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At least 775 records · Page 43

An Approach to Quantitative Risk Assessment for Combined Spaceflight Hazards: Evaluating the Impact of Short Sleep Durations on Space Crew Cardiovascular Health

Astronauts embarking on long-duration missions will be exposed to multiple spaceflight hazards including radiation, isolation and confinement, distance from Earth, hostile closed environments, and altered gravity. These hazards pose health risks to the crew in-mission and postflight, including risks to cardiovascular health. For radiation, quantitative risk models have been developed that are based on large-scale epidemiological evidence from exposed terrestrial populations, which are extrapolated to account for the difference in radiological effectiveness between ground-based and in-flight exposures. •Cardiovascular diseases (CVD) are multifactorial, therefore multiple risk factors can influence disease risk estimates. •Astronauts with spaceflight experience is a very small population. •To overcome limitations of cohort, population data from presumed equivalent stressors on Earth can be used to quantitatively assess possible risks. •Sleep disruption and short sleep duration are known consequences of spaceflight and are also established risk factors for cardiovascular disease on earth (Pateletal.,2020). •Coronary Heart Disease (CHD), Myocardial Infarction (MI), and stroke are negative health effects due to short sleep durations and sleep disruptions (Yinetal.,2017); (Cappuccio et al., 2010). •A combined CVD risk model including spaceflight stressor such as sleep, stress, radiation, etc.) will provide more precise estimate of risks.

Spaceflight Hazards↗

Lakshmi Planum, Venus - Characteristics and models of origin

The distinctive and unique Venusian geological structure, Lakshmi Planum, is an expansive relatively smooth flat plateau containing two large shield volcanos and abundant volcanic plains in the midst of a region of extreme relief. The characteristics which distinguish Lakshmi from other volcanic regions known on the planet, such as Beta Regio, are identified. These include its high altitude and plateaulike nature; the presence of two very large low shield structures with distinctive central paterae and long radiating flows; and its compressional tectonic environment. The detailed nature and significance of the volcanic deposits on Lakshmi are determined; the erruption styles and conditions are interpreted; and the link between the observed volcanism and tectonic environment of the region is discussed. Models for the formation of Lakshmi Planum are presented and evaluated.

Roberts, Kari M.↗

A Review of Aerothermal Modeling for Mars Entry Missions

The current status of aerothermal analysis for Mars entry missions is reviewed. The aeroheating environment of all Mars missions to date has been dominated by convective heating. Two primary uncertainties in our ability to predict forebody convective heating are turbulence on a blunt lifting cone and surface catalysis in a predominantly CO2 environment. Future missions, particularly crewed vehicles, will encounter additional heating from shock-layer radiation due to a combination of larger size and faster entry velocity. Localized heating due to penetrations or other singularities on the aeroshell must also be taken into account. The physical models employed to predict these phenomena are reviewed, and key uncertainties or deficiencies inherent in these models are explored. Capabilities of existing ground test facilities to support aeroheating validation are also summarized. Engineering flight data from the Viking and Pathfinder missions, which may be useful for aerothermal model validation, are discussed, and an argument is presented for obtaining additional flight data. Examples are taken from past, present, and future Mars entry missions, including the twin Mars Exploration Rovers and the Mars Science Laboratory, scheduled for launch by NASA in 2011.

Wright, Michael J↗

Spectroscopic Measurements and Models of Energy Deposition in the Substrate of Quantum Circuits by Natural Ionizing Radiation

