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Search indexed NASA NTRS and DOE OSTI research on propulsion, heat transfer, battery materials and energy systems. Follow report and document links to the original sources.

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At least 775 records · Page 43
All sourcesNASA NTRSDOE OSTI
NASA NTRS1996

Bioprocessing in Microgravity: Applications of Continuous Flow Electrophoresis to Rat Anterior Pituitary Particles

In this report we describe the results of a continuous flow electrophoresis (CFE) experiment done on STS-65 in which we tested the idea that intracellular growth hormone (GH) particles contained in a cell lysate prepared from cultured rat anterior pituitary cells in microgravity might have different electrophoretic mobilities from those in a synchronous ground control cell lysate. Collectively, the results suggested that CFE processing in microgravity was better than on earth; more samples could be processed at a time (6 x) and more variant forms of GH molecules could be resolved as well. We had also hoped to carry out a pituitary cell CFE experiment, but failure of the hardware required that the actual cell electrophoresis trials be done on earth shortly after Shuttle landing. Data from these experiments showed that space-flown cells possessed a higher electrophoretic mobility than ground control cells, thereby offering evidence for the idea that exposure of cultured cells to microgravity can change their net surface charge-density especially when the cells are fed. Collectively, the results from this pituitary cell experiment document the advantage of using coupled cell culture and CFE techniques in the microgravity environment.

Hymer, W. C.↗
NASA NTRS2013

Understanding the Effects of Spaceflight on Head-trunk Coordination during Walking and Obstacle Avoidance

Prolonged exposure to spaceflight conditions results in a battery of physiological changes, some of which contribute to sensorimotor and neurovestibular deficits. Upon return to Earth, functional performance changes are tested using the Functional Task Test (FTT), which includes an obstacle course to observe post‐flight balance and postural stability, specifically during turning. Aims: To quantify changes in movement strategies during turning events by observing the latency between head‐andtrunk coordinated movement. Hypothesis: It is hypothesized that subjects experiencing neurovestibular adaptations will exhibit head‐to‐trunk locking ('en bloc' movement) during turning, exhibited by a decrease in latency between head and trunk movement. Sample: FTT data samples were collected from Shuttle and ISS missions. Samples were analyzed three times pre exposure, immediately post‐exposure (0 or 1 day post) and 2‐to‐3 times during recovery from the microgravity environment. Methods: Two 3D inertial measurements units (XSens MTx) were attached to subjects, one on the head and one on the upper back. This study focused primarily on the yaw movements about the subject's center of rotation. Time differences (latency) between head and trunk movement were calculated at two points: the first turn (Fturn) to enter the obstacle course (approximately 90⁰ turn) and averaged across a slalom obstacle portion, consisting of three turns (approximately three 90⁰ turns). Results: Preliminary analysis of the data shows a trend toward decreasing head‐to‐trunk movement latency during post‐flight ambulation, after reintroduction to Earth gravity in Shuttle and ISS astronauts. Conclusion: It is clear that changes in movement strategies are adopted during exposure to the microgravity environment and upon reintroduction to a gravity environment. Some subjects exhibit symptoms of neurovestibular neuropathy ('en bloc movement') that may impact their ability to perform post‐flight functional tasks.

Madansingh, S.↗
NASA NTRS2001

Theoretical Prediction of Microgravity Ignition Delay of Polymeric Fuels in Low Velocity Flows

