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SU-E-I-65: The Joint Commission's Requirements for Annual Diagnostic Physics Testing of Nuclear Medicine Equipment, and a Clinically Relevant Methodology for Testing Low-Contrast Resolution

Purpose: To introduce the Joint Commission's requirements for annual diagnostic physics testing of all nuclear medicine equipment, effective 7/1/2014, and to highlight an acceptable methodology for testing lowcontrast resolution of the nuclear medicine imaging system. Methods: The Joint Commission's required diagnostic physics evaluations are to be conducted for all of the image types produced clinically by each scanner. Other accrediting bodies, such as the ACR and the IAC, have similar imaging metrics, but do not emphasize testing low-contrast resolution as it relates clinically. The proposed method for testing low contrast resolution introduces quantitative metrics that are clinically relevant. The acquisition protocol and calculation of contrast levels will utilize a modified version of the protocol defined in AAPM Report #52. Results: Using the Rose criterion for lesion detection with a SNRpixel = 4.335 and a CNRlesion = 4, the minimum contrast levels for 25.4 mm and 31.8 mm cold spheres were calculated to be 0.317 and 0.283, respectively. These contrast levels are the minimum threshold that must be attained to guard against false positive lesion detection. Conclusion: Low contrast resolution, or detectability, can be properly tested in a manner that is clinically relevant by measuring the contrast level of cold spheres within a Jaszczak phantom using pixel values within ROI's placed in the background and cold sphere regions. The measured contrast levels are then compared to a minimum threshold calculated using the Rose criterion and a CNRlesion = 4. The measured contrast levels must either meet or exceed this minimum threshold to prove acceptable lesion detectability. This research and development activity was performed by the authors while employed at West Physics Consulting, LLC. It is presented with the consent of West Physics, which has authorized the dissemination of the information and/or techniques described in the work.

46 INSTRUMENTATION RELATED TO NUCLEAR SCIENCE AND ↗

Poster — Thur Eve — 30: 4D VMAT dose calculation methodology to investigate the interplay effect: experimental validation using TrueBeam Developer Mode and Gafchromic film

The interplay effect between the tumor motion and the radiation beam modulation during a VMAT treatment delivery alters the delivered dose distribution from the planned one. This work present and validate a method to accurately calculate the dose distribution in 4D taking into account the tumor motion, the field modulation and the treatment starting phase. A QUASAR™ respiratory motion phantom was 4D scanned with motion amplitude of 3 cm and with a 3 second period. A static scan was also acquired with the lung insert and the tumor contained in it centered. A VMAT plan with a 6XFFF beam was created on the averaged CT and delivered on a Varian TrueBeam and the trajectory log file was saved. From the trajectory log file 10 VMAT plans (one for each breathing phase) and a developer mode XML file were created. For the 10 VMAT plans, the tumor motion was modeled by moving the isocentre on the static scan, the plans were re-calculated and summed in the treatment planning system. In the developer mode, the tumor motion was simulated by moving the couch dynamically during the treatment. Gafchromic films were placed in the QUASAR phantom static and irradiated using the developer mode. Different treatment starting phase were investigated (no phase shift, maximum inhalation and maximum exhalation). Calculated and measured isodose lines and profiles are in very good agreement. For each starting phase, the dose distribution exhibit significant differences but are accurately calculated with the methodology presented in this work.

60 APPLIED LIFE SCIENCES↗

Comprehensive MRI simulation methodology using a dedicated MRI scanner in radiation oncology for external beam radiation treatment planning