Naturally occurring background radiation is a potential source of correlated decoherence events in superconducting qubits that will challenge error-correction schemes. In order to characterize the radiation environment in an unshielded laboratory representative of superconducting qubits’ environments, we performed broadband, spectroscopic measurements of background radiation events inside a millikelvin refrigerator. The spectrometer was designed to mimic the size and composition of a quantum circuit. Specifically, we measured the background radiation spectra in silicon substrates of two thicknesses, 500 and 1500 µm, and one area, 25 mm 2 . The observed spectra span energies from a few kilo-electron-volts up to nearly 10 MeV, are nearly featureless, and decrease in intensity by a factor of 40 000 between 100 keV and 3 MeV for the 500-µm substrate. We integrate the spectra to obtain the average event rates and deposited power levels. These quantities correspond to a rate of 0.023 events per second and a power of 4.9 keV s -1 , when counting events that deposit at least 40 keV for the 500-µm-thick substrate. We find that the cryogenic measurements are in good agreement with predictions based on simple measurements of the terrestrial gamma-ray flux outside the refrigerator, published models of cosmic-ray fluxes, a crude model of the cryostat, and radiation-transport simulations. This model requires no free parameters to predict the background radiation spectra in the silicon substrates. The agreement between measurements and predictions demonstrates that the model we present can be used to assess the relative contributions of terrestrial and cosmic-ray sources to background radiation interactions in silicon substrates of varying thickness. These spectroscopic measurements are performed with a novel combination of superconducting microresonators located on micromachined silicon islands that define the interaction volume with background radiation. The resonators transduce deposited energy to a readily detectable electrical signal. Microresonator readout closely resembles dispersive superconducting qubit readout, so similar devices—with or without micromachined islands—are suitable for integration with superconducting quantum circuits as detectors for background radiation events. For our specific laboratory conditions, we find that gamma-ray emissions from radioisotopes are responsible for the majority of events that deposit E < 1 ⁢Me⁢V. We present results demonstrating that the background radiation spectrum contains relevant contributions from cosmic-ray particles other than muons, particularly a tail of multi-mega-electron-volt events due to protons and neutrons. These observations suggest several paths to reducing the impact of background radiation on quantum circuits, supported by an empirically validated model for generating reliable predictions of radiation interactions with silicon substrates.

71 CLASSICAL AND QUANTUM MECHANICS, GENERAL PHYSIC↗

Enabling Wireless Avionics Intra-Communications

The Electromagnetics and Sensors Branch of NASA Langley Research Center (LaRC) is investigating the potential of an all-wireless aircraft as part of the ECON (Efficient Reconfigurable Cockpit Design and Fleet Operations using Software Intensive, Networked and Wireless Enabled Architecture) seedling proposal, which is funded by the Convergent Aeronautics Solutions (CAS) project, Transformative Aeronautics Concepts (TAC) program, and NASA Aeronautics Research Institute (NARI). The project consists of a brief effort carried out by a small team in the Electromagnetic Environment Effects (E3) laboratory with the intention of exposing some of the challenges faced by a wireless communication system inside the reflective cavity of an aircraft and to explore potential solutions that take advantage of that environment for constructive gain. The research effort was named EWAIC for "Enabling Wireless Aircraft Intra-communications." The E3 laboratory is a research facility that includes three electromagnetic reverberation chambers and equipment that allow testing and generation of test data for the investigation of wireless systems in reflective environments. Using these chambers, the EWAIC team developed a set of tests and setups that allow the intentional variation of intensity of a multipath field to reproduce the environment of the various bays and cabins of large transport aircraft. This setup, in essence, simulates an aircraft environment that allows the investigation and testing of wireless communication protocols that can effectively be used as a tool to mitigate some of the risks inherent to an aircraft wireless system for critical functions. In addition, the EWAIC team initiated the development of a computational modeling tool to illustrate the propagation of EM waves inside the reflective cabins and bays of aircraft and to obtain quantifiable information regarding the degradation of signals in aircraft subassemblies. The nose landing gear of a UAV CAD model was used to model the propagation of a system in a "deployed" configuration versus a "stowed" configuration. The differences in relative field strength provide valuable information about the distribution of the field that can be used to engineer RF links with optimal radiated power and antenna configuration that accomplish the intended system reliability. Such modeling will be necessary in subsequent studies for managing multipath propagation characteristics inside a main cabin and to understand more complex environments, such as the inside wings, landing gear bays, cargo bays, avionics bays, etc. The results of the short research effort are described in the present document. The team puts forth a set of recommendations with the intention of informing the project and program leadership of the future work that, in the opinion of the EWAIC team, would assist the ECON team reach the intended goal of developing an all-wireless aircraft.

