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At least 793 records · Page 44

DNA Break Clustering as a Predictor of Cell Death across Various Radiation Qualities: Influence of Cell Size, Cell Asymmetry, and Beam Orientation

Cosmic radiation, composed of high charge and energy (HZE) particles, causes cellular DNA damage that can result in cell death or mutation that can evolve into cancer. In this work, a cell death model is applied to several cell lines exposed to HZE ions spanning a broad range of linear energy transfer (LET) values. We hypothesize that chromatin movement leads to the clustering of multiple double strand breaks (DSB) within one radiation-induced foci (RIF). The survival probability of a cell population is determined by averaging the survival probabilities of individual cells, which is function of the number of pairwise DSB interactions within RIF. The simulation code RITCARD was used to compute DSB. Two clustering approaches were applied to determine the number of RIF per cell. RITCARD outputs were combined with experimental data from four normal human cell lines to derive the model parameters and expand its predictions in response to ions with LET ranging from ∼0.2keV/μmto∼3000keV/μm. Spherical and ellipsoidal nuclear shapes and two ion beam orientations were modeled to assess the impact of geometrical properties on cell death. The calculated average number of RIF per cell reproduces the saturation trend for high doses and high-LET values that is usually experimentally observed. The cell survival model generates the recognizable bell shape of LET dependence for the relative biological effectiveness (RBE). At low LET, smaller nuclei have lower survival due to increased DNA density and DSB clustering. At high LET, nuclei with a smaller irradiation area either because of a smaller size or a change in beam orientation have a higher survival rate due to a change in the distribution of DSB/RIF per cell. If confirmed experimentally, the geometric characteristics of cells would become a significant factor in predicting radiation-induced biological effects.

cell survival↗

Prediction of Airfoil Characteristics With Higher Order Turbulence Models

This study focuses on the prediction of airfoil characteristics, including lift and drag over a range of Reynolds numbers. Two different turbulence models, which represent two different types of models, are tested. The first is a standard isotropic eddy-viscosity two-equation model, and the second is an explicit algebraic stress model (EASM). The turbulent flow field over a general-aviation airfoil (GA(W)-2) at three Reynolds numbers is studied. At each Reynolds number, predicted lift and drag values at different angles of attack are compared with experimental results, and predicted variations of stall locations with Reynolds number are compared with experimental data. Finally, the size of the separation zone predicted by each model is analyzed, and correlated with the behavior of the lift coefficient near stall. In summary, the EASM model is able to predict the lift and drag coefficients over a wider range of angles of attack than the two-equation model for the three Reynolds numbers studied. However, both models are unable to predict the correct lift and drag behavior near the stall angle, and for the lowest Reynolds number case, the two-equation model did not predict separation on the airfoil near stall.

Gatski, Thomas B.↗

New Constraints on Titan's Stratospheric n-Butane Abundance

Curiously, n-butane has yet to be detected at Titan, though it is predicted to be present in a wide range of abundances that span over 2.5 orders of magnitude. We have searched infrared spectroscopic observations of Titan for signals from n-butane (n-C4H10) in Titan's stratosphere. Three sets of Cassini Composite Infrared Spectrometer Focal Plane 4 (1050–1500 cm−1) observations were selected for modeling, having been collected from different flybys and pointing latitudes. We modeled the observations with the Nonlinear Optimal Estimator for MultivariatE Spectral AnalySIS radiative transfer tool. Temperature profiles were retrieved for each of the data sets by modeling the ν4 emission from methane near 1305 cm−1. Then, incorporating the temperature profiles, we retrieved abundances of all of Titan's known trace gases that are active in this spectral region, reliably reproducing the observations. We then systematically tested a set of models with varying abundances of n-butane, investigating how the addition of this gas affected the fits. We did this for several different photochemically predicted abundance profiles from the literature, as well as for a constant-with-altitude profile. Ultimately, though we did not produce any firm detection of n-butane, we derived new upper limits on its abundance specific to the use of each profile and to multiple different ranges of stratospheric altitudes. These results will tightly constrain the C4 chemistry of future photochemical modeling of Titan's atmosphere and also motivate the continued search for n-butane and its isomer, isobutane.