Purpose: The use of magnetic resonance imaging (MRI) in radiation oncology is expanding rapidly, and more clinics are integrating MRI into their radiation therapy workflows. However, radiation therapy presents a new set of challenges and places additional constraints on MRI compared to diagnostic radiology that, if not properly addressed, can undermine the advantages MRI offers for radiation treatment planning (RTP). The authors introduce here strategies to manage several challenges of using MRI for virtual simulation in external beam RTP. Methods: A total of 810 clinical MRI simulation exams were performed using a dedicated MRI scanner for external beam RTP of brain, breast, cervix, head and neck, liver, pancreas, prostate, and sarcoma cancers. Patients were imaged in treatment position using MRI-optimal immobilization devices. Radiofrequency (RF) coil configurations and scan protocols were optimized based on RTP constraints. Off-resonance and gradient nonlinearity-induced geometric distortions were minimized or corrected prior to using images for RTP. A multidisciplinary MRI simulation guide, along with window width and level presets, was created to standardize use of MR images during RTP. A quality assurance program was implemented to maintain accuracy and repeatability of MRI simulation exams. Results: The combination of a large bore scanner, high field strength, and circumferentially wrapped, flexible phased array RF receive coils permitted acquisition of thin slice images with high contrast-to-noise ratio (CNR) and image intensity uniformity, while simultaneously accommodating patient setup and immobilization devices. Postprocessing corrections and alternative acquisition methods were required to reduce or correct off-resonance and gradient nonlinearity induced geometric distortions. Conclusions: The methodology described herein contains practical strategies the authors have implemented through lessons learned performing clinical MRI simulation exams. In their experience, these strategies provide robust, high fidelity, high contrast MR images suitable for external beam RTP.

60 APPLIED LIFE SCIENCES↗

Technical Note: Impact on detective quantum efficiency of edge angle determination method by International Electrotechnical Commission methodology for cardiac x-ray image detectors

Purpose: Cardiac x-ray detectors are used to acquire moving images in real-time for angiography and interventional procedures. Detective quantum efficiency (DQE) is not generally measured on these dynamic detectors; the required “for processing” image data and control of x-ray settings have not been accessible. By 2016, USA hospital physicists will have the ability to measure DQE and will likely utilize the International Electrotechnical Commission (IEC) standard for measuring DQE of dynamic x-ray imaging devices. The current IEC standard requires an image of a tilted tungsten edge test object to obtain modulation transfer function (MTF) for DQE calculation. It specifies the range of edge angles to use; however, it does not specify a preferred method to determine this angle for image analysis. The study aimed to answer the question “will my choice in method impact my results?” Four different established edge angle determination methods were compared to investigate the impact on DQE. Methods: Following the IEC standard, edge and flat field images were acquired on a cardiac flat-panel detector to calculate MTF and noise power spectrum, respectively, to determine DQE. Accuracy of the methods in determining the correct angle was ascertained using a simulated edge image with known angulations. Precision of the methods was ascertained using variability of MTF and DQE, calculated via bootstrapping. Results: Three methods provided near equal angles and the same MTF while the fourth, with an angular difference of 6%, had a MTF lower by 3% at 1.5 mm{sup −1} spatial frequency and 8% at 2.5 mm{sup −1}; corresponding DQE differences were 6% at 1.5 mm{sup −1} and 17% at 2.5 mm{sup −1}; differences were greater than standard deviations in the measurements. Conclusions: DQE measurements may vary by a significant amount, depending on the method used to determine the edge angle when following the IEC standard methodology for a cardiac x-ray detector. The most accurate and precise methods are recommended for absolute assessments and reproducible measurements, respectively.

46 INSTRUMENTATION RELATED TO NUCLEAR SCIENCE AND ↗

SU-A-BRA-02: Making the Most of a One Hour Lecture with Alternative Teaching Methodologies: Implementing Project-Based and Flipped Learning