Torres, Omar↗

Ultra-low-level measurements of airborne fission products from the Fukushima Daiichi reactor accident using high volume collection systems at Savannah River National Laboratory

For this study, ultra-low-level measurements of radionuclides in air have been conducted at the Savannah River National Laboratory (SRNL) to determine the atmospheric concentration of fission products released following the Fukushima Daiichi reactor accident on March 11, 2011. Air filter samples were acquired from two high-volume collection systems (a traditional filter-based system and an electrostatic precipitator-based system) to monitor airborne radionuclide concentrations in the period covering from 2 weeks to 3 years after the disaster. The world-wide spread of low-level concentrations of airborne fission products from the Fukushima event provided a unique opportunity to demonstrate SRNL's electrostatic particle collection technology and other improvements in environmental monitoring developed at the Savannah River Site (SRS). Detecting and analyzing the release allowed a comprehensive test of SRS systems for monitoring environmental radioactivity. Gamma-ray-emitting fission products ( 131,132 I, 134,136,137 Cs, and 129,132 Te) and cosmogenic isotopes ( 7 Be and 22 Na) in air were detected and quantified by high-resolution gamma-ray spectroscopy at concentrations as low as 0.07 μBq per standard cubic meter (SCM) (50 mBq total 137 Cs), while plutonium content was quantified by thermal ionization mass spectrometry (TIMS) at concentrations as low as 6.5 × 10 –21 g/SCM (3.0 fg 239+240 Pu). Isotope concentrations measured at SRNL from gamma-ray spectroscopy were compared to independent measurements from Chapel Hill, NC, located approximately 370 km (230 mi) NE of SRNL. Meteorological modeling was also used to predict radionuclide transport from the location of release to both measurement locations.

63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTAN↗

DNA Damage Response to Low and High-LET in a Large Cohort of Mice and Humans and Latest Advancement in NASA Space Omics

This presentation will first focus on a thorough evaluation of the DNA damage response to both low and high-LET in a cohort of 76 mice primary skin fibroblast derived from 15 different strains or in human blood mononuclear cells derived from 550 healthy donors. In both the human and mice work, we have hypothesized that DNA repair capacity can be used as a marker to evaluate and differentiate individual radiation sensitivity. More specifically, this work is based on the concept that the combined time-dose dependence of radiation-induced foci (RIF) of p53-binding protein 1 (53BP1) following low-LET exposure contains sufficient information to infer sensitivity to any other LET. This work is one of the most extensive studies on the kinetics and possible genetic underpinnings of radiation-induced DNA damage and repair. Results on humans are still preliminary as we are still in the process of collecting and isolating primary blood mononuclear cells from 500 to 800 healthy subjects of European descent, 18-75 years of age, 50/50 male/female distribution. We have analyzed 53BP1+ RIF formation as well as oxidative stress and cell death in primary cells from 192 subjects in response to the same HZE particles as used in mice: 600 MeV/n Fe, 350 MeV/n Ar and 350 MeV/n Si, 1.1 and 3 particles/100m2, 4 and 24 hours after irradiation. The second part of the talk will focus on describing GeneLab: The NASA Systems Biology Platform for Space Omics Repository, Analysis and Visualization. NASA GeneLab is an open-access repository for omics datasets generated by biological experiments conducted in space or experiments relevant to spaceflight (e.g. simulated cosmic radiation, simulated microgravity, bed rest studies). Started as a repository designed to archive precious omics from space experiments, GeneLab has expanded its scope to maximize the intelligibility of the raw data (e.g. RNAseq, microarray, WGBS, metagenome), particularly for users with limited bioinformatics knowledge. As such GeneLab is now providing processed data derived from the raw data covering a large spectrum of omics (genome, epigenome, transcriptome, epitranscriptome, proteome, metabolome), to help users explore important questions: Which genes or proteins are expressed differently in space for various living organisms? What are the consequences arising from these changes? What specifics DNA mutations or epigenetic changes happen in space? What species or genetic features lead to better adaption to such a unique environment? In this presentation, we will report on the current and future objectives for GeneLab, and review recent published studies relating molecular changes observed in various animal models and tissue with microgravity, radiation, circadian rhythm, hydration and carbon dioxide conditions.

