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Microgravity nucleation and particle coagulation experiments support

A hollow sphere model is developed to predict the range of supersaturation ratio values for refractory metal vapors in a proposed experimental nucleation apparatus. Since the experiments are to be carried out in a microgravity environment, the model neglects the effects of convection and assumes that the only transfer of vapors through an inert gas atmosphere is by conduction and molecular diffusion. A consistent set of physical properties data is assembled for the various candidate metals and inert ambient gases expected to be used in the nucleation experiments. Transient partial pressure profiles are computed for the diffusing refractory species for two possible temperature distributions. The supersaturation ratio values from both candidate temperature profiles are compared with previously obtained experimetnal data on a silver-hydrogen system. The model is used to simulate the diffusion of magnesium vapor through argon and other inert gas atmospheres over ranges of initial and boundary conditions. These results identify different combinations of design and operating parameters which are liekly to produce supersaturation ratio values high enough to induce homogeneous nucleation in the apparatus being designed for the microgravity nucleation experiments.

Lilleleht, L. U.↗

NASA Lewis' Telescience Support Center Supports Orbiting Microgravity Experiments

The Telescience Support Center (TSC) at the NASA Lewis Research Center was developed to enable Lewis-based science teams and principal investigators to monitor and control experimental and operational payloads onboard the International Space Station. The TSC is a remote operations hub that can interface with other remote facilities, such as universities and industrial laboratories. As a pathfinder for International Space Station telescience operations, the TSC has incrementally developed an operational capability by supporting space shuttle missions. The TSC has evolved into an environment where experimenters and scientists can control and monitor the health and status of their experiments in near real time. Remote operations (or telescience) allow local scientists and their experiment teams to minimize their travel and maintain a local complement of expertise for hardware and software troubleshooting and data analysis. The TSC was designed, developed, and is operated by Lewis' Engineering and Technical Services Directorate and its support contractors, Analex Corporation and White's Information System, Inc. It is managed by Lewis' Microgravity Science Division. The TSC provides operational support in conjunction with the NASA Marshall Space Flight Center and NASA Johnson Space Center. It enables its customers to command, receive, and view telemetry; monitor the science video from their on-orbit experiments; and communicate over mission-support voice loops. Data can be received and routed to experimenter-supplied ground support equipment and/or to the TSC data system for display. Video teleconferencing capability and other video sources, such as NASA TV, are also available. The TSC has a full complement of standard services to aid experimenters in telemetry operations.

Hawersaat, Bob W.↗

Studies of Two-Phase Gas-Liquid Flow in Microgravity

Two-phase gas-liquid flows are expected to occur in many future space operations. Due to a lack of buoyancy in the microgravity environment, two-phase flows are known to behave differently than those in earth gravity. Despite these concerns, little research has been conducted on microgravity two-phase flow and the current understanding is poor. This dissertation describes an experimental and modeling study of the characteristics of two-phase flows in microgravity. An experiment was operated onboard NASA aircraft capable of producing short periods of microgravity. In addition to high speed photographs of the flows, electronic measurements of void fraction, liquid film thickness, bubble and wave velocity, pressure drop and wall shear stress were made for a wide range of liquid and gas flow rates. The effects of liquid viscosity, surface tension and tube diameter on the behavior of these flows were also assessed. From the data collected, maps showing the occurrence of various flow patterns as a function of gas and liquid flow rates were constructed. Earth gravity two-phase flow models were compared to the results of the microgravity experiments and in some cases modified. Models were developed to predict the transitions on the flow pattern maps. Three flow patterns, bubble, slug and annular flow, were observed in microgravity. These patterns were found to occur in distinct regions of the gas-liquid flow rate parameter space. The effect of liquid viscosity, surface tension and tube diameter on the location of the boundaries of these regions was small. Void fraction and Weber number transition criteria both produced reasonable transition models. Void fraction and bubble velocity for bubble and slug flows were found to be well described by the Drift-Flux model used to describe such flows in earth gravity. Pressure drop modeling by the homogeneous flow model was inconclusive for bubble and slug flows. Annular flows were found to be complex systems of ring-like waves and a substrate film. Pressure drop was best fitted with the Lockhart- Martinelli model. Force balances suggest that droplet entrainment may be a large component of the total pressure drop.

