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At least 775 records · Page 43

Selected contribution: a three-dimensional model for assessment of in vitro toxicity in balaena mysticetus renal tissue

This study established two- and three-dimensional renal proximal tubular cell cultures of the endangered species bowhead whale (Balaena mysticetus), developed SV40-transfected cultures, and cloned the 61-amino acid open reading frame for the metallothionein protein, the primary binding site for heavy metal contamination in mammals. Microgravity research, modulations in mechanical culture conditions (modeled microgravity), and shear stress have spawned innovative approaches to understanding the dynamics of cellular interactions, gene expression, and differentiation in several cellular systems. These investigations have led to the creation of ex vivo tissue models capable of serving as physiological research analogs for three-dimensional cellular interactions. These models are enabling studies in immune function, tissue modeling for basic research, and neoplasia. Three-dimensional cellular models emulate aspects of in vivo cellular architecture and physiology and may facilitate environmental toxicological studies aimed at elucidating biological functions and responses at the cellular level. Marine mammals occupy a significant ecological niche (72% of the Earth's surface is water) in terms of the potential for information on bioaccumulation and transport of terrestrial and marine environmental toxins in high-order vertebrates. Few ex vivo models of marine mammal physiology exist in vitro to accomplish the aforementioned studies. Techniques developed in this investigation, based on previous tissue modeling successes, may serve to facilitate similar research in other marine mammals.

Whales/genetics/physiology↗

Cellular Responses to Mechanical Stress Selected Contribution: A Three-Dimensional Model for Assessment of in Vitro Toxicity in Balaena Mysticetus Renal Tissue

This study established two- and three-dimensional renal proximal tubular cell cultures of the endangered species bowhead whale (Balaena mysticetus), developed SV40-transfected cultures, and cloned the 61-amino acid open reading frame for the metallothionein protein, the primary binding site for heavy metal contamination in mammals. Microgravity research, modulations in mechanical culture conditions (modeled microgravity), and shear stress have spawned innovative approaches to understanding the dynamics of cellular interactions, gene expression, and differentiation in several cellular systems. These investigations have led to the creation of ex vivo tissue models capable of serving as physiological research analogs for three-dimensional cellular interactions. These models are enabling studies in immune function, tissue modeling for basic research, and neoplasia. Three-dimensional cellular models emulate aspects of in vivo cellular architecture and physiology and may facilitate environmental toxicological studies aimed at elucidating biological functions and responses at the cellular level. Marine mammals occupy a significant ecological niche (72% of the Earth's surface is water) in terms of the potential for information on bioaccumulation and transport of terrestrial and marine environmental toxins in high-order vertebrates. Few ex vivo models of marine mammal physiology exist in vitro to accomplish the aforementioned studies. Techniques developed in this investigation, based on previous tissue modeling successes, may serve to facilitate similar research in other marine mammals.

Goodwin, T. J.↗

ROSAT EUV and soft X-ray studies of atmospheric composition and structure in G191-B2B

Previous studies of the hot DA white dwarf GI91-B2B have been unable to determine whether the observed soft X-ray and EUV opacity arises from a stratified hydrogen and helium atmosphere or from the presence of trace metals in the photosphere. New EUV and soft X-ray photometry of this star, made with the ROSAT observatory, when analyzed in conjunction with the earlier data, shows that the stratified models cannot account for the observed fluxes. Consequently, we conclude that trace metals must be a substantial source of opacity in the photosphere of G191-B2B.

Barstow, M. A.↗

Damped Lyman-alpha absorption by disk galaxies with large redshifts. IV - More intermediate-resolution spectroscopy

Intermediate-resolution spectra of six QSOs exhibiting seven Ly-alpha absorption troughs that are candidates for damped Ly-alpha absorption lines are presented. The metal content of the confirmed damped systems is investigated by examining the metal-line velocity profiles, and by performing curve-of-growth analyses for four of the six confirmed damped systems. The low-ionization lines associated with the z(metals) = 2.0399 damped system toward Q0458-020 have velocity widths up to 10 times wider than the width of the 21-cm absorption feature found at the same redshift. Since the 21-cm absorption arises in a low velocity dispersion layer of H I that extends more than 8/h kpc transverse to the line of sight, the H I absorption cannot arise from the same clouds responsible for the bulk of the metal-line absorption. This is strong evidence for a two-component model consisting of high column density 'quiescent' gas which gives rise to damped Ly-alpha and 21-cm absorption, and low column density 'turbulent' gas which dominates equivalent widths of saturated metal lines.

