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At least 775 records · Page 43
All sourcesNASA NTRSDOE OSTI
NASA NTRS1995

Risk cross sections and their application to risk estimation in the galactic cosmic-ray environment

Radiation risk cross sections (i.e. risks per particle fluence) are discussed in the context of estimating the risk of radiation-induced cancer on long-term space flights from the galactic cosmic radiation outside the confines of the earth's magnetic field. Such quantities are useful for handling effects not seen after low-LET radiation. Since appropriate cross-section functions for cancer induction for each particle species are not yet available, the conventional quality factor is used as an approximation to obtain numerical results for risks of excess cancer mortality. Risks are obtained for seven of the most radiosensitive organs as determined by the ICRP [stomach, colon, lung, bone marrow (BFO), bladder, esophagus and breast], beneath 10 g/cm2 aluminum shielding at solar minimum. Spectra are obtained for excess relative risk for each cancer per LET interval by calculating the average fluence-LET spectrum for the organ and converting to risk by multiplying by a factor proportional to R gamma L Q(L) before integrating over L, the unrestricted LET. Here R gamma is the risk coefficient for low-LET radiation (excess relative mortality per Sv) for the particular organ in question. The total risks of excess cancer mortality obtained are 1.3 and 1.1% to female and male crew, respectively, for a 1-year exposure at solar minimum. Uncertainties in these values are estimated to range between factors of 4 and 15 and are dominated by the biological uncertainties in the risk coefficients for low-LET radiation and in the LET (or energy) dependence of the risk cross sections (as approximated by the quality factor). The direct substitution of appropriate risk cross sections will eventually circumvent entirely the need to calculate, measure or use absorbed dose, equivalent dose and quality factor for such a high-energy charged-particle environment.

NASA Discipline Radiation Health↗
NASA NTRS1992

Pulmonary function in microgravity

We report the successful collection of a large quantity of human resting pulmonary function data on the SLS-1 mission. Preliminary analysis suggests that cardiac stroke volumes are high on orbit, and that an adaptive reduction takes at least several days, and in fact may still be in progress after 9 days on orbit. It also suggests that pulmonary capillary blood volumes are high, and remain high on orbit, but that the pulmonary interstitium is not significantly impacted. The data further suggest that the known large gravitational gradients of lung function have only a modest influence on single breath tests such as the SBN washout. They account for only approximately 25% of the phase III slope of nitrogen, on vital capacity SBN washouts. These gradients are only a moderate source of the cardiogenic oscillations seen in argon (bolus gas) and nitrogen (resident gas), on such tests. They may have a greater role in generating the normal CO2 oscillations, as here the phase relationship to argon and nitrogen reverses in microgravity, at least at mid exhalation in those subjects studied to date. Microgravity may become a useful tool in establishing the nature of the non-gravitational mechanisms that can now be seen to play such a large part in the generation of intra-breath gradients and oscillations of expired gas concentration. Analysis of microgravity multibreath nitrogen washouts, single breath washouts from more physiological pre-inspiratory volumes, both using our existing SLS-1 data, and data from the upcoming D-2 and SLS-2 missions, should be very fruitful in this regard.(ABSTRACT TRUNCATED AT 250 WORDS).