Brendan L. Steffens↗

Comparison of theory with experiment in convectionless growth of crystals from solution

Wilcox's computer program for predicting the growth rates of crystals in convectionless supersaturated solution is used to model experiments to measure the crystal growth experiments of Simon (1978) and of Nerad and Shlichta (1984), and the results are compared with the experimental data. The predictions of Wilcox's model are found to be in remarkably good agreement with the results of Simon. The data of Nerad and Shlichta are 30 to 90 percent higher than the predictions of the Wilcox model for a certain range of temperature dependence, consistent with the observation of occasional low-level convection in these experiments. These comparisons indicate that the Wilcox model can be used to make reliable order-of-magnitude predictions of growth rates in the absence of convection.

Schlom, D. G.↗

A Simple Two Aircraft Conflict Resolution Algorithm

Conflict detection and resolution methods are crucial for distributed air-ground traffic management in which the crew in, the cockpit, dispatchers in operation control centers sad and traffic controllers in the ground-based air traffic management facilities share information and participate in the traffic flow and traffic control functions. This paper describes a conflict detection, and a conflict resolution method. The conflict detection method predicts the minimum separation and the time-to-go to the closest point of approach by assuming that both the aircraft will continue to fly at their current speeds along their current headings. The conflict resolution method described here is motivated by the proportional navigation algorithm, which is often used for missile guidance during the terminal phase. It generates speed and heading commands to rotate the line-of-sight either clockwise or counter-clockwise for conflict resolution. Once the aircraft achieve a positive range-rate and no further conflict is predicted, the algorithm generates heading commands to turn back the aircraft to their nominal trajectories. The speed commands are set to the optimal pre-resolution speeds. Six numerical examples are presented to demonstrate the conflict detection, and the conflict resolution methods.

Chatterji, Gano B.↗

Measurements of reactive gaseous rocket injector admittances

The paper describes the results of an experimental study of the quantitative determination of the capabilities of the combustion processes associated with coaxial gaseous propellant rocket injectors to drive combustor pressure oscillations. The data, obtained by employing the modified impedance tube technique with compressed air as the oxidizer and acetylene gas as the fuel, describe the frequency dependence of the admittance of the combined injector-combustion process. The measured data are compared with the predictions of the Feiler and Heidmann analytical model utilizing different values for the characteristic combustion time tau sub b. The values of tau sub b which result in a best fit between the measured and predicted data are indicated for different equivalence ratios. It is shown that for the coaxial injector investigated in this study the tau sub b varies between 0.7 and 1.2 msec for equivalence ratios in the range of 0.57 to 1.31. In addition, the experimental data indicate that the tested injector system could drive combustion instabilities over a frequency range that is in qualitative agreement with the predictions of the Feiler and Heidmann model.

Janardan, B. A.↗

Prediction of unsuppressed jet engine exhaust noise in flight from static data

In order to assess the impact of aircraft noise on the environment in the vicinity of an airport, it is essential that a methodology be developed for predicting in-flight exhaust noise from static data. Such a methodology is presented in this paper and is compared with experimental data for several unsuppressed turbojet engines. For each engine, static data over a range of jet velocities are compared with the predicted jet mixing noise and shock-cell noise. The static engine noise over and above the jet and shock noises is identified as 'excess' noise. The excess noise data are then empirically correlated to smooth the spectral and directivity relations and account for variations in test conditions. This excess noise is then projected to flight based on the assumption that the only effects of flight are a Doppler frequency shift and a level change. The effects of flight on jet mixing noise and shock noise are computed by published NASA methods.

Stone, J. R.↗

Two-phase choked flow of cryogenic fluids in converging-diverging nozzles

Data are presented for the two phase choked flow of three cryogenic fluids - nitrogen, methane, and hydrogen - in four converging-diverging nozzles. The data cover a range of inlet stagnation conditions, all single phase, from well below to well above the thermodynamic critical conditions. In almost all cases the nozzle throat conditions were two phase. The results indicate that the choked flow rates were not very sensitive to nozzle geometry. However, the axial pressure profiles, especially the throat pressure and the point of vaporization, were very sensitive to both nozzle geometry and operating conditions. A modified Henry-Fauske model correlated all the choked flow rate data to within + or - 10 percent. Neither the equilibrium model nor the Henry-Fauske model predicted throat pressures well over the whole range of data. Above the thermodynamic critical temperature the homogeneous equilibrium model was preferred for both flow rate and pressure ratio. The data of the three fluids could be normalized by the principle of corresponding states.