A new flammability apparatus and protocol, FIST (Forced Flow Ignition and Flame Spread Test), is under development. Based on the LIFT (Lateral Ignition and Flame Spread Test) protocol, FIST better reflects the environments expected in spacebased facilities. The final objective of the FIST research is to provide NASA with a test methodology that complements the existing protocol and provides a more comprehensive assessment of material flammability of practical materials for space applications. Theoretical modeling, an extensive normal gravity data bank and a few validation space experiments will support the testing methodology. The objective of the work presented here is to predict the ignition delay and critical heat flux for ignition of solid fuels in microgravity at airflow velocities below those induced in normal gravity. This is achieved through the application of a numerical model previously developed of piloted ignition of solid polymeric materials exposed to an external radiant heat flux. The model predictions will provide quantitative results about ignition of practical materials in the limiting conditions expected in space facilities. Experimental data of surface temperature histories and ignition delay obtained in the KC-135 aircraft are used to determine the critical pyrolysate mass flux for ignition and this value is subsequently used to predict the ignition delay and the critical heat flux for ignition of the material. Surface temperature and piloted ignition delay calculations for Polymethylmethacrylate (PMMA) and a Polypropylene/Fiberglass (PP/GL) composite were conducted under both reduced and normal gravity conditions. It was found that ignition delay times are significantly shorter at velocities below those induced by natural convection.

Fernandez-Pello, A. C.↗
NASA NTRS1994

Surface characterization through shape oscillations of drops in microgravity and 1-g

The goal of these experiments is to determine the rheological properties of liquid drops of single or multiple components in the presence or absence of surface active materials by exciting drops into their quadrupole resonance and observing their free decay. The resulting data coupled with appropriate theory should give a better description of the physics of the underlying phenomena, providing a better foundation than earlier empirical results could. The space environment makes an idealized geometry available (spherical drops) so that theory and experiment can be properly compared, and allows a 'clean' environment, by which is meant an environment in which no solid surfaces come in contact with the drops during the test period. Moreover, by considering the oscillations of intentionally deformed drops in microgravity, a baseline is established for interpreting surface characterization experiments done on the ground by other groups and ours. Experiments performed on the United States Microgravity Laboratory Laboratory (USML-1) demonstrated that shape oscillation experiments could be performed over a wide parameter range, and with a variety of surfactant materials. Results, however, were compromised by an unexpected, slow drop tumbling, some problems with droplet injection, and the presence of bubbles in the drop samples. Nevertheless, initial data suggests that the space environment will be useful in providing baseline data that can serve to validate theory and permit quantitative materials characterization at 1-g.

Apfel, Robert E.↗
NASA NTRS1997

A Critical Assessment of Protein Crystal Growth in Microgravity

Experiments to grow higher diffraction quality protein crystals in the microgravity environment of an orbiting spacecraft are one of the most frequently flown space experiments. Ground-based research has shown that convective flows occur even about protein crystals growing in the Earth's gravitational field. Further, this research has shown that the resultant flow velocities can cause growth cessation, and probably affect the measured X-ray data quality obtained. How flow deleteriously affects protein crystal growth (PCG) is still not known, and is the subject of ongoing research. Failing a rational method for ameliorating flow effects on Earth, one can, through NASA and other nations space agency sponsored programs, carry out protein crystal growth in the microgravity environment of an orbiting spacecraft. Early first generation PCG hardware was characterized by a very low success rate and a steep design learning curve. Subsequent hardware designs have improved upon their predecessors. Now the crystal grower has a wide variety of hardware configurations and crystal growth protocols to choose from, many of which implement "standard" laboratory protein crystal growth methods. While many of these are first or early second generation hardware the success rate, defined as growing crystals giving data better than has been obtained on Earth, is at least 20% overall and may be considerably higher if one only considers latter experiments. There are a large number of protein crystals grown every year, with hundreds of structures determined. Those crystallized in microgravity represent a small proportion of this total, and there is concern that the costs of the microgravity PCG program(s) do not justify such limited returns. Empirical evidence suggests that optimum crystal growth conditions in microgravity differ from those determined on Earth, further exacerbating the chances of success. Microgravity PCG is probably best suited for "mature" crystallizations, where one has considerable experience with the particular macromolecular system and has reached an apparent limit in diffraction resolution. Under such circumstances the cost of one or two successful flight experiments may more than offset the equivalent cost of several years effort to obtain the same improvement in data quality.