Vic Montemayor - No one has been more passionate about improving the quality and effectiveness of the teaching of Medical Physics than Bill Hendee. It was in August of 2008 that the first AAPM Workshop on Becoming a Better Teacher of Medical Physics was held, organized and run by Bill Hendee. This was followed up in July of 2010 with a summer school on the same topic, again organized by Bill. There has been continued interest in alternate approaches to teaching medical physics since those initial gatherings. The momentum established by these workshops is made clear each year in the annual Innovation in Medical Physics Education session, which highlights work being done in all forms of medical physics education, from one-on-one residencies or classroom presentations to large-scale program revisions and on-line resources for international audiences. This symposium, presented on behalf of the Education Council, highlights the work of three finalists from past Innovation in Education sessions. Each will be presenting their approaches to and innovations in teaching medical physics. It is hoped that audience members interested in trying something new in their teaching of medical physics will find some of these ideas and approaches readily applicable to their own classrooms. Rebecca Howell - The presentation will discuss ways to maximize classroom learning, i.e., increasing the amount of material covered while also enhancing students’ understanding of the broader implications of the course topics. Specifically, the presentation will focus on two teaching methodologies, project based learning and flip learning. These teaching methods will be illustrated using an example of graduate medical physics course where both are used in conjunction with traditional lectures. Additionally, the presentation will focus on our experience implementing these methods including challenges that were overcome. Jay Burmeister - My presentation will discuss the incorporation of active learning techniques into a traditional medical physics classroom course. I will describe these techniques and how they were implemented as well as student performance before and after implementation. Student feedback indicated that these course changes improved their ability to actively assimilate the course content, thus improving their understanding of the material. Shahid Naqvi - My talk will focus on ways to help students visualize crucial concepts that lie at the core of radiation physics. Although particle tracks generated by Monte Carlo simulations have served as an indispensable visualization tool, students often struggle to resolve the underlying physics from a simultaneous jumble of tracks. We can clarify the physics by “coding” the tracks, e.g., by coloring the tracks according to their “starting” or “crossing” regions. The regionally-coded tracks when overlaid with dose distributions help the students see the elusive connection between dose, kerma and electronic disequilibrium. Tracks coded according to local energy or energy-loss rate can illustrate the need for stopping power corrections in electron beams and explain the Bragg peak in a proton beam. Coding tracks according to parent interaction type and order can clarify the often misunderstood distinction between primary and scatter dose. The students can thus see the “whole” simultaneously with the “sum of the parts,” which enhances their physical insight and creates a sustainable foundation for further learning. After the presentations the speakers and moderator will be open to questions and discussion with the audience members. Learning Objectives: Be able to explain Project-Based Learning and how can it be incorporated into a Medical Physics classroom. Be able to explain Flipped Learning and how can it be incorporated into a Medical Physics classroom. Be able to explain active-learning strategies for the teaching of Medical Physics. Be able to explain how Monte Carlo simulations can be used to deepen a student’s understanding of radiation physics and dosimetry.

07 ISOTOPE AND RADIATION SOURCES↗

Methodology of Calculation of Hypothetical Isomeric γ-Reactors by the Example of {sup 178m2}Hf

The methodology of description of kinetic phenomena in isomeric γ-reactors is developed by the example of the {sup 178m2}Hf nuclear isomer. The consideration of processes in the isomer medium is based on an assumption that the use of the resonance NEET mechanism would make it possible to put the isomer in the trigger state and thereby to create the conditions for the chain reaction of γ decays similar to that of fissions in neutron nuclear reactors.

73 NUCLEAR PHYSICS AND RADIATION PHYSICS↗

The methodology of the search for a correlated signal from a supernova explosion using the data of gravitational wave detectors and neutrino observatories

The proposed methodology developed in cooperation of the LIGO, VIRGO, Borexino, LVD, and IceCube collaborations is based on a joint analysis of data from neutrino and gravitational wave detectors which record corresponding radiations, almost undistorted by the interstellar medium and propagating with similar speeds. This approach allows to increase the reliability of observations, detect the so-called Silent supernovae and explore the properties and generation mechanisms of gravitational waves.

79 ASTRONOMY AND ASTROPHYSICS↗

Development of the Active Correlation Method: Theoretical-Methodological Aspect

The Dubna Gas-Filled Recoil Separator (DGFRS) of the Flerov Laboratory of Nuclear Reactions (FLNR), JINR, is the most advanced facility for the synthesis and study of new superheavy nuclei. In the recent years, new elements with Z = 114 to 118 (Fl, Mc, Lv, Ts, Og) have been successfully synthesized. The DGFRS detection system and a unique method of active correlations for background suppression have played a significant role in these discoveries. Theoretical-methodological aspects of further development of the active correlation method are considered, especially in view of the upcoming commissioning of the new FLNR high-intensity DC-280 cyclotron for acceleration of heavy ions and the new gas-filled recoil separator. A numerical model of the edge effects between the neighboring strips on the p – n junction side of the DSSSD detector is presented. The corresponding empirical examples are given. A more flexible real-time algorithm is considered as a possible substitute for the current version with the rigidly set parameters. Since stability of the calibration parameters is strongly required for applying the method, the radiation stability factor is also briefly considered.

