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At least 793 records · Page 44

Black Carbon Deposited in Hariqin Glacier of the Central Tibetan Plateau Record Changes in the Emission from Eurasia

Black carbon (BC), by the combustion of fossil fuels and biomass, has profound effects on climate change and glacier retreat in industrial eras. In the present study, we report refractory BC (rBC) in an ice core spanning 1850–2014, retrieved from the Hariqin Glacier of the Tanggula Mountains in the central Tibetan Plateau, measured using a single particle soot photometer (SP2). The rBC concentration shows a three-fold increase since the 1950s. The mean rBC concentration was 0.71±0.52 ng mL-1 during 1850s–1940s and 2.11±1.60 ng mL-1 during 1950s–2010s. The substantial increase in rBC since the 1950s is consistent with rBC ice core records from the Tibetan Plateau and Eastern Europe. According to the predominant atmospheric circulation patterns over the glacier and timing of changes in regional emissions, the post-1950 amplification of rBC concentration in the central Tibetan Plateau most likely reflects increases in emissions in Eastern Europe, former USSR, the Middle East, and South Asia. Despite the low-level background rBC concentrations in the ice cores from the Tibetan Plateau, the present study highlights a remarkable increase in anthropogenic BC emissions in recent decades and the consequent influence on glaciers in the Tibetan Plateau.

Black carbon, Ice core, Tibetan Plateau, Industria↗

Enhancing Network Visibility and Security through Tensor Analysis

The increasing size, variety, rate of growth and change, and complexity of network data has warranted advanced network analysis and services. Tools that provide automated analysis through traditional or advanced signature-based systems or machine learning classifiers suffer from practical difficulties. These tools fail to provide comprehensive and contextual insights into the network when put to practical use in operational cyber security. In this paper, we present an effective tool for network security and traffic analysis that uses high-performance data analytics based on a class of unsupervised learning algorithms called tensor decompositions. The tool aims to provide a scalable analysis of the network traffic data and also reduce the cognitive load of network analysts and be network-expert-friendly by presenting clear and actionable insights into the network. With this being said, In this paper, we demonstrate the successful use of the tool in two completely diverse operational cyber security environments, namely, (1) security operations center (SOC) for the SCinet network at the SuperComputing (SC) Conference in 2016 and 2017 and (2) Reservoir Labs’ Local Area Network (LAN). In each of these environments, we produce actionable results for cyber security specialists including (but not limited to) (1) finding malicious network traffic involving internal and external attackers using port scans, SSH brute forcing, and NTP amplification attacks, (2) uncovering obfuscated network threats such as data exfiltration using DNS port and using ICMP traffic, and (3) finding network misconfiguration and performance degradation patterns.

97 MATHEMATICS AND COMPUTING↗

Fluorescence In Situ mRNA Hybridization for Gene Expression Detection in a Wood Decay Fungus

Wood-degrading fungi efficiently decompose wood using a series of steps that are regulated across time and space. RNA sequencing with “bulk” sampling method has indicated processes controlled at the transcription level at different decay stages and locations along hyphal networks. To further understand these regulatory mechanisms, a high-resolution technique for gene expression determination is required. In this work, Fluorescence In Situ Hybridization (FISH) of mRNA was tested and optimized in the ‘brown rot’-type (carbohydrate-selective; lignin-rich residues) model fungus Postia (Rhodonia) placenta to image gene expression at the hyphal scale, <10 micrometers. The mRNA of one housekeeping gene Tef1a and three wood-decaying genes Cel28a, Cel5b and Qrd1 were tested in hyphae grown in liquid nutrients and wood substrate. The 20 bp-long DNA probes were successfully delivered intracellularly to give sufficient hybridization signal for imaging. Ahead of hybridization, permeabilization by lyticase and proteinase K treatments proved to be the critical step to increase probe and mRNA accessibility. Tyramide signal amplification was used after hybridization to enhance signal. This gave qualitative measures of mRNA of the four target genes, which were generally in line with previous expression patterns generated from coarser-scale RNA-seq and qRT-PCR studies. These techniques were not without challenges, and future optimization using multiple probe fragments for each mRNA molecule is proposed.