Simoneau, R. J.↗

Nonequilibrium radiation and chemistry models for aerocapture vehicle flowfields, volume 2

A technique was developed for predicting the character and magnitude of the shock wave precursor ahead of an entry vehicle and the effect of this precursor on the vehicle flow field was ascertained. A computational method and program were developed to properly model this precursor. Expressions were developed for the mass production rates of each species due to photodissociation and photoionization reactions. Also, consideration was given to the absorption and emission of radiation and how it affects the energy in each of the energy modes of both the atomic and diatomic species. A series of parametric studies were conducted covering a range of entry conditions in order to predict the effects of the precursor on the shock layer and the radiative heat transfer to the body.

Carlson, Leland A.↗

Measurements of reactive gaseous rocket injector response factors

The results presented represent the first successful attempt at the measurement of the driving capabilities of coaxial gaseous propellant rocket injectors. The required data have been obtained by employing the modified impedance tube technique with compressed air as the oxidizer and acetylene gas as the fuel. The data describe the frequency dependence of the injector admittances, from which the frequency dependence of the injection response factors can be calculated. The measured injector admittances have been compared with the predictions of the Feiler and Heidmann (1967) analytical model assuming different values for the characteristic combustion time. The values of combustion time which result in a best fit between the measured and predicted data are indicated for different equivalence ratios. It is shown that for the coaxial injector system investigated in this study the characteristic combustion times vary between .7 and 1.2 msec for equivalence ratios in the range of .57 to 1.31. The experimental data clearly show that the tested injector system could indeed drive combustion instabilities over a frequency range that is in qualitative agreement with the predictions of the Feiler and Heidmann model.

Janardan, B. A.↗

Electric fields in the solar atmosphere - A review

A review is presented of remote sensing techniques which measure the electric field component transverse to the line of sight and achieve a sensitivity range of 5-10 V/cm. Three models are shown to predict quasistatic, macroscopic values of E(parallel), the electric field component parallel to the magnetic vector, beyond the sensitivity range considered. These processes are: the discharge model of flares; the models of return currents related to flare particle beams; and the models of neutral sheets related to two-ribbon flares and postflare loops. Time dependent electric fields related to MHD and plasma waves, and to plasma disturbance, may allow the detection of both E components (parallel and perpendicular). The uncertainty relating to the emission measures, time scales, volumes, and plasma conditions of these flares and electrified plasma volumes is emphasized. It is pointed out, however, that important information can be obtained by observing electric fields at existing sensitivity levels. By measuring these E-fields, the understanding of flares and related dynamic events can be improved.

Foukal, P.↗

Probability of US Heat Waves Affected by a Subseasonal Planetary Wave Pattern

Heat waves are thought to result from subseasonal atmospheric variability. Atmospheric phenomena driven by tropical convection, such as the Asian monsoon, have been considered potential sources of predictability on subseasonal timescales. Mid-latitude atmospheric dynamics have been considered too chaotic to allow significant prediction skill of lead times beyond the typical 10-day range of weather forecasts. Here we use a 12,000-year integration of an atmospheric general circulation model to identify a pattern of subseasonal atmospheric variability that can help improve forecast skill for heat waves in the United States. We find that heat waves tend to be preceded by 15-20 days by a pattern of anomalous atmospheric planetary waves with a wavenumber of 5. This circulation pattern can arise as a result of internal atmospheric dynamics and is not necessarily linked to tropical heating.We conclude that some mid-latitude circulation anomalies that increase the probability of heat waves are predictable beyond the typical weather forecast range.

Mid-Latitude Circulation↗

Gravitational matter-antimatter asymmetry and four-dimensional Yang-Mills gauge symmetry

A formulation of gravity based on the maximum four-dimensional Yang-Mills gauge symmetry is studied. The theory predicts that the gravitational force inside matter (fermions) is different from that inside antimatter. This difference could lead to the cosmic separation of matter and antimatter in the evolution of the universe. Moreover, a new gravitational long-range spin-force between two fermions is predicted, in addition to the usual Newtonian force. The geometrical foundation of such a gravitational theory is the Riemann-Cartan geometry, in which there is a torsion. The results of the theory for weak fields are consistent with previous experiments.