DNA repair kinetics↗

VA EDH Data Curation Documentation (FY24-Q1)

The U.S. Department of Veterans Affairs (VA) places the health and well-being of our nation’s veterans as its top priority. VA is dedicated to offering timely access to high-quality, evidence-based mental health care that meets the needs of veterans and supports their reintegration into society. One of our core missions is to prevent suicide among veterans through innovative approaches and resources. Health outcomes, including suicide, are typically influenced by both genetics and environmental factors, such as air quality, transportation access, food availability, homelessness, and more. Mental health outcomes are associated with various stressors across socioeconomic, economic, and physical environments. Analyzing the connections between these stressors, covariates, and health outcomes relies on standardized data, which can be integrated into models like the VA’s Recovery Engagement and Coordination for Health, Veterans Enhanced Treatment (REACH VET). The World Health Organization (WHO) defines Environmental Determinants of Health (EDH) as factors like clean air, stable climate, water and sanitation, chemical safety, radiation protection, safe workplaces, sustainable agriculture, healthy urban environments, and nature preservation, all of which are crucial for good health.

54 ENVIRONMENTAL SCIENCES↗

VA EDH Data Curation Documentation (FY24-Q2)

The U.S. Department of Veterans Affairs (VA) places the health and well-being of our nation’s veterans as its top priority. VA is dedicated to offering timely access to high-quality, evidence-based mental health care that meets the needs of veterans and supports their reintegration into society. One of our core missions is to prevent suicide among veterans through innovative approaches and resources. Health outcomes, including suicide, are typically influenced by both genetics and environmental factors, such as air quality, transportation access, food availability, homelessness, and more. Mental health outcomes are associated with various stressors across socioeconomic, economic, and physical environments. Analyzing the connections between these stressors, covariates, and health outcomes relies on standardized data, which can be integrated into models like the VA’s Recovery Engagement and Coordination for Health, Veterans Enhanced Treatment (REACH VET). The World Health Organization (WHO) defines Environmental Determinants of Health (EDH) as factors like clean air, stable climate, water and sanitation, chemical safety, radiation protection, safe workplaces, sustainable agriculture, healthy urban environments, and nature preservation, all of which are crucial for good health.

99 GENERAL AND MISCELLANEOUS↗

VA EDH Data Curation Documentation (FY24-Q3)

The U.S. Department of Veterans Affairs (VA) places the health and well-being of our nation’s veterans as its top priority. VA is dedicated to offering timely access to high-quality, evidence-based mental health care that meets the needs of veterans and supports their reintegration into society. One of our core missions is to prevent suicide among veterans through innovative approaches and resources. Health outcomes, including suicide, are typically influenced by both genetics and environmental factors, such as air quality, transportation access, food availability, homelessness, and more. Mental health outcomes are associated with various stressors across socioeconomic, economic, and physical environments. Analyzing the connections between these stressors, covariates, and health outcomes relies on standardized data, which can be integrated into models like the VA’s Recovery Engagement and Coordination for Health, Veterans Enhanced Treatment (REACH VET). The World Health Organization (WHO) defines Environmental Determinants of Health (EDH) as factors like clean air, stable climate, water and sanitation, chemical safety, radiation protection, safe workplaces, sustainable agriculture, healthy urban environments, and nature preservation, all of which are crucial for good health.

54 ENVIRONMENTAL SCIENCES↗

VA EDH Data Curation Documentation FY24-Q4

The U.S. Department of Veterans Affairs (VA) places the health and well-being of our nation’s veterans as its top priority. VA is dedicated to offering timely access to high-quality, evidence-based mental health care that meets the needs of veterans and supports their reintegration into society. One of our core missions is to prevent suicide among veterans through innovative approaches and resources. Health outcomes, including suicide, are typically influenced by both genetics and environmental factors, such as air quality, transportation access, food availability, homelessness, and more. Mental health outcomes are associated with various stressors across socioeconomic, economic, and physical environments. Analyzing the connections between these stressors, covariates, and health outcomes relies on standardized data, which can be integrated into models like the VA’s Recovery Engagement and Coordination for Health, Veterans Enhanced Treatment (REACH VET). The World Health Organization (WHO) defines Environmental Determinants of Health (EDH) as factors like clean air, stable climate, water and sanitation, chemical safety, radiation protection, safe workplaces, sustainable agriculture, healthy urban environments, and nature preservation, all of which are crucial for good health.