72 PHYSICS OF ELEMENTARY PARTICLES AND FIELDS↗

Tools, Techniques, and Methodologies: A Survey of Digital Forensics for SCADA Systems

Security aspects of SCADA environments and the systems within are increasingly a center of interest to researchers and security professionals. As the rise of sophisticated and nation-state malware targeting such systems flourishes, traditional digital forensics tools struggle to transfer the same capabilities to systems lacking typical volatile memory primitives, monitoring software, and the compatible operating-system primitives necessary for conducting forensic investigations. Even worse, SCADA systems are typically not designed and implemented with security in mind, nor were they purpose-built to monitor and record system data at the granularity associated with traditional IT systems. Rather, these systems are often built to control field devices and drive industrial processes. More succinctly, SCADA systems were not designed with a primary goal of interacting with the digital world. Consequently, forensics investigators well-versed in the world of digital forensics and incident response face an array of challenges that prevent them from conducting effective forensic investigation in environments with vast amounts of critical infrastructure. In order to bring SCADA systems within the reach of the armies of digital forensics professionals and tooling already available, both researchers and practitioners need a guide to the current state-of-the-art techniques, a road-map to the challenges lying on the path forward, and insight into the future directions R&D must move towards. To that end, this paper presents a survey into the literature on digital forensics applied to SCADA systems. We cover not only the challenges to applying digital forensics to SCADA like most other reviews, but also the range of proposed frameworks, methodologies, and actual implementations in literature.

Asmar Awad, Rima↗

Mastering HPC Runtime Prediction: From Observing Patterns to a Methodological Approach

The continual expansion of high-performance computing (HPC) brings with it an increasing need for efficiency. Heavy investment in energy, hardware, and software infrastructure to support peta- and exascale computing requires the optimization of existing systems and, wherever possible, the discernment and adoption of best-practices towards these goals. Such is the case for runtime prediction. When a job is submitted to an HPC system, an estimate of its runtime is provided by the user in the form of "requested wallclock". Error in this user-provided estimate can lead to jobs being prematurely killed by the scheduler, increased wait time on the queue, and decreased system utilization. More than fifteen years of research has been directed at mitigating these effects by using data-driven runtime predictions. Codified here is a set of commonalities and insights emerging from this body of work, which we present as recommendations and best practices. These practices are combined into a methodological approach described and evaluated on an 11-million-job dataset from the National Renewable Energy Laboratory's petascale HPC system, Eagle. This dataset and the accompanying codebase have been released to the public domain for the benefit of the wider HPC research community.

high performance computing↗

Adapting CLUTCH methodology to multigroup TSUNAMI-3D for eigenvalue sensitivity calculations

The sensitivity of the eigenvalue to uncertainties in nuclear data and its evaluation are important for nuclear criticality safety. TSUNAMI-3D sequences within the SCALE code system offer several options to the user community for calculating eigenvalue sensitivity coefficients with multigroup (MG) and continuous energy (CE) 3D transport capabilities. TSUNAMI-3D sequences implement the adjoint-based perturbation theory with MG KENO code, the Contributon Linked eigenvalue sensitivity/Uncertainty estimation via Track length importance CHaracterization (CLUTCH) method with CE KENO code, and the Iterated Fission Probability (IFP) method with CE KENO and Shift codes. Each method has benefits and limitations depending on the problem that is run. The work presented here aims to adapt the CLUTCH method, which enables the Contributon method's mesh-free, memory-efficient approach for calculating adjoint-weighted tallies for sensitivity calculations, to the MG TSUNAMI-3D sequence. This application would eliminate the explicit adjoint KENO calculation, as well as the memory-consuming mesh flux moment tallies required by the conventional MG TSUNAMI-3D. Smaller memory footprints in the CLUTCH methodology and relatively shorter runtimes in MG KENO transport can make MG TSUNAMI-3D a viable method for some complex problems. Moreover, this adaptation allows MG sensitivity calculations with Shift, ORNL's next-generation high-performance Monte Carlo transport code, which currently does not offer any sensitivity capabilities with MG particle transport simulations. Initial implementation of the new MG TSUNAMI-3D sequence and its preliminary results with a selected critical benchmark experiment in the Verified, Archived Library of Inputs and Data (VALID) are presented in this study.

KENO↗

Evaluation of Mesoscale Convective Systems in Climate Simulations: Methodological Development and Results from MPAS-CAM over the U.S.

