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At least 793 records · Page 44

Omics-Lethal Human Viruses, MERS-CoV Experiment MHAE001

The purpose of this experiment was to evaluate the human host response to wild-type Middle Eastern Respiratory Syndrome coronavirus (icMERS-CoV, EMC2012) virus infection. Sample data was obtained from human airway epithelial cells for mRNA, miRNA, proteomics, lipidomics, and metabolomics expression analysis. Secondary host-associated viral dataset downloads contain one or more statistically processed (normalization data transformation) quantitative dataset collections resulting in qualitative expression analyses of primary host-pathogen experimental study designs. Leveraging unique high-resolution Omics capabilities for proteomics, metabolomics, lipidomics, and transcriptomics dataset downloads each have a direct relationship to a primary sample submission corresponding to a specific MERS-CoV virus infection.

59 BASIC BIOLOGICAL SCIENCES↗

Omics-Lethal Human Viruses, MERS-CoV Experiment MHAE002

The purpose of this experiment was to evaluate the human host response to wild-type Middle Eastern Respiratory Syndrome coronavirus (icMERS-CoV, EMC2012) virus infection. Sample data was obtained from human microvascular endothelial cells for mRNA, proteomics, lipidomics, and metabolomics expression analysis. Secondary host-associated viral dataset downloads contain one or more statistically processed (normalization data transformation) quantitative dataset collections resulting in qualitative expression analyses of primary host-pathogen experimental study designs. Leveraging unique high-resolution Omics capabilities for proteomics, metabolomics, lipidomics, and transcriptomics dataset downloads each have a direct relationship to a primary sample submission corresponding to a specific MERS-CoV virus infection.

59 BASIC BIOLOGICAL SCIENCES↗

Omics-Lethal Human Viruses, MERS-CoV Experiment MHAE003

The purpose of this experiment was to evaluate the human host response to wild-type Middle Eastern Respiratory Syndrome coronavirus (icMERS-CoV, EMC2012) virus infection. Sample data was obtained from primary human airway epithelial cells for mRNA, proteomics, lipidomics, and metabolomics expression analysis. Secondary host-associated viral dataset downloads contain one or more statistically processed (normalization data transformation) quantitative dataset collections resulting in qualitative expression analyses of primary host-pathogen experimental study designs. Leveraging unique high-resolution Omics capabilities for proteomics, metabolomics, lipidomics, and transcriptomics dataset downloads each have a direct relationship to a primary sample submission corresponding to a specific MERS-CoV virus infection.

59 BASIC BIOLOGICAL SCIENCES↗

Omics-Lethal Human Viruses, MERS-CoV Experiment MMVE001

The purpose of this experiment was to evaluate the human host response to wild-type Middle Eastern Respiratory Syndrome coronavirus (icMERS-CoV) virus infection. Sample data was obtained from human microvascular endothelial cells for mRNA, miRNA, proteomics, lipidomics, and metabolomics expression analysis. Secondary host-associated viral dataset downloads contain one or more statistically processed (normalization data transformation) quantitative dataset collections resulting in qualitative expression analyses of primary host-pathogen experimental study designs. Leveraging unique high-resolution Omics capabilities for proteomics, metabolomics, lipidomics, and transcriptomics dataset downloads each have a direct relationship to a primary sample submission corresponding to a specific MERS-CoV virus infection.

59 BASIC BIOLOGICAL SCIENCES↗

Omics-Lethal Human Viruses, MERS-CoV Experiment MMVE002

The purpose of this experiment was to evaluate the human host response to wild-type Middle Eastern Respiratory Syndrome coronavirus (icMERS-CoV EMC2012) virus infection. Sample data was obtained from primary human fibroblast cells for mRNA, proteomics, lipidomics, and metabolomics expression analysis. Secondary host-associated viral dataset downloads contain one or more statistically processed (normalization data transformation) quantitative dataset collections resulting in qualitative expression analyses of primary host-pathogen experimental study designs. Leveraging unique high-resolution Omics capabilities for proteomics, metabolomics, lipidomics, and transcriptomics dataset downloads each have a direct relationship to a primary sample submission corresponding to a specific MERS-CoV virus infection.