Brown rot fungi, decomposition, FISH, gene express↗

Bio-inspired non self-similar hierarchical elastic metamaterials

Hierarchy provides unique opportunities for the design of advanced materials with superior properties that arise from architecture, rather than from constitutive material response. Contrary to the quasi-static regime, where the potential of hierarchy has been largely explored, its role in vibration mitigation and wave manipulation remains elusive. So far, the majority of the studies concerning hierarchical elastic metamaterials have proposed a self-similar repetition of a specific unit cell at multiple scale levels, leading to the activation of the same bandgap mechanism at different frequencies. On the contrary, here, we show that by designing non self-similar hierarchical geometries allows us to create periodic structures supporting multiple, highly attenuative and broadband bandgaps involving (independently or simultaneously) different scattering mechanisms, namely, Bragg scattering, local resonance and/or inertial amplification, at different frequencies. The type of band gap mechanism is identified and discussed by examining the vibrational mode shapes and the imaginary component of the wavenumber in the dispersion diagram of the unit cell. Finally, we also experimentally confirm this by performing measurements in the lowest frequency regime on a 3D printed structure. Hierarchical design strategies may find application in vibration mitigation for civil, aerospace and mechanical engineering.

36 MATERIALS SCIENCE↗

A prognostic risk model for glioma patients by systematic evaluation of genomic variations

The overall survival rate of gliomas has not significantly improved despite new effective treatments, mainly due to tumor heterogeneity and drug delivery. Here, we perform an integrated clinic-genomic analysis of 1, 477 glioma patients from a Chinese cohort and a TCGA cohort and propose a potential prognostic model for gliomas. We identify that SBS11 and SBS23 mutational signatures are associated with glioma recurrence and indicate worse prognosis only in low-grade type of gliomas and IDH-Mut subtype. We also identify 42 genomic features associated with distinct clinical outcome and successfully used ten of these to develop a prognostic risk model of gliomas. The high-risk glioma patients with shortened survival were characterized by high level of frequent copy number alterations including PTEN, CDKN2A/B deletion, EGFR amplification, less IDH1 or CIC gene mutations, high infiltration levels of immunosuppressive cells and activation of G2M checkpoint and Oxidative phosphorylation oncogenic pathway.

60 APPLIED LIFE SCIENCES↗

Plasmonic hybrid core-shell (HyCoS) AgPt NP template hybridized with GQDs for SERS enhancement of 4-MBA and BT

Surface-enhanced Raman spectroscopy (SERS) is an attractive vibrational spectroscopic technique that can enable a non-destructive and ultra-sensitive detection down to the single-molecule level. Herein, a novel hybrid SERS platform is developed based on hybrid core-shell (HyCoS) AgPt nanoparticles (NPs) and graphene quantum dots (GQDs) for the enhancement of Raman vibration of 4-mercaptobenzoic acid (4-MBA) and benzenethiol (BT). The unique design of HyCoS AgPt NPs induces strong electromagnetic mechanism (EM) enhancement through the amplification of electromagnetic fields by the excitation of high-density surface plasmons and hot spots. Superior localized surface plasmon resonance (LSPR) is generated by the AgPt core-shell and background Ag NP coupling, which is systematically investigated by the optical properties and FDTD simulations. The background Ag NPs can further increase the coverage of metallic NPs, leading to higher-density hot spots and enhanced SERS response. At the same time, GQDs can provide plentiful accessible edges for the charge transfer to the HOMO and LUMO of 4-MBA and BT based on the chemical mechanism (CM) enhancement. The mixing approach of GQDs and target molecules on the HyCoS AgPt NPs can significantly amplify the Raman signals via the strong adsorption of probe molecules by the π – π interaction. The enhancement factors of proposed SERS platform can reach ~107 and ~105 for the 4-MBA and BT respectively.

