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At least 811 records · Page 45

Slycat v 2.0

Slycat™ is a web-based system for analysis of large, high-dimensional data such as that produced by High Performance Computing (HPC) platforms. The Slycat™ server integrates data ingestion, scalable analysis, data management, and visualization with commodity web clients using a multi-tiered hierarchy of data and model storage. Analysis inputs are pushed or pulled into Slycat™, where models are generated and analysis artifacts are stored in a project database. These artifacts are the basis for visualizations that are delivered to users’ desktops through ordinary web browsers, eliminating the need to build and deploy platform-specific client applications. Slycat™ currently provides four types of analysis: canonical correlation analysis (CCA) to model relationships between inputs and output metrics, time series analysis featuring clustering and comparative visualization of waveforms, parameter space visualization including remote retrieval of images and movies from HPC disks, and VideoSwarm for modeling video similarities over time.

Letter, Matthew↗

An Implicit Approach to Phase Field Modeling of Solidification for Additively Manufactured Alloys [Slides]

We are leveraging modern algorithms and computational science to provide a route to predictive simulation of microstructure evolution on emerging exascale architectures. We are utilizing the fastest supercomputers in the world for modeling and simulation of microstructure evolution for generation of data under AM conditions. Solidification conditions in AM can be tailored for the reliable design of materials to specific performance requirements. Developing computational tools to further characterize alloys and correlate the processing-structure-properties-performance (PSPP) relationship.

36 MATERIALS SCIENCE↗

Resilience of the slow component in timescale separated synchronized oscillators

Physiological networks are usually made of a large number of biological oscillators evolving on a multitude of different timescales. Phase oscillators are particularly useful in the modelling of the synchronization dynamics of such systems. If the coupling is strong enough compared to the heterogeneity of the internal parameters, synchronized states might emerge where phase oscillators start to behave coherently. Here, we focus on the case where synchronized oscillators are divided into a fast and a slow component so that the two subsets evolve on separated timescales. We assess the resilience of the slow component by, first, reducing the dynamics of the fast one using Mori-Zwanzig formalism. Second, we evaluate the variance of the phase deviations when the oscillators in the two components are subject to noise with possibly distinct correlation times. From the general expression for the variance, we consider specific network structures and show how the noise transmission between the fast and slow components is affected. Interestingly, we find that oscillators that are among the most robust when there is only a single timescale, might become the most vulnerable when the system undergoes a timescale separation. We also find that layered networks seem to be insensitive to such timescale separations.

97 MATHEMATICS AND COMPUTING↗

A computational fluid dynamics simulation framework for ventricular catheter design optimization

OBJECTIVE Cerebrospinal fluid (CSF) shunts are the primary treatment for patients suffering from hydrocephalus. While proven effective in symptom relief, these shunt systems are plagued by high failure rates and often require repeated revision surgeries to replace malfunctioning components. One of the leading causes of CSF shunt failure is obstruction of the ventricular catheter by aggregations of cells, proteins, blood clots, or fronds of choroid plexus that occlude the catheter’s small inlet holes or even the full internal catheter lumen. Such obstructions can disrupt CSF diversion out of the ventricular system or impede it entirely. Previous studies have suggested that altering the catheter’s fluid dynamics may help to reduce the likelihood of complete ventricular catheter failure caused by obstruction. However, systematic correlation between a ventricular catheter’s design parameters and its performance, specifically its likelihood to become occluded, still remains unknown. Therefore, an automated, open-source computational fluid dynamics (CFD) simulation framework was developed for use in the medical community to determine optimized ventricular catheter designs and to rapidly explore parameter influence for a given flow objective. METHODS The computational framework was developed by coupling a 3D CFD solver and an iterative optimization algorithm and was implemented in a high-performance computing environment. The capabilities of the framework were demonstrated by computing an optimized ventricular catheter design that provides uniform flow rates through the catheter’s inlet holes, a common design objective in the literature. The baseline computational model was validated using 3D nuclear imaging to provide flow velocities at the inlet holes and through the catheter. RESULTS The optimized catheter design achieved through use of the automated simulation framework improved significantly on previous attempts to reach a uniform inlet flow rate distribution using the standard catheter hole configuration as a baseline. While the standard ventricular catheter design featuring uniform inlet hole diameters and hole spacing has a standard deviation of 14.27% for the inlet flow rates, the optimized design has a standard deviation of 0.30%. CONCLUSIONS This customizable framework, paired with high-performance computing, provides a rapid method of design testing to solve complex flow problems. While a relatively simplified ventricular catheter model was used to demonstrate the framework, the computational approach is applicable to any baseline catheter model, and it is easily adapted to optimize catheters for the unique needs of different patients as well as for other fluid-based medical devices.