In this study, a process-oriented approach is developed to evaluate warm-season mesoscale convective system (MCS) precipitation and their favorable large-scale meteorological patterns (FLSMPs) over the U.S. This approach features a novel observation-driven MCS-tracking algorithm using infrared brightness temperature and precipitation feature at 12, 25 and 50 km resolution and metrics to evaluate the model large-scale environment favorable for MCS initiation. The tracking algorithm successfully reproduces the observed MCS statistics from a reference 4-km radar MCS database. To demonstrate the utility of the new methodologies in evaluating MCS in climate simulations with mesoscale resolution, the process-oriented approach is applied to two climate simulations produced by the Variable-Resolution Model for Prediction Across Scales coupled to the Community Atmosphere Model physics, with refined horizontal grid spacing at 50 km and 25 km over North America. With the tracking algorithm applied to simulations and observations at equivalent resolutions, the simulated number of MCS and associated precipitation amount, frequency and intensity are found to be consistently underestimated in the Central U.S., particularly from May to August. The simulated MCS precipitation shows little diurnal variation and lasts too long, while MCS precipitation area is too large and intensity is too weak. The model is able to simulate four types of observed FLSMP associated with frontal systems and low-level jets (LLJ) in spring, but the frequencies are underestimated because of low-level dry bias and weaker LLJ. Precipitation simulated under different FLSMPs peak during daytime, in contrast to the observed nocturnal peak. Implications of these findings for future model development and diagnostics are discussed.

54 ENVIRONMENTAL SCIENCES↗

Columnar Vertical Profile (CVP) Methodology for Validating Polarimetric Radar Retrievals in Ice Using In Situ Aircraft Measurements

Abstract A novel way to process polarimetric radar data collected via plan position indicator (PPI) scans and display those data in a time–height format is introduced. The columnar vertical profile (CVP) methodology uses radar data collected via multiple elevation scans, limited to data within a set region in range and azimuth relative to the radar, to create vertical profiles of polarimetric radar data representative of that limited region in space. This technique is compared to others existing in the literature, and various applications are discussed. Polarimetric ice microphysical retrievals are performed on CVPs created within the stratiform rain region of two mesoscale convective systems sampled during two field campaigns, where CVPs follow the track of research aircraft. Aircraft in situ data are collocated to microphysical retrieval data, and the accuracy of these retrievals is tested against other retrieval techniques in the literature.

Engineering↗

Coupling of the Liquid Sampling–Atmospheric Pressure Glow Discharge to Orbitrap Mass Analyzers for Uranium Isotope Ratio Analysis: Evolution of the Methodology and Implications to the Field

Just over a decade ago, a truly outside-of-the-box approach to isotope ratio mass spectrometry (IRMS) was undertaken between research groups at Clemson University and the Pacific Northwest National Laboratory. The original motivation dealt with projections as to whether or not microplasmas could be developed into practical elemental ionization sources, perhaps for transportable analysis applications. In particular, the use of the liquid sampling–atmospheric pressure glow discharge (LS-APGD) was pursued. Its interfacing to an ultra-high resolution Orbitrap platform, proved not only facile, but opened up a wealth of potential applications. Here, we lay out a historical, tutorial description of the interfacing and the evolution of the methodology regarding IRMS of uranium. Practical challenges and opportunities are described, which hopefully provide guidance to further applications in high resolution IRMS. It is hoped that, while detailed and lengthy, the didactic nature of the presentation provides experimental insights and tips, and also serves as an homage to our very good friend, Professor Gary M. Hieftje, whose scientific inspiration and comradery have been immeasurably important in our own careers.

Koppenaal, David W.↗

Parallel methodology to capture cyclic variability in motored engines

Numerical prediction of of cycle-to-cycle variability (CCV) in SI engines is extremely challenging for two key reasons: (i) high-fidelity methods such as large eddy simulation (LES) are require to accurately capture the in-cylinder turbulent flowfield, and (ii) CCV is experienced over long timescales and hence the simulations need to be performed for hundreds of consecutive cycles. In this study, a new methodology is proposed to dissociate this long time-scale problem into several shorter time-scale problems, which can considerably reduce the computational time without sacrificing the fidelity of the simulations. The strategy is to perform multiple single-cycle simulations in parallel by effectively perturbing the simulation parameters such as the initial and boundary conditions. It is shown that by perturbing the initial velocity field effectively based on the intensity of the in-cylinder turbulence, the mean and variance of the in-cylinder flowfield is captured reasonably well. Adding perturbations in the initial pressure field and the boundary pressure improves the predictions. It is shown that this new approach is able to give accurate predictions of the flowfield statistics in less than one-tenth of time required for the conventional approach of simulating consecutive engine cycles.