manned↗
NASA NTRS2004

Using Piezoelectric Ceramics for Dust Mitigation of Space Suits

The particles that make up moon dust and Mars soil can be hazardous to an astronaut s health if not handled properly. In the near future, while exploring outer space, astronauts plan to wander the surfaces of unknown planets. During these explorations, dust and soil will cling to their space suits and become imbedded in the fabric. The astronauts will track moon dust and mars soil back into their living quarters. This not only will create a mess with millions of tiny air-born particles floating around, but will also be dangerous in the case that the fine particles are breathed in and become trapped in an astronaut s lungs. research center are investigating ways to remove these particles from space suits. This problem is very difficult due to the nature of the particles: They are extremely small and have jagged edges which can easily latch onto the fibers of the fabric. For the past summer, I have been involved in researching the potential problems, investigating ways to remove the particles, and conducting experiments to validate the techniques. The current technique under investigation uses piezoelectric ceramics imbedded in the fabric that vibrate and shake the particles free. The particles will be left on the planet s surface or collected a vacuum to be disposed of later. The ceramics vibrate when connected to an AC voltage supply and create a small scale motion similar to what people use at the beach to shake sand off of a beach towel. Because the particles are so small, similar to volcanic ash, caution must be taken to make sure that this technique does not further inbed them in the fabric and make removal more difficult. Only a very precise range of frequency and voltage will produce a suitable vibration. My summer project involved many experiments to determine the correct range. Analysis involved hands on experience with oscilloscopes, amplifiers, piezoelectrics, a high speed camera, microscopes and computers. perfect this technology. Someday, vibration to remove dust may a vital component to the space exploration program. In order to mitigate this problem, engineers and scientists at the NASA-Glenn Further research and experiments are planned to better understand and ultimately

Angel, Heather K.↗
NASA NTRS2006

Three-Dimensionally Engineered Normal Human Broncho-epithelial Tissue-Like Assemblies: Target Tissues for Human Respiratory Viral Infections

In vitro three-dimensional (3D) human broncho-epithelial (HBE) tissue-like assemblies (3D HBE TLAs) from this point forward referred to as TLAs were engineered in Rotating Wall Vessel (RWV) technology to mimic the characteristics of in vivo tissues thus providing a tool to study human respiratory viruses and host cell interactions. The TLAs were bioengineered onto collagen-coated cyclodextran microcarriers using primary human mesenchymal bronchial-tracheal cells (HBTC) as the foundation matrix and an adult human bronchial epithelial immortalized cell line (BEAS-2B) as the overlying component. The resulting TLAs share significant characteristics with in vivo human respiratory epithelium including polarization, tight junctions, desmosomes, and microvilli. The presence of tissue-like differentiation markers including villin, keratins, and specific lung epithelium markers, as well as the production of tissue mucin, further confirm these TLAs differentiated into tissues functionally similar to in vivo tissues. Increasing virus titers for human respiratory syncytial virus (wtRSVA2) and parainfluenza virus type 3 (wtPIV3 JS) and the detection of membrane bound glycoproteins over time confirm productive infections with both viruses. Therefore, TLAs mimic aspects of the human respiratory epithelium and provide a unique capability to study the interactions of respiratory viruses and their primary target tissue independent of the host's immune system.

Goodwin, T. J.↗
NASA NTRS2006

Airborne Dust in Space Vehicles and Habitats

Airborne dust, suspended inside a space vehicle or in future celestial habitats, can present a serious threat to crew health if it is not controlled. During the Apollo missions to the moon, lunar dust brought inside the capsule caused eye irritation and breathing difficulty to the crew when they launched from the moon and re-acquired "microgravity." During Shuttle flights reactive and toxic dusts such as lithium hydroxide have created a risk to crew health, and fine particles from combustion events can be especially worrisome. Under nominal spaceflight conditions, airborne dusts and particles tend to be larger than on earth because of the absence of gravity settling. Aboard the ISS, dusts are effectively managed by HEPA filters, although floating dust in newly-arrived modules can be a nuisance. Future missions to the moon and to Mars will present additional challenges because of the possibility that external dust will enter the breathing atmosphere of the habitat and reach the crew's respiratory system. Testing with simulated lunar and Martian dust has shown that these materials are toxic when placed into the lungs of test animals. Defining and evaluating the physical and chemical properties of Martian dusts through robotic missions will challenge our ability to prepare better dust simulants and to determine the risk to crew health from exposure to such dusts.