Neurosciences & Neurology↗

Resilience of the slow component in timescale-separated synchronized oscillators

Physiological networks are usually made of a large number of biological oscillators evolving on a multitude of different timescales. Phase oscillators are particularly useful in the modelling of the synchronization dynamics of such systems. If the coupling is strong enough compared to the heterogeneity of the internal parameters, synchronized states might emerge where phase oscillators start to behave coherently. Here, we focus on the case where synchronized oscillators are divided into a fast and a slow component so that the two subsets evolve on separated timescales. We assess the resilience of the slow component by, first, reducing the dynamics of the fast one using Mori-Zwanzig formalism. Second, we evaluate the variance of the phase deviations when the oscillators in the two components are subject to noise with possibly distinct correlation times. From the general expression for the variance, we consider specific network structures and show how the noise transmission between the fast and slow components is affected. Interestingly, we find that oscillators that are among the most robust when there is only a single timescale, might become the most vulnerable when the system undergoes a timescale separation. We also find that layered networks seem to be insensitive to such timescale separations.

59 BASIC BIOLOGICAL SCIENCES↗

Development of software fault-tolerance techniques

As computers become more widely used, and in particular as they become used in more safety critical applications, the reliability of the computer system and its software becomes more important. There is also an increasing need for high levels of reliability in applications involving very large numbers of inexpensive units where recall of the units would be disproportionately expensive. The nature of faults and the assumptions made by different approaches to correct operation are considered. The recovery block approach is described and a probabilistic analysis of its effectiveness, with and without correlated design errors is provided. Mechanisms for generating acceptance tests from specifications, and for providing recovery in the presence of asynchrony, are described. An analysis of, and design for, the provision of recovery blocks in the microprogram of the Bendix BDX930 processor is provided. An example of the use of recovery blocks in a simple operating system is also provided.

Melliar-Smith, P. M.↗

Metals Electroprocessing in Molten Salts

The present study seeks to explain the poor quality of solid electrodeposits in molten salts through a consideration of the effects of fluid flow of the electrolyte. Transparent cells allow observation of electrolyte circulation by a laser schlieren optical technique during the electrodeposition of solid zinc from the molten salt electrolyte, ZnCl2 - LiCl-KCl. Experimental variables are current, density, electrolyte composition, and cell geometry. Based on the results of earlier electrodeposition studies as well as reports in the literature, these parameters are identified as having the primary influence on cell performance and deposit quality. Experiments are conducted to measure the fluid flow patterns and the electrochemical cell characteristics, and to correlate this information with the morphology of the solid electrodeposit produced. Specifically, cell voltage, cell current, characteristic time for dendrite evolution, and dendrite growth directions are noted. Their relationship to electrolyte flow patterns and the morphology of the resulting electrodeposit are derived. Results to date indicate that laser schlieren imaging is capable of revealing fluid flow patterns in a molten salt electrolyte.

Sadoway, D. R.↗

Deformation and damage of composite plates under impact loading

Transient deformation and damage were studied in impacted graphite/epoxy plates. The plates were 8-ply and 16-ply quasi-isotropic laminates clamped around a 12.7 cm diameter circumference. They were instrumented with surface and embedded strain gages and loaded by a 202 gr mass dropped from a height of 1.8 m. The load history and imparted energy were obtained by means of an accelerometer attached to the impactor. Transient strains at various locations through the thickness and at various distances from the loading point were obtained. The characteristic features of the strain records are associated with specific failure modes in the laminate. The deformation history was also correlated with the induced damage as detected by X-radiography and ultrasonics. Impact damage is more extensive in the thicker laminate. Damage takes the form of delaminated strips parallel to the fiber direction in each ply and increasing in length from top to bottom.

Daniel, I. M.↗

Far-infrared and submillimeter wavelength observations of star-forming dense cores. II - Images

This paper reports on far-infrared and submillimeter wavelength observations of low-mass protostellar candidates. The data set comprises emission maps of nine sources observed over a wavelength range 100-800 microns. The emission is extended at all wavelengths longer than 100 microns. The apparent size of the emission regions is weakly correlated with the beam size and is consistent with an underlying specific intensity profile which is scale-free. The observed emission maps are not circular, but have a mean aspect ratio of 1.3, and the position angles are similar to those determined from maps of molecular emission. The observational results are used in conjunction with theoretical considerations to constrain the physical properties of the putative protostellar envelopes.

