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Search indexed NASA NTRS and DOE OSTI research on propulsion, heat transfer, battery materials and energy systems. Follow report and document links to the original sources.

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At least 811 records · Page 45
All sourcesNASA NTRSDOE OSTI
NASA NTRS2014

Radiation Quality Effects on Transcriptome Profiles in 3-d Cultures After Particle Irradiation

In this work, we evaluate the differential effects of low- and high-LET radiation on 3-D organotypic cultures in order to investigate radiation quality impacts on gene expression and cellular responses. Reducing uncertainties in current risk models requires new knowledge on the fundamental differences in biological responses (the so-called radiation quality effects) triggered by heavy ion particle radiation versus low-LET radiation associated with Earth-based exposures. We are utilizing novel 3-D organotypic human tissue models that provide a format for study of human cells within a realistic tissue framework, thereby bridging the gap between 2-D monolayer culture and animal models for risk extrapolation to humans. To identify biological pathway signatures unique to heavy ion particle exposure, functional gene set enrichment analysis (GSEA) was used with whole transcriptome profiling. GSEA has been used extensively as a method to garner biological information in a variety of model systems but has not been commonly used to analyze radiation effects. It is a powerful approach for assessing the functional significance of radiation quality-dependent changes from datasets where the changes are subtle but broad, and where single gene based analysis using rankings of fold-change may not reveal important biological information. We identified 45 statistically significant gene sets at 0.05 q-value cutoff, including 14 gene sets common to gamma and titanium irradiation, 19 gene sets specific to gamma irradiation, and 12 titanium-specific gene sets. Common gene sets largely align with DNA damage, cell cycle, early immune response, and inflammatory cytokine pathway activation. The top gene set enriched for the gamma- and titanium-irradiated samples involved KRAS pathway activation and genes activated in TNF-treated cells, respectively. Another difference noted for the high-LET samples was an apparent enrichment in gene sets involved in cycle cycle/mitotic control. It is plausible that the enrichment in these particular pathways results from the complex DNA damage resulting from high-LET exposure where repair processes are not completed during the same time scale as the less complex damage resulting from low-LET radiation.

Patel, Z. S.↗
NASA NTRS1971

Solar wind radiation damage effects in lunar material

The research on solar wind radiation damage and other effects in lunar samples which was conducted to understand the optical properties of lunar materials is reported. Papers presented include: solar radiation effects in lunar samples, albedo of the moon, radiation effects in lunar crystalline rocks, valence states of 3rd transition elements in Apollo 11 and 12 rocks, and trace ferric iron in lunar and meteoritic titanaugites.

Hapke, B.↗
NASA NTRS2010

Advanced Avionics and Processor Systems for a Flexible Space Exploration Architecture

The Advanced Avionics and Processor Systems (AAPS) project, formerly known as the Radiation Hardened Electronics for Space Environments (RHESE) project, endeavors to develop advanced avionic and processor technologies anticipated to be used by NASA s currently evolving space exploration architectures. The AAPS project is a part of the Exploration Technology Development Program, which funds an entire suite of technologies that are aimed at enabling NASA s ability to explore beyond low earth orbit. NASA s Marshall Space Flight Center (MSFC) manages the AAPS project. AAPS uses a broad-scoped approach to developing avionic and processor systems. Investment areas include advanced electronic designs and technologies capable of providing environmental hardness, reconfigurable computing techniques, software tools for radiation effects assessment, and radiation environment modeling tools. Near-term emphasis within the multiple AAPS tasks focuses on developing prototype components using semiconductor processes and materials (such as Silicon-Germanium (SiGe)) to enhance a device s tolerance to radiation events and low temperature environments. As the SiGe technology will culminate in a delivered prototype this fiscal year, the project emphasis shifts its focus to developing low-power, high efficiency total processor hardening techniques. In addition to processor development, the project endeavors to demonstrate techniques applicable to reconfigurable computing and partially reconfigurable Field Programmable Gate Arrays (FPGAs). This capability enables avionic architectures the ability to develop FPGA-based, radiation tolerant processor boards that can serve in multiple physical locations throughout the spacecraft and perform multiple functions during the course of the mission. The individual tasks that comprise AAPS are diverse, yet united in the common endeavor to develop electronics capable of operating within the harsh environment of space. Specifically, the AAPS tasks for the Federal fiscal year of 2010 are: Silicon-Germanium (SiGe) Integrated Electronics for Extreme Environments, Modeling of Radiation Effects on Electronics, Radiation Hardened High Performance Processors (HPP), and and Reconfigurable Computing.