Bousman, William Scott↗

The Effects of Gravity on Wrinkled Laminar Flames

The effects of gravity are significant to the dynamics of idealized unconfined open premixed flames. Moderate to low turbulence Reynolds number flames, i.e., wrinkled laminar flames, of various unconfined geometries have been used extensively for investigating fundamental processes of turbulent flame propagation and to validate theoretical models. Without the wall constraints, the flames are free to expand and interact with surrounding ambient air. The flow field in which the flame exists is determined by a coupling of burner geometry, flame orientation and the gravity field. These complex interactions raise serious questions regarding the validity of comparing the experimental data of open flames with current theoretical and numerical models that do not include the effects of gravity nor effects of the larger aerodynamic flowfield. Therefore, studies of wrinkled laminar flame in microgravity are needed for a better understanding of the role of gravity on flame characteristics such as the orientation, mean aerodynamics stretch, flame wrinkle size and burning rate. Our approach to characterize and quantify turbulent flame structures under microgravity is to exploit qualitative and quantitative flow visualization techniques coupled with video recording and computer controlled image analysis technologies. The experiments will be carried out in the 2.2 second drop tower at the NASA Lewis Research Center. The longest time scales of typical wrinkled laminar flames in the geometries considered here are in the order of 10 msec. Hence, the duration of the drop is sufficient to obtain the amount of statistical data necessary for characterize turbulent flame structures.

Kostiuk, Larry W.↗

KSC to EDEN ISS: Outredgeous Lettuce Growth on the Passive Porous Tube Nutrient Delivery System (PPTNDS)

EDEN ISS is a controlled environment greenhouse established near the Neumayer Station III in Antarcticawith the mission to enable fresh crop production for the crew who are working in this remote location. EDEN provides a space to conduct plant biology and related research in a unique and isolated controlled environment (CE), while providing a platform to test developing methods relevant to long duration manned space missions. In 2021, Kennedy Space Center (KSC) scientist Jess Bunchek fulfilled a one-year mission at EDEN. During that time a variety of fresh crops were grown to record horticultural and microbiological data as well as provide the crew with fresh food to eat. One method for crop growth included an experimental irrigation system called the Passive Porous Tube Nutrient Delivery System (PPTNDS) which was developed at KSC as a microgravity-capable plant irrigation system designed to support Space Plant Biology investigations and/or crop growth during space missions. The PPTNDS was employed to grow Outredgeous Lettuce (OL) during two growouts at EDEN, (harvesting at Day After Planting (DAP) 61 and 63) and two growouts at KSC where plant growth and micro sample data were captured. This paper presents the data collected from the PPTNDS and compares it to growth on a Nutrient Film Technique (NFT) hydroponic system operated in the same environment. The result shows a system that grows OL at a reduced rate compared to the NFT system but uses less water and crew interaction to operate.

Jacob Torres↗

A Review and Comparison of Mouse and Rat Responses to Micro Gravity, Hyper Gravity and Simulated Models of Partial Gravity; Species Differences, Gaps in the Available Data, and Consideration of the Advantages and Caveats of Each Model for Spaceflight

