An automated system for chromosome analysis. Volume 2: System construction, programming, operation, and maintenance
The operation, programming, construction, and maintenance of an automated chromosome analysis system is described.
SEARCH · Engineering Papers
Search indexed NASA NTRS and DOE OSTI research on propulsion, heat transfer, battery materials and energy systems. Follow report and document links to the original sources.
Quote a phrase for an exact phrase match. Source license links do not imply unrestricted reuse.
The operation, programming, construction, and maintenance of an automated chromosome analysis system is described.
A method for rapidly examining the probable applicability of weight estimating formulae to a specific aerospace vehicle design is presented. The Multivariate Analysis Retrieval and Storage System (MARS) is comprised of three computer programs which sequentially operate on the weight and geometry characteristics of past aerospace vehicles designs. Weight and geometric characteristics are stored in a set of data bases which are fully computerized. Additional data bases are readily added to the MARS system and/or the existing data bases may be easily expanded to include additional vehicles or vehicle characteristics.
The interactions that occur in human-teaming are inspiring novel aerospace designs aimed at improving how humans and machines, or multiple machines, work together. Unfortunately, current Systems Engineering processes are ill-equipped to handle these complex relationships and are unable to design and assure the safety for these systems. To close part of this gap, this paper introduces a novel system-theoretic analytical process to identify unsafe collaborative control actions. It is part of a broader set of techniques that extend the state-of-the-art in hazard analysis, System Theoretic Process Analysis (STPA), to systematically address collaboration. The method rigorously expresses the different ways multiple commands may be unsafe together. Using Systems Theory, it employs abstraction to manage the combinatorial complexity in enumerating control contributions from multiple collaborating components. An algorithm integrates these concepts into an end-to-end process and is supported by automation to enumerate, refine, prune, and prioritize unsafe combinations of control actions. The output of the method feeds the specification of system requirements to implement safety-guided design starting early in concept development. The process is demonstrated on a manned-unmanned aircraft teaming case study and finds new causal factors that were not previously found in a past hazard analysis of the same system.
The author has identified the following significant results. The integration of the available methods provided the analyst with the unified scanner analysis package (USAP), the flexibility and versatility of which was superior to many previous integrated techniques. The USAP consisted of three main subsystems; (1) a spatial path, (2) a spectral path, and (3) a set of analytic classification accuracy estimators which evaluated the system performance. The spatial path consisted of satellite and/or aircraft data, data correlation analyzer, scanner IFOV, and random noise model. The output of the spatial path was fed into the analytic classification and accuracy predictor. The spectral path consisted of laboratory and/or field spectral data, EXOSYS data retrieval, optimum spectral function calculation, data transformation, and statistics calculation. The output of the spectral path was fended into the stratified posterior performance estimator.
Analysis of space stabilized inertial navigation systems
An automatic chromosome analysis system is provided wherein a suitably prepared slide with chromosome spreads thereon is placed on the stage of an automated microscope. The automated microscope stage is computer operated to move the slide to enable detection of chromosome spreads on the slide. The X and Y location of each chromosome spread that is detected is stored. The computer measures the chromosomes in a spread, classifies them by group or by type and also prepares a digital karyotype image. The computer system can also prepare a patient report summarizing the result of the analysis and listing suspected abnormalities.
Space power systems analysis, using computer program to correlate systems characteristics with mission parameters for automated satellite repair vehicle and space stations
A systems analysis of synchronous, orbit-based power generation and relay systems that could be operational in the 1990's is described along with a comparison with earth-based systems to be operational in the same time frame. Operational and economic requirements for the orbiting systems and near term research activities which will be required to assure feasibility, development, launch and operational capabilities of such systems in the post- 1990 time frame are examined.
Analysis of area coverage by orbital photoimaging systems
Numerical procedure for structural systems analysis, discussing computer application to hydrodynamic, electric, magnetic, thermodynamic, elastostatic and elastodynamic problems
The present conference considers topics in the fields of optical systems design software, the design and analysis of optical systems, illustrative cases of advanced optical system design, the integration of optical designs into greater systems, and optical fabrication and testing techniques. Attention is given to an extended range diffraction-based merit function for lens design optimization, an assessment of technologies for stray light control and evaluation, the automated characterization of IR systems' spatial resolution, a spectrum of design techniques based on aberration theory, a three-field IR telescope, a large aperture zoom lens for 16-mm motion picture cameras, and the use of concave holographic gratings as monochomators. Also discussed are the use of aspherics in optical systems, glass choice procedures for periscope design, the fabrication and testing of unconventional optics, low mass mirrors for large optics, and the diamond grinding of optical surfaces on aspheric lens molds.
Analysis of condensing pressure control for SNAP-8 system
Analysis of error propagation in aircraft inertial guidance systems using flight simulation and mathematical models
Satellite electric power system configurations for maximum utilization of power - systems analysis
Analysis and design of space vehicle linear flight control systems
Analysis and design of nonlinear space vehicle flight control systems
Fluid systems, or networks, consist of multiple components that work together to achieve some desired thermofluid state. For any generic application, this fluid state can be a combination of the fluid pressure, flow rate, enthalpy, or species concentration. Fluid system components, such as pumps and valves, are often governed by nonlinear differential equations, resulting in complex component-to-component interactions. System-level fluid network stability occurs when the flow through the system can maintain a steady-state solution in the presence of small perturbations, which depends on these component interactions. System instability, however, can go undetected until issues arise during integrated system testing. This presentation explores a method for system designers to think of the fluid network as an assembly of components, each with their own thermofluid surfaces of partial stability, called nullclines. The intersections of all nullclines yields system-level solutions, called equilibrium points. When designers define operating points, they are tuning system parameters so that these equilibrium points move to the desired location in the thermofluid state plane. However, linearization theory shows us that the dynamic behavior around these points can be unstable. The local stability of these equilibrium points can be assessed analytically with eigen-analysis, or numerically by propagating state-plane samples to construct a phase portrait. Investigating a phase portrait can help designers gain a qualitative understanding of a system’s dynamic performance. This understanding can then help inform requirement definitions, component selection, and operational procedures. This presentation includes an example of the phase portrait technique on a system featuring a centrifugal pump and a back-pressure regulator (BPR). Numerical modeling of this system suggests that equilibrium points on the left-hand side of the pump curve are dynamically unstable.
SAMSAN aids control-system analyst by providing self-consistent set of computer algorithms that support large-order control-system design and evaluation studies, with emphasis placed on sampled system analysis. Program provides set of algorithms readily integrated for solving control-system problems.