James, John↗
NASA NTRS2006

Studying Host-Pathogen Interactions In 3-D: Organotypic Models For Infectious Disease And Drug Development

Representative, reproducible and high-throughput models of human cells and tissues are critical for a meaningful evaluation of host-pathogen interactions and are an essential component of the research developmental pipeline. The most informative infection models - animals, organ explants and human trials - are not suited for extensive evaluation of pathogenesis mechanisms and screening of candidate drugs. At the other extreme, more cost effective and accessible infection models such as conventional cell culture and static co-culture may not capture physiological and three-dimensional aspects of tissue biology that are important in assessing pathogenesis, and effectiveness and cytotoxicity of therapeutics. Our lab has used innovative bioengineering technology to establish biologically meaningful 3-D models of human tissues that recapitulate many aspects of the differentiated structure and function of the parental tissue in vivo, and we have applied these models to study infectious disease. We have established a variety of different 3-D models that are currently being used in infection studies - including small intestine, colon, lung, placenta, bladder, periodontal ligament, and neuronal models. Published work from our lab has shown that our 3-D models respond to infection with bacterial and viral pathogens in ways that reflect the infection process in vivo. By virtue of their physiological relevance, 3-D cell cultures may also hold significant potential as models to provide insight into the neuropathogenesis of HIV infection. Furthermore, the experimental flexibility, reproducibility, cost-efficiency, and high throughput platform afforded by these 3-D models may have important implications for the design and development of drugs with which to effectively treat neurological complications of HIV infection.

Nickerson, Cheryl A.↗
NASA NTRS2006

Modeling the Optical Properties of Biomass Burning Aerosols: Young Smoke Aerosols From Savanna Fires and Comparisons to Observations from SAFARI 2000

Annually, farmers in southern Africa manage their land resources and prepare their fields for cultivation by burning crop residual debris, with a peak in the burning season occurring during August and September. The emissions from these fires in southern Africa are among the greatest from fires worldwide, and the gases and aerosol particles produced adversely affect air quality large distances from their source regions, and can even be tracked in satellite imagery as they cross the Atlantic and Pacific Ocean basins. During August and September 2000 an international group of researchers participating in the Southern African Regional Science Initiate field experiment (SAFARI 2000) made extensive ground-based, airborne, and satellite measurements of these gases and aerosols in order to quantify their amounts and effects on Earth's atmosphere. In this study we interpreted the measurements of smoke aerosol particles made during SAFARI 2000 in order to better represent these particles in a numerical model simulating their transport and fate. Typically, smoke aerosols emitted from fires are concentrated by mass in particles about 0.3 micrometers in diameter (1,000,000 micrometers = 1 meter, about 3 feet); for comparison, the thickness of a human hair is about 50 micrometers, almost 200 times as great. Because of the size of these particles, at the surface they can be easily inhaled into the lungs, and in high concentrations have deleterious health effects on humans. Additionally, these particles reflect and absorb sunlight, impacting both visibility and the balance of sunlight reaching -Earth's surface, and ultimately play a role in modulating Earth's climate. Because of these important effects, it is important that numerical models used to estimate Earth's climate response to changes in atmospheric composition accurately represent the quantity and evolution of smoke particles. In our model, called the Community Aerosol and Radiation Model for Atmospheres (CARMA) we used estimates of smoke emissions based on field studies and observations made with the NASA Terra and TRMM satellites. The meteorology used to calculate the transport was based on an assimilation of observed meteorological conditions provided by the National Center for Atmospheric Research.

Matichuk, R. I.↗
NASA NTRS2006

Pulmonary Toxicity of Carbon Nanotubes: Ethical Implications and Human Risk Assessment

Presentation viewgraphs review the health considerations of working with and manufacturing Carbon Nanotubes. The inherent toxicity of Single Walled Carbon Nanotubes (SWNT) are reviewed, and how the preparation of the SWNTs are reviewed. The experimental protocol that was used is reviewed, and the results in lungs of rodents are shown. The presentation ends with posing the ethical questions in reference to the manufacture and use of carbon nanotubes.