33 ADVANCED PROPULSION SYSTEMS↗

Impact of genotype-calling methodologies on genome-wide association and genomic prediction in polyploids

This dataset contains all data used in the paper "Impact of genotype-calling methodologies on genome-wide association and genomic prediction in polyploids". The dataset includes genotypes and phenotypic data from two autotetraploid species Miscanthus sacchariflorus and Vaccinium corymbosum that was used used for genome wide association studies and genomic prediction and the scripts used in the analysis. In this V2, 2 files have the raw data are added: "Miscanthus_sacchariflorus_RADSeq.vcf" is the VCF file with the raw SNP calls of the Miscanthus sacchariflorus data used for genotype calling using the 6 genotype calling methods. "Blueberry_data_read_depths.RData" is the a RData file with the read depth data that was used for genotype calling in the Blueberry dataset.

allelic dosage↗

Classification methodology for tritiated waste requiring interim storage

Fusion machines like the ITER experimental research facility will use tritium as fuel. Therefore, most of the solid radioactive waste will result not only from activation by 14 MeV neutrons, but also from contamination by tritium. As a consequence, optimizing the treatment process for waste containing tritium (tritiated waste) is a major challenge. This paper summarizes the studies conducted in France within the framework of the French national plan for the management of radioactive materials and waste. The paper recommends a reference program for managing this waste based on its sorting, treatment and packaging by the producer. It also recommends setting up a 50-year temporary storage facility to allow for tritium decay and designing future disposal facilities using tritiated radwaste characteristics as input data. This paper first describes this waste program and then details an optimized classification methodology which takes into account tritium decay over a 50-year storage period. The paper also describes a specific application for purely tritiated waste and discusses the set-up expected to be implemented for ITER decommissioning waste (current assumption). Comparison between this optimized approach and other viable detritiation techniques will be drawn. (authors)

70 PLASMA PHYSICS AND FUSION TECHNOLOGY↗

VERA Core Simulator methodology for pressurized water reactor cycle depletion

This paper describes the methodology developed and implemented in the Virtual Environment for Reactor Applications Core Simulator (VERA-CS) to perform high-fidelity, pressurized water reactor (PWR), multicycle, core physics calculations. Depletion of the core with pin-resolved power and nuclide detail is a significant advance in the state of the art for reactor analysis, providing the level of detail necessary to address the problems of the U.S. Department of Energy Nuclear Reactor Simulation Hub, the Consortium for Advanced Simulation of Light Water Reactors (CASL). VERA-CS has three main components: the neutronics solver MPACT, the thermal-hydraulic (T-H) solver COBRA-TF (CTF), and the nuclide transmutation solver ORIGEN. This paper focuses on MPACT and provides an overview of the resonance self-shielding methods, macroscopic-cross-section calculation, two-dimensional/one-dimensional (2-D/1-D) transport, nuclide depletion, T-H feedback, and other supporting methods representing a minimal set of the capabilities needed to simulate high-fidelity models of a commercial nuclear reactor. Results are presented from the simulation of a model of the first cycle of Watts Bar Unit 1. The simulation is within 16 parts per million boron (ppmB) reactivity for all state points compared to cycle measurements, with an average reactivity bias of <5 ppmB for the entire cycle. Comparisons to cycle 1 flux map data are also provided, and the average 2-D root-mean-square (rms) error during cycle 1 is 1.07%. To demonstrate the multicycle capability, a state point at beginning of cycle (BOC) 2 was also simulated and compared to plant data. The comparison of the cycle 2 BOC state has a reactivity difference of +3 ppmB from measurement, and the 2-D rms of the comparison in the flux maps is 1.77%. Lastly, these results provide confidence in VERA-CS’s capability to perform high-fidelity calculations for practical PWR reactor problems.

21 SPECIFIC NUCLEAR REACTORS AND ASSOCIATED PLANTS↗