Ladd, E. F.↗

An experimental investigation of film condensation in porous structures

Local heat flux measurements are made using thermoelectric devices along a condenser section of a gravity-assisted heat pipe filled with porous media. Freon 113 is used as the working fluid in runs made with both constant-porosity and variable-porosity porous media, specifically, fibrous material and packed spheres. The experimental results can be correlated in a simple manner in terms of two new dimensionless groups based on the Nusselt number and the distance from the top of the condenser section.

White, S. M.↗

Volcanism, Cold Temperature, and Paucity of Sunspot Observing Days (1818-1858): A Connection?

During the interval of 1818-1858, several curious decreases in the number of sunspot observing days per year are noted in the observing record of Samuel Heinrich Schwabe, the discoverer of the sunspot cycle, and in the reconstructed record of Rudolf Wolf, the founder of the now familiar relative sunspot number. These decreases appear to be nonrandom in nature and often extended for 13 yr (or more). Comparison of these decreases with equivalent annual mean temperature (both annual means and 4-yr moving averages). as recorded at Armagh Observatory (Northern Ireland), indicates that the temperature during the years of decreased number of observing days trended downward near the start of' each decrease and upward (suggesting some sort of recovery) just before the end of each decrease. The drop in equivalent annual mean temperature associated with each decrease, as determined from the moving averages, measured about 0.1-0.7 C. The decreases in number of observing days are found to be closely related to the occurrences of large, cataclysmic volcanic eruptions in the tropics or northern hemisphere. In particular, the interval of increasing number of observing days at the beginning of the record (i.e., 1818-1819) may be related to the improving atmospheric conditions in Europe following the 1815 eruption of Tambora (Indonesia; 8 deg. S), which previously, has been linked to "the year without a summer" (in 1816) and which is the strongest eruption in recent history, while the decreases associated with the years of 1824, 1837, and 1847 may, be linked, respectively, to the large, catacivsmic volcanic eruptions of Galunggung (Indonesia; 7 deg. S) in 1822, Cosiguina (Nicaragua) in 1835, and, perhaps, Hekla (Iceland; 64 deg. N) in 1845. Surprisingly, the number of observing days per year, as recorded specifically b), SchAabe (from Dessau, Germany), is found to be linearly correlated against the yearly mean temperature at Armagh Observatory (r = 0.5 at the 2 percent level of significance); thus. years of fewer sunspot observing days in the historical record seem to indicate years of probable cooler clime, while years (if many sunspot observing days seem to indicate years of probable warmer clime (and Vice versa). Presuming this relationship to be real, one infers that the observed decrease in the number of observing days near 1830 (i.e., during "the lost record years" of 1825 to 1833) provides a strong indication that temperatures at Armagh (and, perhaps, most of Europe, as well) were correspondingly cooler. If true, then, the inferred cooling may have resulted from the eruption of Kliuchevsoi(Russia; 56 deg. N) in 1829.

Wilson, Robert M.↗

Multi-Gas Sensor

A multi-gas sensor is provided which modulates a polarized light beam over a broadband of wavelengths between two alternating orthogonal polarization components. The two orthogonal polarization components of the polarization modulated beam are directed along two distinct optical paths. At least one optical path contains one or more spectral discrimination element, with each spectral discrimination element having spectral absorption features of one or more gases of interest being measured. The two optical paths then intersect, and one orthogonal component of the intersected components is transmitted and the other orthogonal component is reflected. The combined polarization modulated beam is partitioned into one or more smaller spectral regions of interest where one or more gases of interest has an absorption band. The difference in intensity between the two orthogonal polarization components is then determined in each partitioned spectral region of interest as an indication of the spectral emission/absorption of the light beam by the gases of interest in the measurement path. The spectral emission/absorption is indicative of the concentration of the one or more gases of interest in the measurement path. More specifically, one embodiment of the present invention is a gas filter correlation radiometer which comprises a polarizer, a polarization modulator, a polarization beam splitter, a beam combiner, wavelength partitioning element, and detection element. The gases of interest are measured simultaneously and, further, can be measured independently or non-independently. Furthermore, optical or electronic element are provided to balance optical intensities between the two optical paths.