James, John T.↗
NASA NTRS2006

Lunar Dust Activation and Related Studies

The primary objective of the presentation is to identify a set of experiments to activate the lunar dust and monitor the mode of deactivation process using various analytical methods. To satisfy the objective, a large set of experiments will be carried out using lunar dust stimulant (JSC-1a-vf obtained from Dr. V. Carter from University of Texas at Dallas) to optimize the methodology. After refining the methodology to carry out the experiments using the simulant, real lunar dust will be used to obtain the necessary results. The secondary objective of the presentation is to identify a set of experiments to assess the potential toxicity of the dust using cellular systems. One of the cell lines that we identified is WI-38 human lung cell line.

Jeevarajan, Antony↗
NASA NTRS2007

Subclinical Reactivation and Shed of Infectious Varicella Zoster Virus in Saliva of Astronauts

We have previously detected VZV in healthy astronauts both during spaceflight and shortly after landing. Herein, we show that VZV shed in seropositive astronauts is infectious. A total of 40 saliva samples were obtained from each of the 3 astronauts. From each astronaut, 14 samples were taken 109 to 133 days before liftoff, 1 sample was taken every day during 12 days in space, and one sample was taken for 14 consecutive days beginning the second day after landing. Quantitative PCR was used to detect VZV DNA in saliva. None of 42 preflight saliva samples contained VZV DNA. VZV DNA was detected in saliva from 2 of 3 astronauts. In 1 astronaut, 6 of 12 samples obtained during space flight contained 120 to 2,500 copies of VZV DNA per ml; after landing, 1250 copies of VZV DNA were present on day 2, 45 copies on day 3, and 110 copies on day 5. All samples taken 6 to 15 days after touchdown were negative for VZV DNA. In the second astronaut, 5 of 12 samples obtained during space flight contained 18 to 650 copies of VZV DNA per ml; after landing, 560 copies of VZV DNA were present in saliva on day 2, 340 copies on day 4, 45 copies on day 5, and 23 copes on day 6. All samples taken 7 to 15 days after touchdown were negative for VZV DNA. Saliva taken 2 to 6 days after landing from all 3 astronauts was cultured on human fetal lung cells. After one subcultivation, a cytopathic effect developed in cultures inoculated with saliva from the two astronauts whose saliva contained VZV DNA. Both PCR and immunostaining identified the isolates to be VZV and not HSV-1. Importantly, the astronaut in whom no VZV was detected had a history of zoster 9 years earlier. It is possible that a boost in cell-mediated immunity to VZV which is known to develop after zoster protected him from subclinical reactivation. The genotype of the two VZV isolates was determined by VZV ORF22-based PCR/sequencing along with FRET-based PCR assays that target specific nucleotide polymorphisms. Both VZV isolates were found to be the European genotype which also contained a rare MspI restriction enodnuclease site in VZV ORF62 at position 107,252. These findings extend our previous demonstration of VZV DNA in saliva of astronauts by showing that infectious VZV is also present. Thus, like HSV-1 and HSV-2, VZV can reactivate and shed infectious virus in the absence of clinical disease.

Cohrs, Randall J.↗
NASA NTRS2006

Effect of 16-Day Spaceflight on the Morphology of Thick-Toed Geckos (Pachydactylus Bibronii Smith, 1846)

There are grounds to believe that space flown experiments on thick-toed geckos may help solve the problem of floatation of vertebrates in microgravity. Geckos of this species carry on the lower surface of their toes numerous setae, which allow them to remain attached to any surfaces regardless of the gravitational effects. Experiments were performed on 5 animals in each of the following groups: flight, basal, synchronous and laboratory controls. 32 hours after a 16- day flight the animals were euthanazed and examined using traditional histology and X-ray microtomography. Body mass losses were 10% in the flight animals, 7.4% in the synchronous controls, and 12.3% in the laboratory controls. Since the flight and synchronous animals were kept at 15-19 C, whereas the laboratory controls - at 26-28 C, it can be inferred that environmental temperatures impacted animal metabolism no less than flight induced stress. Blood tests of the flown animals showed a 12% decrease of erythrocytes and a 40% decrease of dark-nuclear granulocytes, with the number of light-nuclear granulocytes remaining unchanged. In the small intestine the number of goblet cells increased allowing them to occupy a large portion of the cyptal surface. Enhanced secretion was accompanied by the appearance of dead intestinal cells in the lumen. Clusters of degraded hepatocytes were found at the liver edges of flight animals. Signs of liver involution were similar to the changes produced by alcohol consumption but did not spread to its central part. In the heart, insignificant hypertrophy and excessive blood supply that still remained within the physiological norm were detected. No significant changes were found in the pancreas, lungs, nervous systems or the snouts of the flown animals, but the volume of their gallbladders was greater than in controls. The epithelium of toe pads of the flight animals became thinner. Histological examination of the humerus did not demonstrate significant mineral losses. However, X-ray microtomography showed changes in the trabecular structure in the subepyphyseal zone of bones in flight animals compared to the controls. In summary, all the changes detected in the flight animals were adaptive. Therefore, geckos of this species can be used as an animal model for morphological studies in longer-duration space flights.