Wolfe, Arthur M.↗

Model Atmospheres for Novae in Outburst: Summary of Research

This paper presents a final report and summary of research on Model Atmospheres for Novae in Outburst. Some of the topics include: 1) Detailed NLTE (non-local thermodynamic equilibrium) Model Atmospheres for Novae during Outburst: II. Modeling optical and ultraviolet observations of Nova LMC 1988 #1; 2) A Non-LTE Line-Blanketed Stellar Atmosphere Model of the Early B Giant epsilon CMa; 3) Spectroscopy of Low Metallicity Stellar atmospheres; 4) Infrared Colors at the Stellar/Substellar Boundary; 5) On the abundance of Lithium in T CrB; 6) Numerical Solution of the Expanding Stellar Atmosphere Problem; and 7) The NextGen Model Atmosphere grid for 3000 less than or equal to T (sub eff) less than or equal to 10000K.

Hauschildt, Peter H.↗

An experimental and theoretical evaluation of increased thermal diffusivity phase change devices

This study was to experimentally evaluate and mathematically model the performance of phase change thermal control devices containing high thermal conductivity metal matrices. Three aluminum honeycomb filters were evaluated at five different heat flux levels using n-oct-adecane as the test material. The system was mathematically modeled by approximating the partial differential equations with a three-dimensional implicit alternating direction technique. The mathematical model predicts the system quite well. All of the phase change times are predicted. The heating of solid phase is predicted exactly while there is some variation between theoretical and experimental results in the liquid phase. This variation in the liquid phase could be accounted for by the fact that there are some heat losses in the cell and there could be some convection in the experimental system.

White, S. P.↗

Micro-Mechanical Modeling of Ductile Fracture in Welded Aluminum-Lithium Alloys

This study describes a 3-D computational framework to model stable extension of a macroscopic crack under mode I conditions in ductile metals. Material separation occurs through a local fracture mechanism based on the growth and coalescence of micro voids dispersed in the material. The Gurson-Tvergaard plasticity model for void materials describes the eventual loss of material stress capacity under sustained loading. Fixed-sized computational cell elements defined on a thin layer adjacent to the crack plane provide an implicit length scale for continuum damage model. Outside this layer, the material remains undamaged by void growth, consistent with metallurgical observations. The key micro-mechanics parameters are D, the thickness of cell layer, and f 0 , the initial cell porosity.

Ahmed Ibrahim↗

Sizing and Lifecycle Cost Analysis of an Ares V Composite Interstage

The Interstage Element of the Ares V launch vehicle was sized using a commercially available structural sizing software tool. Two different concepts were considered, a metallic design and a composite design. Both concepts were sized using similar levels of analysis fidelity and included the influence of design details on each concept. Additionally, the impact of the different manufacturing techniques and failure mechanisms for composite and metallic construction were considered. Significant details were included in analysis models of each concept, including penetrations for human access, joint connections, as well as secondary loading effects. The designs and results of the analysis were used to determine lifecycle cost estimates for the two Interstage designs. Lifecycle cost estimates were based on industry provided cost data for similar launch vehicle components. The results indicated that significant mass as well as cost savings are attainable for the chosen composite concept as compared with a metallic option.

Mann, Troy↗

Effects Of Heat Sinks On VPPA Welds

Report describes theoretical and experimental study of absorption of heat by metal blocks in contact with metal plate while plate subjected to variable-polarity plasma-arc (VPPA) welding. Purpose of study to contribute to development of comprehensive mathematical model of temperature in weld region. Also relevant to welding of thin sheets of metal to thick blocks of metal, heat treatment of metals, and hotspots in engines.

