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Poor air quality (AQ) is one of the most important human-health and environmental problems facing the United States (US). In addition to the detrimental impacts on human- and environmental-health, poor AQ has an economic cost of ~5% of the US gross domestic product (~$790 billion). AQ managers use AQ analyses and modeling to better understand, anticipate, and avoid poor AQ events. Our research focuses on improving AQ analysis/forecast skill, predictability, and emission estimates through improved and more efficient: (i) modeling and data assimilation strategies; (ii) dynamic emissions adjustment strategies; and (iii) use of satellite remote-sensing Earth observations (e.g., MOPITT, IASI, MODIS, OMI, TROPOMI, TEMPO, etc.). This seminar will review: (i) regional chemical weather forecasting/data assimilation with dynamic emissions adjustment with WRF-Chem/DART; (ii) strategies for efficiently assimilating satellite retrieval profiles with ‘compact phase space retrievals’ (CPSRs); (iii) results from joint assimilation of multiple satellite retrievals at medium (12 km × 12 km) and high (4 km × 4 km) spatial resolutions; and (iv) results from observing system simulation experiments (OSSEs) to investigate whether we can recover COVID-period anthropogenic emissions by assimilating synthetic TEMPO NO2 tropospheric column retrievals with dynamic emissions adjustment. Biographical Sketch: Dr. Mizzi is a Senior Research Fellow working and Dr. Johnson at the NASA Ames Research Center. He holds BA and MS degrees in Environmental Science from the University of Virginia, MS and PhD degrees in Applied Mathematics from the University of Colorado at Boulder (CUB), and a JD degree (with an emphasis in Environmental Law) from the University of Colorado School of Law. He worked at the National Center for Atmospheric Research for nearly 25 years on global atmospheric modeling, dynamic and physical initialization, regional hybrid data assimilation, and most recently on regional chemical data assimilation. He also worked as an environmental attorney and consultant for nearly 15 years. He is an expert in numerical modeling and is recognized internationally as a leading expert in regional, chemical data assimilation with dynamic emissions adjustment. Dr. Mizzi became affiliated with NASA Ames in March 2020 to work on improving AQ analysis/forecast skill, predictability, and ‘top-down’ emissions adjustment though the assimilation of Earth observations. An emphasis of his current work is developing methods for assimilating synthetic TEMPO retrievals to quantify the expected benefits of TEMPO relative to existing AQ observations.