Gulimova, V. I.↗
NASA NTRS2007

Subclinical Shed of Infectious Varicella zoster Virus in Astronauts

Aerosol borne varicella zoster virus (VZV) enters the nasopharynx and replicates in tonsillar T-cells, resulting in viremia and varicella (chickenpox). Virus then becomes latent in cranial nerve, dorsal root and autonomic nervous system ganglia along the entire neuraxis (1). Decades later, as cell-mediated immunity to VZV declines (4), latent VZV can reactivate to produce zoster (shingles). Infectious VZV is present in patients with varicella or zoster, but shed of infectious virus in the absence of disease has not been shown. We previously detected VZV DNA in saliva of astronauts during and shortly after spaceflight, suggesting stress induced subclinical virus reactivation (3). We show here that VZV DNA as well as infectious virus in present in astronaut saliva. VZV DNA was detected in saliva during and after a 13-day spaceflight in 2 of 3 astronauts (Fig. panel A). Ten days before liftoff, there was a rise in serum anti-VZV antibody in subjects 1 and 2, consistent with virus reactivation. In subject 3, VZV DNA was not detected in saliva, and there was no rise in anti-VZV antibody titer. Subject 3 may have been protected from virus reactivation by having zoster <10 years ago, which provides a boost in cell-medicated immunity to VZV (2). No VZV DNA was detected in astronaut saliva months before spaceflight, or in saliva of 10 age/sex-matched healthy control subjects sampled on alternate days for 3 weeks (88 saliva samples). Saliva taken 2-6 days after landing from all 3 subjects was cultured on human fetal lung cells (Fig. panel B). Infectious VZV was recovered from saliva of subjects 1 and 2 on the second day after landing. Virus specificity was confirmed by antibody staining and DNA analysis which showed it to be VZV of European descent, common in the US (5). Further, both antibody staining and DNA PCR demonstrated that no HSV-1 was detected in any infected culture. This is the first report of infectious VZV shedding in the absence of clinical disease. Spaceflight presents a uniquely stressful environment which includes physical isolation and confinement, anxiety, sleep deprivation, as well as exposure to increased radiation and microgravity. It is interesting that in our study, VZV and not HSV-1 reactivation was detected, since stress-induced HSV-1 reactivation has been reported (6). Future studies are needed to determine the specific inducer of VZV reactivation.

Cohrs, Randall J.↗
NASA NTRS2006

A Comprehensive Assessment of Biologicals Contained Within Commercial Airliner Cabin Air

