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At least 793 records · Page 44

TU-F-BRF-03: Effect of Radiation Therapy Planning Scan Registration On the Dose in Lung Cancer Patient CT Scans

Purpose: To characterize the effect of deformable registration of serial computed tomography (CT) scans on the radiation dose calculated from a treatment planning scan. Methods: Eighteen patients who received curative doses (≥60Gy, 2Gy/fraction) of photon radiation therapy for lung cancer treatment were retrospectively identified. For each patient, a diagnostic-quality pre-therapy (4–75 days) CT scan and a treatment planning scan with an associated dose map calculated in Pinnacle were collected. To establish baseline correspondence between scan pairs, a researcher manually identified anatomically corresponding landmark point pairs between the two scans. Pre-therapy scans were co-registered with planning scans (and associated dose maps) using the Plastimatch demons and Fraunhofer MEVIS deformable registration algorithms. Landmark points in each pretherapy scan were automatically mapped to the planning scan using the displacement vector field output from both registration algorithms. The absolute difference in planned dose (|ΔD|) between manually and automatically mapped landmark points was calculated. Using regression modeling, |ΔD| was modeled as a function of the distance between manually and automatically matched points (registration error, E), the dose standard deviation (SD-dose) in the eight-pixel neighborhood, and the registration algorithm used. Results: 52–92 landmark point pairs (median: 82) were identified in each patient's scans. Average |ΔD| across patients was 3.66Gy (range: 1.2–7.2Gy). |ΔD| was significantly reduced by 0.53Gy using Plastimatch demons compared with Fraunhofer MEVIS. |ΔD| increased significantly as a function of E (0.39Gy/mm) and SD-dose (2.23Gy/Gy). Conclusion: An average error of <4Gy in radiation dose was introduced when points were mapped between CT scan pairs using deformable registration. Dose differences following registration were significantly increased when the Fraunhofer MEVIS registration algorithm was used, spatial registration errors were larger, and dose gradient was higher (i.e., higher SD-dose). To our knowledge, this is the first study to directly compute dose errors following deformable registration of lung CT scans.

60 APPLIED LIFE SCIENCES↗

The lattice extraction of the TMD soft function using the auxiliary field representation of the Wilson line

The transverse momentum dependent (TMD) soft function can be obtained by formulating the Wilson line in terms of auxiliary 1-dimensional fermion fields on the lattice. In this formulation, the directional vector of the auxiliary field in Euclidean space has the form ˜ 𝑛 = ¹𝑖𝑛0– ®0?– 𝑛3º, where the time component is purely imaginary. The components of these complex directional vectors in the Euclidean space can be mapped directly to the rapidities of the Minkowski space soft function. We present the results of the one-loop calculation of the Euclidean space analog to the soft function using these complex directional vectors. As a result, we show that the calculation is valid only when the directional vectors obey the relation: j𝑟 j = j𝑛3𝑛0j ¡ 1, and that this result corresponds to a computation in Minkowski space with space-like directed Wilson lines. Finally, we show that a lattice calculable object can be constructed that has the desired properties of the soft function.

Francis, Anthony↗

Constraining primordial non-Gaussianity with high-redshift probes

We present an analysis of the constraints on the amplitude of primordial non-Gaussianity of local type described by the dimensionless parameter f{sub NL}. These constraints are set by the auto-correlation functions (ACFs) of two large scale structure probes, the radio sources from NRAO VLA Sky Survey (NVSS) and the QSO catalogue of Sloan Digital Sky Survey Release Six (SDSS DR6 QSOs), as well as by their cross-correlation functions (CCFs) with the cosmic microwave background (CMB) temperature map (Integrated Sachs-Wolfe effect). Several systematic effects that may affect the observational estimates of the ACFs and of the CCFs are investigated and conservatively accounted for. Our approach exploits the large-scale scale-dependence of the non-Gaussian halo bias. The derived constraints on (f{sub NL}) coming from the NVSS CCF and from the QSO ACF and CCF are weaker than those previously obtained from the NVSS ACF, but still consistent with them. Finally, we obtain the constraints on f{sub NL} = 53±25 (1 σ) and f{sub NL} = 58±24 (1 σ) from NVSS data and SDSS DR6 QSO data, respectively.