59 BASIC BIOLOGICAL SCIENCES↗

Omics-Lethal Human Viruses, MERS-CoV Experiment MMVE003

The purpose of this experiment was to evaluate the human host response to wild-type Middle Eastern Respiratory Syndrome coronavirus (icMERS-CoV EMC2012) virus infection. Sample data was obtained from human microvascular endothelial cells for mRNA, proteomics, lipidomics, and metabolomics expression analysis. Secondary host-associated viral dataset downloads contain one or more statistically processed (normalization data transformation) quantitative dataset collections resulting in qualitative expression analyses of primary host-pathogen experimental study designs. Leveraging unique high-resolution Omics capabilities for proteomics, metabolomics, lipidomics, and transcriptomics dataset downloads each have a direct relationship to a primary sample submission corresponding to a specific MERS-CoV virus infection.

59 BASIC BIOLOGICAL SCIENCES↗

Spatial Sampling of Weather Data for Regional Crop Yield Simulations

Field-scale crop models are increasingly applied at spatio-temporal scales that range from regions to the globe and from decades up to 100 years. Sufficiently detailed data to capture the prevailing spatio-temporal heterogeneity in weather, soil, and management conditions as needed by crop models are rarely available. Effective sampling may overcome the problem of missing data but has rarely been investigated. In this study the effect of sampling weather data has been evaluated for simulating yields of winter wheat in a region in Germany over a 30-year period (1982-2011) using 12 process-based crop models. A stratified sampling was applied to compare the effect of different sizes of spatially sampled weather data (10, 30, 50, 100, 500, 1000 and full coverage of 34,078 sampling points) on simulated wheat yields. Stratified sampling was further compared with random sampling. Possible interactions between sample size and crop model were evaluated. The results showed differences in simulated yields among crop models but all models reproduced well the pattern of the stratification. Importantly, the regional mean of simulated yields based on full coverage could already be reproduced by a small sample of 10 points. This was also true for reproducing the temporal variability in simulated yields but more sampling points (about 100) were required to accurately reproduce spatial yield variability. The number of sampling points can be smaller when a stratified sampling is applied as compared to a random sampling. However, differences between crop models were observed including some interaction between the effect of sampling on simulated yields and the model used. We concluded that stratified sampling can considerably reduce the number of required simulations. But, differences between crop models must be considered as the choice for a specific model can have larger effects on simulated yields than the sampling strategy. Assessing the impact of sampling soil and crop management data for regional simulations of crop yields is still needed.

upscaling↗

Omics-Lethal Human Viruses, MERS-CoV Experiment MM001

The purpose of this experiment was to evaluate the host response to wild-type Middle Eastern Respiratory Syndrome coronavirus (MERS-CoV) virus infection. Sample data was obtained from primary mouse lung for mRNA, proteomics, lipidomics, and metabolomics expression analysis. Secondary host-associated viral dataset downloads contain one or more statistically processed (normalization data transformation) quantitative dataset collections resulting in qualitative expression analyses of primary host-pathogen experimental study designs. Leveraging unique high-resolution Omics capabilities for proteomics, metabolomics, lipidomics, and transcriptomics dataset downloads each have a direct relationship to a primary sample submission corresponding to a specific MERS-CoV virus infection.

59 BASIC BIOLOGICAL SCIENCES↗

J/ψ production at midrapidity in p-Pb collisions at $ \sqrt{s_{\textrm{NN}}}$ = 8.16 TeV

The production of inclusive, prompt and non-prompt J/ψ was studied for the first time at midrapidity (–1.37 < y cms < 0.43) in p-Pb collisions at $\sqrt{s_{NN}}$ = 8.16 TeV with the ALICE detector at the LHC. The inclusive J/ψ mesons were reconstructed in the dielectron decay channel in the transverse momentum (p T ) interval 0 < p T < 14 GeV/c and the prompt and non-prompt contributions were separated on a statistical basis for p T > 2 GeV/c. The study of the J/ψ mesons in the dielectron channel used for the first time in ALICE online single-electron triggers from the Transition Radiation Detector, providing a data sample corresponding to an integrated luminosity of 689 ± 13 μb –1 . The proton-proton reference cross section for inclusive J/ψ was obtained based on interpolations of measured data at different centre-of-mass energies and a universal function describing the p T -differential J/ψ production cross sections. The p T -differential nuclear modification factors R pPb of inclusive, prompt, and non-prompt J/ψ are consistent with unity and described by theoretical models implementing only nuclear shadowing.