Keys, Andrew S.↗
NASA NTRS2015

Radiation 101: Effects on Hardware and Robotic Systems

We present basic information on different types of radiation effects, including total ionizing dose, displacement damage, and single-event effects. The content is designed to educate space weather professionals, space operations professionals, and other science and engineering stakeholders.

radiation effects↗
NASA NTRS2015

Radiation 101: Effects on Hardware and Robotic Systems

We present basic information on different types of radiation effects, including total ionizing dose, displacement damage, and single-event effects. The content is designed to educate space weather professionals, space operations professionals, and other science and engineering stakeholders.

non-ionizing energy loss (NIEL)↗
NASA NTRS2003

Radiative Enhancement Effects on Flame Spread (REEFS) Project Studied "Green House" Effects on Fire Spread

The Radiative Enhancement Effects on Flame Spread (REEFS) project, slated for flight aboard the International Space Station, reached a major milestone by holding its Science Concept Review this year. REEFS is led by principal investigator Paul Ronney from the University of Southern California in conjunction with a project team from the NASA Glenn Research Center. The study is focusing on flame spread over flat solid fuel beds to improve our understanding of more complex fires, such as those found in manned spacecraft and terrestrial buildings. The investigation has direct implications for fire safety, both for space and Earth applications, and extends previous work with emphasis on the atmospheres and flow environments likely to be present in fires that might occur in microgravity. These atmospheres will contain radiatively active gases such as carbon dioxide (CO2) from combustion products, and likely gaseous fuels such as carbon monoxide (CO) from incomplete combustion of solid fuel, as well as flows induced by ventilation currents. During tests in the 2.2-Second Drop Tower and KC-135 aircraft at Glenn, the principal investigator introduced the use of foam fuels for flame spread experiments over thermally thick fuels to obtain large spread rates in comparison to those of dense fuels such as PMMA. This enables meaningful results to be obtained even in the 2.2 s available in drop tower experiments.

Gokoglu, Suleyman A.↗
NASA NTRS2017

Particle Radiation Sources, Propagation and Interactions in Deep Space, at Earth, the Moon, Mars, and Beyond: Examples of Radiation Interactions and Effects

Particle radiation has significant effects for astronauts, satellites and planetary bodies throughout the Solar System. Acute space radiation hazards pose risks to human and robotic exploration. This radiation also naturally weathers the exposed surface regolith of the Moon, the two moons of Mars, and other airless bodies, and contributes to chemical evolution of planetary atmospheres at Earth, Mars, Venus, Titan, and Pluto. We provide a select review of recent areas of research covering the origin of SEPs from coronal mass ejections low in the corona, propagation of events through the solar system during the anomalously weak solar cycle 24 and important examples of radiation interactions for Earth, other planets and airless bodies such as the Moon.

Schwadron, Nathan A.↗
DOE OSTI2024

Multifaceted aerosol effects on precipitation

Aerosols have been proposed to influence precipitation rates and spatial patterns from scales of individual clouds to the globe. However, large uncertainty remains regarding the underlying mechanisms and importance of multiple effects across spatial and temporal scales. Here, in this study, we review the evidence and scientific consensus behind these effects, categorized into radiative effects via modification of radiative fluxes and the energy balance, and microphysical effects via modification of cloud droplets and ice crystals. Broad consensus and strong theoretical evidence exist that aerosol radiative effects (aerosol–radiation interactions and aerosol–cloud interactions) act as drivers of precipitation changes because global mean precipitation is constrained by energetics and surface evaporation. Likewise, aerosol radiative effects cause well-documented shifts of large-scale precipitation patterns, such as the intertropical convergence zone. The extent of aerosol effects on precipitation at smaller scales is less clear. Although there is broad consensus and strong evidence that aerosol perturbations microphysically increase cloud droplet numbers and decrease droplet sizes, thereby slowing precipitation droplet formation, the overall aerosol effect on precipitation across scales remains highly uncertain. Global cloud-resolving models provide opportunities to investigate mechanisms that are currently not well represented in global climate models and to robustly connect local effects with larger scales. This will increase our confidence in predicted impacts of climate change.

54 ENVIRONMENTAL SCIENCES↗
NASA NTRS2006

Effects of Radiation on Commercial Power Devices

The effects of radiation on various commercial power devices are presented. The devices have proved to be very fragile to single event effects, with some of the devices actually succumbing to catastrophic SEE with protons.

power semiconductor devices↗
NASA NTRS1972

Biological effects of radiation, metabolic and replication kinetics alterations

The biological effects of radiation upon normal and cancerous tissues were studied. A macromolecular precursor of DNA, 3ETdR, was incorporated into the cell nucleus during synthesis and provided intranuclear beta radiation. Tritium labeled cells were studied with autoradiographic methods; cell cycle kinetics were determined and cell functions modified by radiation dosage or by drugs were also evaluated. The long term program has included; (1) effects of radiation on cell replication and the correlation with incorporated dose levels, (2) radiation induced changes in cell function, viz., the response of beta irradiated spleen lymphocytes to antigenic stimulation by sheep red blood cells (SRBC), (3) kinetics of tumor and normal cell replication; and (4) megakaryocyte formation and modification by radiomimetic drugs.

Post, J.↗
DOE OSTI2022

Radiation Therapy Enhanced by NBTXR3 Nanoparticles Overcomes Anti-PD1 Resistance and Evokes Abscopal Effects

Radiation combined with PD1 blockade offers significant treatment benefits in several tumor types; however, anti-PD1 resistance precludes such benefits in many cases. Here we attempted to overcome anti-PD1 resistance by combining localized radiation with a radioenhancing nanoparticle (NBTXR3) and systemic anti-PD1 treatment to achieve abscopal effects in an anti-PD1–resistant mouse model of lung cancer.

62 RADIOLOGY AND NUCLEAR MEDICINE↗