependence of the critical-current density might be determined by a minority phase of d-wave superconductivity that is present as a consequence of doped-charge inhomogeneity.

75 CONDENSED MATTER PHYSICS, SUPERCONDUCTIVITY AND↗

Measurement of C P Violation in B 0 → ψ ( → ℓ + ℓ − ) K S 0 ( → π + π − ) Decays

A measurement of time-dependent C P violation in the decays of B 0 and B ¯ 0 mesons to the final states J / ψ ( → μ + μ − ) K S 0 , ψ ( 2 S ) ( → μ + μ − ) K S 0 and J / ψ ( → e + e − ) K S 0 with K S 0 → π + π − is presented. The data correspond to an integrated luminosity of 6 fb − 1 collected at a center-of-mass energy of s = 13 TeV with the LHCb detector. The C P -violation parameters are measured to be S ψ K S 0 = 0.717 ± 0.013 ( stat ) ± 0.008 ( syst ) and C ψ K S 0 = 0.008 ± 0.012 ( stat ) ± 0.003 ( syst ) . This measurement of S ψ K S 0 represents the most precise single measurement of the CKM angle β to date and is more precise than the current world average. In addition, measurements of the C P -violation parameters of the individual channels are reported and a combination with the LHCb Run 1 measurements is performed. © 2024 CERN, for the LHCb Collaboration 2024 CERN

Aaij, R. (ORCID:0000000305331952)↗

Diesel Oxidation Catalyst Performance with Biodiesel Formulations

Biodiesel (i.e., mono-alkyl esters of long chain fatty acids derived from vegetable oils and animal fats) is a renewable diesel fuel providing life-cycle greenhouse gas emission reductions relative to petroleum-derived diesel. With the expectation that there would be widespread use of biodiesel as a substitute for ultra-low sulfur diesel (ULSD), there have been many studies looking into the effects of biodiesel on engine and aftertreatment, particularly its compatibility to the current aftertreatment technologies. The objective of this study was to generate experimental data to measure the effectiveness of a current technology diesel oxidation catalysts (DOC) to oxidize soy-based biodiesel at various blend levels with ULSD. Biodiesel blends from 0 to 100% were evaluated on an engine using a conventional DOC. In the steady-state performance test where fuel dosing rate was increased at fixed DOC inlet temperature, B20 performed similarly to ULSD at the lowest flow rate or exhaust temperature over 340 degrees C for medium and high flows. B50 blends performed nearly as well under most conditions. Higher blends exhibited reduced thermal efficiency and DOC outlet temperature with increasing dosing rate under most conditions and required exhaust temperatures over 400 degrees C to achieve or nearly achieve performance similar to ULSD. In the steady-state light of test where fuel dosing rate is fixed but exhaust temperature is increased incrementally, B20 generally performed similarly to ULSD at the highest inlet temperature, with only minor deficiencies at lower temperatures. Higher blends exhibited lower thermal efficiency and did not achieve as high DOC outlet temperatures. In the transient light-off test light-off temperature for ULSD was typically less than 225 degrees C, while for B100 it ranged from 290 degrees C to 330 degrees C. Based on the data set, it can be concluded that biodiesel fuels have a higher light-off temperature primarily because of their higher boiling points, with a minor secondary impact of their lower energy content.

ADVANCED PROPULSION SYSTEMS,BIOMASS FUELS↗

Interferometer response to geontropic fluctuations

We model vacuum fluctuations in quantum gravity with a scalar field, characterized by a high occupation number, coupled to the metric. The occupation number of the scalar is given by a thermal density matrix, whose form is motivated by fluctuations in the vacuum energy, which have been shown to be conformal near a light-sheet horizon. For the experimental measurement of interest in an interferometer, the size of the energy fluctuations is fixed by the area of a surface bounding the volume of spacetime being interrogated by an interferometer. We compute the interferometer response to these “geontropic” scalar-metric fluctuations, and apply our results to current and future interferometer measurements, such as LIGO and the proposed GQuEST experiment.