79 ASTRONOMY AND ASTROPHYSICS↗

A functional global sensitivity measure and efficient reliability sensitivity analysis with respect to statistical parameters

Sensitivity analysis and reliability assessment are two important aspects of structural and system safety. Epistemic uncertainty with respect to probabilistic model of input parameters due to lack of knowledge is present in many scarce-data applications and complicates the characterization of uncertainty in model response. In this article, we present two importance measures to evaluate the impact of distribution parameters on the probability distribution function (PDF) of the output and the failure probability. The epistemic uncertainty associated with the distribution parameters is modeled as random variables. Additionally, a modified extended polynomial chaos expansion (MEPCE) approach is introduced in which aleatory and epistemic random variables are modeled and propagated simultaneously while allowing the separate assessment for any single epistemic variable. A MEPCE-based kernel density estimation (KDE) construction provides a composite map from each epistemic variable to the response PDF. The functional global sensitivity index of the PDF with respect to the distribution parameters is thus derived, as a function of output, which is both more informative and more efficient than standard scalar sensitivity measures. Reliability sensitivity indices can be readily evaluated by integrating the global sensitivity index function over the failure zone. Three illustrative examples are used to demonstrate the proposed methodology.

42 ENGINEERING↗

Heliospheric influence on the anisotropy of TeV cosmic rays

This paper provides a theory of using Liouville's theorem to map the anisotropy of TeV cosmic rays seen at Earth using the particle distribution function in the local interstellar medium (LISM). The ultimate source of cosmic ray anisotropy is the energy, pitch angle, and spatial dependence of the cosmic ray distribution function in the LISM. Because young nearby cosmic ray sources can make a special contribution to the cosmic ray anisotropy, the anisotropy depends on the source age, distance and magnetic connection, and particle diffusion of these cosmic rays, all of which make the anisotropy sensitive to the particle energy. When mapped through the magnetic and electric field of a magnetohydrodynamic model heliosphere, the large-scale dipolar and bidirectional interstellar anisotropy patterns become distorted if they are seen from Earth, resulting in many small structures in the observations. Best fits to cosmic ray anisotropy measurements have allowed us to estimate the particle density gradient and pitch angle anisotropies in the LISM. It is found that the heliotail, hydrogen deflection plane, and the plane perpendicular to the LISM magnetic field play a special role in distorting cosmic ray anisotropy. These features can lead to an accurate determination of the LISM magnetic field direction and polarity. The effects of solar cycle variation, the Sun's coronal magnetic field, and turbulence in the LISM and heliospheric magnetic fields are minor but clearly visible at a level roughly equal to a fraction of the overall anisotropy amplitude. The heliospheric influence becomes stronger at lower energies. Below 1 TeV, the anisotropy is dominated by small-scale patterns produced by disturbances in the heliosphere.

79 ASTRONOMY AND ASTROPHYSICS↗

Lieb-Liniger gas in a constant-force potential

We use Gaudin's Fermi-Bose mapping operator to calculate exact solutions for the Lieb-Liniger model in a linear (constant-force) potential (the constructed exact stationary solutions are referred to as the Lieb-Liniger-Airy wave functions). The ground-state properties of the gas in the wedgelike trapping potential are calculated in the strongly interacting regime by using Girardeau's Fermi-Bose mapping and the pseudopotential approach in the 1/c approximation (c denotes the strength of the interaction). We point out that quantum dynamics of Lieb-Liniger wave packets in the linear potential can be calculated by employing an N-dimensional Fourier transform as in the case of free expansion.

71 CLASSICAL AND QUANTUM MECHANICS, GENERAL PHYSIC↗

Local nanoscale strain mapping of a metallic glass during in situ testing

The local elastic strains during tensile deformation in a CuZrAlAg metallic glass are obtained by fitting an elliptic shape function to the characteristic amorphous ring in electron diffraction patterns. Scanning nanobeam electron diffraction enables strain mapping with a resolution of a few nanometers. Here, a fast direct electron detector is used to acquire the diffraction patterns at a sufficient speed to map the local transient strain during continuous tensile loading in situ in the transmission electron microscope. The elastic strain in tensile direction was found to increase during loading. After catastrophic fracture, a residual elastic strain that relaxes over time was observed.