Both culture-based and culture-independent, biomarker-targeted microbial enumeration and identification technologies were employed to estimate total microbial and viral burden and diversity within the cabin air of commercial airliners. Samples from each of twenty flights spanning three commercial carriers were collected via air-impingement. When the total viable microbial population was estimated by assaying relative concentrations of the universal energy carrier ATP, values ranged from below detection limits (BDL) to 4.1 x 106 cells/cubic m of air. The total viable microbial population was extremely low in both of Airline A (approximately 10% samples) and C (approximately 18% samples) compared to the samples collected aboard flights on Airline A and B (approximately 70% samples). When samples were collected as a function of time over the course of flights, a gradual accumulation of microbes was observed from the time of passenger boarding through mid-flight, followed by a sharp decline in microbial abundance and viability from the initiation of descent through landing. It is concluded in this study that only 10% of the viable microbes of the cabin air were cultivable and suggested a need to employ state-of-the art molecular assay that measures both cultivable and viable-but-non-cultivable microbes. Among the cultivable bacteria, colonies of Acinetobacter sp. were by far the most profuse in Phase I, and Gram-positive bacteria of the genera Staphylococcus and Bacillus were the most abundant during Phase II. The isolation of the human pathogens Acinetobacter johnsonii, A. calcoaceticus, Janibacter melonis, Microbacterium trichotecenolyticum, Massilia timonae, Staphylococcus saprophyticus, Corynebacterium lipophiloflavum is concerning, as these bacteria can cause meningitis, septicemia, and a handful of sometimes fatal diseases and infections. Molecular microbial community analyses exhibited presence of the alpha-, beta-, gamma-, and delta- proteobacteria, as well as Gram-positive bacteria, Fusobacteria, Cyanobacteria, Deinococci, Bacterioidetes, Spirochetes, and Planctomyces in varying abundance. Neisseria meningitidis rDNA sequences were retrieved in great abundance from Airline A followed by Streptococcus oralis/mitis sequences. Pseudomonas synxantha sequences dominated Airline B clone libraries, followed by those of N. meningitidis and S. oralis/mitis. In Phase II, Airline C, sequences representative of more than 113 species, enveloping 12 classes of bacteria, were retrieved. Proteobacterial sequences were retrieved in greatest frequency (58% of all clone sequences), followed in short order by those stemming from Gram-positives bacteria (31% of all clone sequences). As for overall phylogenetic breadth, Gram-positive and alpha-proteobacteria seem to have a higher affinity for international flights, whereas beta-and gamma-proteobacteria are far more common about domestic cabin air parcels in Airline C samples. Ultimately, the majority of microbial species circulating throughout the cabin airs of commercial airliners are commensal, infrequently pathogenic normal flora of the human nasopharynx and respiratory system. Many of these microbes likely originate from the oral and nasal cavities, and lungs of passengers and flight crew and are disseminated unknowingly via routine conversation, coughing, sneezing, and stochastic passing of fomites. The data documented in this study will be useful to generate a baseline microbial population database and can be utilized to develop biosensor instrumentation for monitoring microbial quality of cabin or urban air.

microbial diversity↗
NASA NTRS2007

Circulation-Enhancing Device Improves CPR

Advanced Circulatory Systems, Inc. and NASA's Kennedy Space Center collaborated for five years on impedance threshold device technology. The resulting technology is encapsulated in a device called the ResQPOD Circulatory Enhancer, which improves the standard of care provided to patients with a variety of clinical conditions due to low blood flow. ResQPOD generates negative intrathoracic pressure during respiration to increase blood flow to the body's vital organs. It is unique in that it non-invasively enhances the body's biophysical performance without depending on pharmaceutical or other outside agents. ResQPOD uses the relationship of the heart, brain, lungs and chest cavity in a manner similar to a bellows to increase venous blood return to the heart. Multiple studies have shown a significant improvement in cardiac output and blood flow to the brain with the use of the impedance threshold device, as well as the device's ability to prevent shock secondary to blood loss. ResQPOD has been added to the set of medical equipment that is available for returning astronaut crews, and commercial applications have fallen into two categories: Non-spontaneously breathing patients who can benefit from enhanced circulation, and spontaneously breathing patients who suffer from transient hypotension or low blood pressure.