72 PHYSICS OF ELEMENTARY PARTICLES AND FIELDS↗

Search for gauge-mediated supersymmetry in events with at least one photon and missing transverse momentum in pp collisions at s = 13 TeV

A search for gauge-mediated supersymmetry (SUSY) in final states with photons and large missing transverse momentum is presented. The data sample of pp collisions at $\sqrt{s} = $ 13 TeV was collected with the CMS detector at the CERN LHC and corresponds to an integrated luminosity of 35.9 fb$^{-1}$. Data are compared with models in which the lightest neutralino has bino- or wino-like components, resulting in decays to photons and gravitinos, where the gravitinos escape detection. The event selection is optimized for both electroweak (EWK) and strong production SUSY scenarios. The observed data are consistent with standard model predictions, and limits are set in the context of a general gauge mediation model in which gaugino masses up to 980 GeV are excluded at 95% confidence level. Gaugino masses below 780 and 950 GeV are excluded in two simplified models with EWK production of mass-degenerate charginos and neutralinos. Stringent limits are set on simplified models based on gluino and squark pair production, excluding gluino (squark) masses up to 2100 (1750) GeV depending on the assumptions made for the decay modes and intermediate particle masses. This analysis sets the highest mass limits to date in the studied EWK models, and in the considered strong production models when the mass difference between the gauginos and the squarks or gluinos is small.

72 PHYSICS OF ELEMENTARY PARTICLES AND FIELDS↗

Search for heavy top-like quarks decaying to a Higgs boson and a top quark in the lepton plus jets final state in p p collisions at s = 8 TeV with the ATLAS detector

Study of events with final states consisting of a single isolated lepton + jets + missing transverse momentum produced in proton-proton collisions at a centre-of-mass energy of 8 TeV. The data sample has an integrated luminosity of 14.3 fb-1 collected during 2012. The leptons (electron or muon) are required to be isolated and have moderately high transverse momentum. The data is used in a search for a heavy up-type quark together with its antiparticle, assuming a significant branching ratio for subsequent decay into a SM Higgs boson and a top quark. The search exploits the high total transverse momentum of all final state objects and a high multiplicity of b jets. This record gives the HT distribution where HT is the scalar sum of the PT of the charged lepton, ET(missing) and the PT of the jets.

72 PHYSICS OF ELEMENTARY PARTICLES AND FIELDS↗

A Taxonomic Classification Approach for Global Spatio-temporal Data

The World Bank, World Health Organization, and other major vendors collectively provide thousands of global time series datasets that focus on issues of the environment, public health, economics, violence, education, and national security. Sorting these data into meaningful information requires the use of data mining techniques to cluster trends into an orderly and manageable number of cases. The World SpatioTemporal Analytics and Mapping (WSTAMP) project database (wstamp.ornl.gov) was developed to spatiotemporally harmonize global vendor data (23,300+ attributes, 200+ locations, 50+ years). Within the WSTAMP analytical environment, Dynamic Time Warping (DTW) has been a highly effective data-driven approach for clustering and mapping these time series into national spatiotemporal behavior maps. Two significant properties have surfaced from this work. First, several recognizable cluster patterns have emerged and persist across a range of locations, attributes, and time frames (e.g., increasing, decreasing, rebounding, peak, oscillating). Secondly, practitioners engaging WSTAMP have noted the explanatory and anticipatory value of these patterns and articulated particular interest in detecting them within the spatiotemporal cube. This need was addressed by shifting DTW-based clustering from an open ended, data-driven implementation to a taxonomic pattern matching approach. This paper presents the method including implementation strategies for visualization and human computer interaction and applies the approach to a sample data set and concludes with next steps.