36 MATERIALS SCIENCE↗

Observational requirements for Lyα forest tomographic mapping of large-scale structure at z ∼ 2

The z ≳ 2 Lyα forest traces the underlying dark matter distribution on large scales and, given sufficient sightlines, can be used to create three-dimensional (3D) maps of large-scale structures. We examine the observational requirements to construct such maps and estimate the signal-to-noise as a function of exposure time and sightline density. Sightline densities at z = 2.25 are n {sub los} ≈ [360, 1200, 3300] deg{sup –2} at limiting magnitudes of g = [24.0, 24.5, 25.0], resulting in transverse sightline separations of (d ) ≈ [3.6, 1.9, 1.2] h {sup –1} Mpc, which roughly sets the reconstruction scale. We simulate these reconstructions using mock spectra with realistic noise properties and find that spectra with S/N ≈ 4 per angstrom can be used to generate maps that clearly trace the underlying dark matter at overdensities of ρ/(ρ) ∼ 1. For the VLT/VIMOS spectrograph, exposure times t {sub exp} = [4, 6, 10] hr are sufficient for maps with spatial resolution ε{sub 3D} = [5.0, 3.2, 2.3] h {sup –1} Mpc. Assuming ∼250 h {sup –1} Mpc is probed along the line of sight, 1 deg{sup 2} of survey area would cover a comoving volume of ≈10{sup 6} h {sup –3} Mpc{sup 3} at (z) ∼ 2.3, enabling the efficient mapping of large volumes with 8-10 m telescopes. These maps could be used to study galaxy environments, the topology of large-scale structures at high z, and to detect proto-clusters.

79 ASTRONOMY AND ASTROPHYSICS↗

Observational diagnostics of self-gravitating MHD turbulence in giant molecular clouds

We study the observable signatures of self-gravitating magnetohydrodynamics (MHD) turbulence by applying the probability density functions (PDFs) and the spatial density power spectrum to synthetic column density maps. We find that there exists three characterizable stages of the evolution of the collapsing cloud which we term “early,” “intermediate,” and “advanced.” At early times, i.e., t<0.15t{sub ff}, the column density has a power spectral slope similar to nongravitating supersonic turbulence and a lognormal distribution. At an intermediate stage, i.e., 0.15t{sub ff} 0.35t{sub ff}, the power spectral slope is positive valued, and a dramatic increase is observed in the PDF moments and the Tsallis incremental PDF parameters, which gives rise to deviations between PDF-sonic Mach number relations. Finally, we show that the imprint of gravity on the density power spectrum can be replicated in non-gravitating turbulence by introducing a delta-function with amplitude equivalent to the maximum valued point in a given self-gravitating map. We find that the turbulence power spectrum restored through spatial filtering of the high density material.

79 ASTRONOMY AND ASTROPHYSICS↗

Intensity mapping across cosmic times with the Lyα line

We present a quantitative model of Lyα emission throughout cosmic history and determine the prospects for intensity mapping spatial fluctuations in the Lyα signal. Since (1) our model assumes at z > 6 the minimum star formation required to sustain reionization and (2) is based at z < 6 on a luminosity function (LF) extrapolated from the few observed bright Lyα emitters, this should be considered a lower limit. Mapping the line emission allows probes of reionization, star formation, and large-scale structure (LSS) as a function of redshift. While Lyα emission during reionization has been studied, we also predict the postreionization signal to test predictions of the intensity and motivate future intensity mapping probes of reionization. We include emission from massive dark matter halos and the intergalactic medium (IGM) in our model. We find agreement with current, measured LFs of Lyα emitters at z < 8. However, diffuse IGM emission, not associated with Lyα emitters, dominates the intensity up to z ∼ 10. While our model is applicable for deep-optical or near-infrared observers like the James Webb Space Telescope, only intensity mapping will detect the diffuse IGM emission. We also construct a three-dimensional power spectrum model of the Lyα emission. Finally, we consider the prospects of an intensity mapper for measuring Lyα fluctuations while identifying interloper contamination for removal. Our results suggest that while the reionization signal is challenging, Lyα fluctuations can be an interesting new probe of LSS at late times when used in conjunction with other lines, e.g., Hα, to monitor low-redshift foreground confusion.