Hsu, J. P.↗

Assessment of 3D Codes for Predicting Liner Attenuation in Flow Ducts

This paper presents comparisons of seven propagation codes for predicting liner attenuation in ducts with flow. The selected codes span the spectrum of methods available (finite element, parabolic approximation, and pseudo-time domain) and are collectively representative of the state-of-art in the liner industry. These codes are included because they have two-dimensional and three-dimensional versions and can be exported to NASA's Columbia Supercomputer. The basic assumptions, governing differential equations, boundary conditions, and numerical methods underlying each code are briefly reviewed and an assessment is performed based on two predefined metrics. The two metrics used in the assessment are the accuracy of the predicted attenuation and the amount of wall clock time to predict the attenuation. The assessment is performed over a range of frequencies, mean flow rates, and grazing flow liner impedances commonly used in the liner industry. The primary conclusions of the study are (1) predicted attenuations are in good agreement for rigid wall ducts, (2) the majority of codes compare well to each other and to approximate results from mode theory for soft wall ducts, (3) most codes compare well to measured data on a statistical basis, (4) only the finite element codes with cubic Hermite polynomials capture extremely large attenuations, and (5) wall clock time increases by an order of magnitude or more are observed for a three-dimensional code relative to the corresponding two-dimensional version of the same code.

Watson, W. R.↗

The Impact on EOP Predictions of AAM Forecasts from the ECMWF and NCEP

Predictions of UT1 are improved when dynamical model-based forecasts of the axial component of atmospheric angular momentum (AAM) are used as proxy length-of-day (LOD) forecasts (Freedman et al. 1994; Johnson et al. 2005). For example, the accuracy of JPL's predictions of UT1 are improved by nearly a factor of 2 when AAM forecast data from the National Centers for Environmental Prediction (NCEP) are used. Given the importance of AAM forecasts on the accuracy of UT1 predictions, other sources of AAM forecasts should be sought. Here, the angular momentum of the forecasted wind fields from the European Centre for Medium-Range Weather Forecasts (ECMWF) are computed and used to predict UT1. The results are compared to those obtained using NCEP forecasts.

atmospheric angular momentum (AAM)↗

A comparison of two contemporary creep-fatigue life prediction methods

A comparison of two contemporary approaches to creep fatigue life prediction, the Continuous Damage Mechanics as developed at ONERA, and Strain Range Partitioning, is presented. The general framework of each of these approaches, both being crack initiation life prediction tools, are examined. The basis for, and implications of each predictive method are discussed, relative to the material class(es) for which each was developed, as well as to their general applicability. Evident is a need for critical experiments capable of discriminating among the models; to this end, the question of choice of experiment and material is addressed.

Mcgaw, M. A.↗

Worldwide satellite market demand forecast

The forecast is for the years 1981 - 2000 with benchmark years at 1985, 1990 and 2000. Two typs of markets are considered for this study: Hardware (worldwide total) - satellites, earth stations and control facilities (includes replacements and spares); and non-hardware (addressable by U.S. industry) - planning, launch, turnkey systems and operations. These markets were examined for the INTELSAT System (international systems and domestic and regional systems using leased transponders) and domestic and regional systems. Forecasts were determined for six worldwide regions encompassing 185 countries using actual costs for existing equipment and engineering estimates of costs for advanced systems. Most likely (conservative growth rate estimates) and optimistic (mid range growth rate estimates) scenarios were employed for arriving at the forecasts which are presented in constant 1980 U.S. dollars. The worldwide satellite market demand forecast predicts that the market between 181 and 2000 will range from $35 to $50 billion. Approximately one-half of the world market, $16 to $20 billion, will be generated in the United States.

Bowyer, J. M.↗

Heat Transfer in Adhesively Bonded Honeycomb Core Panels

The Swann and Pittman semi-empirical relationship has been used as a standard in aerospace industry to predict the effective thermal conductivity of honeycomb core panels. Recent measurements of the effective thermal conductivity of an adhesively bonded titanium honeycomb core panel using three different techniques, two steady-state and one transient radiant step heating method, at four laboratories varied significantly from each other and from the Swann and Pittman predictions. Average differences between the measurements and the predictions varied between 17 and 61% in the temperature range of 300 to 500 K. In order to determine the correct values of the effective thermal conductivity and determine which set of the measurements or predictions were most accurate, the combined radiation and conduction heat transfer in the honeycomb core panel was modeled using a finite volume numerical formulation. The transient radiant step heating measurements provided the best agreement with the numerical results. It was found that a modification of the Swann and Pittman semi-empirical relationship which incorporated the facesheets and adhesive layers in the thermal model provided satisfactory results. Finally, a parametric study was conducted to investigate the influence of adhesive thickness and thermal conductivity on the overall heat transfer through the panel.

Daryabeigi, Kamran↗