Laboratory strains of mice and rat are widely used to study mammalian responses to stimulus, and both have been studied under a variety of gravity conditions, including space flight. We compared results obtained from exposure to spaceflight and microgravity, hyper gravity via centrifugation, earth gravity, and models of simulated partial gravity (hind-limb unloading and partial weight bearing treatments). We examined the reported changes in survival, body mass, circadian rhythm (body temperature and activity levels), behavior, bone, muscle, immune, cardio-vasculature, vestibular, reproduction and neonate survival, microbiome, and the visual system. Not all categories have published data for both species, some have limited data, and there are variations in experiment design that allow for only relative comparisons to be considered. The data reveal species differences in both the level of gravity required to obtain a response, degree of response, and in temporal expression of responses. Examination of the data across the gravity levels allows consideration of the hypothesis that gravitational responses follow a continuum, and organ specific differences are noted. In summary, we present advantages and caveats of each model system as pertains to gravitational biology research and identify gaps in our knowledge of how these mammals respond to gravity.

mouse rat gravity↗

Parabolic Flight Investigation for Advanced Exercise Concept Hardware Hybrid Ultimate Lifting Kit (HULK)

Long-duration space flight poses many hazards to the health of the crew. Among those hazards is the physiological deconditioning of the musculoskeletal and cardiovascular systems due to prolonged exposure to microgravity. To combat this erosion of physical condition space flight may take on the crew, the Human Research Program (HRP) is charged with developing Advanced Exercise Concepts to maintain astronaut health and fitness during long-term missions, while keeping device mass, power, and volume to a minimum. The goal of this effort is to preserve the physical capability of the crew to perform mission critical tasks in transit and during planetary surface operations. The HULK is a pneumatic-based exercise system, which provides both resistive and aerobic modes to protect against human deconditioning in microgravity. Its design targeted the International Space Station (ISS) Advanced Resistive Exercise Device (ARED) high level performance characteristics and provides up to 600 foot pounds resitive loading with the capability to allow for eccentric to concentric (E:C) ratios of higher than 1:1 through a DC motor assist component. The device's rowing mode allows for high cadence aerobic activity. The HULK parabolic flight campaign, conducted through the NASA Flight Opportunities Program at Ellington Field, resulted in the creation of device specific data sets including low fidelity motion capture, accelerometry and both inline and ground reaction forces. These data provide a critical link in understanding how to vibration isolate the device in both ISS and space transit applications. Secondarily, the study of human exercise and associated body kinematics in microgravity allows for more complete understanding of human to machine interface designs to allow for maximum functionality of the device in microgravity.

