Breaking the Vendor Lock - Performance Portable Programming Through OpenMP as Target Independent Runtime Layer
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Computer science↗
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Late Breaking Results: COPPER: Computation Obfuscation by Producing Permutations for Encoding Randomly
Deployed embedded devices face security risks due to increased ease of physical access to the devices by unauthorized users. Capable adversaries can intercept a device to recover the data in memory, including results of performed sensitive computations. Device owners require data confidentiality on their physically insecure devices. To satisfy this goal we implement a novel method, COPPER (Computation Obfuscation by Producing Permutations for Encoding Randomly), to create data which never exists on the device digitally in plaintext format and which is subsequently used for computation. In this paper we utilize COPPER to calculate a moving average computation on encoded data.
embedded systems↗
The advancing wave front on a sloping channel covered by a rod canopy following an instantaneous dam break
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54 ENVIRONMENTAL SCIENCES↗
Breaking Boundaries: Deformation Processing Techniques for the Next Generation of Lightweight and High-Strength Materials
This chapter emphasizes the importance of solid phase processing (SPP) techniques in developing advanced materials for lightweight and high-strength applications. SPP methods like friction stir welding, and shear-assisted processing can create new microstructures and process materials in novel ways. SPP can enhance mechanical performance via various strengthening mechanisms like solid solution supersaturation, Hall-Petch and Orowan effects, and misorientation angle grain boundaries. The potential for in situ alloying or joining of components with near-net shape and low energy inputs, even for immiscible systems with high enthalpies of mixing, is also discussed. The chapter explores the concept of metastability through microstructural manipulation and the role of advanced characterization for atomistic understanding. The formation of metastable grain, shear-driven chemical mixing, and transformation pathways are also discussed. Finally, the emerging trends for SPP and the challenges that need to be addressed before realizing the full potential of these techniques are presented.
Lastovich, Michael↗
Arbiter with random tie breaking
Candidates for selection in a weighted arbitration system are assigned priority weights and random weights. The winning candidate is determined using a tree of selectors such as a comparators. At each stage of the tree, the candidate having the greatest priority weight is selected to pass to the next stage. If multiple candidates are tied for the greatest priority weight, the candidate having the greatest random weight is selected to pass to the next stage.
Lesartre, Gregg B.↗
Novel Cryogenic High Voltage Breaks (CHVB)
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Rey, Christopher M. [Energy to Power Solutions]↗
Breaking the System Noise Barrier at Exascale
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Computer science↗
High-LET radiation-induced aberrations in prematurely condensed G2 chromosomes of human fibroblasts
PURPOSE: To determine the number of initial chromatid breaks induced by low- or high-LET irradiations, and to compare the kinetics of chromatid break rejoining for radiations of different quality. MATERIAL AND METHODS: Exponentially growing human fibroblast cells AG1522 were irradiated with gamma-rays, energetic carbon (290MeV/u), silicon (490MeV/u) and iron (200 and 600 MeV/u). Chromosomes were prematurely condensed using calyculin A. Chromatid breaks and exchanges in G2 cells were scored. PCC were collected after several post-irradiation incubation times, ranging from 5 to 600 min. RESULTS: The kinetics of chromatid break rejoining following low- or high-LET irradiation consisted of two exponential components representing a rapid and a slow time constant. Chromatid breaks decreased rapidly during the first 10min after exposure, then continued to decrease at a slower rate. The rejoining kinetics were similar for exposure to each type of radiation. Chromatid exchanges were also formed quickly. Compared to low-LET radiation, isochromatid breaks were produced more frequently and the proportion of unrejoined breaks was higher for high-LET radiation. CONCLUSIONS: Compared with gamma-rays, isochromatid breaks were observed more frequently in high-LET irradiated samples, suggesting that an increase in isochromatid breaks is a signature of high-LET radiation exposure.