Pusey, Marc↗
NASA NTRS1998

Post-spaceflight orthostatic intolerance: possible relationship to microgravity-induced plasticity in the vestibular system

Even after short spaceflights, most astronauts experience at least some postflight reduction of orthostatic tolerance; this problem is severe in some subjects. The mechanisms leading to postflight orthostatic intolerance are not well-established, but have traditionally been thought to include the following: changes in leg hemodynamics, alterations in baroreceptor reflex gain, decreases in exercise tolerance and aerobic fitness, hypovolemia, and altered sensitivity of beta-adrenergic receptors in the periphery. Recent studies have demonstrated that signals from vestibular otolith organs play an important role in regulating blood pressure during changes in posture in a 1-g environment. Because spaceflight results in plastic changes in the vestibular otolith organs and in the processing of inputs from otolith receptors, it is possible that another contributing factor to postflight orthostatic hypotension is alterations in the gain of vestibular influences on cardiovascular control. Preliminary data support this hypothesis, although controlled studies will be required to determine the relationship between changes in the vestibular system and orthostatic hypotension following exposure to microgravity. Copyright 1998 Elsevier Science B.V.

NASA Discipline Neuroscience↗
NASA NTRS1994

Development of a Metabolic Cage for Simulation of Weightlessness in a Laboratory Environment

Astronauts experience many physiological changes during spaceflight and exposure to microgravity. There is a headwardshift of fluids, muscles atrophy, and changes occur in the body's bone structure and hormone levels. This paper describes a unique metabolic cage that was developed to evaluate ground simulation of these effects. Hindlimb or tail suspension in rats has been studied as a model to create the effects of microgravity in order to study how to counteract them. This suspension model, developed by Holton, accurately simulates the effects of weightlessness during spaceflight by unloading the hindlimbs and producing a head-ward shift of fluids. However, obtaining quantitative data on the nutritional state, the gastrointestinal and renal function of these animals has not been possible, until now. Using Holton's tail suspension model, the new metabolic suspension cage effectively separates urine and feces samples for analysis allowing investigators to examine the effects of microgravity in many complex body systems. A description of the cage system, its design, and results of its use is provided along with pictures and details for replication of the cages.

Mulenburg, Gerald M.↗
NASA NTRS2003

Analysis Of MSL-1 Measurements Of Heptane Droplet Combustion

A droplet combustion experiment (DCE) was performed on the MSL-1 mission of the Space Shuttle Columbia. There were two flights of this mission - STS-83 in April of 1997 and STS-94 in July of 1997. The reflight occurred because a fuel-cell power problem onboard the shuttle forced an early termination of the first flight; this was the only shuttle mission to be flown twice. DCE data were obtained during both flights. A fiber-supported droplet combustion (FSDC) experiment also was run on STS-94. This smaller 'glovebox' experiment, which investigated the combustion of fiber-supported droplets in Spacelab cabin air, had previously flown on the first United States Microgravity Laboratory (USML-1) mission of STS-73, but successful measurements with heptane as the fuel in this experiment were first obtained on STS-94. Although heptane droplet combustion in convective flow also was studied on STS-94, only data without forced convection are considered here. The objective of the present paper is to analyze the results on heptane droplet combustion in quiescent atmospheres.

Ackerman, Malissa↗
NASA NTRS2021

Topical: Boiling, Condensation and Two-Phase Flows in Microgravity

The white paper addresses both fundamental and technological questions in the science of phase-change fluid flows aimed at understanding thermal transport in flow boiling and condensation and the use of these processes in space and terrestrial thermal systems. While flow boiling and condensation are widely employed in Earth-based thermal equipment to reduce the cost, size, and power required to transfer heat, a lack of data and predictive models on the impact of gravity on these phenomena hinders the use of two-phase heat transport in a low-gravity environment. The white paper presents research tasks in long-duration microgravity recommended to expand our knowledge on phase-changing flows. Due to elimination of the masking gravity effects, the proposed research will provide a unique opportunity to bring new insights into the role of capillary and hydrodynamic forces in phase-changing flows. The potential impact of the proposed research ranges from the space power, thermal and cryogenic systems to various terrestrial applications in the petrochemical, pharmaceutical, biochemical, nuclear, and metallurgical industries.