Nunes, Arthur C.↗

Predicted and measured effects of pressure and crossflow velocity on composite propellant burning rate

A theoretical model for prediction of burning rates of composite (ammonium perchlorate oxidizer) solid propellants as a function of pressure and crossflow velocity was developed. Included in this model is the capability for treatment of multimodal oxidizer particle sizes and metalized formulations. In addition, an experimental device for measuring the effects of crossflow velocity on propellant burning rate was developed and used to characterize a series of AP/HTPB propellants with systematically varied formulation parameters. Model predictions of zero-crossflow burning rate versus pressure characteristics were found to be in agreement with data, while the agreement between erosive burning predictions and data is, in general, good. The experimental data indicate that the dominant factor influencing the sensitivity of composite propellant burning rate to crossflow is the base (no-crossflow) burning rate versus pressure characteristics of the propellant (lower base burning rate leading to increased crossflow sensitivity). Finally, the model was used to examine the effects of motor scaling on erosive burning: erosive burning is predicted to diminish with increasing motor size, in agreement with experience.

King, M. K.↗

Surface field analysis of splitting of orbitals of atoms and ions approaching a metal surface.

The splitting of p- and d-orbitals of an atom or an ion which is caused by the locally varying potential near the surface of a realistic metal has been studied for bcc and fcc substrates. A quasi-ionic model is reasonable at close distance, inasmuch as the electron gas does not completely screen the ionic cores. The arrangement of ion cores near the surface causes the potential to vary in three dimensions. Expressions for energy levels were derived for an unsymmetric group using the quasi-ionic model and techniques used in the treatment of crystal field of nearest neighbors. A number of cases involving ions, as well as atoms in the vicinity of a metal substrate were numerically evaluated.

Rao, P. V. S.↗

Jupiter

The physical structure of Jupiter is discussed on the basis of data obtained by Pioneers 10 and 11. It is argued that the elemental composition of Jupiter is similar to that of the sun, and it is shown that this argument is supported by measurements of the planet's density and H/He ratio. Jupiter's shape and gravitational field are described, and a model of the planet is proposed in which there are a small iron-silicate core at the center, a very thick liquid-hydrogen stratum divided into metallic (inner) and molecular (outer) layers, and a gaseous atmosphere. According to this model, the excess heat radiated by Jupiter is simply a remnant of the heat generated when the planet coalesced from the solar nebula. The appearance of the planetary disk is described together with the Jovian magnetic field, and the Great Red Spot is shown to be a cyclonic disturbance similar to a hurricane. Effects of the Galilean satellites on the magnetic field are considered.

Wolfe, J. H.↗

Integrated analysis and applications

A select overview is provided of ongoing research focusing on the development and verification of integrated structural analysis and optimal design capabilities for advanced aerospace propulsion and power systems. Subjects discussed include the following: (1) Composites - analytical models (composite mechanics), integrated computational methods, and characterization of composite structural response and durability for resin-, metal-, and ceramic-matrix systems; (2) Advanced inelastic analysis - algorithm/numerical methods for more accurate and efficient analysis; (3) Constitutive modeling - theoretical formulation and characterization of thermoviscoplastic material behavior; (4) Computational simulation - engine structures from components to assembly, and up to an entire engine system subjected to simulated test-stand and mission load histories; (5) Probabilistic structural analysis - quantification of the effects of uncertainty in geometry, material, loads, and boundary conditions on structural response for true reliability assessment; and (6) Interdisciplinary optimization - incorporation of mathematical optimization and multidisciplinary analyses to provide streamlined, autonomous optimal design systems.