99 GENERAL AND MISCELLANEOUS↗

Modeling Natural Space Ionizing Radiation Effects on External Materials

Predicting the effective life of materials for space applications has become increasingly critical with the drive to reduce mission cost. Programs have considered many solutions to reduce launch costs including novel, low mass materials and thin thermal blankets to reduce spacecraft mass. Determining the long-term survivability of these materials before launch is critical for mission success. This presentation will describe an analysis performed on the outer layer of the passive thermal control blanket of the Hubble Space Telescope. This layer had degraded for unknown reasons during the mission, however ionizing radiation (IR) induced embrittlement was suspected. A methodology was developed which allowed direct comparison between the energy deposition of the natural environment and that of the laboratory generated environment. Commercial codes were used to predict the natural space IR environment model energy deposition in the material from both natural and laboratory IR sources, and design the most efficient test. Results were optimized for total and local energy deposition with an iterative spreadsheet. This method has been used successfully for several laboratory tests at the Marshall Space Flight Center. The study showed that the natural space IR environment, by itself, did not cause the premature degradation observed in the thermal blanket.

Alstatt, Richard L.↗

An X-Ray Study of Grain Evolution behind Non-Radiative Shock

We model the dynamics, the destruction by sputtering, and the infrared (IR) emission from collisionally heated dust grains in fast (>/= 400 km s(exp -1)) astrophysical shocks in order to develop IR diagnostics for the destruction of grains in these environments. The calculations take into account the feedback from sputtering and IR emission on the gas-phase abundances, the cooling, and the ionization and thermal structure of the shock. Sputtering changes the initial grain size distribution, creating a deficiency of small (radius <50 A) grains compared to their preshock abundances. The altered grain size distribution depends on shock velocity and the density of the interstellar medium. Dust particles with sizes below approximately equal 300 A are stochastically heated, undergo temperature fluctuations, and radiate an excess of near-infrared emission (i </= 40 (micron)meter) over that expected for grains in thermal equilibrium. This near-infrared excess is a measure of the abundance of small grains and therefore a powerful diagnostic for the amount of destruction the grains were subjected to in the shock. We present here IR spectra from collisionally heated dust for a variety of shocks, and depict the changes in the spectra as a function of postshock column density. Our studies compliment those of Vancura et at. that examined the effects of the release of the sputtered refractory elements on the ultraviolet and X-ray emission. Multiwavelength observations at X-ray, Ultraviolet (UV), and IR wavelengths are therefore essential in piecing together a comprehensive picture of the physics of grain destruction in fast astrophysical shocks.

Vancura, Olaf↗

The Goddard Cumulus Ensemble Model (GCE): Improvements and Applications for Studying Precipitation Processes

Convection is the primary transport process in the Earth's atmosphere. About two-thirds of the Earth's rainfall and severe floods derive from convection. In addition, two-thirds of the global rain falls in the tropics, while the associated latent heat release accounts for three-fourths of the total heat energy for the Earth's atmosphere. Cloud-resolving models (CRMs) have been used to improve our understanding of cloud and precipitation processes and phenomena from micro-scale to cloud-scale and mesoscale as well as their interactions with radiation and surface processes. CRMs use sophisticated and realistic representations of cloud microphysical processes and can reasonably well resolve the time evolution, structure, and life cycles of clouds and cloud systems. CRMs also allow for explicit interaction between clouds, outgoing longwave (cooling) and incoming solar (heating) radiation, and ocean and land surface processes. Observations are required to initialize CRMs and to validate their results. The Goddard Cumulus Ensemble model (GCE) has been developed and improved at NASA/Goddard Space Flight Center over the past three decades. It is amulti-dimensional non-hydrostatic CRM that can simulate clouds and cloud systems in different environments. Early improvements and testing were presented in Tao and Simpson (1993) and Tao et al. (2003a). A review on the application of the GCE to the understanding of precipitation processes can be found in Simpson and Tao (1993) and Tao (2003). In this paper, recent model improvements (microphysics, radiation and land surface processes) are described along with their impact and performance on cloud and precipitation events in different geographic locations via comparisons with observations. In addition, recent advanced applications of the GCE are presented that include understanding the physical processes responsible for diurnal variation, examining the impact of aerosols (cloud condensation nuclei or CCN and ice nuclei or IN) on precipitation processes, utilizing a satellite simulator to improve the microphysics, providing better simulations for satellite-derived latent heating retrieval, and coupling with a general circulation model to improve the representation of precipitation processes.