Sachse, Glenn W.↗

Method for Balancing Detector Output to a Desired Level of Balance at a Frequency

A multi-gas sensor is provided which modulates a polarized light beam over a broadband of wavelengths between two alternating orthogonal polarization components. The two orthogonal polarization components of the polarization modulated beam are directed along two distinct optical paths. At least one optical path contains one or more spectral discrimination elements, with each spectral discrimination element having spectral absorption features of one or more gases of interest being measured. The two optical paths then intersect, and one orthogonal component of the intersected components is transmitted and the other orthogonal component is reflected. The combined polarization modulated beam is partitioned into one or more smaller spectral regions of interest where one or more gases of interest has an absorption band. The difference in intensity between the two orthogonal polarization components is then determined in each partitioned spectral region of interest as an indication of the spectral emission/absorption of the light beam by the gases of interest in the measurement path. The spectral emission/absorption is indicative of the concentration of the one or more gases of interest in the measurement path. More specifically, one embodiment of the present invention is a gas filter correlation radiometer which comprises a polarizer, a polarization modulator, a polarization beam splitter, a beam combiner, wavelength partitioning element, and detection element. The gases of interest are measured simultaneously and, further, can be measured independently or non-independently. Furthermore, optical or electronic element are provided to balance optical intensities between the two optical paths.

Sachse, Glenn W.↗

Drug marker absorption in relation to pellet size, gastric motility and viscous meals in humans

PURPOSE: The objective of this study was to evaluate drug marker absorption in relation to the gastric emptying (GE) of 0.7 mm and 3.6 mm enteric coated pellets as a function of viscosity and the underlying gastric motility. METHODS: Twelve subjects were evaluated in a 3-way crossover study. 0.7 mm caffeine and 3.6 mm acetaminophen enteric coated pellets were concurrently administered with a viscous caloric meal at the levels of 4000, 6000 and 8000 cP. Gastric motility was simultaneously measured with antral manometry and compared to time events in the plasma profiles of the drug markers. RESULTS: Caffeine, from the 0.7 mm pellets, was observed significantly earlier in the plasma than acetaminophen, from the 3.6 mm pellets, at all levels of viscosity. Motility related size differentiated GE was consistently observed at all viscosity levels, however, less variability was observed with the 4000 cP meal. Specifically, the onset of absorption from the of 3.6 mm pellets correlated with the onset of Phase II fasted state contractions (r = 0.929, p < 0.01). CONCLUSIONS: The timeframe of drug marker absorption and the onset of motility events were not altered within the range of viscosities evaluated. Rather, the differences in drug marker profiles from the non-digestible solids were most likely the result of the interaction between viscosity and motility influencing antral flow dynamics. The administration of the two sizes of pellets and a viscous caloric meal with subsequent monitoring of drug marker profiles is useful as a reference to assess the influence of motility patterns on the absorption profile of orally administered agents.

NASA Center JSC↗

A Biomechanical Approach to Assessing Hip Fracture Risk

Bone loss in microgravity is well documented, but it is difficult to quantify how declines in bone mineral density (BMD) contribute to an astronaut's overall risk of fracture upon return. This study uses a biomechanical approach to assessing hip fracture risk, or Factor of Risk (Phi), which is defined as the ratio of applied load to bone strength. All long-duration NASA astronauts from Expeditions 1-18 were included in this study (n=25), while crewmembers who flew twice (n=2) were treated as separate subjects. Bone strength was estimated based on an empirical relationship between areal BMD at the hip, as measured by DXA, and failure load, as determined by mechanical testing of cadaver femora. Fall load during a sideways fall was calculated from a previously developed biomechanical model, which takes into account body weight, height, gender, and soft tissue thickness overlying the lateral aspect of the hip that serves to attenuate the impact force. While no statistical analyses have been performed yet, preliminary results show that males in this population have a higher FOR than females, with a post- flight Phi of 0.87 and 0.36, respectively. FOR increases 5.1% from preflight to postflight, while only one subject crossed the fracture "threshold" of Phi = 1, for a total of 2 subjects with a postflight Phi > 1. These results suggest that men may be at greater risk for hip fracture due largely in part to their relatively thin soft tissue padding as compared to women, since soft tissue thickness has the highest correlation (R(exp 2)= .53) with FOR of all subject-specific parameters. Future work will investigate changes in FOR during recovery to see if baseline risk levels are restored upon return to 1-g activity. While dual x-ray absorptiometry (DXA) is the most commonly used clinical measure of bone health, it fails to provide compartment-specific information that is useful in assessing changes to bone quality as a result of microgravity exposure. Peripheral quantitative computed tomography (pQCT) accomplishes this by imaging transverse "slices" of the long bones. This project was a re-analysis of a 90 day bed rest study to determine if changes to cortical and trabecular compartments could be detected in the distal tibia with statistical significance using a new pQCT image analysis method. Nearly all changes in bone mineral density (BMD) and cross sectional area (CSA) measures were seen with statistical significance, with the exception of a change in cortical BMD. Total bone CSA increased by 1.1 % (p =0.01), cortical CSA decreased by - 5.6% (p<0.001) and trabecular CSA increased by 1.76% (p=0.007); the combination of which suggests bone resorption occurred at the endocortical surface in response to mechanical unloading by bed rest. Furthermore, total BMD and trabecular BMD decreased (-3.8%, p=0.001 and -2.8%, p =0.007, respectively), while decreases in cortical BMD failed to reach significance (-1.2%, p=0.07). Given that compartment-specific changes are seen with significance and are likely to influence bone strength, it is recommended that pQCT remain a standard measure used in bed rest because it provides a unique measure by which to better evaluate the efficacy of countermeasures to microgravity-induced bone loss.