countermeasures↗

A Study of Nucleate Boiling with Forced Convection in Microgravity

The ultimate objective of basic studies of flow boiling in microgravity is to improve the understanding of the processes involved, as manifested by the ability to predict its behavior. This is not yet the case for boiling heat transfer even in earth gravity, despite the considerable research activity over the past 30 years. The elements that constitute the nucleate boiling process - nucleation, growth, motion, and collapse of the vapor bubbles (if the bulk liquid is subcooled) - are common to both pool and flow boiling. It is well known that the imposition of bulk liquid motion affects the vapor bubble behavior relative to pool boiling, but does not appear to significantly influence the heat transfer. Indeed, it has been recommended in the past that empirical correlations or experimental data of pool boiling be used for design purposes with forced convection nucleate boiling. It is anticipated that such will most certainly not be possible for boiling in microgravity, based on observations made with pool boiling in microgravity. In earth gravity buoyancy will act to remove the vapor bubbles from the vicinity of the heater surface regardless of how much the imposed bulk velocity is reduced, depending, of course, on the geometry of the system. Vapor bubbles have been observed to dramatically increase in size in pool boiling in microgravity, and the heat flux at which dryout took place was reduced considerably below what is generally termed the critical heat flux (CHF) in earth gravity, depending on the bulk liquid subcooling. However, at heat flux levels below dryout, the nucleate pool boiling process was enhanced considerably over that in earth gravity, in spite of the large vapor bubbles formed in microgravity and perhaps as a consequence. These large vapor bubbles tended to remain in the vicinity of the heater surface, and the enhanced heat transfer appeared to be associated with the presence of what variously has been referred to as a liquid microlayer between the bubble and the heater surface. The enhancement of the boiling process with low velocities in earth gravity for those orientations producing the formation of a liquid macrolayer described above, accompanied by "sliding" vapor bubbles, has been demonstrated. The enhancement was presented as a function of orientation, subcooling, and heated length, while a criterion for the heat transfer for mixed natural/forced convection nucleate boiling was given previously. A major unknown in the prediction and application of flow boiling heat transfer in microgravity is the upper limit of the heat flux for the onset of dryout (or critical heat flux - CHF), for given conditions of fluid-heater surfaces, including geometry, system pressure and bulk liquid subcooling. It is clearly understood that the behavior in microgravity will be no different than on earth with sufficiently high flow velocities, and would require no space experimentation. However, the boundary at which this takes place is still an unknown. Previous results of CHF measurements were presented for low velocity flow boiling at various orientations in earth gravity as a function of flow velocity and bulk liquid subcooling, along with preliminary measurements of bubble residence times on a flat heater surface. This showed promise as a parameter to be used in modeling the CHF, both in earth gravity and in microgravity. The objective of the work here is to draw attention to and show results of current modeling efforts for the CHF, with low velocities in earth gravity at different orientations and subcoolings. Many geometrical possibilities for a heater surface exist in flowing boiling, with boiling on the inner and outer surfaces of tubes perhaps being the most common. If the vapor bubble residence time on and departure size from the heater surface bear a relationship to the CHF, as results to be given indicate, it is important that visualization of and access to vapor bubble growth be conveniently available for research purposes. In addition, it is desirable to reduce the number of variables as much as possible in a fundamental study. These considerations dictated the use of a flat heater surface, which is rectangular in shape, 1.91 cm by 3.81 cm (0.75 x 1.5 inches), consisting either of a 400 Angstrom thick semi-transparent gold film sputtered on a quartz substrate which serves simultaneously as a heater and a resistance thermometer, or a copper substrate of the same size. The heater substrate is a disc which can be rotated so that the heated length in the flow direction can be changed from 1.91 to 3.81 cm (0.75 to 1.5 inches). The fluid is R-113, and the velocities can be varied between 0.5 cm/s and 60 cm/s. For a sufficiently low velocity the CHF can be modeled reasonably well at various orientations by the correlation for pool boiling corrected for the influence of bulk liquid subcooling, multiplied by the square root of q, the angle relative to horizontal. This arises from equating buoyancy and drag forces in the inverted positions where the vapor bubbles are held against the heater surface as they slide. A distortion of the measurements relative to pool boiling occurs as the flow velocity increases. In modeling this effect at different levels of subcooling it appeared appropriate to estimate the volumetric rate of vapor generation, using measurements of bubble frequency (or residence time), void fraction and average bubble boundary layer thickness. These were determined with the use of a platinum hot wire probe 0.025 mm in diameter by 1.3 mm long, applying a constant current to distinguish between contact with liquid or vapor. Two-dimensional spatial variations are obtained with a special mechanism to resolve displacements in increments of 0.025 mm. From such measurements it was determined that the fraction of the surface heat transfer resulting in evaporation varies inversely with the subcooling correction factor for the CHF. The measured inverse bubble residence time is normalized relative to that predicted for an infinite horizontal flat plate at the CHF, and is correlated well with the CHF normalized relative to that for pool boiling, for various orientation angles and subcooling levels. This correspondence is then combined with a normalizing factor for the energy flux leaving the heater surface at the CHF and the computed bubble radius at departure, determined from the balance between the outward velocity of the interface due to evaporation and the buoyance induced velocity of the center of mass of the bubble. The product of the CHF and the corresponding residence time was determined to be a constant for all orientations at a given bulk flow velocity and liquid subcooling, and must be determined empirically for each velocity and subcooling at present. It then becomes possible to predict the CHF for the different orientations, velocities, and subcoolings. These are compared with normalized measurements of the CHF for velocities ranging from 4 cm/s to 55 cm/s, subcoolings from 2.8 to 22.2 K, over orientations angles of 360 degrees.