Non-NASA Center↗
The Late-time Afterglow Evolution of Long Gamma-Ray Bursts GRB 160625B and GRB 160509A
We present post-jet-break Hubble Space Telescope, Very Large Array, and Chandra observations of the afterglow of the long γ-ray bursts GRB 160625B (between 69 and 209 days) and GRB 160509A (between 35 and 80 days). We calculate the post-jet-break decline rates of the light curves and find the afterglow of GRB 160625B is inconsistent with a simple t−3/4 steepening over the break, expected from the geometric effect of the jet edge entering our line of sight. However, the favored optical post-break decline (fv alpha t-1.96+-0.07) is also inconsistent with the fν alpha t−p decline (where p ≈ 2.3 from the pre-break light curve), which is expected from exponential lateral expansion of the jet; perhaps suggesting lateral expansion that only affects a fraction of the jet. The post break decline of GRB 160509A is consistent with both the t−3/4 steepening and with fν alpha t−p. We also use BOXFIT to fit afterglow models to both light curves and find both to be energetically consistent with a millisecond magnetar central engine, but the magnetar parameters need to be extreme (i.e., E ~ 3 × 1052 erg). Finally, the late-time radio light curves of both afterglows are not reproduced well by BOXFIT and are inconsistent with predictions from the standard jet model; instead, both are well represented by a single power-law decline (roughly fν alpha t−1) with no breaks. This requires a highly chromatic jet break (tj, radio > 10 x tj, optical) and possibly a two-component jet for both bursts.
Gamma-ray bursts↗
Gravitational Waves and Proton Decay: Complementary Windows into Grand Unified Theories
Proton decay is a smoking gun signature of grand unified theories (GUTs). Searches by Super-Kamiokande have resulted in stringent limits on the GUT symmetry-breaking scale. The large-scale multipurpose neutrino experiments DUNE, Hyper-Kamiokande, and JUNO will either discover proton decay or further push the symmetry-breaking scale above 10 16 GeV. Another possible observational consequence of GUTs is the formation of a cosmic string network produced during the breaking of the GUT to the standard model gauge group. The evolution of such a string network in the expanding Universe produces a stochastic background of gravitational waves which will be tested by a number of gravitational wave detectors over a wide frequency range. We demonstrate the nontrivial complementarity between the observation of proton decay and gravitational waves produced from cosmic strings in determining SO(10) GUT-breaking chains. We show that such observations could exclude SO(10) breaking via flipped SU(5) × U(1) or standard SU(5), while breaking via a Pati-Salam intermediate symmetry, or standard SU(5) × U(1), may be favored if a large separation of energy scales associated with proton decay and cosmic strings is indicated. We note that recent results by the NANOGrav experiment have been interpreted as evidence for cosmic strings at a scale of ~10 14 GeV. This would strongly point toward the existence of GUTs, with SO(10) being the prime candidate. We show that the combination with already available constraints from proton decay allows us to identify preferred symmetry-breaking routes to the standard model.
72 PHYSICS OF ELEMENTARY PARTICLES AND FIELDS↗
Chromosomal Aberrations in Normal and AT Cells Exposed to High Dose of Low Dose Rate Irradiation
Ataxia telangiectasia (A-T) is a human autosomally recessive syndrome characterized by cerebellar ataxia, telangiectases, immune dysfunction, and genomic instability, and high rate of cancer incidence. A-T cell lines are abnormally sensitive to agents that induce DNA double strand breaks, including ionizing radiation. The diverse clinical features in individuals affected by A-T and the complex cellular phenotypes are all linked to the functional inactivation of a single gene (AT mutated). It is well known that cells deficient in ATM show increased yields of both simple and complex chromosomal aberrations after high-dose-rate irradiation, but, less is known on how cells respond to low-dose-rate irradiation. It has been shown that AT cells contain a large number of unrejoined breaks after both low-dose-rate irradiation and high-dose-rate irradiation, however sensitivity for chromosomal aberrations at low-dose-rate are less often studied. To study how AT cells respond to low-dose-rate irradiation, we exposed confluent normal and AT fibroblast cells to up to 3 Gy of gamma-irradiation at a dose rate of 0.5 Gy/day and analyzed chromosomal aberrations in G0 using fusion PCC (Premature Chromosomal Condensation) technique. Giemsa staining showed that 1 Gy induces around 0.36 unrejoined fragments per cell in normal cells and around 1.35 fragments in AT cells, whereas 3Gy induces around 0.65 fragments in normal cells and around 3.3 fragments in AT cells. This result indicates that AT cells can rejoin breaks less effectively in G0 phase of the cell cycle? compared to normal cells. We also analyzed chromosomal exchanges in normal and AT cells after exposure to 3 Gy of low-dose-rate rays using a combination of G0 PCC and FISH techniques. Misrejoining was detected in the AT cells only? When cells irradiated with 3 Gy were subcultured and G2 chromosomal aberrations were analyzed using calyculin-A induced PCC technique, the yield of unrejoined breaks decreased in both normal and AT cells and misrejoined breaks increased in both cell lines. The present study suggests that AT cells begin to rejoin breaks when a certain number of breaks are accumulated and an increased number of exchanges were observed in G0 AT cells, which is similar situation after high-dose-rate irradiation.