Source record↗
NASA NTRS2004

Proton-transfer-reaction/ion-mobility-spectrometer and method of using the same

A high-pressure hollow cathode ionizer is combined with an ion-mobility-spectrometer (IMS) for the detection of trace amounts of organic compounds in gas. The ionizer uses H.sub.3 0.sup.+, ions which do not react with air to ionize the organic compounds and the organic compounds are soft ionized. The ionized organic compounds are detected in the IMS at levels of parts per billion and identified using calibrated reference tables. Applications include but are not limited to the fields of: (1) medicine as a breath analyzer for detection of lung cancer, diabetes, liver cirrhosis, (2) law enforcement in drug interdiction and explosives detection, (3) food monitoring and control, (4) environmental monitoring and (5) space applications.

Kanik, Isik↗
NASA NTRS2008

Description of the NASA Hypobaric Decompression Sickness Database (1982-1998)

The availability of high-speed computers, data analysis software, and internet communication are compelling reasons to describe and make available computer databases from many disciplines. Methods: Human research using hypobaric chambers to understand and then prevent decompression sickness (DCS) during space walks has been conducted at the Johnson Space Center (JSC) from 1982 to 1998. The data are archived in the NASA Hypobaric Decompression Sickness Database, within an Access 2003 Relational Database. Results: There are 548 records from 237 individuals that participated in 31 unique tests. Each record includes physical characteristics, the denitrogenation procedure that was tested, and the outcome of the test, such as the report of a DCS symptom and the intensity of venous gas emboli (VGE) detected with an ultrasound Doppler bubble detector as they travel in the venous blood along the pulmonary artery on the way to the lungs. We documented 84 cases of DCS and 226 cases where VGE were detected. The test altitudes were 10.2, 10.1, 6.5, 6.0, and 4.3 pounds per square inch absolute (psia). 346 records are from tests conducted at 4.3 psia, the operating pressure of the current U.S. space suit. 169 records evaluate the Staged 10.2 psia Decompression Protocol used by the Space Shuttle Program. The mean exposure time at altitude was 242.3 minutes (SD = 80.6), with a range from 120 to 360 minutes. Among our test subjects, 96 records of exposures are females. The mean age of all test subjects was 31.8 years (SD = 7.17), with a range from 20 to 54 years. Discussion: These data combined with other published databases and evaluated with metaanalysis techniques would extend our understanding about DCS. A better understanding about the cause and prevention of DCS would benefit astronauts, aviators, and divers.

Wessel, J. H., III↗
NASA NTRS2009

Understanding the Potential Toxic Properties of Lunar Dust

Lunar dust causes a variety of problems for spacecraft. It can obscure vision, clog equipment, cause seal failures and abrade surfaces. Additionally, lunar dust is potentially toxic and therefore hazardous to astronauts. Lunar dust can be activated by meteorites, UV radiation and elements of solar wind and, if inhaled, could produce reactive species in the lungs (freshly fractured quartz). Methods of lunar dust deactivation must be determined before new lunar missions. This requires knowledge of how to reactivate lunar dust on Earth - thus far crushing/grinding, UV activation and heating have been tested as activation methods. Grinding of lunar dust leads to the production of hydroxyl radicals in solution and increased dissolution of lunar simulant in buffers of different pH. Decreases in pH lead to increased lunar simulant leaching. Additionally, both ground and unground lunar simulant and unground quartz have been shown to promote the production of IL-6 and IL-8, pro-inflammatory cytokines, by alveolar epithelial cells. The results suggest the need for further studies on lunar dust and simulants prior to returning to the lunar surface.

Source record↗
NASA NTRS2009

The Elephant in the Room: Biomedical Challenges for Long Duration Lunar Habitation

This slide presentation reviews 4 biomedical challenges that are involved in long duration lunar habitation: dust, radiation, hypogravity and synergistic effects. The first two of these challenges are reviewed with more in-depth information. The dangers of dust relate to the particle deposition in the lungs. The dangers of radiation are related to the permissible exposure limit (PEL) and the Risk of Exposure Induced Death (REID), a statistical approach pegged to a single radiation effect: Death from cancer directly attributable to the exposure. There has been a realization that radiation is more harmful than predicted. This is demonstrated by showing the change in the recommended career dose limits, have changed between 1989 and 2000.

Logan, James S.↗