Merte, Herman, Jr.↗

Cross Kingdom Analysis of Data Within the GeneLab Repository Identifies a Potential Conserved Response of Life to the Stress Associated with Spaceflight

It is important to determine the health risks and potential survival for astronauts associated with long-term space missions. This entails not only understanding the impact the space environment will have on humans, but also how it will affect other organisms needed for humans to survive in space such as plants. In addition, it has been reported in the literature that hundreds of genes seem to be conserved and/or transferred between different organisms from bacteria, archaea, fungi, microorganisms, and plants to animals. Since space travel involves humans in a closed environment over a long period of time, we hypothesize that potential conserved biological factors will occur between the different organisms in that environment possibly due to transfer of genes. Determining the conserved factors that are commonly being regulated in space can shed insight into possible universal master regulators and also determine the symbiotic relationship between the organisms in space. Utilizing NASA's GeneLab Data Repository (a rapidly expanding, curated clustering of spaceflight-related ‘omics-level datasets for all organisms), we were able to uncover a novel pathway and factors that were commonly shared between humans, mice, plants, C. Elegans, and drosophilas. Through ChIP-Seq enrichment analysis techniques utilizing various GeneLab datasets from each species that were flown in space, we found the following factors to be conserved across all species: oxidative stress, DNA damage (through GABPA/NRFs and NFY), SIX5, GTF2B and glutamine synthetase. Such commonalities would likely reflect the effects of factors such as microgravity and the increased radiation exposure inherent in spaceflight on basic physical processes shared by all biological systems at the cellular level. Differences between organismal responses revealed by GeneLab's data should also help understand the unique reactions to life in space that arise from the very different lifestyles of microbes, animals and plants.

Barker, Richard↗

Constitutive and Stability Behavior of Granular Materials Under Very Low Effective Stresses

The study of the behavior of granular materials such as sand is of great importance to the understanding of the response of foundations resting on surface and near-surface soil deposits. A clear understanding of the behavior of such materials can also provide insights into other related issues where low effective stresses are encountered such as liquefaction. The main sources of the constitutive and stability properties of cohesionless granular materials is interparticle friction, which in turn under low confinement stress levels is strongly affected by gravitational body forces under terrestrial (1 gravity) conditions. Under moderate-to-high stress levels, the influence of gravity on the behavior of experiments may not be pronounced and therefore the test results in a terrestrial environment may be acceptable for engineering purposes. However, the conduct of experiments on granular materials under very low stress levels and under quasi-static conditions can only be performed in a microgravity environment. A series of displacement-controlled cyclic triaxial compression experiments were performed in a SPACEHAB module on the Space Shuttle during the STS-79 mission to Mir in September, 1996, and the STS-89 mission in January, 1998. The experiments were conducted on six right cylindrical specimens 75 mm in diameter and 150 mm long at effective confining pressures of 0.05, 0.52 and 1.30 kPa. The results show very high peak strength friction angles in the range of 47.6 to 70.0 degrees, which are mainly due to overconsolidation and grain interlocking effects. It was observed that the residual strength levels were in the same range as that observed at higher confining stress levels. The dilatancy angles were unusually high in the range of 30 to 31 degrees. All specimens display substantial initial stiffnesses and elastic moduli during unloading and reloading events, which are nearly an order of magnitude higher than conventional theories predict. A periodic instability phenomenon which appears to result from buckling of multiple internal arches and columnar systems, augmented by stick-slips was observed in the experiments. Computed Tomography (CT) measurements revealed valuable data about the internal fabric and the specimens deformation patterns. Uniform diffuse bifurcation with multiple radial shear bands was observed in the specimens tested in a microgravity environment. In the axial direction, two major conical surfaces were developed. Spatial nonsymmetrical deformations were observed in specimens tested in terrestrial laboratory.