36 MATERIALS SCIENCE↗

A spin-wave magnetometer with a positive feedback

In this work, we demonstrate experimentally the operation of a spin-wave magnetometer integrated into a circuit with a positive feedback. The circuit consists of the passive magnetic and active electric parts. The magnetic part includes a sensing element, which is a magnetic cross junction made of Y 3 Fe 2 (FeO 4 ) 3 . The electric part includes a non-linear amplifier and a phase shifter. The electric and magnetic parts are connected via micrometer size antennae. Spin waves are excited by two of these antennae while the output inductive voltage produced by the interfering spin waves is detected by the third antenna. Spin waves propagating in the orthogonal arms of the cross can accumulate significantly different phase shifts, depending on the direction and the strength of the external magnetic field. The output inductive voltage reaches its maximum in the case of constructive spin wave interference. The positive feedback provides further signal amplification. It appears possible to enhance the response function, compared to the passive circuits without a feedback, by a factor of ×100 without an increase in the noise level. The experimental data show a prominent response to the external magnetic field variation, exceeding 5 x 10 3 V/T. The intrinsic noise spectral density of the device can be as low as 10 -16 V 2 /Hz. The estimated sensitivity of the prototype device is 2 x 10 -12 T/√Hz at room temperature. We argue that spin-wave magnetometers can potentially be as sensitive as SQUIDs while operating at room temperature.

36 MATERIALS SCIENCE↗

Facile hyperpolarization chemistry for molecular imaging and metabolic tracking of [1– 13 C]pyruvate in vivo

Hyperpolarization chemistry based on reversible exchange of parahydrogen, also known as Signal Amplification By Reversible Exchange (SABRE), is a particularly simple approach to attain high levels of nuclear spin hyperpolarization, which can enhance NMR and MRI signals by many orders of magnitude. SABRE has received significant attention in the scientific community since its inception because of its relative experimental simplicity and its broad applicability to a wide range of molecules, however, in vivo detection of molecular probes hyperpolarized by SABRE has remained elusive. Here we describe a first demonstration of SABRE-hyperpolarized contrast detected in vivo, specifically using hyperpolarized [1– 13 C]pyruvate. Biocompatible formulations of hyperpolarized [1– 13 C]pyruvate in, both, methanol-water, and ethanol-water mixtures followed by dilution with saline and catalyst filtration were prepared and injected into healthy Sprague Dawley and Wistar rats. Effective hyperpolarization-catalyst removal was performed with silica filters without major losses in hyperpolarization. Metabolic conversion of pyruvate to lactate, alanine, and bicarbonate was detected in vivo. Pyruvate-hydrate was also observed as a minor byproduct. Measurements were performed on the liver and kidney at 4.7 T via time-resolved spectroscopy and chemical-shift-resolved MRI. In addition, whole-body metabolic measurements were obtained using a cryogen-free 1.5 T MRI system, illustrating the utility of combining lower-cost MRI systems with simple, low-cost hyperpolarization chemistry to develop safe and scalable molecular imaging.

37 INORGANIC, ORGANIC, PHYSICAL, AND ANALYTICAL CH↗

Efficient 15 N hyperpolarization of [ 15 N 3 ]metronidazole antibiotic via spin-relayed pulsed SABRE-SHEATH