Kawata, T.↗
Umbilical Deployment Device
The landing scheme for NASA's next-generation Mars rover will encompass a novel landing technique (see figure). The rover will be lowered from a rocket-powered descent stage and then placed onto the surface while hanging from three bridles. Communication between the rover and descent stage will be maintained through an electrical umbilical cable, which will be deployed in parallel with structural bridles. The -inch (13-mm) umbilical cable contains a Kevlar rope core, around which wires are wrapped to create a cable. This cable is helically coiled between two concentric truncated cones. It is deployed by pulling one end of the cable from the cone. A retractable mechanism maintains tension on the cable after deployment. A break-tie tethers the umbilical end attached to the rover even after the cable is cut after touchdown. This break-tie allows the descent stage to develop some velocity away from the rover prior to the cable releasing from the rover deck, then breaks away once the cable is fully extended. The descent stage pulls the cable up so that recontact is not made. The packaging and deployment technique can store a long length of cable in a relatively small volume while maintaining compliance with the minimum bend radius requirement for the cable being deployed. While the packaging technique could be implemented without the use of break-ties, they were needed in this design due to the vibratory environment and the retraction required by the cable. The break-ties used created a series of load-spikes in the deployment signature. The load spikes during the deployment of the initial three coils of umbilical showed no increase between the different temperature trials. The cold deployment did show an increased load requirement for cable extraction in the region where no break-ties were used. This increase in cable drag was superimposed on the loads required to rupture the last set of break-ties, and as such, these loads saw significant increase when compared to their ambient counterparts. While the loads showed spikes of high magnitude, they were of short duration. Because of this, neither the deployment of the rover, nor the motion of the descent stage, would be adversely affected. In addition, the umbilical was found to have a maximum of 1.2 percent chance for recontact with the ultra-high frequency antenna due to the large margin of safety built in.
Shafer, Michael W.↗
The Late-time Afterglow of the Extremely Energetic Short Burst GRB 090510 Revisited
Context. The Swift discovery of the short burst GRB 090510 has raised considerable attention mainly because of two reasons: first, it had a bright optical afterglow, and second it is among the most energetic events detected so far within the entire GRB population (long plus short). The afterglow of GRB 090510 was observed with Swift/UVOT and Swift/XRT and evidence of a jet break around 1.5 ks after the burst has been reported in the literature, implying that after this break the optical and X-ray light curve should fade with the same decay slope. Aims. As noted by several authors, the post-break decay slope seen in the UVOT data is much shallower than the steep decay in the X-ray band, pointing to a (theoretically hard to understand) excess of optical flux at late times. We assess here the validity of this peculiar behavior. Methods. We reduced and analyzed new afterglow light-curve data obtained with the multichannel imager GROND. These additional g'r'i'z' data were then combined with the UVOT and XRT data to study the behavior of the afterglow at late times more stringently. Results. Based on the densely sampled data set obtained with GROND, we find that the optical afterglow of GRB 090510 did indeed enter a steep decay phase starting around 22 ks after the burst. During this time the GROND optical light curve is achromatic, and its slope is identical to the slope of the X-ray data. In combination with the UVOT data this implies that a second break must have occurred in the optical light curve around 22 ks post burst, which, however, has no obvious counterpart in the X-ray band, contradicting the interpretation that this could be another jet break. Conclusions. The GROND data provide the missing piece of evidence that the optical afterglow of GRB 090510 did follow a post-jet break evolution at late times. The break seen in the optical light curve around 22 ks in combination with its missing counterpart in the X-ray band could be due to the passage of the injection frequency across the optical bands, as already theoretically proposed in the literature. This is possibly the first time that this passage has been clearly seen in an optical afterglow. In addition, our results imply that there is no more evidence for an excess of flux in the optical bands at late times.