Alshibli, Khalid A.↗

Bioavailability and Pharmacodynamics of Promethazine in Human Subjects

Space Motion Sickness (SMS) is often treated in space with promethazine (PMZ). Anecdotal reports indicate that the common side effects of drowsiness and decrements in cognitive performance that are associated with PMZ administration (50 mg IM on the ground, are absent or less pronounced in space suggesting I that-the bioavailability and/or pharmacodynamic behavior of PMZ may be altered during space flight. There are limited flight opportunities available for clinical research in space, the NRA-99, therefore, solicits research required to improve, or answer specific questions about in-flight diagnosis, therapy, and post-flight rehabilitation. We propose here, to establish a noninvasive method for pharmacodynamic and therapeutic assessment of PMZ. The specific objectives of the proposed research are to, 1. Establish a saliva to plasma ratio of PMZ after administration, 2. Estimate the relative bioavailability of the three flight-specific dosage forms of PMZ, and 3. Establish the dose-response relationship of PMZ. We will estimate the bioavailability of intramuscular injection (IM), oral tablets and rectal suppositories in normal subjects during ambulatory and antiorthostatic; bed rest (ABR) conditions using novel stable isotope techniques. Drowsiness, cognitive performance and salivary flow rate will be measured as a function of circulating drug concentrations after administration of three IM doses of PMZ. We will compare and contrast the bioavailability of PMZ during normal and ABR conditions to examine whether or not ABR can simulate changes in drug, absorption and availability similar to those anticipated in a microgravity environment. Results of this study will validate methods for an approved study with this medication awaiting a flight opportunity for manifestation. These data will also provide the much needed information on the dynamics and therapeutic index. of this medication and their implications on crew fatigue and performance in space. Key words: Promethazine, stable isotopes, bioavailability, pharmacodynamics, cognitive performance, antiorthostatic bed rest.

Putcha, Lakshmi↗

Biological Dosimetry in Astronauts

Biodosimetry data provides a direct measurement of space radiation damage, which takes into account individual radiosensitivity in the presence of confounding factors such as microgravity and other stress conditions. In contrast to physical measurements, which are external to body and require multiple devices to detect all radiation types all of which have poor sensitivity to neutrons, biodosimetry is internal and includes the effects of shielding provided by the body itself plus chromosome damage shows excellent sensitivity to protons, heavy ions, and neutrons. Moreover, chromosome damage maybe reflective of cancer risk and biodosimetry values can therefore be used to validate and develop risk assessment models that can be used to characterize excess health risk incurred by crewmembers. Cytogenetic biodosimetry methods have been used extensively for assessing terrestrial radiation exposures, and remain the most sensitive in vivo indicator of dose available to date. The main cellular radiation target is the DNA, and radiation-induced damage in the DNA molecule can be visualized as aberrations in the chromosomes (breaks in the chromosomes or exchanges of DNA material between different chromosomes). Normal chromosomes contain a single condensed and constricted area called a centromere that helps the chromosome number to remain stable when a cell divides.