Stewart, Robert↗

Trial-based calibration for audio-based identification, recognition, and detection system

The disclosed technologies include methods for generating a calibration model using data that is selected to match the conditions of a particular trial that involves an automated comparison of data samples, such as a comparison-based trial performed by an audio-based recognition, identification, or detection system. The disclosed technologies also include improved methods for selecting candidate data used to build the calibration model. The disclosed technologies further include methods for evaluating the performance of the calibration model and for rejecting a trial when not enough matched candidate data is available to build the calibration model. The disclosed technologies additionally include the use of regularization and automated data generation techniques to further improve the robustness of the calibration model.

McLaren, Mitchell Leigh↗

Latent bone modelling for estimation of plutonium concentration in skeleton of former nuclear workers

Abstract The skeleton is a major plutonium retention site in the human body. Estimation of the total plutonium activity in the skeleton is a challenging problem. For most tissue donors at the United States Transuranium and Uranium Registries, a limited number of bone samples is available. The skeleton activity is calculated using plutonium activity concentration (Cskel) and skeleton weight. In this study, latent bone modelling was used to estimate Cskel from the limited number of analysed bone samples. Data from 13 non-osteoporotic whole-body donors were used to develop latent bone model (LBM) to estimate Cskel for seven cases with four to eight analysed bone samples. LBM predictions were compared to Cskel estimated using an arithmetic mean in terms of accuracy and precision. For the studied cases, LBM offered a significant reduction of uncertainty of Cskel estimate.

Environmental Sciences & Ecology↗

Search for New Physics with Top and Bottom Quarks with ATLAS

The studies performed by the principal investigator during the period of the grant constitute the ground work for search for new physics in channels including top and bottom quarks with the ATLAS detector at the Large Hadron Collider. The PI has been involved in search for heavy charged Higgs bosons decaying into top and bottom quark pairs, and top quark rare decays involving Higgs bosons and c -quarks. Both channels have the top quark pair production as their main background, which was studied in detail. The search for heavy charged Higgs and top quark rare decays requires significant amount of data accumulated by the experiment. In case no signal is observed in the present data sample collected by ATLAS (5 fb -1 of integrated luminosity at proton-anti proton center-of-mass energy of 7 TeV and 20 fb -1 at 8 TeV), data from the upgraded detector running at 14 TeV needs to be analyzed. The PI has been working on physics and performance studies at upgraded detector.

72 PHYSICS OF ELEMENTARY PARTICLES AND FIELDS↗

Tracking the Sun: Installed Price Trends for Distributed Photovoltaic Systems in the United States - 2018 Edition

Berkeley Lab’s Tracking the Sun report series is dedicated to summarizing installed prices and other trends among grid-connected, distributed solar photovoltaic (PV) systems in the United States. The present report, the 11th edition in the series, focuses on systems installed through year-end 2017, with preliminary trends for the first half of 2018. As in years past, the primary emphasis is on describing changes in installed prices over time and variation in pricing across projects based on location, project ownership, system design, and other attributes. New to this year, however, is an expanded discussion of other project characteristics in the large underlying data sample. Future editions will include more of such material, beyond the report’s traditional focus on installed pricing. The trends described in this report derive primarily from project-level data reported to state agencies and utilities that administer PV incentive programs, solar renewable energy credit (SREC) registration systems, or interconnection processes. In total, data were collected and cleaned for more than 1.3 million individual PV systems, representing 81% of U.S. residential and non-residential PV systems installed through 2017. The analysis of installed pricing trends is based on a subset of roughly 770,000 systems with available installed price data. Key findings from this year’s report include the following: -Installed Prices Continued to Fall through 2017 and into 2018. National median installed prices in 2017 were $3.7 per watt (W) for residential systems (a $0.2/W or 6% decline from the prior year), $3.1/W for small non-residential systems (a $0.4/W or 11% decline), and $2.2/W (a $0.1/W or 5% decline) for large non-residential systems. Data for the first half of 2018 show an additional drop of $0.1/W for residential and small non-residential systems, and effectively no change for large non-residential systems. These recent trends are generally consistent with the pace of price declines since 2014, and mark a slowing from the years immediately preceding (2009-2013) when prices fell by roughly $1/W per year. -Installed Prices Vary Widely Across Individual Projects. Among residential systems installed in 2017, 20% were priced below $3.0/W (the 20th percentile value) while another 20% were above the 80th percentile at $4.5/W. Non-residential systems also exhibit wide spreads, albeit shifted downward, from $2.4/W to $4.1/W for small non-residential and from $1.8/W to $2.8/W for large non-residential projects. These pricing spreads have persisted over time and are both reflective of the heterogeneity in PV systems and markets, as well as suggestive of the potential for further price declines. -Pronounced Pricing Disparities Exist Across States. State-level median installed prices in 2017 ranged from $2.6/W to $4.5/W for residential systems, from $2.2/W to $4.0/W for small non-residential systems, and from $2.1/W to $2.4/W for large non-residential systems. Three of the largest state markets (California, Massachusetts, and New York) are relatively high-priced, pulling overall U.S. median prices upward. These cross-state pricing differences reflect both idiosyncratic features of particular states as well as more-fundamental differences related to market and policy conditions. -Installed Pricing Variation Also Reflects Differences in System Design, Installer, and Customer Characteristics (among other factors). Significant pricing differences were also observed across system sizes within each customer segment (with median prices ranging from $3.2/W to $4.5/W across residential systems of varying size, and from $2.1/W to $3.7/W across non-residential systems), between third-party owned (TPO) and host-owned residential systems ($3.3/W vs. $3.8/W), across residential installers ($2.1/W to $9.6/W for host-owned systems and $1.1/W to $5.1/W for TPO systems), between residential new construction and retrofit systems in California ($2.3/W vs. $3.9/W), between large non-residential systems at commercial sites and tax-exempt customer sites ($2.1/W vs. $2.6/W), and between systems with standard vs. premium efficiency modules ($3.6/W vs. $4.2/W among residential systems). A public version of the underlying dataset can be downloaded at https://emp.lbl.gov/tracking-the-sun.

