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At least 811 records · Page 45

An energy-resolved atomic scanning probe

We propose a method to probe the local density of states (LDOS) of atomic systems that provides both spatial and energy resolution. The method combines atomic and tunneling techniques to supply a simple, yet quantitative and operational, definition of the LDOS for both interacting and non-interacting systems: it is the rate at which particles can be siphoned from the system of interest by a narrow energy band of non-interacting states contacted locally to the many-body system of interest. Ultracold atoms in optical lattices are a natural platform for implementing this broad concept to visualize the energy and spatial dependence of the atom density in interacting, inhomogeneous lattices. This includes models of strongly correlated condensed matter systems, as well as ones with non-trivial topologies.

71 CLASSICAL AND QUANTUM MECHANICS, GENERAL PHYSIC↗

Visualization of Simulation and TAP Interaction

The Temporal Analysis of Products (TAP) Reactor applies transient kinetics to analyze sophisticated chemical reaction mechanisms, rapidly changing temperature, flow rate, pressure or concentration and then monitoring the system’s time dependent response. A simulation tool exists for the TAP reactor, but it requires a visualization platform to interface effectively with researchers. This graphical user interface remedies this problem, fixing many of the difficulties caused by users interacting directly with the simulation code by providing an intuitive web application that satisfies the simulation input parameters for fast generation of data. This tool will ensure robust and repeatable simulation results, expedite the data generating process and enhance the overall ability of TAP to produce significant findings.

37 INORGANIC, ORGANIC, PHYSICAL, AND ANALYTICAL CH↗

WE-D-BRD-01: New Linac Designs for MR-Guided Therapy Systems

The advantages that make MR highly desirable for in-room treatment guidance, i.e. soft-tissue visualization and physiological assessment of healthy/tumor tissues, are largely recognized in the research community. However, the MR absorption in practical clinical workflows is still hindered by lack of sufficient technological infrastructure. Recent advances have been made towards filling that gap such as the development of integrated therapy systems relying on an MR scanner and a radiation source (linac, Co-60) and/or brachytherapy. The session is intended to present new efforts and methods aimed at facilitating the adoption of MR guidance for treatment delivery. Specifically, the discussion will focus on a) linac designs for reduced footprint and seamless integration with MR/linac systems, b) tracking coils for brachytherapy applications, and c) procedures for the commissioning and monitoring of MR and MR/linac performance. Learning Objectives: Understand limitations and proposed solutions for linac designs and associated integration with MR/linac systems; Understand current issues with MR-guided brachytherapy procedures Understand the issues and needs for new MR commissioning and QC. License agreement with Modus Medical Devices to develop a phantom for the quantification of MR image distortions.

60 APPLIED LIFE SCIENCES↗

Deep Active Learning for Solvability Prediction in Power Systems

Traditional methods for solvability region analysis can only have inner approximations with inconclusive conservatism and handle limited types of power flow models. In this letter, we propose a deep active learning framework for solvability prediction in power systems. Compared with passive learning where the training is performed after all instances are labeled, active learning selects most informative instances to be labeled and therefore significantly reduces the size of the labeled dataset for training. In the active learning framework, the acquisition functions, which correspond to different sampling strategies, are defined in terms of the on-the-fly posterior probability from the classifier. First, the IEEE 39-bus system is employed to validate the proposed framework, where a two-dimensional case is illustrated to visualize the effectiveness of the sampling method followed by the high-dimensional numerical experiments. Then, the Northeast Power Coordinating Council (NPCC) 140-bus system is used to validate the performance on large-scale power systems.

42 ENGINEERING↗

Multifunctional Biomedical Imaging in Physiological and Pathological Conditions Using a NIR-II Probe