George, Kerry↗

Evaluation of Aerobic Standards for Lunar Surface Extravehicular Activities

Introduction: As NASA prepares to return to the Moon, astronauts will need to be physically primed to successfully execute Extravehicular Activities (EVA) on the Lunar surface. Compared to past Apollo missions, Artemis missions will include EVAs of increased physical demand, frequency, intensity, and duration, thus requiring adequate fitness to successfully and safely complete mission objectives. The physical demand associated with partial gravity (g) EVAs on the Moon is expected to be greater compared to microgravity EVAs based on initial workload estimation. Currently, aerobic fitness standards for partial g EVAs are not well supported by high-fidelity data and require further research for establishing standards to protect crew health and performance during Lunar surface missions. Therefore, the aim of this investigation is to characterize metabolic data from Lunar analog simulations and in-flight crew population aerobic capacity data to validate the current NASA 3001 standard for celestial partial g aerobic fitness (aerobic capacity (VO_2pk) ≥36.5ml/kg/min). Methods: In order to evaluate aerobic fitness requirements for Lunar EVAs, the following were performed: 1) preliminary analysis of long-duration (6 hr) EVA analog simulations in the Neutral Buoyancy Laboratory (NBL) and the Active Response Gravity Offload System (ARGOS) to evaluate expected metabolic rates for 1/6 g EVAs (NBL: n=1 female; ARGOS: n=1 male) and 2) assessment of the current NASA 3001 celestial surface EVA aerobic standard (aerobic capacity (VO_2pk) ≥36.5ml/kg/min) with data from an ISS astronaut population (n=30 male + 13 female) captured before and during space flight (flight day 15). Preliminary Results: Average fractional aerobic capacity during simulated EVAs were 33%±7% VO_2pk and 23.3±7% VO_2pk in the NBL and ARGOS, respectively. This was within a previously predicted 30–40% sustainable work rate. Average metabolic rates for some tasks performed in the NBL, such as traverse (40.4% VO_2pk) and ingress (47.1% VO_2pk) were higher than the predicted sustainable work range. In ARGOS, the tasks with the greatest metabolic rates were object relocation (34.2% VO_2pk) and incapacitated crew rescue (27.0% VO_2pk). Characterization of ISS crewmember aerobic capacity determined that the average preflight VO_2pk was 42.1±5.4 ml/kg/min for females and 37.5±5.4 ml/kg/min for males. At preflight, 21.5% of crewmembers were below the 36.5 ml/kg/min in-mission aerobic standard for celestial surface EVA as outlined in NASA-STD-3001. In-flight, both female and male crewmembers experienced reductions in VO_2pk (11.7% and 10.9%, respectively), such that, during the mission, 62% of crewmembers were below the standard aerobic capacity level for celestial surface EVAs. Conclusions: Our preliminary data suggest that while average metabolic rates for simulated Lunar EVA fall within the 30–40% sustainable work range, task specific metabolic rates exceed this range and may indicate that greater fitness is necessary for more strenuous tasks expected to be performed on the Lunar surface. Additionally, deconditioning due to space flight results in most crewmembers falling below the current celestial partial g EVA standard, which may increase risk to crew health and performance and completing mission objectives for surface missions. Further research is necessary in Artemis-specific analog environments to validate the current NASA-3001 aerobic standard for celestial EVAs. Additionally, work is ongoing to validate the current NASA-3001 strength standard for celestial EVAs.

N.C. Strock↗

Evaluation of Aerobic Standards for Lunar Surface Extravehicular Activities

As NASA prepares to return to the Moon, astronauts will need to be physically primed to successfully execute Extravehicular Activities (EVA) on the Lunar surface. Compared to past Apollo missions, Artemis missions will include EVAs of increased physical demand, frequency, intensity, and duration, thus requiring adequate fitness to successfully and safely complete mission objectives. The physical demand associated with partial gravity (g) EVAs on the Moon is expected to be greater compared to microgravity EVAs based on initial workload estimation. Currently, aerobic fitness standards for partial g EVAs are not well supported by high-fidelity data and require further research for establishing standards to protect crew health and performance during Lunar surface missions. Therefore, the aim of this investigation is to characterize metabolic data from Lunar analog simulations and in-flight crew population aerobic capacity data to validate the current NASA 3001 standard for celestial partial g aerobic fitness (aerobic capacity (VO_2pk) ≥36.5ml/kg/min).