79 ASTRONOMY AND ASTROPHYSICS↗

Local measurements of the pedestal magnetic field profile throughout the ELM cycle on DIII-D

We report new high speed localized measurements of the pedestal magnetic field during the edge localized mode (ELM) cycle of a DIII-D High confinement mode (H-mode) discharge indicate a temporally and spatial complex redistribution of the edge current density profile, $j_{edge}$. The measurement technique extracts the magnetic field magnitude, $\textit{B}$, via the spectral separation of Stark-split neutral beam radiation in the pedestal. Single spatial channel measurements from a novel spatial heterodyne spectrometer are validated in discharges with core current profile changes. The technique measures Stark-splitting changes that imply $\textit{B}$ changes as small as 1 mT with high time resolution (50 μs). At normalized poloidal flux $ψ_n$ = 1.0, $\textit{B}$ appears saturated in the inter-ELM period and then rapidly decreases in <200 μs by ~1%, before edge recycling emission begins to increase. Radially inboard of $j_{edge}$, $\textit{B}$ increases at the ELM crash. The behavior is consistent with a rapid collapse of $j_{edge}$ at the ELM crash and subsequent pedestal recovery. In some discharges, at $ψ_n$ < 0.96, changes in $\textit{B}$ are observed throughout the ELM cycle. In others, $\textit{B}$ recovers and is relatively stable until a few ms leading up to the next crash. Measurements of $\textit{B}$ during the H-mode transition show a large increase at $ψ_n$ = 1 with little change at $ψ_n$ = 0.9, consistent with the formation of the edge bootstrap current density peak. The $ψ_n$ = 0.9 spectrum is complicated by predicted changes to the Stark component intensities with density at the L–H transition.

70 PLASMA PHYSICS AND FUSION TECHNOLOGY↗

Validation of galvanomagnetic and thermomagnetic transport measurements using Standard Reference Material 3451

In the “method of four coefficients,” electrical resistivity (ρ), Seebeck coefficient (S), Hall coefficient (RH), and Nernst coefficient (Q) of a material are measured and typically fit or modeled with theoretical expressions based on Boltzmann transport theory to glean experimental insights into features of electronic structure and/or charge carrier scattering mechanisms in materials. Although well-defined and readily available reference materials exist for validating measurements of ρ and S, none currently exists for R H or Q. We show that measurements of all four transport coefficients—ρ, S, R H , and Q—can be validated using a single reference sample, namely, the low-temperature Seebeck coefficient Standard Reference Material® (SRM) 3451 (composition Bi 2 Te 3+x ) available from the National Institute for Standards and Technology (NIST) without the need for inter-laboratory sample exchange. Here, R H and Q data for NIST SRM 3451 reported here for the temperature range 80–400 K complement the data already available for ρ and S and will therefore be of interest to researchers desiring to validate new or existing galvanomagnetic and thermomagnetic transport properties measurement systems.

47 OTHER INSTRUMENTATION↗

High-Energy to Ultrahigh-Energy Neutrino Interactions

The cross sections for neutrino interactions with nucleons have been measured directly in accelerator experiments and through the zenith-angle and energy dependence of neutrino events at the IceCube Neutrino Observatory. Fluxes of high-energy neutrinos are produced at the Large Hadron Collider and by cosmic rays in the atmosphere. High-energy neutrinos also come from astrophysical and cosmic sources. The theory of neutrino interactions is reviewed. Current cross-section measurements and prospects for the future are discussed. The focus here is on neutrino interactions for energies larger than 1 TeV.

72 PHYSICS OF ELEMENTARY PARTICLES AND FIELDS↗

Measurement of Multi-Proton Zero Pion Final States with the NuMI Neutrino Beam at ICARUS

Evidence suggests that charge-parity (CP) symmetry, or the principle that matter and antimatter must obey the same physics, might be violated in neutrino flavor mixing. The next-generation long-baseline experiment DUNE is designed to confirm whether or not neutrinos oscillate differently from antineutrinos. The magnitude of systematic uncertainties contributing to current long-baseline oscillation measurements, if left unimproved, is enough to jeopardize DUNE's ability to measure CP violation. Neutrino cross section measurements on argon targets are an essential input for improving neutrino interaction modelling and reducing the systematic uncertainties before DUNE turns on. The ICARUS experiment at Fermilab is well suited perform such measurements due to the NuMI neutrino beam providing neutrinos at the same energy as DUNE's first oscillation maximum. This work presents a measurement of muon neutrino charged-current interactions with multiple energetic protons and zero final state mesons in ICARUS. Multi-proton topologies are sensitive to contributions from two-particle two hole effects as well as resonant pion production and subsequent absorption via final state interactions (FSI) within the argon nucleus. Single-differential cross sections are measured in lab-frame opening angles and transverse kinematic imbalance variables, characterizing the initial sate momentum sharing between correlated nucleons and strength of FSI in argon.