Contrasted with imaging in the visible (400–650 nm) and near-infrared window I (NIR-I, 650–900 nm) regions, imaging in near-infrared window II (NIR-II, 1000–1700 nm) is a highly promising in vivo imaging modality with improved resolution and deeper tissue penetration. Here, a small molecule NIR-II dye,5,5'-(1H,5H-benzo[1,2-c:4,5-c'] bis[1,2,5]thiadiazole)-4,8-diyl)bis(N,N-bis(4-(3-((tert-butyldimethylsilyl)oxy)propyl)phenyl) thiophen-2-amine), is successfully encapsulated into phospholipid vesicles to prepare a probe CQS1000. The novel NIR-II probe is studied for in vivo multifunctional biological imaging. The results of this study indicate that the NIR-II vesicle CQS1000 can noninvasively and dynamically visualize and monitor many physiological and pathological conditions of circulatory systems, including lymphatic drainage and routing, angiogenesis of tumor, and vascular deformity such as arterial thrombus formation and ischemia with high spatial and temporal resolution. More importantly, by virtue of the favorable half-life of blood circulation of CQS1000, NIR-II imaging is capable of aiding precise resection of tumor such as osteosarcoma and accelerating the process of lymph node dissection to complete sentinel lymph node biopsy for better decision making during the tumor surgery. Overall, CQS1000 is a highly promising NIR-II probe for multifunctional biomedical imaging in physiological and pathological conditions, surpassing traditional NIR-I imaging modality and pathologic assessments for clinical diagnosis and treatment.

36 MATERIALS SCIENCE↗

Fabrication of Arrays of Topological Solitons in Patterned Chiral Liquid Crystals for Real-Time Observation of Morphogenesis

Topological solitons have knotted continuous field configurations embedded in a uniform background, and occur in cosmology, biology, and electromagnetism. However, real-time observation of their morphogenesis and dynamics is still challenging because their size and timescale are enormously large or tiny. Liquid crystal (LC) structures are promising candidates for a model-system to study the morphogenesis of topological solitons, enabling direct visualization due to the proper size and timescale. We report a new way is found to rationalize the real-time observation of the generation and transformation of topological solitons using cholesteric LCs confined in patterned substrates. The experimental demonstration shows the topologically protected structures arise via the transformation of topological defects. Numerical modeling based on minimization of free energy closely reconstructs the experimental findings. The fundamental insights obtained from the direct observations pose new theoretical challenges in understanding the morphogenesis of different types of topological solitons within a broad range of scales.

36 MATERIALS SCIENCE↗

Visualization of specific collagen-producing cells by Col1-GFP transgenic mice revealed novel type I collagen-producing cells other than fibroblasts in systemic organs/tissues

Highlights: • A new reporter mouse was generated to label type I collagen-producing cells. • Type I collagen-producing cells were specifically labeled in this reporter mouse. • Podocytes and Leydig cells showed the ability to produce type I collagen. Type I collagen is one of the most abundant proteins in mammals and plays important roles in maintaining the integrity of many tissues. Although fibroblasts are the main source of type I collagen, other cells also produce it; however, these cells are not well-defined owing to the lack of a specific marker. A transgenic (Tg) mouse line has been generated in which type I collagen-producing cells are labeled with enhanced green fluorescent protein (EGFP), which enables the monitoring of these cells without requiring an additional cell marker. This Tg mouse line has since been widely used to study type I collagen-producing cells and fibrosis; one study revealed that podocytes, which were not previously considered to produce type I collagen, expressed EGFP. This raises a question regarding the specificity of EGFP expression in this Tg mouse line. To exclude the possibility of non-specific EGFP expression in the existing Tg mouse line and specifically monitor type I collagen-producing cells, we generated a new Tg mouse line and histologically confirmed the specificity of EGFP expression throughout the body. Moreover, we explored type I collagen-producing cells other than fibroblasts and revealed for the first time that Leydig cells have the ability to produce type I collagen. Because of its highly specific and physiologically accurate expression, our new Tg mouse line will help to accurately elucidate not only type I collagen-producing cells in normal tissues but also the potential cells in fibrotic tissues, providing new insights into the pathology of fibrosis.

60 APPLIED LIFE SCIENCES↗

COSMIC: A Regimen of Intensity Modulated Radiation Therapy Plus Dose-Escalated, Raster-Scanned Carbon Ion Boost for Malignant Salivary Gland Tumors: Results of the Prospective Phase 2 Trial