gamma-ray burst↗
PARP1-HPF1 structure and dynamics on nicked DNA suggest a mechanism for acute and localized ADP-ribosylation
PARP1 detection of DNA strand breaks allosterically leads to PARP1 synthesis of poly(ADP-ribose) modifications that signal DNA damage. HPF1 engages activated PARP1 to control modification site selection. Understanding of the mechanism of DNA break detection and catalytic activation is incomplete, due largely to limited structural information for full-length PARP1. Here, single-particle cryo-EM provides views of the full complement of PARP1 domains engaging a DNA single-strand break in the presence of HPF1 and a fragment of binding partner Timeless. Cryo-EM, single-molecule DNA dynamics, and small-angle X-ray scattering analysis indicate that PARP1 remains dynamic even when the multi-domain structure is organized on a DNA break, with the minimal catalytic region displaying high mobility relative to domains engaging damage. We propose that the organization of PARP1 domains on a DNA break releases a tethered, constitutively active catalytic region to modify molecules in a radius surrounding the DNA break site.
59 BASIC BIOLOGICAL SCIENCES↗
Hard X-Ray Variability of the Black Hole Candidate GRO J0422+32 During its 1992 Outburst
We have studied the hard X-ray variability of the soft X-ray transient GRO J0422+32 with BATSE (Burst and Transient Source Experiment) in the 20-100 keV energy band. Our analysis covers 180 days following the first X-ray detection of the source on August 5, 1992, fully covering its primary and secondary X-ray outbursts. We compute power density spectra (PDSs) in the 20-50, 50-100, and 20-100 keV energy bands, in the frequency interval 0.002-0.488 Hz. The PDSs of GRO J0422+32 are approximately flat up to a break frequency, and decay as a power law above it, with index approximately 1. During the first 70 days of the X-ray outburst, the PDSs of GRO J0422+32 show a significant quasi-periodic oscillation (QPO) peak near approximately 0.2 Hz, superposed on the power-law tail. The break frequency of the PDSs obtained during the primary X-ray outburst of GRO J0422+32 occurs at 0.041 +/- 0.006 Hz; during the secondary outburst, the break is at 0.081 +/- 0.015 Hz. The power density at the break ranged between 44% and 89% / square root of Hz (20-100 keV). The canonical anticorrelation between the break frequency and the power density at the break, observed in Cyg X-1 and other BHCs in the low state, is not observed in the PDSs of GRO J0422+32. We compare our results with those of similar variability studies of Cyg X-1. The relation between the spectral slope and the amplitude of the X-ray variations of GRO J0422+32 is similar to that of Cyg X-1; however, the relation between the hard X-ray flux and the amplitude of its variation is opposite to what has been found in Cyg X-1. Phase lags between the X-ray flux variations of GRO J0422+32 at high and low photon energies could only be derived during the first 30 days of its outburst. During this period, the variations in the 50-100 keV band lag those in the 20-50 keV energy band by an approximately constant phase difference of 0.039(3) rad in the frequency interval 0.02-0.20 Hz. The time lags of GRO J0422+32 during the first 30 days of the outburst decrease with frequency as a power law with index 0.9 for v > 0.01 Hz.