14 SOLAR ENERGY↗

The REDTOP experiment: Rare $\eta/\eta^{\prime}$ Decays To Probe New Physics

The $\eta$ and $\eta^{\prime}$ mesons are nearly unique in the particle universe since they are almost Goldstone bosons and the dynamics of their decays are strongly constrained. The integrated $\eta$-meson samples collected in earlier experiments amount to $\sim10^{9}$ events. A new experiment, REDTOP (Rare Eta Decays To Probe New Physics), is being proposed, with the intent of collecting a data sample of order 10$^{14}$ $\eta$ (10$^{12}$ $\eta^{\prime}$) for studying very rare decays. Such statistics are sufficient for investigating several symmetry violations, and for searching for particles and fields beyond the Standard Model. In this work we present several studies evaluating REDTOP sensitivity to processes that couple the Standard Model to New Physics through all four of the so-called \emph{portals}: the Vector, the Scalar, the Axion and the Heavy Lepton portal. The sensitivity of the experiment is also adequate for probing several conservation laws, in particular $CP$, $T$ and Lepton Universality, and for the determination of the $\eta$ form factors, which is crucial for the interpretation of the recent measurement of muon $g-2$.

72 PHYSICS OF ELEMENTARY PARTICLES AND FIELDS↗

Coastal Atmosphere and Sea Time Series (CoASTS)

The Coastal Atmosphere and Sea Time Series (CoASTS) Project aimed at supporting ocean color research and applications, from 1995 up to the time of publication of this document, has ensured the collection of a comprehensive atmospheric and marine data set from an oceanographic tower located in the northern Adriatic Sea. The instruments and the measurement methodologies used to gather quantities relevant for bio-optical modeling and for the calibration and validation of ocean color sensors, are described. Particular emphasis is placed on four items: (1) the evaluation of perturbation effects in radiometric data (i.e., tower-shading, instrument self-shading, and bottom effects); (2) the intercomparison of seawater absorption coefficients from in situ measurements and from laboratory spectrometric analysis on discrete samples; (3) the intercomparison of two filter techniques for in vivo measurement of particulate absorption coefficients; and (4) the analysis of repeatability and reproducibility of the most relevant laboratory measurements carried out on seawater samples (i.e., particulate and yellow substance absorption coefficients, and pigment and total suspended matter concentrations). Sample data are also presented and discussed to illustrate the typical features characterizing the CoASTS measurement site in view of supporting the suitability of the CoASTS data set for bio-optical modeling and ocean color calibration and validation.

Hooker, Stanford B.↗