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Search indexed NASA NTRS and DOE OSTI research on propulsion, heat transfer, battery materials and energy systems. Follow report and document links to the original sources.
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Asymmetric Volcano Trend in Oxygen Reduction Activity of Pt and Non-Pt Catalysts: In Situ Identification of the Site-Blocking Effect
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Potent Activation of Indoleamine 2,3-Dioxygenase by Polysulfides
Abstract not provided
Sulfated glycopeptide nanostructures for multipotent protein activation
Biological systems have evolved to utilize numerous proteins with capacity to bind polysaccharides for the purpose of optimizing their function. A well-known subset of these proteins with binding domains for the highly diverse sulfated polysaccharides are important growth factors involved in biological development and tissue repair. Here, we report on supramolecular sulfated glycopeptide nanostructures, which display a trisulfated monosaccharide on their surfaces and bind five critical proteins with very different polysaccharide binding domains. Binding does not disrupt the filamentous shape of the nanostructures or their internal β-sheet backbone, but must involve accessible adaptive configurations to interact with such different proteins. The glycopeptide nanostructures amplified signaling of bone morphogenetic protein 2 significantly more than the natural sulfated polysaccharide heparin, and promoted regeneration of bone in the spine with a protein dose that is 100-fold lower than expected. These super-bioactive nanostructures may enable many therapies in the horizon involving proteins.
Characterization of activating mutations of NOTCH3 in T-cell acute lymphoblastic leukemia and anti-leukemic activity of NOTCH3 inhibitory antibodies
Abstract not provided
Efficient upgrading of CO to C3 fuel using asymmetric C-C coupling active sites
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Anchor extension: a structure-guided approach to design cyclic peptides targeting enzyme active sites
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Supramolecular-covalent hybrid polymers for light-activated mechanical actuation
Abstract not provided
Identification of a cellularly active SIRT6 allosteric activator
Abstract not provided
Crystal structure of human PLD1 provides insight into activation by PI(4,5)P2 and RhoA
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Structure and activity of human TMPRSS2 protease implicated in SARS-CoV-2 activation
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On the role of the surface oxygen species during A–H (A = C, N, O) bond activation: a density functional theory study
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Rational design of MoS 2 catalysts: tuning the structure and activity via transition metal doping
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Simultaneous spin-coating and solvent annealing: Manipulating the active layer morphology to a power conversion efficiency of 9.6% in polymer solar cells
Here, we developed a simultaneous spin-coating/solvent-annealing process and demonstrated morphology optimization for PTB7 based organic photovoltaics. This novel processing method enhances the edge-on crystalline content in thin films and induces the formation of weak PCBM aggregates. As a result, the efficiency of polymer solar cells increased from 9.2% to a certified high efficiency of 9.61%, owing to an enhanced short-circuit current (J sc , 18.4 mA cm –2 vs. 17. 5 mA cm –2 ) and an improved fill factor.
Metal–organic layers stabilize earth-abundant metal–terpyridine diradical complexes for catalytic C–H activation
Metal–organic layers stabilize Fe II or Co II -terpyridine diradical complexes to catalyze alkylazide C sp3 –H amination and benzylic C–H borylation, respectively.
Tunable assembly of biomimetic peptoids as templates to control nanostructure catalytic activity
Tunable peptoid assembly directs the control over structure and function of Pd nanomaterial catalysts.