Purpose: To investigate the effect of intensity modulated radiation therapy (IMRT) and dose-escalated carbon ion (C12) therapy in adenoid cystic carcinoma (ACC) and other malignant salivary gland tumors (MSGTs) of the head and neck. Patients and Methods: COSMIC (combined treatment of malignant salivary gland tumors with intensity modulated radiation therapy and carbon ions) is a prospective phase 2 trial of 24 Gy(RBE) C12 followed by 50 Gy IMRT in patients with pathologically confirmed MSGT. The primary endpoint is mucositis Common Terminology Criteria grade 3; the secondary endpoints are locoregional control (LC), progression-free survival (PFS), overall survival (OS), and toxicity. Toxicity was scored according to the Common Terminology Criteria for Adverse Events version 3; treatment response was scored according to Response Evaluation Criteria in Solid Tumors 1.1. Results: Between July 2010 and August 2011, 54 patients were accrued, and 53 were available for evaluation. The median follow-up time was 42 months; patients with microscopically incomplete resections (R1, n=20), gross residual disease (R2, n=17), and inoperable disease (n=16) were included. Eighty-nine percent of patients had ACC, and 57% had T4 tumors. The most common primary sites were paranasal sinus (34%), submandibular gland, and palate. At the completion of radiation therapy, 26% of patients experienced grade 3 mucositis, and 20 patients reported adverse events of the ear (38%). The most common observed late effects were grade 1 xerostomia (49%), hearing impairment (25%, 2% ipsilateral hearing loss), and adverse events of the eye (20%), but no visual impairment or loss of vision. Grade 1 central nervous system necrosis occurred in 6%, and 1 grade 4 ICA hemorrhage without neurologic sequelae. The best response was 54% (complete response/partial remission). At 3 years, the LC, PFS, and OS were 81.9%, 57.9%, and 78.4%, respectively. No difference was found regarding resection status. The most common site of failure was distant (55%). Local relapse was predominantly in field (79%). Conclusion: Treatment was tolerated, with moderate acute and late toxicity. The LC at 3 years was promising. No significant difference could be shown regarding resection status; hence, extensive and mutilating surgical procedures should be rediscussed. Further dose escalation may be limited in view of potential vascular adverse events.

62 RADIOLOGY AND NUCLEAR MEDICINE↗

Quantitative impact characterization of aeronautical CFRP materials with non-destructive testing methods

In recent years, an increasing number of safety-relevant structures are designed and manufactured from carbon fiber reinforced polymers (CFRP) in order to reduce weight of airplanes by taking the advantage of their specific strength into account. Non-destructive testing (NDT) methods for quantitative defect analysis of damages are liquid- or air-coupled ultrasonic testing (UT), phased array ultrasonic techniques, and active thermography (IR). The advantage of these testing methods is the applicability on large areas. However, their quantitative information is often limited on impact localization and size. In addition to these techniques, Airbus Group Innovations operates a micro x-ray computed tomography (μ-XCT) system, which was developed for CFRP characterization. It is an open system which allows different kinds of acquisition, reconstruction, and data evaluation. One main advantage of this μ-XCT system is its high resolution with 3-dimensional analysis and visualization opportunities, which enables to gain important quantitative information for composite part design and stress analysis. Within this study, different NDT methods will be compared at CFRP samples with specified artificial impact damages. The results can be used to select the most suitable NDT-method for specific application cases. Furthermore, novel evaluation and visualization methods for impact analyzes are developed and will be presented.

42 ENGINEERING↗

Real-time data-intensive computing

Today users visit synchrotrons as sources of understanding and discovery—not as sources of just light, and not as sources of data. To achieve this, the synchrotron facilities frequently provide not just light but often the entire end station and increasingly, advanced computational facilities that can reduce terabytes of data into a form that can reveal a new key insight. The Advanced Light Source (ALS) has partnered with high performance computing, fast networking, and applied mathematics groups to create a “super-facility”, giving users simultaneous access to the experimental, computational, and algorithmic resources to make this possible. This combination forms an efficient closed loop, where data—despite its high rate and volume—is transferred and processed immediately and automatically on appropriate computing resources, and results are extracted, visualized, and presented to users or to the experimental control system, both to provide immediate insight and to guide decisions about subsequent experiments during beamtime. We will describe our work at the ALS ptychography, scattering, micro-diffraction, and micro-tomography beamlines.