Smedley, John [Rochester U.] (ORCID:00000002848611↗

A multidimensional approach to quantum state tomography of photoelectron wavepackets

There is a growing interest in reconstructing the density matrix of photoelectron wavepackets, in particular in complex systems where decoherence can be introduced either by a partial measurement of the system or through coupling with a stochastic environment. To this end, several methods to reconstruct the density matrix, quantum state tomography protocols, have been developed and tested on photoelectrons ejected from noble gases following absorption of extreme ultraviolet (XUV) photons from attosecond pulses. It remains a challenge to obtain model-free, single scan protocols that can reconstruct the density matrix with high fidelities. Current methods require extensive measurements or involve complex fitting of the signal. Efficient single-scan reconstructions would be of great help to increase the number of systems that can be studied. We propose a new and more efficient protocol that is able to reconstruct the continuous variable density matrix of a photoelectron in a single time delay scan. It is based on measuring the coherences of a photoelectron created by absorption of an XUV pulse using a broadband infrared (IR) probe that is scanned in time and a narrowband IR reference that is temporally fixed to the XUV pulse. We illustrate its performance for a Fano resonance in He as well as mixed states in Ar arising from spin-orbit splitting. We show that the protocol results in excellent fidelities and near-perfect estimation of the purity.

72 PHYSICS OF ELEMENTARY PARTICLES AND FIELDS↗

Probing Nuclear Effects with Transverse Kinematic Imbalance in Muon-neutrino Induced Charged-Current $π^0$ Production on Argon with the MicroBooNE Detector

Neutrino-nucleus cross-section measurements are needed to improve interaction modeling and to enable precision neutrino oscillation measurements in upcoming experiments such as the Deep Underground Neutrino Experiment (DUNE), Hyper-Kamiokande, and the Short-Baseline Neutrino program. Baryon-resonance neutrino interactions constitute a dominant contribution near the peak of the DUNE neutrino energy spectrum. We present the first measurement of muon neutrino charged-current resonance-like interactions on argon using transverse kinematic imbalance variables with the MicroBooNE detector. These observables are highly sensitive to the modeling of final-state interactions. This measurement probes kinematic imbalances using the reconstructed momenta of the muon, leading proton, and neutral pion. A comprehensive characterization of the $π^0$-proton final state is presented; however, none of the models considered are able to simultaneously reproduce all measured observables.

Abratenko, P. [Tufts U. (main)]↗

Measurements of dynamic surface changes by digital holography for in situ plasma erosion applications

There are currently few viable diagnostic techniques for in situ measurement of plasma facing component erosion. Digital holography is intended to fill this gap. Progress on the development of single and dual CO 2 laser digital holography diagnostics for in situ plasma facing component erosion is discussed. The dual laser mode’s synthetic wavelength allows the measurable range to be expanded by a factor of ~400 compared to single laser digital holography. This allows the diagnostic to measure surface height changes of up to 4.5 μm in single laser mode and up to 2 mm in dual laser mode. Results include ex situ measurements of plasma eroded targets and also dynamic measurements of nm and μm scale motion of a target mounted on a precision translation stage. Dynamic measurements have successfully been made with the system operating in both single and dual laser modes, from ~50 nm to ~4 μm in single laser mode and up to ~400 μm in dual laser mode (limited only by the stage speed and camera acquisition duration). These results demonstrate the feasibility of using digital holography to characterize plasma facing component erosion dynamically, i.e., during plasma exposure. Results of proof-of-principle in situ digital holographic measurements of targets exposed to an electrothermal arc plasma source are presented.