Signal Amplification by Reversible Exchange in SHield Enables Alignment Transfer to Heteronuclei (SABRE-SHEATH) is an NMR hyperpolarization technique that relies of the simultaneous exchange of parahydrogen and a to-be-hyperpolarized molecule on the metal center of a polarization-transfer catalyst in a microtesla magnetic field. Until recently, this method has been understood to perform hyperpolarization by establishing level anti-crossings between the nuclear spins of the parahydrogen derived hydrides (acting as a source of hyperpolarization) and those of the substrate. Recently, the application of highly non-intuitive pulse sequences (comprising pulses of microtesla DC fields) was predicted to hyperpolarize nuclear spins more efficiently than the canonical (static-field) SABRE-SHEATH approach. Here we show that by employing a basic “on-off” pulse sequence of rectangular microtesla pulses, it is possible to improve the hyperpolarization efficiency for SABRE-SHEATH of [ 15 N 3 ]metronidazole, an FDA-approved antibiotic (in non-enriched and non-hyperpolarized form) and potential hypoxia sensing molecule. Specifically, we demonstrate that 15N polarization of 18.5 % can be obtained in 80 s of parahydrogen bubbling parahydrogen through a solution containing 20 mM [ 15 N 3 ]metronidazole. In practice, (1.32 ± 0.14)-fold improvements in P 15N was obtained with the pulsed method described here compared to static field technique variant. These results show that pulsed SABRE-SHEATH was successfully applied to 15 N-labeled biologically relevant molecule. Moreover, we also demonstrate that although the pulsed SABRE-SHEATH sequence was designed for polarization transfer from parahydrogen derived hydrides to the metronidazole’s 15 N catalyst-binding site, all three 15 N sites of [ 15 N 3 ]metronidazole attained the hyperpolarized state. This spin-relayed polarization transfer becomes possible due to the 15 N relay network established by their spin-spin J-couplings. The feasibility of the spin-relayed polarization transfer is demonstrated here for the first time for pulsed SABRE-SHEATH (as opposed to the static-field SABRE-SHEATH reported previously) and it paves the way to broad applicability of the technique.

Hyperpolarization↗

An empirical study of I/O separation for burst buffers in HPC systems

To meet the exascale I/O requirements for the High-Performance Computing (HPC), a new I/O subsystem, Burst Buffer, based on solid state drives (SSD), has been developed. However, the diverse HPC workloads and the bursty I/O pattern cause severe data fragmentation that requires costly garbage collection (GC) and increases the number of bytes written to the SSD. To address this data fragmentation challenge, a new multi-stream feature has been developed for SSDs. In this work, we develop an I/O Separation scheme called BIOS to leverage this multi-stream feature to group the I/O streams based on the user IDs. We propose a stream-aware scheduling policy based on burst buffer pools in the workload manager, and integrate the BIOS with the workload manager to optimize the I/O separation scheme in burst buffer. We evaluate the proposed framework with a burst buffer I/O traces from Cori Supercomputer including a diverse set of applications. Experimental results show that the BIOS could improve the performance by 1.44x on average and reduce the Write Amplification Factor (WAF) by up to 1.20x. Finally, these demonstrate the potential benefits of the I/O separation scheme for solid state storage systems.

97 MATHEMATICS AND COMPUTING↗

Oxygen deficiency induced nickel based oxides for UV & IR sensitive photo-conductive devices

Ni(NO{sub 3}){sub 3}.6H{sub 2}O has been thermally decomposed to synthesize NiO{sub x} (0 3-δ synthesis. These metal oxides have been characterized by XRD, SEM, TEM, XPS and UV–vis spectroscopy for the determination of their crystal structures, structural morphologies, oxidation states and optical band gaps. The devices, made of nanocrystalline-composites or nanocomposites, have been fabricated on gold coated soda lime glasses, where the device based on NiO{sub x} has been found applicable for UV photo-conducting and LaNiO{sub 3-δ} has been recognized as a potential IR photo-conducting sensors. Their respective current amplifications have been recorded 8 and 2.2 times more than the dark current at 2 V of DC bias. The UV sensor has been explained by direct band gap semiconducting nature of NiO{sub x} and IR sensitivity of LaNiO{sub 3-δ} was explained in terms oxygen deficiency induced band gap opening.