79 ASTRONOMY AND ASTROPHYSICS↗

Segmented strings and the McMillan map

We present new exact solutions describing motions of closed segmented strings in AdS 3 in terms of elliptic functions. The existence of analytic expressions is due to the integrability of the classical equations of motion, which in our examples reduce to instances of the McMillan map. Here, we also obtain a discrete evolution rule for the motion in AdS 3 of arbitrary bound states of fundamental strings and D1-branes in the test approximation.

71 CLASSICAL AND QUANTUM MECHANICS, GENERAL PHYSIC↗

Transport studies in a gate-tunable three-terminal Josephson junction

Josephson junctions with three or more superconducting leads have been predicted to exhibit topological effects in the presence of few conducting modes within the interstitial normal material. Such behavior, of relevance for topologically protected quantum bits, would lead to specific transport features measured between terminals, with topological phase transitions occurring as a function of phase and voltage bias. Although conventional, two-terminal Josephson junctions have been studied extensively, multiterminal devices have received relatively little attention to date. Motivated in part by the possibility to ultimately observe topological phenomena in multiterminal Josephson devices, as well as their potential for coupling gatemon qubits, here we describe the superconducting features of a top-gated mesoscopic three-terminal Josephson device. The device is based on an InAs two-dimensional electron gas proximitized by epitaxial aluminum. We map out the transport properties of the device as a function of bias currents, top gate voltage, and magnetic field. Finally, we find a very good agreement between the zero-field experimental phase diagram and a resistively and capacitively shunted junction computational model.

75 CONDENSED MATTER PHYSICS, SUPERCONDUCTIVITY AND↗

Atomic electrostatic maps of 1D channels in 2D semiconductors using 4D scanning transmission electron microscopy

Defects in materials give rise to fluctuations in electrostatic fields that reflect the local charge density, but imaging this with single atom sensitivity is challenging. However, if possible, this provides information about the energetics of adatom binding, localized conduction channels, molecular functionality and their relationship to individual bonds. Here, ultrastable electron-optics are combined with a high-speed 2D electron detector to map electrostatic fields around individual atoms in 2D monolayers using 4D scanning transmission electron microscopy. Simultaneous imaging of the electric field, phase, annular dark field and the total charge in 2D MoS 2 and WS 2 is demonstrated for pristine areas and regions with 1D wires. The in-gap states in sulphur line vacancies cause 1D electron-rich channels that are mapped experimentally and confirmed using density functional theory calculations. We show how electrostatic fields are sensitive in defective areas to changes of atomic bonding and structural determination beyond conventional imaging.

36 MATERIALS SCIENCE↗

Effects of the local structure dependence of evaporation fields on field evaporation behavior

Accurate three dimensional reconstructions of atomic positions and full quantification of the information contained in atom probe microscopy data rely on understanding the physical processes taking place during field evaporation of atoms from needle-shaped specimens. However, the modeling framework for atom probe microscopy has only limited quantitative justification. Building on the continuum field models previously developed, we introduce a more physical approach with the selection of evaporation events based on density functional theory calculations. This model reproduces key features observed experimentally in terms of sequence of evaporation, evaporation maps, and depth resolution, and provides insights into the physical limit for spatial resolution.