Hopkins, Dale A.↗

Dendritic Alloy Solidification Experiment (DASE)

A space experiment, and supporting ground-based research, is proposed to study the microstructural evolution in free dendritic growth from a supercooled melt of the transparent model alloy succinonitrile-acetone (SCN-ACE). The research is relevant to equiaxed solidification of metal alloy castings. The microgravity experiment will establish a benchmark for testing of equiaxed dendritic growth theories, scaling laws, and models in the presence of purely diffusive, coupled heat and solute transport, without the complicating influences of melt convection. The specific objectives are to: determine the selection of the dendrite tip operating state, i.e. the growth velocity and tip radius, for free dendritic growth of succinonitrile-acetone alloys; determine the growth morphology and sidebranching behavior for freely grown alloy dendrites; determine the effects of the thermal/solutal interactions in the growth of an assemblage of equiaxed alloy crystals; determine the effects of melt convection on the free growth of alloy dendrites; measure the surface tension anisotropy strength of succinon itrile -acetone alloys establish a theoretical and modeling framework for the experiments. Microgravity experiments on equiaxed dendritic growth of alloy dendrites have not been performed in the past. The proposed experiment builds on the Isothermal Dendritic Growth Experiment (IDGE) of Glicksman and coworkers, which focused on the steady growth of a single crystal from pure supercooled melts (succinonitrile and pivalic acid). It also extends the Equiaxed Dendritic Solidification Experiment (EDSE) of the present investigators, which is concerned with the interactions and transients arising in the growth of an assemblage of equiaxed crystals (succinonitrile). However, these experiments with pure substances are not able to address the issues related to coupled heat and solute transport in growth of alloy dendrites.

Beckermann, C.↗

Elastic-Poroelastic Simulation of Locally Resonant Ultrasound for Aging Li-Metal Batteries

An elastic-poroelastic simulation of ultrasound inspection for lithium-metal batteries is presented and compared to empirical reflection spectra measured during battery cycling. Simulated reflection spectra were obtained using a two-dimensional (2D) plane strain model, comprised of dozens of individual microns-thick layers within a Li-metal pouch cell. The simulated reflection spectra were then compared to ultrasonic reflection spectra measurements taken intermittently during cell cycling. A sensitivity analysis and parameter calibration were performed for the pristine pouch cell simulation prior to cycling, providing a baseline to account for difficult to measure poroelastic material parameters. Then, the reduction in solid Li anode thickness and corresponding growth into a mossy lithium layer was modeled to represent aging conditions. Results from both simulations and empirical inspections show similar trends in through-thickness resonance frequencies due to cell aging.

Battery↗

Dynamic Creep Buckling: Analysis of Shell Structures Subjected to Time-dependent Mechanical and Thermal Loading

The objective of the present research is to develop a general mathematical model and solution methodologies for analyzing the structural response of thin, metallic shell structures under large transient, cyclic, or static thermomechanical loads. Among the system responses associated with these loads and conditions are thermal buckling, creep buckling, and ratcheting. Thus geometric and material nonlinearities (of high order) can be anticipated and must be considered in developing the mathematical model. A complete, true ab-initio rate theory of kinematics and kinetics for continuum and curved thin structures, without any restriction on the magnitude of the strains or the deformations, was formulated. The time dependence and large strain behavior are incorporated through the introduction of the time rates of metric and curvature in two coordinate systems: fixed (spatial) and convected (material). The relations between the time derivative and the covariant derivative (gradient) were developed for curved space and motion, so the velocity components supply the connection between the equations of motion and the time rates of change of the metric and curvature tensors.

Simitses, G. J.↗

Formulation of the nonlinear analysis of shell-like structures, subjected to time-dependent mechanical and thermal loading

The object of the research reported herein was to develop a general mathematical model and solution methodologies for analyzing the structural response of thin, metallic shell structures under large transient, cyclic, or static thermomechanical loads. Among the system responses associated with these loads and conditions are thermal buckling, creep buckling, and ratcheting. Thus geometric and material nonlinearities (of high order) can be anticipated and must be considered in developing the mathematical model. The methodology is demonstrated through different problems of extension, shear, and of planar curved beams. Moreover, importance of the inclusion of large strain is clearly demonstrated, through the chosen applications.

Simitses, George J.↗