75 CONDENSED MATTER PHYSICS, SUPERCONDUCTIVITY AND↗

Cascading economic losses from port disruptions under capacity constrained multimodal freight networks

This study quantifies how throughput disruptions at major seaports cascade through capacity-constrained multimodal freight networks and interregional production systems. We couple an agent-based model (ABM) multimodal freight simulation that resolves rerouting, terminal queueing, and inventory drawdown under binding modal and facility capacities with a multiregional output loss input-output (MRIIM) model that propagates realized delivery shortfalls across regions and sectors. The framework is demonstrated for the Port of Los Angeles using Freight Analysis Framework flows and Bureau of Economic Analysis input-output accounts and is evaluated over a 52-week horizon under deterministic sector targeted shocks and stochastic disruption realizations with uncertain severity and duration. Results indicate nonlinear amplification: realized national losses concentrate in manufacturing and transportation/warehousing even when exogenous port shocks are dispersed, suggesting that congestion spillback and limited short-run substitution can dominate the initial shock allocation. We further evaluate a tabular reinforcement-learning (Q-learning) intervention layer that selects among a small set of implementable system level levers (truck-to-rail and truck-to-barge shift settings) without overriding shipper routing, finding that such interventions reduce total losses for moderate disruptions but yield diminishing returns once substitute modes approach capacity. By linking operational freight behavior to system wide impacts under uncertainty, the proposed ABM-MRIIM pipeline provides a reusable workflow for port disruption stress testing, identification of structurally critical sectors/corridors, and evaluation of resilience interventions under realistic capacity limits.

42 ENGINEERING↗

Mu2e Calorimeter Readout System

The Mu2e electromagnetic calorimeter is made of two disks of un-doped parallelepiped CsI crystals readout by SiPM. There are 674 crystals in one disk and each crystal is readout by an array of two SiPM. The readout electronics is composed of two types of modules: (1) the front-end module hosts the shaping amplifier and the high voltage linear regulator; since one front-end module is interfaced to one SiPM, a total of 2696 modules are needed for the entire calorimeter; (2) a waveform digitizer provides a further level of amplification and digitizes the SiPM signal at the sampling frequency of 200MHz with 12-bits ADC resolution; since one board digitizes the data received from 20 SiPMs, a total of 136 boards are needed. The readout system operational conditions are hostile: ionization dose of 20krads , neutron flux of 10 12 n(1MeVeq)/cm 2 , magnetic field of 1T and in vacuum level of 10 -4 Torr . A description of the readout system and qualification tests is reported.

46 INSTRUMENTATION RELATED TO NUCLEAR SCIENCE AND ↗

The electronics of the energy plane of the NEXT-White detector

This paper describes the electronics of NEXT-White (NEW) detector PMT plane, a high pressure xenon TPC with electroluminescent amplification (HPXe-EL) currently operating at the Laboratorio Subterráneo de Canfranc (LSC) in Huesca, Spain. In NEXT-White the energy of the event is measured by a plane of photomultipliers (PMTs) located behind a transparent cathode. The PMTs are Hamamatsu R11410-10 chosen due to their low radioactivity. The electronics have been designed and implemented to fulfill strict requirements: an overall energy resolution below 1% and a radiopurity budget of 20 mBq unit -1 in the chain of 214 Bi . All the components and materials have been carefully screened to assure a low radioactivity level and at the same time meet the required front-end electronics specifications. In order to reduce low frequency noise effects and enhance detector safety a grounded cathode connection has been used for the PMTs. This implies an AC-coupled readout and baseline variations in the PMT signals. A detailed description of the electronics and a novel approach based on a digital baseline restoration to obtain a linear response and handle AC coupling effects is presented. The final PMT channel design has been characterized with linearity better than 0.4% and noise below 0.4 mV.