43 PARTICLE ACCELERATORS↗

Simplification of femtosecond transient absorption microscopy data from CH 3 NH 3 PbI 3 perovskite thin films into decay associated amplitude maps

Our work aims to simplify multi-dimensional femtosecond transient absorption microscopy (TAM) data into decay associated amplitude maps that describe the spatial distributions of dynamical processes occurring on various characteristic timescales. Application of this method to TAM data obtained from a model methyl-ammonium lead iodide (CH 3 NH 3 PbI 3 ) perovskite thin film allows us to simplify the dataset consisting of a 68 time-resolved images into 4 decay associated amplitude maps. Furthermore, these maps provide a simple means to visualize the complex electronic excited-state dynamics in this system by separating distinct dynamical processes evolving on characteristic timescales into individual spatial images. This approach provides new insight into subtle aspects of ultrafast relaxation dynamics associated with excitons and charge carriers in the perovskite thin film, which have recently been found to coexist at spatially distinct locations.

75 CONDENSED MATTER PHYSICS, SUPERCONDUCTIVITY AND↗

Simulation of Helium Flow Visualization Apparatus for Studies of Blanket Cooling in Fusion Reactors

Flow visualization is essential to understanding helium cooling performance. This article investigates helium flow visualization in an apparatus to support the design of the blanket first wall for a fusion reactor. Helium’s safety advantages make it an attractive coolant, but effective cooling and flow visualization remain challenging. Sophisticated simulations are conducted in different test sections to address three key areas in the design of a test apparatus and cooling channel enhancements: the influence of viewing glass windows on flow patterns, the impact of increased heating, and the effectiveness of cooling structures like baffles. Viewing glass windows introduce flow recirculation region bifurcation and flow asymmetry, affecting flow patterns and necessitating careful analysis in future experiments. Increased heating results in helium flow detachment from the heated surface, leading to hot spots. Cooling structures, particularly baffles, prove effective in maintaining consistent attachment to the heated surface, improving the heat transfer performance. Further, this study also examines a tunable parameter in the turbulence model, highlighting the importance of accurate model tuning for future fusion reactor cooling designs. With an imminent helium flow visualization facility, these simulations will be used to optimize cooling structures on the heated wall to improve flow attachment and heat transfer efficiency. This work serves as a first investigation of the helium flow visualization apparatus for blanket cooling enhancement in fusion reactor design.

70 PLASMA PHYSICS AND FUSION TECHNOLOGY↗

SU-E-J-235: Varian Portal Dosimetry Accuracy at Detecting Simulated Delivery Errors

Purpose: To use receiver operating characteristic (ROC) analysis to quantify the Varian Portal Dosimetry (VPD) application's ability to detect delivery errors in IMRT fields. Methods: EPID and VPD were calibrated/commissioned using vendor-recommended procedures. Five clinical plans comprising 56 modulated fields were analyzed using VPD. Treatment sites were: pelvis, prostate, brain, orbit, and base of tongue. Delivery was on a Varian Trilogy linear accelerator at 6MV using a Millenium120 multi-leaf collimator. Image pairs (VPD-predicted and measured) were exported in dicom format. Each detection test imported an image pair into Matlab, optionally inserted a simulated error (rectangular region with intensity raised or lowered) into the measured image, performed 3%/3mm gamma analysis, and saved the gamma distribution. For a given error, 56 negative tests (without error) were performed, one per 56 image pairs. Also, 560 positive tests (with error) with randomly selected image pairs and randomly selected in-field error location. Images were classified as errored (or error-free) if percent pixels with γ<κ was < (or ≥) τ. (Conventionally, κ=1 and τ=90%.) A ROC curve was generated from the 616 tests by varying τ. For a range of κ and τ, true/false positive/negative rates were calculated. This procedure was repeated for inserted errors of different sizes. VPD was considered to reliably detect an error if images were correctly classified as errored or error-free at least 95% of the time, for some κ+τ combination. Results: 20mm{sup 2} errors with intensity altered by ≥20% could be reliably detected, as could 10mm{sup 2} errors with intensity was altered by ≥50%. Errors with smaller size or intensity change could not be reliably detected. Conclusion: Varian Portal Dosimetry using 3%/3mm gamma analysis is capable of reliably detecting only those fluence errors that exceed the stated sizes. Images containing smaller errors can pass mathematical analysis, though may be detected by visual inspection. This work was not funded by Varian Oncology Systems. Some authors have other work partly funded by Varian Oncology Systems.