Smith, Cary↗

𝐵⁡(𝐸⁢2) measurements in the yrast band of 28 Mg: Implications for the 𝑁 = 20 island of inversion

High-precision lifetime measurements in 28 Mg were performed to study neutron shell evolution in Mg isotopes and the onset of the N = 20 island of inversion. Here, using both the recoil distance and Doppler shift attenuation methods, five lifetimes were measured in addition to six upper limits. The observation of two long-lived, negative-parity states demonstrate the importance of studying Mg isotopes for the contribution of intruder configurations to sd-shell nuclei. Lifetimes of the $2^+_1$ and $4^+_1$ states of 1.81(5) ps and 172⁢($^{+11}_{–10}$) stat.⁢ (4) stop. ⁢(8) feed.⁢ (4) targ. fs, respectively, demonstrate a loss of collectivity with increasing spin in the yrast band, permitting for distinguishing between current theoretical models. These measurements also highlight the progression of yrast structure across the Mg isotopic chain from rotational at N = 12 to large shape mixing at N = 16 and back to collective behavior at N = 20 but with dominating intruder configurations.

20 ≤ A ≤ 38↗

Resilience of High-Efficiency CdSeTe:As and CdSeTe:Cu Solar Cells to Proton Irradiation

Power generation in space is currently dominated by expensive III-V multi-junction photovoltaic (PV) devices and cheap crystalline silicon (c-Si) PV devices. Both of these technologies degrade rapidly in proton-radiation-rich space environments, such as the Van Allen belt. The present study of cadmium selenide telluride- (CdSeTe-) based PV devices exposed to 150-to-1500 keV proton irradiation with fluences up to 9 x 1013 cm-2 reveal a more radiation-hard alternative to III-V and c-Si PV technologies. We report on measurement and analysis of current density vs voltage (JV), external quantum efficiency (EQE), external radiative efficiency, and capacitance vs voltage (CV) characteristics. JV characteristics of As-doped CdSeTe devices show 80% remaining power conversion efficiency (PCE) relative to unexposed controls when exposed to 650 keV protons at a fluence of 1012 cm-2. Under these same irradiation conditions, Cu-doped CdSeTe devices demonstrate an even better 95% PCE retention compared with unirradiated control devices. Evidence of radiation-induced absorber p-type doping compensation is observed in the glass-side EQE at 0 V and CV characteristics of most of the irradiated CdSeTe:As devices, but clear compensation is evident only for the most heavily irradiated CdSeTe:Cu devices. Elevated blue-green photocurrent in the film-side 0 V EQE suggests a buried junction in the most heavily irradiated CdSeTe:As devices. Although CdSeTe:Cu devices are the more resilient of the CdSeTe structures, both CdSeTe-based technologies are radiation-hard when compared to c-Si and III-V multi-junction PV.

14 SOLAR ENERGY↗

The contribution of magnetized galactic outflows to extragalactic Faraday rotation

ABSTRACT Galactic outflows driven by star formation and active galactic nuclei blow bubbles into their local environments, causing galactic magnetic fields to be carried into intergalactic space. We explore the redshift-dependent effect of these magnetized bubbles on the Faraday rotation measure (RM) of extragalactic radio sources. Using the IllustrisTNG cosmological simulations, we separate the contribution from magnetic bubbles from that of the volume-filling magnetic component expected to be due to the seed field originating in the early universe. We use this separation to extract the redshift dependence of each component and to compare IllustrisTNG model predictions with observation measurements of the NRAO VLA sky survey (NVSS). We find that magnetized bubbles provide a sizeable contribution to the extragalactic RM, with redshift-independent 〈|RM|〉 ≃ 13 rad/m2 for sources at redshifts z ≥ 2. This is close to the mean residual RM of 16 rad/m2 found from NVSS data in this redshift range. Using the IllustrisTNG simulations, we also evaluate a simple model for the contribution to residual RM from individual host galaxies and show that this contribution is negligible at high-redshift. While the contribution from magnetic bubbles in the IllustrisTNG model is currently compatible with observational measurements of residual RM, the next-generation RM sky surveys, which will be free from the wrapping uncertainty, have larger statistics and better sensitivity should be able to observe predicted flat contribution from magnetic bubbles at large redshifts. This should allow to experimentally probe magnetic bubbles and check models of galaxy feedback in cosmological simulations.

79 ASTRONOMY AND ASTROPHYSICS↗