Ellman, Rachel↗

Mechanistic Modeling of Departure from Nucleate Boiling under Transient Scenarios

The critical heat flux (CHF) corresponding to the departure from nucleate boiling (DNB) is one of the major limiting factors in the design and operation of pressurized water reactors (PWRs). Various predictive tools have been proposed for steady-state conditions. Empirical correlations and look-up tables yield relatively good agreement with specific experimental datasets and are widely used in subchannel codes for PWR transient simulations. However, experimental studies have revealed that during fast transients, the CHF values can become significantly higher than those in steady-state or slow transient scenarios, causing this modeling approach to result in overly conservative DNB prediction. This paper presents a mechanistic transient CHF model. Based on prior work, two DNB triggering mechanisms prevail in this model—the hydrodynamic thinning process and the thermal thinning process—both of which rely on the generally admitted liquid sublayer dryout theory. These mechanisms evaluate the depletion of the liquid sublayer underneath vapor slugs flowing over the channel. This model is further validated against three sets of power transient experiments at different operating conditions. While it clearly outperforms steady-state approaches and generally agrees closely with measurements, it still remarkably under-estimates CHF for very fast transients at low pressure. Future investigations will address this limitation.

Zhao, X. G.↗

Unravelling competing microscopic interactions at a phase boundary: A single-crystal study of the metastable antiferromagnetic pyrochlore Yb 2 Ge 2 O 7

We report inelastic neutron scattering measurements from our newly synthesized single crystals of the structurally metastable antiferromagnetic pyrochlore Yb 2 Ge 2 O 7 . We determine the four symmetry-allowed nearest-neighbor anisotropic exchange parameters via fits to linear spin wave theory supplemented by fits of the high-temperature specific heat using the numerical linked-cluster expansion method. The exchange parameters so-determined are strongly correlated to the values determined for the g-tensor components, as previously noted for the related Yb pyrochlore Yb 2 Ti 2 O 7 . To address this issue, we directly determined the g-tensor from electron paramagnetic resonance of 1% Yb-doped Lu 2 Ge 2 O 7 , thus enabling an unambiguous determination of the exchange parameters. Our results show that Yb 2 Ge 2 O 7 resides extremely close to the classical phase boundary between an antiferromagnetic Γ 5 phase and a splayed ferromagnet phase. By juxtaposing our results with recent ones on Yb 2 Ti 2 O 7 , our work illustrates that the Yb pyrochlore oxides represent ideal systems for studying quantum magnets in close proximity to classical phase boundaries.

75 CONDENSED MATTER PHYSICS, SUPERCONDUCTIVITY AND↗

Ultra-Broad-Band Optical Parametric Amplifier or Oscillator

A concept for an ultra-broad-band optical parametric amplifier or oscillator has emerged as a by-product of a theoretical study in fundamental quantum optics. The study was originally intended to address the question of whether the two-photon temporal correlation function of light [in particular, light produced by spontaneous parametric down conversion (SPDC)] can be considerably narrower than the inverse of the spectral width (bandwidth) of the light. The answer to the question was found to be negative. More specifically, on the basis of the universal integral relations between the quantum two-photon temporal correlation and the classical spectrum of light, it was found that the lower limit of two-photon correlation time is set approximately by the inverse of the bandwidth. The mathematical solution for the minimum two-photon correlation time also provides the minimum relative frequency dispersion of the down-converted light components; in turn, the minimum relative frequency dispersion translates to the maximum bandwidth, which is important for the design of an ultra-broad-band optical parametric oscillator or amplifier. In the study, results of an analysis of the general integral relations were applied in the case of an optically nonlinear, frequency-dispersive crystal in which SPDC produces collinear photons. Equations were found for the crystal orientation and pump wavelength, specific for each parametric-down-converting crystal, that eliminate the relative frequency dispersion of collinear degenerate (equal-frequency) signal and idler components up to the fourth order in the frequency-detuning parameter

Strekalov, Dmitry↗