vanderHooft, F.↗
Hard X-Ray Variability of the Black Hole Candidate GRO J0422+32 During its 1992 Outburst
We have studied the hard X-ray variability of the soft X-ray transient GRO J0422+32 with the Burst and Transient Source Experiment (BATSE) in the 20-100 keV energy band. Our analysis covers 180 days following the first X-ray detection of the source on 1992 August 3, fully covering its primary and secondary X-ray outburst. We computed power density spectra (PDSS) in the 20-50, 50-100, and 20-100 keV energy bands., in the frequency interval 0.002-0.488 Hz. The PDSs of GRO J0422+32 are approximately flat up to a break frequency and decay as a power law above, with index about 1. During the first 70 days of the X-ray outburst, the PDSs of GRO J0422+32 show a significant QPO Peak near about 0.2 Hz, superposed on the power-law tail. The break frequency of the PDSs obtained during the primary X-ray outburst of GRO J0422+32 occurs at 0.041+/-0.006 Hz; during the secondary outburst the break is at 0.081q0.01.5 Hz. The power density at the break ranged between 44 and 89% Hz(exp -1/2) 20-100 keV). The canonical anticorrelation between the break frequency and the power density at the break, observed in Cyg X-1 and other BHCs in the low state, is not observed in the PDSs of GRO J0422+32. We compare our results with those of similar variability studies of Cyg X-1. The relation between the spectral slope and the amplitude of the X-ray variations of GRO J0422+32 is similar to that of Cyg X-1.
VanderHooft, F.↗
Large-mutation spectra induced at hemizygous loci by low-LET radiation: evidence for intrachromosomal proximity effects
A mathematical model is used to analyze mutant spectra for large mutations induced by low-LET radiation. The model equations are based mainly on two-break misrejoining that leads to deletions or translocations. It is assumed, as a working hypothesis, that the initial damage induced by low-LET radiation is located randomly in the genome. Specifically, we analyzed data for two hemizygous loci: CD59- mutants, mainly very large-scale deletions (>3 Mbp), in human-hamster hybrid cells, and data from the literature on those HPRT- mutants which involve at least deletion of the whole gene, and often of additional flanking markers (approximately 50-kbp to approximately 4.4-Mbp deletions). For five data sets, we estimated f, the probability that two given breaks on the same chromosome will misrejoin to make a deletion, as a function of the separation between the breaks. We found that f is larger for nearby breaks than for breaks that are more widely separated; i.e., there is a "proximity effect". For acute irradiation, the values of f determined from the data are consistent with the corresponding break misrejoining parameters found previously in quantitative modeling of chromosome aberrations. The value of f was somewhat smaller for protracted irradiation than for acute irradiation at a given total dose; i.e., the mutation data show a decrease that was smaller than expected for dose protraction by fractionation or low dose rate.
Non-NASA Center↗
Clusters of DNA damage induced by ionizing radiation: formation of short DNA fragments. II. Experimental detection
The basic 30-nm chromatin fiber in the mammalian cell consists of an unknown (possibly helical) arrangement of nucleosomes, with about 1.2 kb of DNA per 10-nm length of fiber. Track-structure considerations suggest that interactions of single delta rays or high-LET particles with the chromatin fiber might result in the formation of multiple lesions spread over a few kilobases of DNA (see the accompanying paper: W.R. Holley and A. Chatterjee, Radiat. Res. 145, 188-199, 1996). In particular, multiple DNA double-strand breaks and single-strand breaks may form. To test this experimentally, primary human fibroblasts were labeled with [3H]thymidine and exposed at 0 degrees C to X rays or accelerated nitrogen or iron ions in the LET range of 97-440 keV/microns. DNA was isolated inside agarose plugs and subjected to agarose gel electrophoresis under conditions that allowed good separation of 0.1-2 kb size DNA. The bulk of DNA remained in the well or migrated only a small distance into the gel. It was found that DNA fragments in the expected size range were formed linearly with dose with an efficiency that increased with LET. A comparison of the yield of such fragments with the yield of total DNA double-strand breaks suggests that for the high-LET ions a substantial proportion (20-90%) of DNA double-strand breaks are accompanied within 0.1-2 kb by at least one additional DNA double-strand break. It is shown that these results are in good agreement with theoretical calculations based on treating the 30-nm chromatin fiber as the target for ionizing particles. Theoretical considerations also predict that the clusters will contain numerous single-strand breaks and base damages. It is proposed that such clusters be designated "regionally multiply damaged sites." Postirradiation incubation at 37 degrees C resulted in a decline in the number of short DNA fragments, suggesting a repair activity. The biological significance of regionally multiply damaged sites is presently unknown.
Non-NASA Center↗