60 APPLIED LIFE SCIENCES↗

SU-C-209-05: Monte Carlo Model of a Prototype Backscatter X-Ray (BSX) Imager for Projective and Selective Object-Plane Imaging

Purpose: To develop a Monte Carlo N-Particle (MCNP) model for the validation of a prototype backscatter x-ray (BSX) imager, and optimization of BSX technology for medical applications, including selective object-plane imaging. Methods: BSX is an emerging technology that represents an alternative to conventional computed tomography (CT) and projective digital radiography (DR). It employs detectors located on the same side as the incident x-ray source, making use of backscatter and avoiding ring geometry to enclose the imaging object. Current BSX imagers suffer from low spatial resolution. A MCNP model was designed to replicate a BSX prototype used for flaw detection in industrial materials. This prototype consisted of a 1.5mm diameter 60kVp pencil beam surrounded by a ring of four 5.0cm diameter NaI scintillation detectors. The imaging phantom consisted of a 2.9cm thick aluminum plate with five 0.6cm diameter holes drilled halfway. The experimental image was created using a raster scanning motion (in 1.5mm increments). Results: A qualitative comparison between the physical and simulated images showed very good agreement with 1.5mm spatial resolution in plane perpendicular to incident x-ray beam. The MCNP model developed the concept of radiography by selective plane detection (RSPD) for BSX, whereby specific object planes can be imaged by varying kVp. 10keV increments in mean x-ray energy yielded 4mm thick slice resolution in the phantom. Image resolution in the MCNP model can be further increased by increasing the number of detectors, and decreasing raster step size. Conclusion: MCNP modelling was used to validate a prototype BSX imager and introduce the RSPD concept, allowing for selective object-plane imaging. There was very good visual agreement between the experimental and MCNP imaging. Beyond optimizing system parameters for the existing prototype, new geometries can be investigated for volumetric image acquisition in medical applications. This material is based upon work supported under an Integrated University Program Graduate Fellowship sponsored by the Department of Energy Office of Nuclear Energy.

60 APPLIED LIFE SCIENCES↗

Leading in Los Angeles: Demonstrating scalable emerging energy efficient technologies for integrated façade, lighting, and plug loads INTER System FLEXLAB Test Report

This report is a part of the California Energy Commission (Energy Commission) EPIC study Leading in Los Angeles: Demonstrating scalable emerging energy efficient technologies for integrated façade, lighting, and HVAC. The set of technologies are called the Integrated Technologies for Energy-efficient Retrofits (INTER) and are comprised of automated shading products and LED lighting systems with networked luminaire-level sensors and controls. In addition, the project will include control modifications and assessments of HVAC savings. This document includes the test plan and test results for the FLEXLAB® testing of the shading and lighting INTER system and related energy use impact. The test plan describes the test objectives and features, test cases, schedule, and measurements. The test results cover system performance in the lab; including lighting and HVAC energy, visual comfort, and thermal comfort.

32 ENERGY CONSERVATION, CONSUMPTION, AND UTILIZATI↗

Making Advanced Scientific Algorithms and Big Scientific Data Management More Accessible

Synchrotrons such as the Advanced Light Source (ALS) at Lawrence Berkeley National Laboratory are known as user facilities. They are sources of extremely bright X-ray beams, and scientists come from all over the world to perform experiments that require these beams. As the complexity of experiments has increased, and the size and rates of data sets has exploded, managing, analyzing and presenting the data collected at synchrotrons has been an increasing challenge. The ALS has partnered with high performance computing, fast networking, and applied mathematics groups to create a"super-facility", giving users simultaneous access to the experimental, computational, and algorithmic resources to overcome this challenge. This combination forms an efficient closed loop, where data despite its high rate and volume is transferred and processed, in many cases immediately and automatically, on appropriate compute resources, and results are extracted, visualized, and presented to users or to the experimental control system, both to provide immediate insight and to guide decisions about subsequent experiments during beam-time. In this paper, We will present work done on advanced tomographic reconstruction algorithms to support users of the 3D micron-scale imaging instrument (Beamline 8.3.2, hard X-ray micro-tomography).

97 MATHEMATICS AND COMPUTING↗

Sandia Engineering Analysis Code Access System v. 2.0.1

The Sandia Engineering Analysis Code Access System (SEACAS) is a suite of preprocessing, post processing, translation, visualization, and utility applications supporting finite element analysis software using the Exodus database file format.

Sjaardema, Gregory D.↗