Phase-change fluid flow↗
NASA NTRS1985

Commerce Lab: Mission analysis payload integration study. Appendix A: Data bases

The development of Commerce Lab is detailed. Its objectives are to support the space program in these areas: (1) the expedition of space commercialization; (2) the advancement of microgravity science and applications; and (3) as a precursor to future missions in the space program. Ways and means of involving private industry and academia in this commercialization is outlined.

Source record↗
NASA NTRS1988

Experimental ground-based Bridgman CdTe growth in NASA's advanced automated directional solidification furnace

The role of gravity-induced phenomena in bulk CdTe crystal growth is studied with emphasis placed on the negative effects of buoyancy-driven convection, container effects, and hydrostatic pressure. An earth-bound crystal growth data base utilizing NASA's prototype advanced automated directional solidification furnace is described. Growth procedures that can be employed in a microgravity environment aboard the Space Shuttle or Space Station are presented. It is found that NASA's directional solidification furnace can produce Bridgman-type CdTe and has the potential for producing it in space.

Bostrup, G.↗
NASA NTRS1996

Analysis of the Hydrodynamics and Heat Transfer Aspects of Microgravity Two-Phase Flows

Experimental results for void fractions, flow regimes, and heat transfer rates in two-phase, liquid-gas flows are summarized in this paper. The data was collected on-board NASA's KC-135 reduced gravity aircraft in a 9.525 mm circular tube (i.d.), uniformly heated at the outer surface. Water and air flows were examined as well as three glycerol/water solutions and air. Results are reported for the water-air data.

Rezkallah, Kamiel S.↗
NASA NTRS1999

Influence of Buoyant Convection on the Stability of Enclosed Laminar Flames

An investigation of the stability limits of Enclosed Laminar Flames (ELF) was conducted in the Middeck Glovebox (MGBX) facility on the STS-87 Space Shuttle mission (November to December 1997). The primary objective of the ELF glovebox investigation is to determine the effect of buoyancy on the stability of round, laminar, gas-jet diffusion flames in a co-flow air duct. Comparison tests were conducted in normal gravity to allow isolation and identification of the influence of buoyancy. The results were used to map the lift-off and blow-out stability limits as a function of the fuel and air velocities for the two buoyancy conditions. Approximately 50 tests were conducted during the Space Shuttle mission, using a 50/50 mixture (volume basis) of methane and nitrogen as the fuel. The experimental results verified the hypothesis that substantially greater velocities are required to destabilize the flame in microgravity. The increase in air velocity required to induce lift off in microgravity (compared to normal gravity) was nearly equal to the increase required to induce blow out. Furthermore, the air velocity increase was relatively independent of the fuel flow, except at low fuel flows. At high fuel flows, it was found that the microgravity flames tend to immediately blow out after lift off. This is in agreement with the free-jet theory which suggests that stable lifted flames are not possible for fuels with a Schmidt number of 0.5<Sc<l, such as the diluted methane used in this study. However, stable lifted flames were observed in microgravity at low fuel flows, and in normal gravity, despite the fuel's low Schmidt number. The discrepancy between the experimental data and the theory of Chung and Lee is presumably due to the differences in the flow condition; namely, the ducted flow versus a free jet, and a non-similar velocity profile versus a self-similar profile.

Brooker, John E.↗
NASA NTRS2000

Microgravity Acceleration Measurement System (MAMS) Flight Configuration Verification and Status

The Microgravity Acceleration Measurement System (MAMS) is a precision spaceflight instrument designed to measure and characterize the microgravity environment existing in the US Lab Module of the International Space Station. Both vibratory and quasi-steady triaxial acceleration data are acquired and provided to an Ethernet data link. The MAMS Double Mid-Deck Locker (DMDL) EXPRESS Rack payload meets all the ISS IDD and ICD interface requirements as discussed in the paper which also presents flight configuration illustrations. The overall MAMS sensor and data acquisition performance and verification data are presented in addition to a discussion of the Command and Data Handling features implemented via the ISS, downlink and the GRC Telescience Center displays.