71 CLASSICAL AND QUANTUM MECHANICS, GENERAL PHYSIC↗

Combinatorial Exploration and Mapping of Phase Transformation in a Ni–Ti–Co Thin Film Library

Combinatorial synthesis and high-throughput characterization of a Ni–Ti–Co thin film materials library are reported for exploration of reversible martensitic transformation. The library was prepared by magnetron co-sputtering, annealed in vacuum at 500 °C without atmospheric exposure, and evaluated for shape memory behavior as an indicator of transformation. Composition, structure, and transformation behavior of the 177 pads in the library were characterized using high-throughput wavelength dispersive spectroscopy (WDS), X-ray photoelectron spectroscopy (XPS), X-ray diffraction (XRD), and four-point probe temperature-dependent resistance (R(T)) measurements. A new, expanded composition space having phase transformation with low thermal hysteresis and Co > 10 at. % is found. Unsupervised machine learning methods of hierarchical clustering were employed to streamline data processing of the large XRD and XPS data sets. Through cluster analysis of XRD data, we identified and mapped the constituent structural phases. Finally, composition–structure–property maps for the ternary system are made to correlate the functional properties to the local microstructure and composition of the Ni–Ti–Co thin film library.

37 INORGANIC, ORGANIC, PHYSICAL, AND ANALYTICAL CH↗

Clustering of LRGs in the DECaLS DR8 Footprint: Distance Constraints from Baryon Acoustic Oscillations Using Photometric Redshifts

A photometric redshift sample of luminous red galaxies (LRGs) obtained from the DECam Legacy Survey (DECaLS) is analyzed to probe cosmic distances by exploiting the wedge approach of the two-point correlation function. Although the cosmological information is highly contaminated by the uncertainties existing in the photometric redshifts from the galaxy map, an angular diameter distance can be probed at the perpendicular configuration in which the measured correlation function is minimally contaminated. An ensemble of wedged correlation functions selected up to a given threshold based on having the least contamination was studied in previous work (Sridhar & Song 2019) using simulations, and the extracted cosmological information was unbiased within this threshold. Furthermore, we apply the same methodology for analyzing the LRG sample from DECaLS, which will provide the optical imaging for targeting two-thirds of the Dark Energy Spectroscopic Instrument footprint and measure the angular diameter distances at z = 0.69 and z = 0.87 to be D A (0.697) = (1529 ± 73 Mpe)(r d /r d.fid ) and D A (0.874) = (1674 ± 102 Mpe)(r d /r d.fid ) with a fractional error of 4.77% and 6.09%, respectively. We obtain a value of H 0 = 66.58 ± 5.31 km s -1 Mpc -1 , which supports the H 0 measured by all other baryon acoustic oscillation results and is consistent with the ΛCDM model.

79 ASTRONOMY AND ASTROPHYSICS↗

A new approach to color-coherent parton evolution

We present a simple parton-shower model that replaces the explicit angular ordering of the coherent branching formalism with a differentially accurate simulation of soft-gluon radiation by means of a non-trivial dependence of the splitting functions on azimuthal angles. We introduce a global kinematics mapping and provide an analytic proof that it satisfies the criteria for next-to leading logarithmic accuracy. In the new algorithm, initial and final state evolution are treated on the same footing. We provide an implementation for final-state evolution in the numerical code ALARIC and present a first comparison to experimental data.

72 PHYSICS OF ELEMENTARY PARTICLES AND FIELDS↗

Cosmology from random entanglement

We construct entangled microstates of a pair of holographic CFTs whose dual semiclassical description includes big bang-big crunch AdS cosmologies in spaces without boundaries. The cosmology is supported by inhomogeneous heavy matter and it partially purifies the bulk entanglement of two disconnected auxiliary AdS spacetimes. We show that the island formula for the fine grained entropy of one of the CFTs follows from a standard gravitational replica trick calculation. In generic settings, the cosmology is contained in the entanglement wedge of one of the two CFTs. We then investigate properties of the cosmology-to-boundary encoding map, and in particular, its non-isometric character. Restricting our attention to a specific class of states on the cosmology, we provide an explicit, and state-dependent, boundary representation of operators acting on the cosmology. Finally, under genericity assumptions, we argue for a non-isometric to approximately-isometric transition of the cosmology-to-boundary map for “simple” states on the cosmology as a function of the bulk entanglement, with tensor network toy models of our setup as a guide.

79 ASTRONOMY AND ASTROPHYSICS↗