Nicole Strock↗

Straight Ahead in Microgravity

INTRODUCTION The subjective straight-ahead direction is a very basic perceptual reference for spatial orientation and locomotion. The perceived straight-ahead along the horizontal and vertical meridian is largely determined by both otolith and somatosensory inputs which are altered in microgravity. The Straight Ahead in Microgravity (SAM) experiment will be conducted on the International Space Station (ISS) to examine how this spatial processing changes as a function of spaceflight. METHODS Data will be collected before the flight, at one-month intervals during long-duration stay (180 days) on board ISS, and after return to Earth. Control studies will also be performed during parabolic flights. Three different protocols will be used in each test session: (1) Fixation: The subject will be asked to look at actual targets (normal vision) and then to imagine these same targets (occluded vision) in the straight-ahead direction. Targets will be located at near distance (arm s length, ~0.5m), medium distance (~1 m), and far distance (beyond 2 m). This task will be successively performed with subject s body aligned with the spacecraft interior, and with subject s body tilted forward and backward by an operator. (2) Saccades: The subject will be asked to make horizontal and vertical saccades, first relative to the spacecraft interior reference system, and then relative to the subject s head reference system. This task will be successively performed with subject s body aligned with the spacecraft interior, and with subject s body tilted in roll or in pitch by an operator. (3) Linear Vestibulo-Ocular Reflex (VOR): The subject will be asked to stare at actual visual targets (normal vision) at various distances (near, medium, far) in the straight-ahead direction. Vision will then be occluded, and the subject will be asked to continue staring at the same imagined targets while he/she is passively translated forward-backward, up-down, or side-to-side. The subject's body motion will be performed by the restrained operator while the subject is free-floating. EXPECTED RESULTS The coupling of downward gaze with vergence eye movements observed on Earth is expected to increase in microgravity. Saccadic eye movements made in darkness along perceived axes are expected to be more closely aligned with the body s longitudinal axis in 0g compared to 1g, as the reference system for spatial orientation moves from an allocentric (gravitational) to an egocentric (idiotropic) vector. Changes in the linear VOR will reflect adaptive changes in otolith-ocular reflex contributions to the perceived straight-ahead. DISCUSSION A change in an individual's egocentric reference might have negative consequences on evaluating the direction of an approaching object or on the accuracy of reaching movements or locomotion. Consequently, investigating how microgravity affects the egocenter is important for understanding the problems associated with long-term effects of microgravity on astronauts' and how they re-adapt to the return of gravitational forces on Earth or other planetary surfaces. This project therefore has theoretical, practical and even clinical implications for the sensorimotor research gap "What are the changes in sensorimotor function over the course of a mission?"

Clement, G.↗

Analysis of cryogenic propellant behavior in microgravity and low thrust environments

Predictions of a CFD program calculating a fluid-free surface shape and motion as a function of imposed acceleration are validated against the drop-tower test data collected to support design and performance assessments of the Saturn S-IVB stage liquid-hydrogen tank. The drop-tower facility, experimental package, and experiment procedures are outlined, and the program is described. It is noted that the validation analysis confirms the program's suitability for predicting low-g fluid slosh behavior, and that a similar analysis could examine the effect of incorporating baffles and screens to impede initiation of any unwanted side loads due to slosh. It is concluded that in actual vehicle applications, the engine thrust tailoff profile should be included in computer simulations if the precise interface versus time definition is needed.

Fisher, Mark F.↗

Experiment K-7-22: Growth Hormone Regulation Synthesis and Secretion in Microgravity: Plasma Analysis Hormone Measurements - Part 3

Plasma from space flight and tail suspended rats was analyzed for a number of constituents in order to evaluate their metabolic status and endocrine function. The data presented here cover plasma hormone measurements. Corticosterone, thyroxine, and testosterone were measured by radioimmunoassay. Prolactin and growth hormone were measured by double antibody immunoassays using hormones and antisera prepared in house. Data were evaluated by analysis of variance.

Grindeland, R. E.↗

Observations of Gas-Liquid Flows Through Contractions in Microgravity

Tests were conducted for an air-water flow through two sudden contractions aboard the NASA DC-9 low gravity aircraft. Flow rate, residual accelerations, void fraction, film thickness, and pressure drop data were recorded and flow visualization at 250 images per second were recorded. Some preliminary results based on the flow visualization data are presented for bubbly, slug and annular flow.

McQuillen, John↗