Wagar, William↗
NASA NTRS2002

Transport and Growth Kinetics in Microgravity Protein Crystal Growth

The dynamic coupling between mass transport and incorporation of growth units into the surface of a crystal growing from solution in microgravity is used to derive quantitative information on the crystal growth kinetics. To this end, new procedures for experiment preparation, interferometric data processing and model fitting have been developed. The use of experimental data from the bulk diffusive maw transport together with a model for steady state stagnant crystal growth allows the detailed quantitative understanding of the kinetics of both the concentration depletion zone around the crystal and the growth of the crystal interface. The protein crystal used in the experiment is shown to be growing in the mixed kinetic regime (0.2 x 10(exp -6) centimeters per second less than beta R/D less than 0.9 x 10(exp -6) centimeters per second).

Otalora, F.↗
NASA NTRS2003

Flexor bias of joint position in humans during spaceflight

The ability to estimate ankle and elbow joint position was tested before, during, and after a 17-day spaceflight. Subjects estimated targeted joint angles during isovelocity (IsoV) joint movements with agonist muscle groups either active or relaxed. These movements included elbow extension (EE) and elbow flexion (EF), and plantarflexion (PF) and dorsiflexion (DF) of the ankle. Subjects also estimated these joint positions while moving the dynamometer at their chosen (variable) velocity (VarV) during EE and PF. For IsoV tests, no differences were observed between active and passive movements for either the ankle or elbow. Compared with those of pre-flight test days, estimates of targeted elbow joint angles were approximately 5 degrees to 15 degrees more flexed in-flight, and returned toward the pre-flight values during recovery. The spaceflight effects for the ankle were inconsistent and less prevalent than those for the elbow. The VarV PF test condition for the 120 degrees target angle at the ankle exhibited approximately 5 degrees to 7 degrees more DF target angle estimates in-flight compared with those pre- or post-flight. In contrast, during IsoV PF there was a tendency for ankle estimates to be approximately 2 degrees to 3 degrees more PF after 2-3 days exposure to spaceflight. These data indicate that during spaceflight the perception of elbow extension is greater than actuality, and are consistent with the interpretation that microgravity induced a flexor bias in the estimation of the actual elbow joint position. Moreover, these effects in joint proprioception during spaceflight were observed in individual isolated single-joint movements during tasks in which vestibular function in maintaining posture were minimal.

STS-78 Shuttle Project↗
NASA NTRS2000

[Characteristics of super dwarf wheat metabolism in microgravity]

Metabolism of sLt during Russian-US experiment GREENHOUSE-2 (July 9, 1996-January 17, 1997) within the MIR/NASA space research program and in laboratory Svet experiments in 1995-1996 was studied. Chemical, biochemical and pigment analyses of the flight and laboratory plants were made after the first (dry biomass) and second vegetation (photosynthetically active 41-d old plants). Data on the composition of leaves and stems of ground and flight wheat do not attest any biologically significant shifts in plant metabolism. There were slight changes in accumulation and migration of several macro- and microelements, protein nitrogen and phosphororganic compounds in microgravity. Lowered content of lignin, a critical supportive element for cellular walls was observed only during early stages of vegetation. In the Mir experiment, concentrations of photosynthetically active pigments also decreased a little but the chlorophyills-carotenoids balance was not upset.

Non-NASA Center↗
NASA NTRS1995

The effect of space and parabolic flight on macrophage hematopoiesis and function

We used weak electric fields to monitor macrophage spreading in microgravity. Using this technique, we demonstrated that bone marrow-derived macrophages responded to microgravity within 8 s. We also showed that microgravity differentially altered two processes associated with bone marrow-derived macrophage development. Spaceflight enhanced cellular proliferation and inhibited differentiation. These data indicate that the space/microgravity environment significantly affects macrophages.

NASA Discipline Cell Biology↗