46 INSTRUMENTATION RELATED TO NUCLEAR SCIENCE AND ↗

Front-end ASIC for spectroscopic readout of virtual Frisch-grid CZT bar sensors

Compact multi-channel radiation detectors rely on low noise front-end application specific integrated circuits (ASICs) to achieve high spectral resolution. Here, a new ASIC developed to readout virtual Frisch-grid cadmium zinc telluride (VFG CZT) detectors for gamma ray spectroscopy is presented. Corresponding to each ionizing event in the detector, the ASIC measures the amplitude and timing at the anode, the cathode and four pad sense electrodes associated with each sensor in a detector array. The ASIC is comprised of 52 channels of which there are 4 cathode channels and 48 channels which can be configured as either anode channels with a baseline of 250 mV or pad sense channels to process induced signals with a baseline of 1.2 V. With a static power dissipation of 3 mW, each channel performs low-noise charge amplification, high-order shaping, peak and timing detection along with analog storage and multiplexing. The overall channel linearity was better than ± 1% with timing resolution down to 700 ps for charges greater than 8 fC in the 3 MeV range. With a 4 × 4 array of 6 mm × 6 mm × 20 mm virtual Frisch-grid bar sensors connected and biased, an electronic resolution of ≈270 e - rms for charges up to 100 fC in the 3.2 MeV range was measured. Spectral measurements obtained with the 3D correction technique demonstrated resolutions of 1.8% FWHM at 238 keV and 0.9% FWHM at 662 keV.

3D↗

Timing resolution and rate capability of Photonis miniPlanacon XPM85212/A1-S MCP-PMT

In this paper we report on a set of experiments that focus on measuring the timing performance of the Photonis miniPlanacon XPM85212/A1-S microchannel plate photomultiplier tubes along with the detector response at high event rates. The detector has a single photoelectron timing resolution of 30 ps at low rates ( 10 kHz ). We show that both the gain and the timing start to deteriorate around 1 MHz with 20 photoelectrons per channel at 1 0 4 target gain, giving the current per unit of area limits of 1.38 μ A / cm 2 and 2.38 μ A / cm 2 for the two tested devices. Photo-multiplier tubes with lower micro-channel plate resistivity exhibit a better rate capability due to the faster replenishment of the charge inside the microchannels. As we demonstrate, another method to improve the rate capability is to operate the photon detector tubes at a lower gain by reducing the supply voltage and compensating for the loss of amplitude by an additional amplification stage at the expense of the achieved timing resolution. The tube active area over which the beam is spread also plays a role since the same amount of light yields a better rate capability when spread over a larger area. The tubes exposed to high event rates showed an uncharacteristically slow recovery back to its initial gain with 80 % of the initial gain recovered only after several tens of minutes.

73 NUCLEAR PHYSICS AND RADIATION PHYSICS↗

Large mass single electron resolution detector for dark matter and neutrino elastic interaction searches

Large mass single electron resolution solid state detectors are desirable to search for low mass dark matter candidates and to measure coherent elastic neutrino nucleus scattering (CEvNS). In this paper we present results from a novel 100 g phonon-mediated Si detector with a new interface architecture. This detector gives a baseline resolution of ~ 1e - /h + pair and a leakage current on the order of 10 -16 A. This was achieved by removing the direct electrical contact between the Si crystal and the metallic electrode, and by increasing the phonon absorption efficiency of the sensors. The phonon signal amplification in the detector shows a linear increase while the signal to noise ratio improves with bias voltage, up to 240 V. This feature enables the detector to operate at a low energy threshold which is beneficial for dark matter and CEvNS like searches.

46 INSTRUMENTATION RELATED TO NUCLEAR SCIENCE AND ↗

Phonon-mediated high-voltage detector with background rejection for low-mass dark matter and reactor coherent neutrino scattering experiments

We report the first demonstration of a phonon-mediated silicon detector technology that provides a primary phonon measurement in a low-voltage region, and a simultaneous indirect measurement of the ionization signal through Neganov-Trofimov-Luke amplification in a high voltage region, both in a monolithic crystal. We present characterization of charge and phonon transport between the two stages of the detector and the resulting background discrimination capability at low energies. Furthermore, this new detector technology has the potential to significantly enhance the sensitivity of dark matter and coherent neutrino scattering experiments beyond the capabilities of current technologies that have limited discrimination at low energies.

72 PHYSICS OF ELEMENTARY PARTICLES AND FIELDS↗