GCE↗

Skynet satellite electron precharging experiments

Large surface areas (approximately 1 sq m) of the Skynet I qualification model satellite were exposed to the environments of a flux of monoenergetic electrons and pulsed high-intensity X-ray photons from an exploding-wire-radiator source, separately and simultaneously. Experiments were performed with both the cylindrical solar cell panels and the end thermal blanket exposed to these environments. The satellite was instrumented with fiber-optics isolated fast-response sensors capable of sensing and recording the time-varying electric fields and surface currents on the satellite. Spontaneous discharges of the two surfaces were characterized prior to measurements of the interaction of the system-generated electromagnetic pulse from the X-ray photon burst with the electron precharged surfaces. A two-dimensional self-consistent finite difference computer code was used to predict the currents on the Skynet both with and without precharging of the thermal-blanket. These calculations, which used an thermal-blanket voltage profile, predicted a factor of 2 increase in satellite exterior axial currents.

Vanlint, V. A. J.↗

Model analysis of Space Shuttle dosimetry data

An extensive model analysis of plastic track detector measurements of high-LET particles on the Space Shuttle has been performed. Three Shuttle flights: STS-51F (low-altitude, high-inclination), STS-51J (high-altitude, low-inclination), and STS-61C (low-altitude, low-inclination) are considered. The model includes contributions from trapped protons and Galactic cosmic radiation, as well as target secondary particles. Target secondaries, expected to be of importance in thickly shielded space environments, are found to be a significant component of the measured LET (linear energy transfer) spectra.

Letaw, J. R.↗

CAD-based stand-alone spacecraft radiation exposure analysis system: An application of the early man-tended Space Station

Major improvements have been completed in the approach to analyses and simulation of spacecraft radiation shielding and exposure. A computer-aided design (CAD)-based system has been developed for determining the amount of shielding provided by a spacecraft and simulating transmission of an incident radiation environment to any point within or external to the vehicle. Shielding analysis is performed using a customized ray-tracing subroutine contained within a standard engineering modeling software package. This improved shielding analysis technique has been used in several vehicle design programs such as a Mars transfer habitat, pressurized lunar rover, and the redesigned international Space Station. Results of analysis performed for the Space Station astronaut exposure assessment are provided to demonastrate the applicability and versatility of the system.

Appleby, M. H.↗

Theoretical Studies of Starburst Infrared Emission: Luminosity Indicators in Dusty Photoionized Environments

The luminosity of the central source in ionizing radiation is an essential parameter in a photoionized environment and is one of the most fundamental physical quantities one can measure. We outline a method of determining the luminosity for any emission-line region using only infrared data. In dusty environments, grains compete with hydrogen in absorbing continuum radiation. Grains produce infrared emission, and hydrogen produces recombination lines. We have computed a very large variety of photoionization models, using ranges of abundances, grain mixtures, ionizing continua, densities, and ionization parameters. The conditions were appropriate for such diverse objects as H(II) regions, planetary nebulae, starburst galaxies, and the narrow- and broad-line regions of active nuclei. The ratio of the total thermal grain emission relative to H-Beta (IR/H-Beta) is the primary indicator of whether the cloud behaves as a classical Stroemgren sphere (a hydrogen-bounded nebula) or whether grains absorb most of the incident continuum (a dust-bounded nebula). We find two global limits: when IR/H-Beta < 100, infrared recombination lines determine the source luminosity in ionizing photons; when IR/H-Beta >> 100, the grains act as a bolometer to measure the luminosity.

Bottorff, Mark↗